Stromal influences on breast cancer cell growth - PubMed (original) (raw)
Comparative Study
Stromal influences on breast cancer cell growth
C E van Roozendaal et al. Br J Cancer. 1992 Jan.
Free PMC article
Abstract
Paracrine influences from fibroblasts derived from different sources of breast tissue on epithelial breast cancer cell growth in vitro were investigated. Medium conditioned (CM) by fibroblasts derived from tumours, adjacent normal breast tissue, and normal breast tissue obtained from reduction mammoplasty or from skin tissue significantly stimulated the growth of the steroid-receptor positive cell lines MCF-7 and ZR 75.1. The proliferation index (PI) on MCF-7 cells with CM from fibroblasts derived from breast tumour tissue was significantly higher than that obtained with fibroblasts derived from adjacent normal breast tissue (2p less than 0.05, n = 8). The PI obtained with CM from normal fibroblast cultures from reduction mammoplasty tissue, like normal tissue adjacent to the tumour, fell in the lower range of values. Skin fibroblast, like tumour tissue derived fibroblast, CM caused a high range PI. MDA-MB-231 and Evsa-T, two steroid-receptor negative cell lines, showed only a minor growth stimulatory responses with some of the fibroblast CM's. Evsa-T was occasionally inhibited by CM's. In conclusion, stromal factors play a role in the growth regulation of human breast cancer cells. The effects on cancer cell growth are, however, varying depending on the source of the stroma and the characteristics of the epithelial tumour cells.
Similar articles
- Differential influence of stromal fibroblasts from different breast tissues on human breast tumour cell growth in nude mice.
Brouty-Boye D, Raux H. Brouty-Boye D, et al. Anticancer Res. 1993 Jul-Aug;13(4):1087-90. Anticancer Res. 1993. PMID: 8352530 - Malignant breast epithelium selects for insulin-like growth factor II expression in breast stroma: evidence for paracrine function.
Singer C, Rasmussen A, Smith HS, Lippman ME, Lynch HT, Cullen KJ. Singer C, et al. Cancer Res. 1995 Jun 1;55(11):2448-54. Cancer Res. 1995. PMID: 7757999 - Differential regulation of breast tumor cell proliferation by stromal fibroblasts of various breast tissue sources.
van Roozendaal KE, Klijn JG, van Ooijen B, Claassen C, Eggermont AM, Henzen-Logmans SC, Foekens JA. van Roozendaal KE, et al. Int J Cancer. 1996 Jan 3;65(1):120-5. doi: 10.1002/(SICI)1097-0215(19960103)65:1<120::AID-IJC20>3.0.CO;2-J. Int J Cancer. 1996. PMID: 8543388 - Effect of stromal and epithelial cells derived from normal and tumorous breast tissue on the proliferation of human breast cancer cell lines in co-culture.
Dong-Le Bourhis X, Berthois Y, Millot G, Degeorges A, Sylvi M, Martin PM, Calvo F. Dong-Le Bourhis X, et al. Int J Cancer. 1997 Mar 28;71(1):42-8. doi: 10.1002/(sici)1097-0215(19970328)71:1<42::aid-ijc9>3.0.co;2-3. Int J Cancer. 1997. PMID: 9096664 - Fibroblast stimulation of breast cancer cell growth in a serum-free system.
Ryan MC, Orr DJ, Horgan K. Ryan MC, et al. Br J Cancer. 1993 Jun;67(6):1268-73. doi: 10.1038/bjc.1993.237. Br J Cancer. 1993. PMID: 8512812 Free PMC article.
Cited by
- Mesenchymal Stem/Stromal Cells in Stromal Evolution and Cancer Progression.
Cammarota F, Laukkanen MO. Cammarota F, et al. Stem Cells Int. 2016;2016:4824573. doi: 10.1155/2016/4824573. Epub 2015 Dec 21. Stem Cells Int. 2016. PMID: 26798356 Free PMC article. Review. - Hormonally responsive breast cancer cells in a microfluidic co-culture model as a sensor of microenvironmental activity.
Lang JD, Berry SM, Powers GL, Beebe DJ, Alarid ET. Lang JD, et al. Integr Biol (Camb). 2013 May;5(5):807-16. doi: 10.1039/c3ib20265h. Integr Biol (Camb). 2013. PMID: 23559098 Free PMC article. - STAT3 can be activated through paracrine signaling in breast epithelial cells.
Lieblein JC, Ball S, Hutzen B, Sasser AK, Lin HJ, Huang TH, Hall BM, Lin J. Lieblein JC, et al. BMC Cancer. 2008 Oct 21;8:302. doi: 10.1186/1471-2407-8-302. BMC Cancer. 2008. PMID: 18939993 Free PMC article. - Human breast fibroblasts inhibit growth of the MCF10AT xenograft model of proliferative breast disease.
Sadlonova A, Mukherjee S, Bowe DB, Gault SR, Dumas NA, Van Tine BA, Frolova N, Page GP, Welch DR, Novak L, Frost AR. Sadlonova A, et al. Am J Pathol. 2007 Mar;170(3):1064-76. doi: 10.2353/ajpath.2007.060031. Am J Pathol. 2007. PMID: 17322389 Free PMC article. - Mutual paracrine effects of colorectal tumour cells and stromal cells: modulation of tumour and stromal cell differentiation and extracellular matrix component production in culture.
Mukaratirwa S, Koninkx JF, Gruys E, Nederbragt H. Mukaratirwa S, et al. Int J Exp Pathol. 2005 Aug;86(4):219-29. doi: 10.1111/j.0959-9673.2005.00425.x. Int J Exp Pathol. 2005. PMID: 16045544 Free PMC article.
References
- Br J Cancer. 1990 Sep;62(3):405-9 - PubMed
- Breast Cancer Res Treat. 1991 May;18 Suppl 1:S55-62 - PubMed
- Int J Cancer. 1988 Jul 15;42(1):119-22 - PubMed
- Eur J Cancer Clin Oncol. 1988 Sep;24(9):1425-31 - PubMed
- Cancer Res. 1988 Mar 1;48(5):1343-7 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous