Insulin stimulation of gene expression mediated by p21ras activation - PubMed (original) (raw)
Insulin stimulation of gene expression mediated by p21ras activation
B M Burgering et al. EMBO J. 1991 May.
Abstract
In fibroblasts, insulin is a weak mitogen and does not induce expression of c-fos, c-jun or p33. However, increasing the expression levels of either normal p21Hras or the insulin receptor, but not mutant p21Hras, enables insulin to induce the expression of these genes. In cells expressing elevated levels of insulin receptor, this process involves a rapid increase in p21rasGTP levels (from 20% to 70% GTP as a percentage of total guanine nucleotides). No increase in p21rasGTP levels was observed after PDGF and EGF stimulation of cells expressing high levels of the cognate receptor, stressing the specificity of the insulin-induced increase. We conclude that in fibroblasts, p21ras is an intermediate of the insulin signal transduction pathway involved in the regulation of gene expression and mitogenicity.
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References
- Proc Natl Acad Sci U S A. 1990 Feb;87(4):1411-5 - PubMed
- Proc Natl Acad Sci U S A. 1990 Oct;87(20):7926-9 - PubMed
- Science. 1990 Mar 30;247(4950):1578-81 - PubMed
- Science. 1990 Apr 6;248(4951):67-9 - PubMed
- Proc Natl Acad Sci U S A. 1990 Aug;87(15):5993-7 - PubMed
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