Alexis Komor • UCSD Profiles (original) (raw)

  1. Highly efficient expression of DNA-peptide conjugates in growth-arrested cells. Nat Commun. 2026 Jan 07; 17(1):1422. Mohamedshah ZY, Chi CC, Tota EM, Komor AC, Devaraj NK. PMID: 41501051; PMCID: PMC12881617.
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    Translation:HumansCells
  2. CTRL Enables Gene-Specific RNA Regulation Using CRISPR-Cas7-11. ACS Synth Biol. 2025 Nov 21; 14(11):4597-4605. Wang T, Brogan DJ, Zawalick NM, Chen F, Mkrtchian Y, Komor AC, Akbari OS. PMID: 41202215.
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  3. Genome editing with DNA-dependent polymerases. Nat Biotechnol. 2025 Jun; 43(6):865-867. Cowan QT, Komor AC. PMID: 39179922.
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  4. Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens. Nat Commun. 2025 May 20; 16(1):4685. Gu S, Bodai Z, Anderson RA, So HYA, Cowan QT, Komor AC. PMID: 40394064; PMCID: PMC12092667.
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    Translation:HumansCells
  5. Personalized Gene Editing to Treat an Inborn Error of Metabolism. N Engl J Med. 2025 Jun 12; 392(22):2273-2276. Gropman AL, Komor AC. PMID: 40373054.
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  6. Precision genome editing and in-cell measurements of oxidative DNA damage repair enable functional and mechanistic characterization of cancer-associated MUTYH variants. Nucleic Acids Res. 2025 Mar 20; 53(6). Vasquez CA, Osgood NRB, Zepeda MU, Sandel DK, Cowan QT, Peiris MN, Donoghue DJ, Komor AC. PMID: 40156857; PMCID: PMC11952967.
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    Translation:HumansCells
  7. Genome editing with programmable base editors in human cells. Methods Enzymol. 2025; 712:351-404. Osgood NRB, Zawalick NM, Sawyer CB, Cowan QT, Gu S, Mawson SJ, Ranzau BL, Li L, Gymrek M, Goren A, Komor AC. PMID: 40121079; PMCID: PMC11948366.
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    Translation:HumansCells
  8. Impact of CRISPR in cancer drug discovery. Science. 2024 10 25; 386(6720):378-379. Moffat J, Komor AC, Lum L. PMID: 39446947.
    View in: PubMed Mentions: 1 Fields:
    Translation:HumansAnimals
  9. Development of multiplexed orthogonal base editor (MOBE) systems. Nat Biotechnol. 2025 Apr; 43(4):593-607. Cowan QT, Gu S, Gu W, Ranzau BL, Simonson TS, Komor AC. PMID: 38773305; PMCID: PMC11579250.
    View in: PubMed Mentions: 6 Fields:
    Translation:HumansCells
  10. Functional EPAS1/HIF2A missense variant is associated with hematocrit in Andean highlanders. Sci Adv. 2024 02 09; 10(6):eadj5661. Lawrence ES, Gu W, Bohlender RJ, Anza-Ramirez C, Cole AM, Yu JJ, Hu H, Heinrich EC, O'Brien KA, Vasquez CA, Cowan QT, Bruck PT, Mercader K, Alotaibi M, Long T, Hall JE, Moya EA, Bauk MA, Reeves JJ, Kong MC, Salem RM, Vizcardo-Galindo G, Macarlupu JL, Figueroa-Mujíca R, Bermudez D, Corante N, Gaio E, Fox KP, Salomaa V, Havulinna AS, Murray AJ, Malhotra A, Powel FL, Jain M, Komor AC, Cavalleri GL, Huff CD, Villafuerte FC, Simonson TS. PMID: 38335297; PMCID: PMC10857371.
    View in: PubMed Mentions: 20 Fields:
    Translation:Humans
  11. Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies. Nat Commun. 2024 Jan 29; 15(1):875. Medina-Munoz HC, Kofman E, Jagannatha P, Boyle EA, Yu T, Jones KL, Mueller JR, Lykins GD, Doudna AT, Park SS, Blue SM, Ranzau BL, Kohli RM, Komor AC, Yeo GW. PMID: 38287010; PMCID: PMC10825223.
    View in: PubMed Mentions: 13 Fields:
    Translation:Cells
  12. Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies. bioRxiv. 2023 Sep 25. Medina-Munoz HC, Kofman E, Jagannatha P, Boyle EA, Yu T, Jones KL, Mueller JR, Lykins GD, Doudna AT, Park SS, Blue SM, Ranzau BL, Kohli RM, Komor AC, Yeo GW. PMID: 37808757; PMCID: PMC10557582.
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  13. The Wild-Type tRNA Adenosine Deaminase Enzyme TadA Is Capable of Sequence-Specific DNA Base Editing. Chembiochem. 2023 08 15; 24(16):e202200788. Ranzau BL, Rallapalli KL, Evanoff M, Paesani F, Komor AC. PMID: 36947856; PMCID: PMC10514239.
    View in: PubMed Mentions: 5 Fields:
  14. Curing "GFP-itis" in Bacteria with Base Editors: Development of a Genome Editing Science Program Implemented with High School Biology Students. CRISPR J. 2023 06; 6(3):186-195. Vasquez CA, Evanoff M, Ranzau BL, Gu S, Deters E, Komor AC. PMID: 37083425; PMCID: PMC10277996.
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    Translation:HumansCells
  15. In the business of base editors: Evolution from bench to bedside. PLoS Biol. 2023 04; 21(4):e3002071. Porto EM, Komor AC. PMID: 37043430; PMCID: PMC10096463.
    View in: PubMed Mentions: 24 Fields:
    Translation:Humans
  16. The Design and Application of DNA-Editing Enzymes as Base Editors. Annu Rev Biochem. 2023 06 20; 92:43-79. Rallapalli KL, Komor AC. PMID: 37018843; PMCID: PMC10330504.
    View in: PubMed Mentions: 14 Fields:
  17. Curing "GFP-itis" in Bacteria with Base Editors: Development of a Genome Editing Science Program Implemented with High School Biology Students. bioRxiv. 2023 Feb 07. Vasquez CA, Evanoff M, Ranzau BL, Gu S, Deters E, Komor AC. PMID: 36798336; PMCID: PMC9934571.
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  18. Examination of the Cell Cycle Dependence of Cytosine and Adenine Base Editors. Front Genome Ed. 2022; 4:923718. Burnett CA, Wong AT, Vasquez CA, McHugh CA, Yeo GW, Komor AC. PMID: 35910415; PMCID: PMC9333457.
    View in: PubMed Mentions: 5
  19. Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles. Nat Commun. 2022 May 09; 13(1):2595. Bishop AL, López Del Amo V, Okamoto EM, Bodai Z, Komor AC, Gantz VM. PMID: 35534475; PMCID: PMC9085836.
    View in: PubMed Mentions: 8 Fields:
    Translation:AnimalsCells
  20. Targeting double-strand break indel byproducts with secondary guide RNAs improves Cas9 HDR-mediated genome editing efficiencies. Nat Commun. 2022 05 09; 13(1):2351. Bodai Z, Bishop AL, Gantz VM, Komor AC. PMID: 35534455; PMCID: PMC9085776.
    View in: PubMed Mentions: 14 Fields:
    Translation:AnimalsCells
  21. The use of base editing technology to characterize single nucleotide variants. Comput Struct Biotechnol J. 2022; 20:1670-1680. McDaniel S, Komor A, Goren A. PMID: 35465164; PMCID: PMC9010703.
    View in: PubMed Mentions: 3
  22. Combined Theoretical, Bioinformatic, and Biochemical Analyses of RNA Editing by Adenine Base Editors. CRISPR J. 2022 04; 5(2):294-310. Rallapalli KL, Ranzau BL, Ganapathy KR, Paesani F, Komor AC. PMID: 35353638; PMCID: PMC9347300.
    View in: PubMed Mentions: 4 Fields:
    Translation:Cells
  23. CRISPR-derived genome editing therapies: Progress from bench to bedside. Mol Ther. 2021 Nov 03; 29(11):3125-3139. Rees HA, Minella AC, Burnett CA, Komor AC, Gaudelli NM. PMID: 34619370; PMCID: PMC8572140.
    View in: PubMed Mentions: 11 Fields:
    Translation:HumansAnimalsCells
  24. Single-base editing of rs12603332 on chromosome 17q21 with a cytosine base editor regulates ORMDL3 and ATF6α expression. Allergy. 2022 04; 77(4):1139-1149. Weng N, Miller M, Pham AK, Komor AC, Broide DH. PMID: 34525218; PMCID: PMC8920947.
    View in: PubMed Mentions: 1 Fields:
    Translation:HumansCells
  25. Base Editors: Expanding the Types of DNA Damage Products Harnessed for Genome Editing. Gene Genome Ed. 2021 Jun; 1. Gu S, Bodai Z, Cowan QT, Komor AC. PMID: 34368792; PMCID: PMC8341163.
    View in: PubMed Mentions: 21
  26. Base Editing in Human Cells to Produce Single-Nucleotide-Variant Clonal Cell Lines. Curr Protoc Mol Biol. 2020 12; 133(1):e129. Vasquez CA, Cowan QT, Komor AC. PMID: 33151638; PMCID: PMC7654285.
    View in: PubMed Mentions: 6 Fields:
    Translation:HumansCells
  27. Celebrating Rosalind Franklin's Centennial with a Nobel Win for Doudna and Charpentier. Mol Ther. 2020 12 02; 28(12):2519-2520. Gaudelli NM, Komor AC. PMID: 33181064; PMCID: PMC7704750.
    View in: PubMed Mentions: 1 Fields:
    Translation:HumansCellsPHPublic Health
  28. Base editing: advances and therapeutic opportunities. Nat Rev Drug Discov. 2020 12; 19(12):839-859. Porto EM, Komor AC, Slaymaker IM, Yeo GW. PMID: 33077937; PMCID: PMC7721651.
    View in: PubMed Mentions: 232 Fields:
    Translation:Humans
  29. Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors. Sci Adv. 2020 03; 6(10):eaaz2309. Rallapalli KL, Komor AC, Paesani F. PMID: 32181363; PMCID: PMC7056309.
    View in: PubMed Mentions: 15 Fields:
    Translation:HumansCells
  30. Global chemical effects of the microbiome include new bile-acid conjugations. Nature. 2020 03; 579(7797):123-129. Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. PMID: 32103176; PMCID: PMC7252668.
    View in: PubMed Mentions: 304 Fields:
    Translation:HumansAnimals
  31. Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. Genes (Basel). 2020 01 12; 11(1). Fox K, Rallapalli KL, Komor AC. PMID: 31940934; PMCID: PMC7016644.
    View in: PubMed Mentions: 6 Fields:
    Translation:Humans
  32. Base Editors: Modular Tools for the Introduction of Point Mutations in Living Cells. Emerg Top Life Sci. 2019 Nov; 3(5):483-491. Evanoff M, Komor AC. PMID: 32270050; PMCID: PMC7141416.
    View in: PubMed Mentions: 11 Fields:
    Translation:Cells
  33. The Beginning of Base Editing: An Interview with Alexis C. Komor and Nicole M. Gaudelli. CRISPR J. 2019 04; 2:81-90. Davies K, Komor AC, Gaudelli NM. PMID: 30998094.
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    Translation:Humans
  34. Genome, Epigenome, and Transcriptome Editing via Chemical Modification of Nucleobases in Living Cells. Biochemistry. 2019 02 05; 58(5):330-335. Ranzau BL, Komor AC. PMID: 30500171; PMCID: PMC6720104.
    View in: PubMed Mentions: 6 Fields:
    Translation:HumansCells
  35. Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature. 2018 07; 559(7714):E8. Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. PMID: 29720650.
    View in: PubMed Mentions: 19 Fields:
  36. Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature. 2017 11 23; 551(7681):464-471. Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR. PMID: 29160308; PMCID: PMC5726555.
    View in: PubMed Mentions: 2056 Fields:
    Translation:HumansCells
  37. Editing the Genome Without Double-Stranded DNA Breaks. ACS Chem Biol. 2018 02 16; 13(2):383-388. Komor AC, Badran AH, Liu DR. PMID: 28957631; PMCID: PMC5891729.
    View in: PubMed Mentions: 63 Fields:
    Translation:AnimalsCells
  38. Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Sci Adv. 2017 08; 3(8):eaao4774. Komor AC, Zhao KT, Packer MS, Gaudelli NM, Waterbury AL, Koblan LW, Kim YB, Badran AH, Liu DR. PMID: 28875174; PMCID: PMC5576876.
    View in: PubMed Mentions: 432 Fields:
    Translation:HumansCells
  39. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery. Nat Commun. 2017 06 06; 8:15790. Rees HA, Komor AC, Yeh WH, Caetano-Lopes J, Warman M, Edge ASB, Liu DR. PMID: 28585549; PMCID: PMC5467206.
    View in: PubMed Mentions: 244 Fields:
    Translation:AnimalsCells
  40. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell. 2017 04 20; 169(3):559. Komor AC, Badran AH, Liu DR. PMID: 28431253.
    View in: PubMed Mentions: 117 Fields:
  41. Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions. Nat Biotechnol. 2017 04; 35(4):371-376. Kim YB, Komor AC, Levy JM, Packer MS, Zhao KT, Liu DR. PMID: 28191901; PMCID: PMC5388574.
    View in: PubMed Mentions: 432 Fields:
    Translation:Cells
  42. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. Cell. 2017 Jan 12; 168(1-2):20-36. Komor AC, Badran AH, Liu DR. PMID: 27866654; PMCID: PMC5235943.
    View in: PubMed Mentions: 440 Fields:
    Translation:HumansAnimalsCells
  43. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature. 2016 May 19; 533(7603):420-4. Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR. PMID: 27096365; PMCID: PMC4873371.
    View in: PubMed Mentions: 2617 Fields:
    Translation:HumansAnimalsCells
  44. An unusual ligand coordination gives rise to a new family of rhodium metalloinsertors with improved selectivity and potency. J Am Chem Soc. 2014 Oct 08; 136(40):14160-72. Komor AC, Barton JK. PMID: 25254630; PMCID: PMC4195389.
    View in: PubMed Mentions: 11 Fields:
    Translation:HumansCells
  45. Targeted Chemotherapy with Metal Complexes. Comments Mod Chem A Comments Inorg Chem. 2014 May; 34(3-4):114-123. Weidmann AG, Komor AC, Barton JK. PMID: 25642012; PMCID: PMC4309285.
    View in: PubMed Mentions: 14
  46. An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency. PLoS One. 2013; 8(10):e78726. Bailis JM, Gordon ML, Gurgel JL, Komor AC, Barton JK, Kirsch IR. PMID: 24205301; PMCID: PMC3812133.
    View in: PubMed Mentions: 8 Fields:
    Translation:HumansCells
  47. Biological effects of simple changes in functionality on rhodium metalloinsertors. Philos Trans A Math Phys Eng Sci. 2013 Jul 28; 371(1995):20120117. Weidmann AG, Komor AC, Barton JK. PMID: 23776288; PMCID: PMC3685451.
    View in: PubMed Mentions: 5 Fields:
    Translation:Cells
  48. The path for metal complexes to a DNA target. Chem Commun (Camb). 2013 May 07; 49(35):3617-30. Komor AC, Barton JK. PMID: 23423158; PMCID: PMC3660861.
    View in: PubMed Mentions: 49 Fields:
    Translation:Humans
  49. Cell-selective biological activity of rhodium metalloinsertors correlates with subcellular localization. J Am Chem Soc. 2012 Nov 21; 134(46):19223-33. Komor AC, Schneider CJ, Weidmann AG, Barton JK. PMID: 23137296; PMCID: PMC3740518.
    View in: PubMed Mentions: 23 Fields:
    Translation:HumansCells
  50. Selective cytotoxicity of rhodium metalloinsertors in mismatch repair-deficient cells. Biochemistry. 2011 Dec 20; 50(50):10919-28. Ernst RJ, Komor AC, Barton JK. PMID: 22103240; PMCID: PMC3364161.
    View in: PubMed Mentions: 22 Fields:
    Translation:HumansCells
  51. A hydrogen-bond facilitated cycle for oxygen reduction by an acid- and base-compatible iron platform. Inorg Chem. 2009 Nov 02; 48(21):10024-35. Soo HS, Komor AC, Iavarone AT, Chang CJ. PMID: 19780564.
    View in: PubMed Mentions: 21 Fields:
    Translation:Cells

This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.

This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.

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