Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain - PubMed (original) (raw)

Comparative Study

. 1999 Sep 8;72(1):97-102.

doi: 10.1016/s0169-328x(99)00160-6.

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Comparative Study

Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain

S Numan et al. Brain Res Mol Brain Res. 1999.

Free article

Abstract

The insulin receptor substrate (IRS) proteins are a family of important regulatory adapters that mediate the coupling between receptor-associated tyrosine kinases and downstream effectors including phosphatidylinositol-3'-kinases (PI-3-Ks). In the present study, the distribution of IRS-4 mRNA was determined in rat brain by in situ hybridization. IRS-4 mRNA was widely expressed throughout the hypothalamus, with the most dense labeling observed in the medial preoptic nucleus, ventromedial hypothalamus, and arcuate nucleus. In contrast, and unlike IRS-1 or IRS-2, expression of IRS-4 mRNA in other forebrain and midbrain regions was much more restricted. The expression of IRS-4 mRNA in the hypothalamus suggests a specific role for this factor in the signaling of one or more receptors involved hypothalamic functions including feeding, lactation, sexual and parental behaviors.

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