C-MET as a new therapeutic target for the development of novel anticancer drugs (original) (raw)
Benvenuti S, Comoglio PM (2007) The MET receptor tyrosine kinase in invasion and metastasis. J Cell Physiol 213:316–325 ArticlePubMedCAS Google Scholar
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF (2003) Met, metastasis, motility and more. Nat Rev Mol Cell Biol 4:915–925 ArticlePubMedCAS Google Scholar
Trusolino L, Comoglio PM (2002) Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat Rev Cancer 2:289–300 ArticlePubMedCAS Google Scholar
Peschard P, Fournier TM, Lamorte L et al (2001) Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell 8:995–1004 ArticlePubMedCAS Google Scholar
Abella JV, Peschard P, Naujokas MA et al (2005) Met/hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Mol Cell Biol 25:9632–9645 ArticlePubMedCAS Google Scholar
Stoker M, Gherardi E, Perryman M, Gray J (1987) Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 327:239–242 ArticlePubMedCAS Google Scholar
Gherardi E, Gray J, Stoker M et al (1989) Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement. Proc Natl Acad Sci U S A 86:5844–5848 ArticlePubMedCAS Google Scholar
Nakamura T, Teramoto H, Ichihara A (1986) Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures. Proc Natl Acad Sci U S A 83:6489–6493 ArticlePubMedCAS Google Scholar
Naldini L, Weidner KM, Vigna E et al (1991) Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. Embo J 10:2867–2878 PubMedCAS Google Scholar
Comoglio PM, Giordano S, Trusolino L (2008) Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat Rev Drug Discov 7:504–516 ArticlePubMedCAS Google Scholar
Stamos J, Lazarus RA, Yao X (2004) Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. Embo J 23: 2325–2335 ArticlePubMedCAS Google Scholar
Zhang YW, Vande Woude GF (2003) HGF/SF-met signaling in the control of branching morphogenesis and invasion. J Cell Biochem 88:408–417 ArticlePubMedCAS Google Scholar
Corso S, Comoglio PM, Giordano S (2005) Cancer therapy: can the challenge be MET? Trends Mol Med 11:284–292 ArticlePubMedCAS Google Scholar
Boccaccio C, Comoglio PM (2006) Invasive growth: a MET-driven genetic programme for cancer and stem cells. Nat Rev Cancer 6:637–645 ArticlePubMedCAS Google Scholar
Eder JP, Vande Woude GF, Boerner SA, LoRusso PM (2009) Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin Cancer Res 15:2207–2214 ArticlePubMedCAS Google Scholar
Zeng Q, Chen S, You Z et al (2002) Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B. J Biol Chem 277:25203–25208 ArticlePubMedCAS Google Scholar
Tulasne D, Foveau B (2008) The shadow of death on the MET tyrosine kinase receptor. Cell Death Differ 15:427–434 ArticlePubMedCAS Google Scholar
Migliore C, Giordano S (2008) Molecular cancer therapy: can our expectation be MET? Eur J Cancer 44:641–651 ArticlePubMedCAS Google Scholar
Birchmeier C, Gherardi E (1998) Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase. Trends Cell Biol 8:404–410 ArticlePubMedCAS Google Scholar
Schmidt L, Duh FM, Chen F et al (1997) Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet 16:68–73 ArticlePubMedCAS Google Scholar
Maina F, Casagranda F, Audero E et al (1996) Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell 87:531–542 ArticlePubMedCAS Google Scholar
Maina F, Pante G, Helmbacher F et al (2001) Coupling Met to specific pathways results in distinct developmental outcomes. Mol Cell 7:1293–1306 ArticlePubMedCAS Google Scholar
Huh CG, Factor VM, Sanchez A (2004) Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A 101:4477–4482 ArticlePubMedCAS Google Scholar
Iyer A, Kmiecik TE, Park M et al (1990) Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene. Cell Growth Differ 1:87–95 PubMedCAS Google Scholar
Christensen JG, Burrows J, Salgia R (2005) c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention. Cancer Lett 225:1–26 ArticlePubMedCAS Google Scholar
Zhang YW, Su Y, Volpert OV, Vande Woude GF (2003) Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation. Proc Natl Acad Sci U S A 100:12718–12723 ArticlePubMedCAS Google Scholar
Cooper CS, Park M, Blair DG et al (1984) Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 311:29–33 ArticlePubMedCAS Google Scholar
Liang TJ, Reid AE, Xavier R (1996) Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors. J Clin Invest 97:2872–2877 ArticlePubMedCAS Google Scholar
Soman NR, Correa P, Ruiz BA, Wogan GN (1991) The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions. Proc Natl Acad Sci U S A 88:4892–4896 ArticlePubMedCAS Google Scholar
Smolen GA, Sordella R, Muir B et al (2006) Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proc Natl Acad Sci U S A 103:2316–2321 ArticlePubMedCAS Google Scholar
Engelman JA, Zejnullahu K, Mitsudomi T et al (2007) MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316:1039–1043 ArticlePubMedCAS Google Scholar
Carracedo A, Egervari K, Salido M et al (2009) FISH and immunohistochemical status of the hepatocyte growth factor receptor (c-Met) in 184 invasive breast tumors. Breast Cancer Res 11:402 ArticlePubMedCAS Google Scholar
Taulli R, Scuoppo C, Bersani F et al (2006) Validation of met as a therapeutic target in alveolar and embryonal rhabdomyosarcoma. Cancer Res 66:4742–4749 ArticlePubMedCAS Google Scholar
Houldsworth J, Cordon-Cardo C, Ladanyi M et al (1990) Gene amplification in gastric and esophageal adenocarcinomas. Cancer Res 50:6417–6422 PubMedCAS Google Scholar
Umeki K, Shiota G, Kawasaki H (1999) Clinical significance of c-met oncogene alterations in human colorectal cancer. Oncology 56:314–321 ArticlePubMedCAS Google Scholar
Bean J, Brennan C, Shih JY et al (2007) MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 104:20932–20937 ArticlePubMed Google Scholar
Tong CY, Hui AB, Yin XL (2004) Detection of oncogene amplifications in medulloblastomas by comparative genomic hybridization and arraybased comparative genomic hybridization. J Neurosurg 100:187–193 PubMedCAS Google Scholar
Beroukhim R, Getz G, Nghiemphu L et al (2007) Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci U S A 104:20007–20012 ArticlePubMed Google Scholar
Cappuzzo F, Marchetti A, Skokan M et al (2009) Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J Clin Oncol 27:1667–1674 ArticlePubMed Google Scholar
Go H, Jeon YK, Park HJ et al (2010) High MET gene copy number leads to shorter survival in patients with non-small cell lung cancer. J Thorac Oncol 5(3):305–313 ArticlePubMed Google Scholar
Zeng ZS, Weiser MR, Kuntz E et al (2008) c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer Lett 265:258–269 ArticlePubMedCAS Google Scholar
Park WS, Dong SM, Kim SY et al (1999) Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas. Cancer Res 59:307–310 PubMedCAS Google Scholar
Lee JH, Han SU, Cho H et al (2000) A novel germ line juxtamembrane Met mutation in human gastric cancer. Oncogene 19:4947–4953 ArticlePubMedCAS Google Scholar
Seiwert TY, Jagadeeswaran R, Faoro L et al (2009) The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res 69:3021–3031 ArticlePubMedCAS Google Scholar
Sattler M, Salgia R (2007) c-Met and hepatocyte growth factor: potential as novel targets in cancer therapy. Curr Oncol Rep 9:102–108 ArticlePubMedCAS Google Scholar
Ma PC, Kijima T, Maulik G et al (2003) c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res 63:6272–6281 PubMedCAS Google Scholar
Ma PC, Jagadeeswaran R, Jagadeesh S et al (2005) Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res 65:1479–1488 ArticlePubMedCAS Google Scholar
Jagadeeswaran R, Ma PC, Seiwert TY et al (2006) Functional analysis of c-Met/hepatocyte growth factor pathway in malignant pleural mesothelioma. Cancer Res 66:352–361 ArticlePubMedCAS Google Scholar
Puri N, Ahmed S, Janamanchi V et al (2007) c-Met is a potentially new therapeutic target for treatment of human melanoma. Clin Cancer Res 13:2246–2253 ArticlePubMedCAS Google Scholar
Puri N, Khramtsov A, Ahmed S et al (2007) A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angio genesis in mouse lung cancer xenografts. Cancer Res 67:3529–3534 ArticlePubMedCAS Google Scholar
Jeffers M, Schmidt L, Nakaigawa N et al (1997) Activating mutations for the met tyrosine kinase receptor in human cancer. Proc Natl Acad Sci U S A 94:11445–11450 ArticlePubMedCAS Google Scholar
Kong-Beltran M, Seshagiri S, Zha J et al (2006) Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res 66:283–289 ArticlePubMedCAS Google Scholar
Graveel C, Su Y, Koeman J et al (2004) Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele. Proc Natl Acad Sci U S A 101:17198–17203 ArticlePubMedCAS Google Scholar
Di Renzo MF, Olivero M, Martone T et al (2000) Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas. Oncogene 19:1547–1555 ArticlePubMedCAS Google Scholar
Aebersold DM, Landt O, Berthou S et al (2003) Prevalence and clinical impact of Met Y1253Dactivating point mutation in radiotherapy-treated squamous cell cancer of the oropharynx. Oncogene 22:8519–8523 ArticlePubMedCAS Google Scholar
Lorenzato A, Olivero M, Patane S et al (2002) Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion. Cancer Res 62:7025–7030 PubMedCAS Google Scholar
Cañadas I, Arumi M, Lema L et al (2009) MET in small cell lung carcinoma (SCLC): effects of a MET inhibitor in SCLC cell lines and prognostic role of MET status in patients. J Clin Oncol (ASCO Meeting Abstracts) 27:e14617 Google Scholar
Danilkovitch-Miagkova A, Zbar B (2002) Dysregulation of Met receptor tyrosine kinase activity in invasive tumors. J Clin Invest 109:863–867 PubMedCAS Google Scholar
Ichimura E, Maeshima A, Nakajima T, Nakamura T (1996) Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance. Jpn J Cancer Res 87:1063–1069 PubMedCAS Google Scholar
Cipriani NA, Abidoye OO, Vokes E, Salgia R (2009) MET as a target for treatment of chest tumors. Lung Cancer 63:169–179 ArticlePubMed Google Scholar
Garcia S, Dales JP, Charafe-Jauffret E et al (2007) Poor prognosis in breast carcinomas correlates with increased expression of targetable CD146 and c-Met and with proteomic basal-like phenotype. Hum Pathol 38:830–841 ArticlePubMedCAS Google Scholar
Olivero M, Rizzo M, Madeddu R et al (1996) Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas. Br J Cancer 74:1862–1868 PubMedCAS Google Scholar
Takanami I, Tanana F, Hashizume T et al (1996) Hepatocyte growth factor and c-Met/hepatocyte growth factor receptor in pulmonary adenocarcinomas: an evaluation of their expression as prognostic markers. Oncology 53:392–397 ArticlePubMedCAS Google Scholar
Tsao MS, Liu N, Chen JR et al (1998) Differential expression of Met/hepatocyte growth factor receptor in subtypes of non-small cell lung cancers. Lung Cancer 20:1–16 ArticlePubMedCAS Google Scholar
Natali PG, Prat M, Nicotra MR et al (1996) Overexpression of the met/HGF receptor in renal cell carcinomas. Int J Cancer 69:212–217 ArticlePubMedCAS Google Scholar
Di Renzo MF, Olivero M, Katsaros D et al (1994) Overexpression of the Met/HGF receptor in ovarian cancer. Int J Cancer 58:658–662 ArticlePubMed Google Scholar
Wong AS, Pelech SL, Woo MM et al (2001) Coexpression of hepatocyte growth factor-Met: an early step in ovarian carcinogenesis? Oncogene 20:1318–1328 ArticlePubMedCAS Google Scholar
Garcia S, Dales JP, Jacquemier J et al (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. Br J Cancer 96:329–335 ArticlePubMedCAS Google Scholar
Takeuchi H, Bilchik A, Saha S et al (2003) c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases. Clin Cancer Res 9:1480–1488 PubMedCAS Google Scholar
Sawada K, Radjabi AR, Shinomiya N et al (2007) c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Res 67:1670–1679 ArticlePubMedCAS Google Scholar
Tolgay Ocal I, Dolled-Filhart M, D’Aquila TG et al (2003) Tissue microarray-based studies of patients with lymph node negative breast carcinoma show that met expression is associated with worse outcome but is not correlated with epidermal growth factor family receptors. Cancer 97:1841–1848 ArticlePubMedCAS Google Scholar
Gentile A, Trusolino L, Comoglio PM (2008) The Met tyrosine kinase receptor in development and cancer. Cancer Metastasis Rev 27:85–94 ArticlePubMedCAS Google Scholar
Boccaccio C, Gaudino G, Gambarotta G et al (1994) Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF. J Biol Chem 269:12846–12851 PubMedCAS Google Scholar
Aguirre Ghiso JA, Alonso DF, Farias EF et al (1999) Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype. Eur J Biochem 263:295–304 ArticlePubMedCAS Google Scholar
Michieli P, Basilico C, Pennacchietti S et al (1999) Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists. Oncogene 18:5221–5231 ArticlePubMedCAS Google Scholar
Koochekpour S, Jeffers M, Rulong S et al (1997) Met and hepatocyte growth factor/scatter factor expression in human gliomas. Cancer Res 57:5391–5398 PubMedCAS Google Scholar
Tuck AB, Park M, Sterns EE et al (1996) Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma. Am J Pathol 148:225–232 PubMedCAS Google Scholar
Ferracini R, Olivero M, Di Renzo MF et al (1996) Retrogenic expression of the MET proto-oncogene correlates with the invasive phenotype of human rhabdomyosarcomas. Oncogene 12:1697–1705 PubMedCAS Google Scholar
Ferracini R, Di Renzo MF, Scotlandi K et al (1995) The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. Oncogene 10:739–749 PubMedCAS Google Scholar
Rong S, Segal S, Anver M et al (1994) Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation. Proc Natl Acad Sci U S A 91:4731–4735 ArticlePubMedCAS Google Scholar
Lokker NA, Mark MR, Luis EA et al (1992) Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding. Embo J 11:2503–2510 PubMedCAS Google Scholar
Lietha D, Chirgadze DY, Mulloy B et al (2001) Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor. Embo J 20:5543–5555 ArticlePubMedCAS Google Scholar
Matsumoto K, Kataoka H, Date K, Nakamura T (1998) Cooperative interaction between alpha- and beta-chains of hepatocyte growth factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses. J Biol Chem 273:22913–22920 ArticlePubMedCAS Google Scholar
Trusolino L, Pugliese L, Comoglio PM (1998) Interactions between scatter factors and their receptors: hints for therapeutic applications. Faseb J 12:1267–1280 PubMedCAS Google Scholar
Chan AM, Rubin JS, Bottaro DP et al (1991) Identification of a competitive HGF antagonist encoded by an alternative transcript. Science 254: 1382–1385 ArticlePubMedCAS Google Scholar
Montesano R, Soriano JV, Malinda KM (1998) Differential effects of hepatocyte growth factor isoforms on epithelial and endothelial tubulogenesis. Cell Growth Differ 9:355–365 PubMedCAS Google Scholar
Matsumoto K, Nakamura T (2003) NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics. Cancer Sci 94:321–327 ArticlePubMedCAS Google Scholar
Matsumoto K, Nakamura T (2008) NK4 gene therapy targeting HGF-Met and angiogenesis. Front Biosci 13:1943–1951 ArticlePubMedCAS Google Scholar
Mazzone M, Basilico C, Cavassa S et al (2004) An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice. J Clin Invest 114:1418–1432 PubMedCAS Google Scholar
Michieli P, Mazzone M, Basilico C et al (2004) Targeting the tumor and its microenvironment by a dual-function decoy Met receptor. Cancer Cell 6:61–73 ArticlePubMedCAS Google Scholar
Kong-Beltran M, Stamos J, Wickramasinghe D (2004) The Sema domain of Met is necessary for receptor dimerization and activation. Cancer Cell 6:75–84 ArticlePubMedCAS Google Scholar
Martens T, Schmidt NO, Eckerich C et al (2006) A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo. Clin Cancer Res 12:6144–6152 ArticlePubMedCAS Google Scholar
Petrelli A, Circosta P, Granziero L et al (2006) Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity. Proc Natl Acad Sci U S A 103:5090–5095 ArticlePubMedCAS Google Scholar
Kim KJ, Wang L, Su YC et al (2006) Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts. Clin Cancer Res 12:1292–1298 ArticlePubMedCAS Google Scholar
Jun HT, Sun J, Rex K (2007) AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts. Clin Cancer Res 13:6735–6742 ArticlePubMedCAS Google Scholar
Morotti A, Mila S, Accornero P, et al (2002) K252a inhibits the oncogenic properties of Met, the HGF receptor. Oncogene 21:4885–4893 ArticlePubMedCAS Google Scholar
Sattler M, Pride YB, Ma P et al (2003) A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res 63:5462–5469 PubMedCAS Google Scholar
Christensen JG, Schreck R, Burrows J et al (2003) A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. Cancer Res 63:7345–7355 PubMedCAS Google Scholar
Berthou S, Aebersold DM, Schmidt LS et al (2004) The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants. Oncogene 23:5387–5393 ArticlePubMedCAS Google Scholar
Zou HY, Li Q, Lee JH et al (2007) An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res 67:4408–4417 ArticlePubMedCAS Google Scholar
Zhang Y, Guessous F, Kofman A et al (2010) XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC. IDrugs 13:112–121 PubMed Google Scholar
Welsh JW, Mahadevan D, Ellsworth R et al (2009) The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells. Radiat Oncol 4:69 ArticlePubMedCAS Google Scholar
Buchanan SG, Hendle J, Lee PS et al (2009) SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol Cancer Ther 8:3181–3190 ArticlePubMedCAS Google Scholar