Manish Mishra | Mahatama Gandhi Chitrakoot Gramodaya Vishwavidhyalay Chitrakoot , Satna, Madhya Pradesh, India (original) (raw)

Papers by Manish Mishra

score given by three experts. Score was recorded in points out of 30. Design of Study: The Correl... more score given by three experts. Score was recorded in points out of 30. Design of Study: The Correlational design was used for the study. A single group of units of analysis was obtained preferably randomly; each individual was measured on Reaction Ability and Raider’s performance at more or less the same time. Statistical Analysis: To find out the correlation between Raider’s Performance and Reaction Ability, Product Moment Method of Correlation was used. To estimate Raider’s Performance on the basis of Reaction Ability, Linear Regression Equation was established. Conclusions: Significant relationship was found between Raider’s Performance and Reaction Ability. Regression model for estimating Raider’s performance on the basis of Reaction Ability is: RP = 66.978-.435X. Where: RP= Raider’s Performance & X= Reaction Ability. Key words: Raider’s Performance, Reaction Ability Abstract male Kabaddi Player who participated in Inter-University Kabaddi Championship were selected as the subjects for the study. Age of the subjects was ranging from 18 to 25 years. Objectives: The objective of the study was to find out the correlation between Raider’s Performance in Kabaddi and Reaction Ability. The second objective of the study was to establish a regression equation to estimate Raider’s Performance in Kabaddi on the basis of Reaction Ability. Subjects: For the purpose of the study, 30 Variables: Keeping in the mind about specific purpose of the study, Dependent Variable was Raider’s Performance in kabaddi & Independent Variable was Reaction Ability Criterion Measures: Reaction Ability was measured by Ball Reaction Exercise Test and was recorded in Centimeters. Raider’s performance was measured by the pannel of three experts during the Game. Each expert awarded score out of 10 points. Final score was the addition of

Abstract
male Kabaddi Player who participated in Inter-University Kabaddi Championship were selected as the subjects for the study. Age of the subjects was ranging from 18 to 25 years. Objectives: The objective of the study was to find out the correlation between Raider’s Performance in Kabaddi and Reaction Ability. The second objective of the study was to establish a regression equation to estimate Raider’s Performance in Kabaddi on the basis of Reaction Ability.
Subjects: For the purpose of the study, 30
Variables: Keeping in the mind about specific purpose of the study, Dependent Variable was Raider’s Performance in kabaddi & Independent Variable was Reaction Ability
Criterion Measures: Reaction Ability was measured by Ball Reaction Exercise Test and was recorded in Centimeters. Raider’s performance was measured by the pannel of three experts during the Game. Each expert awarded score out of 10 points. Final score was the addition of

Natural resources are not unlimited. Some indigenous plants in different regions have already bec... more Natural resources are not unlimited. Some indigenous plants in different regions have already become extinct. G. superba linn. is a commercially imperative medicinal plant which has diverse medicinal applications and eventually due to over-exploitation this plant is facing local extinction. A perusal of the literature shows that G. superba linn. has been widely used for diseases. A number of pharmacologically important phytochemicals such as gloriosine and colchicines have been isolated from this plant. On the behalf of previous reports based on this plant we can say how this plant and their contents are important. So the conservation of this plant very important. Cultivation may not be solution to save and at the

52. Mishra,M. (2011).Immature collection of Baibirang (Embelia tsejaram-cottam) fruits and its im... more 52. Mishra,M. (2011).Immature collection of Baibirang (Embelia tsejaram-cottam) fruits and its impact on raw material quality: a case of Katni district, Madhya Pradesh. Life Sciences Leaflets. 12 : 384-395.

Gulbakawali (Hedychium coronarium J.König) belongs to family Zingiberaceae, is a rhizomatous herb... more Gulbakawali (Hedychium coronarium J.König) belongs to family Zingiberaceae, is a rhizomatous herb widely used in India as an febrifuge, eye tonic, anti-rheumatic, anthelmintic and mild tranquilizer in various Ayurvedic medicines. Over-exploitation of its rhizome for medicinal uses and consequent degradation of its natural habitat are reported to be the major threats to this plant. The herb is restricted to Anuppur, Amarkantak region including Chhattisgarh state, India. The results revealed that plant density (2 plant/ha.) and regeneration (< 1/ ha.) in protected areas (Achanakmar-Amarkantak Biosphere Reserve) were found low. On the contrary, in the natural forests the plant population was observed very poor (Avg.0.62/ha.). Almost nil regeneration was observed in the open natural forests of Anuppur and Dindori districts. The major causes for population decline in the study area are habitat destruction, complete uprooting of plants, immature harvesting and increased market demand o...

Life sciences

Mishra, M. Jadhav, P A and M. Shrivastava (2014). Non timber forest products utilization during a... more Mishra, M. Jadhav, P A and M. Shrivastava (2014). Non timber forest products utilization during adverse climatic conditions: a case of Saora tribes of Ganjam district, Odisha. Life Sciences Leaflets. Volume No. 54: 68 to 77.

Publications: (1). Adarsh VK, M Mishra, S. Chowdhury, M Sudarshan, A R Thakur and S Ray Chaudhuri... more Publications: (1). Adarsh VK, M Mishra, S. Chowdhury, M Sudarshan, A R Thakur and S Ray Chaudhuri. Studies on metal microbe interaction of three bacterial isolates from East Calcutta Wetland. Online Journal of Biological Sciences. (2). Chowdhury, S., M Mishra, Adarsh VK, A Mukherjee, A R Thakur and S Ray Chaudhuri. Novel metal accumulator and protease secretor microbes from East Calcutta Wetland, American Journal of Biochemistry and Biotechnology.

In this study, we established some common fixed point theorems for occasionally weakly compatible... more In this study, we established some common fixed point theorems for occasionally weakly compatible mappings in fuzzy metric spaces satisfying integral type inequality.

We obtained fixed point theorem on three metric spaces satisfying integral type inequality.

In this note, a general common fixed point theorem of integral type for two pair of w eakly compa... more In this note, a general common fixed point theorem of integral type for two pair of w eakly compatible mapping satisfying integral type implicit relations is obtained in M-fuzzy metric space.

Journal of the American Chemical Society, Jan 20, 2015

An elastic organic crystal, 2,6-dichlorobenzylidine-4-fluoro-3-nitroaniline (DFNA), which also sh... more An elastic organic crystal, 2,6-dichlorobenzylidine-4-fluoro-3-nitroaniline (DFNA), which also shows thermosalient behavior, is studied. The presence of these two distinct properties in the same crystal is unusual and unprecedented because they follow respectively from isotropy and anisotropy in the crystal packing. Therefore, and while both properties lead from the crystal structure, the mechanisms for bending and thermosalience are quite independent of one another. Crystals of the low temperature () form of the title compound are bent easily without any signs of fracture with the application of deforming stress, and this bending is within the elastic limit. The crystal structure of the -form was determined (P21/c, Z=4, a= 3.927(7) Å, b= 21.98(4) Å, c=15.32(3) Å). There is an irreversible phase transition at 138 °C of this form to the high temperature -form followed by melting at 140 °C. Variable temperature X-ray powder diffraction was used to investigate the structural changes...

Chemistry - An Asian Journal, 2015

The variation of hardness as a function of the number of carbon atoms in α,ω-alkanedicarboxylic a... more The variation of hardness as a function of the number of carbon atoms in α,ω-alkanedicarboxylic acids, CN H2N-2 O4 (4≤N≤9), was examined by recourse to nanoindentation on the major faces of single crystals. Hardness exhibits odd-even alternation, with the odd acids being softer and the even ones harder; the differences decrease with increasing chain length. These variations are similar to those seen for other mechanical, physical, and thermal properties of these diacids. The softness of odd acids is rationalized due to strained molecular conformations in them, which facilitate easier plastic deformation. Relationships between structural features, such as interplanar spacing, interlayer separation distance, molecular chain length, and signatures of the nanoindentation responses, namely, discrete displacement bursts, were also examined. Shear sliding of molecular layers past each other during indentation is key to the mechanism for plastic deformation in these organic crystals.

Ecoprint: An International Journal of Ecology, 2010

MANAGEMENT,(MOEF),NEHRU NAGAR, POST BOX NO.357, BHOPAL (M.P.) INDIA.

Molecular Pharmaceutics, 2015

Crystals of voriconazole, an antifungal drug, are 9 soft in nature, and this is disadvantageous d... more Crystals of voriconazole, an antifungal drug, are 9 soft in nature, and this is disadvantageous during compaction 10 studies where pressure is applied on the solid. Crystal 11 engineering is used to make cocrystals and salts with modified 12 mechanical properties (e.g., hardness). Cocrystals with bio- 13 logically safe coformers such as fumaric acid, 4-hydroxybenzoic 14 acid, and 4-aminobenzoic acid and salts with hydrochloric acid 15 and oxalic acid are prepared through solvent assisted grinding. 16 The presence (salt) or absence (cocrystal) of proton transfer 17 in these multicomponent crystals is unambiguously confirmed 18 with single crystal X-ray diffraction. All the cocrystals have 1:1 19 stoichiometry, whereas salts exhibit variable stoichiometries 20 such as HCl salt (1:2) and oxalate salts (1:1.5 and 1:1). The nanoindentation technique was applied on single crystals of the salts 21 and cocrystals. The salts exhibit better hardness than the drug and cocrystals in the order salts ≫ drug > cocrystals. The 22 molecular origin of this mechanical modulation is explained on the basis of slip planes in the crystal structure and relative 23 orientations of the molecules with respect to the nanoindentation direction. The hydrochloride salt is the hardest solid in this 24 family. This may be useful for tableting of the drug during formulation and in drug development. 25 27 Crystal engineering 1 is widely utilized in designing active 28 pharmaceutical ingredients (APIs) so as to obtain materials that 29 exhibit optimum combinations of important physicochemical 30 properties such as solubility, dissolution rate, and bioavail-31 ability. 2 In the context of industrial-scale pharmaceutical 32 manufacturing, it can also be used to tune mechanical 33 properties such as grindability and tabletability, which often 34 determine the processing steps that are adopted. For example, s1 35 voriconazole (VOR, Scheme 1), which is the compound 36 examined in the current study, is so soft that it becomes a paste 37 during grinding and/or milling 3 processes that are commonly 38 employed during the production stages of APIsconsequently 39 making it unwieldy. To circumvent this problem, regelatinized 40 starch maize is being used to make compressed tablets during 41 formulation of the drug. In this paper, we demonstrate that the 42 mechanical properties of VOR cocrystals, especially hardness, a 43 property that captures a material's resistance to plastic 44 deformation, can be varied systematically, and to the desired 45 levels, by varying the coformer content. 46 Although prior studies on the mechanical properties of 47 cocrystals 4 are available, most of those are performed on 48 polycrystalline aggregates. The key feature of the current paper 49 is the utilization of the nanoindentation technique to study the 50 properties of single crystals of VOR and its salts and cocrystals. 51 This technique allows for measuring the mechanical response 52 of materials that are available only in small sizes; this has been 53 exploited in the recent past to study structure−property 54 correlations in molecular crystals. 5 In particular, fundamental 55 understanding of the influence exerted by structural features 56 such as crystal packing, 5a strength of intermolecular inter-57 actions, 5d domain coexistence, 5b,h polymorphism, 5f layer 58 migration, 5e and solid state reactivity on mechanical properties 59 such as stiffness and strength 5c,g can be explored through 60 nanoindentation studies. In the current context, employing 61 nanoindentation not only allows us to study mechanical 62 properties of cocrystals but (and more importantly) also allows 63 us to correlate the measured changes in properties with the 64 underlying structural features in the context of cocrystal 65 engineering. It is expected that such an understanding will 66 enhance the predictability of powder processing steps such as 67 milling and compaction, which otherwise require large

Biochimica et biophysica acta, Jan 4, 2015

Diabetes has emerged as an epidemic of the 21st century, and retinopathy remains the leading caus... more Diabetes has emerged as an epidemic of the 21st century, and retinopathy remains the leading cause of blindness in young adults and the mechanism of this blinding disease remains evasive. Diabetes-induced metabolic abnormalities have been identified, but a causal relationship between any specific abnormality and the development of this multi-factorial disease is unclear. Reactive oxygen species (ROS) are increased and the antioxidant defense system is compromised. Increased ROS result in retinal metabolic abnormalities, and these metabolic abnormalities can also produce ROS. Sustained exposure to ROS damages the mitochondria and compromises the electron transport system (ETC), and mitochondrial DNA (mtDNA) is damaged. Damaged mtDNA impairs its transcription, and the vicious cycle of ROS continues to propagate. Many genes important in generation and neutralization of ROS are also epigenetically modified further increasing ROS, and the vicious cycle continues to fuel in. Antioxidants ...

Journal of the American Chemical Society, 2015

In the context of processing of molecular solids, especially pharmaceuticals, hardness is an impo... more In the context of processing of molecular solids, especially pharmaceuticals, hardness is an important property that often determines the manufacturing steps employed. Through nanoindentation studies on a series of omeprazole polymorphs, in which the proportions of the 5-and 6-methoxy tautomers vary systematically, we demonstrate that solid-solution strengthening can be effectively employed to engineer the hardness of organic solids. High hardness can be attained by increasing lattice resistance to shear sliding of molecular layers during plastic deformation. Figure 1. Tautomeric forms of omeprazole.

SpringerPlus, 2015

Batch experiments were conducted to study the sorption of uranium (U) onto soil in deionised wate... more Batch experiments were conducted to study the sorption of uranium (U) onto soil in deionised water as a function of its dosage, temperature and humic acid (HA). Furthermore, soils were characterized for particle sizes in the form of sand (>63 µm), silt (>2-<63 µm) and clay (<2 µm). The textural analysis revealed that soils were admixture of mainly sand and silt along with a small abundance of clay. X-ray diffraction analysis indicates that clay factions ranging from 2.8 to 5% dominated by quartz and montmorillonite. Experimental results indicated that soil with high abundance of clays and low sand content has relatively high U sorption which could be due to availability of high exchange surfaces for metal ions. However, at low concentration of HA, sorption of U was maximum and thereby decreased as the HA concentration increased. The maximum sorption may be due to increase in the negative active surface sites on HA and further decrease could be attributed to saturation of sorption site and surface precipitation. Conversely, the thermodynamic data suggested that the sorption is spontaneous and enhanced at higher temperature.

Angewandte Chemie, 2014

Intergrowth polymorphism refers to the existence of distinct structural domains within a single c... more Intergrowth polymorphism refers to the existence of distinct structural domains within a single crystal of a compound. The phenomenon is exhibited by form II of the active pharmaceutical ingredient felodipine, and the associated microstructure is a significant feature of the compounds structural identity. Employing the technique of nanoindentation on form II reveals a bimodal mechanical response on specific single-crystal faces, demonstrating distinct properties for two polymorphic forms within the same crystal.

Progress in Retinal and Eye Research, 2015

Diabetic retinopathy remains the major cause of blindness among working age adults. Although a nu... more Diabetic retinopathy remains the major cause of blindness among working age adults. Although a number of metabolic abnormalities have been associated with its development, due to complex nature of this multi-factorial disease, a link between any specific abnormality and diabetic retinopathy remains largely speculative. Diabetes increases oxidative stress in the retina and its capillary cells, and overwhelming evidence suggests a bidirectional relationship between oxidative stress and other major metabolic abnormalities implicated in the development of diabetic retinopathy. Due to increased production of cytosolic reactive oxygen species, mitochondrial membranes are damaged and their membrane potentials are impaired, and complex III of the electron transport system is compromised. Suboptimal enzymatic and nonenzymatic antioxidant defense system further aids in the accumulation of free radicals. As the duration of the disease progresses, mitochondrial DNA (mtDNA) is damaged and the DNA repair system is compromised, and due to impaired transcription of mtDNA-encoded proteins, the integrity of the electron transport system is encumbered. Due to decreased mtDNA biogenesis and impaired transcription, superoxide accumulation is further increased, and the vicious cycle of free radicals continues to self-propagate. Diabetic milieu also alters enzymes responsible for DNA and histone modifications, and various genes important for mitochondrial homeostasis, including mitochondrial biosynthesis, damage and antioxidant defense, undergo epigenetic modifications. Although antioxidant administration in animal models has yielded encouraging results in preventing diabetic retinopathy, controlled longitudinal human studies remain to be conducted. Furthermore, the role of epigenetic in mitochondrial homeostasis suggests that regulation of such modifications also has potential to inhibit/retard the development of diabetic retinopathy.