Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes - PubMed (original) (raw)
Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes
Manal F Abdelmalek et al. Hepatology. 2012 Sep.
Abstract
Fructose consumption predicts increased hepatic fibrosis in those with nonalcoholic fatty liver disease (NAFLD). Because of its ability to lower hepatic adenosine triphosphate (ATP) levels, habitual fructose consumption could result in more hepatic ATP depletion and impaired ATP recovery. The degree of ATP depletion after an intravenous (IV) fructose challenge test in low- versus high-fructose consumers was assessed. We evaluated diabetic adults enrolled in the Action for Health in Diabetes Fatty Liver Ancillary Study (n = 244) for whom dietary fructose consumption estimated by a 130-item food frequency questionnaire and hepatic ATP measured by phosphorus magnetic resonance spectroscopy and uric acid (UA) levels were performed (n = 105). In a subset of participants (n = 25), an IV fructose challenge was utilized to assess change in hepatic ATP content. The relationships between dietary fructose, UA, and hepatic ATP depletion at baseline and after IV fructose challenge were evaluated in low- (<15 g/day) versus high-fructose (≥ 15 g/day) consumers. High dietary fructose consumers had slightly lower baseline hepatic ATP levels and a greater absolute change in hepatic α-ATP/ inorganic phosphate (Pi) ratio (0.08 versus 0.03; P = 0.05) and γ-ATP /Pi ratio after an IV fructose challenge (0.03 versus 0.06; P = 0.06). Patients with high UA (≥ 5.5 mg/dL) showed a lower minimum liver ATP/Pi ratio postfructose challenge (4.5 versus 7.0; P = 0.04).
Conclusions: High-fructose consumption depletes hepatic ATP and impairs recovery from ATP depletion after an IV fructose challenge. Subjects with high UA show a greater nadir in hepatic ATP in response to fructose. Both high dietary fructose intake and elevated UA level may predict more severe hepatic ATP depletion in response to fructose and hence may be risk factors for the development and progression of NAFLD.
Copyright © 2012 American Association for the Study of Liver Diseases.
Conflict of interest statement
Potential conflict of interest: R.J.J.: Published a lay book “The Sugar Fix” that discusses the potential role of fructose in obesity and fatty liver and has a patent application on lowering uric acid to reduce fatty liver disease. All other authors have no conflict of interest.
Figures
Figure 1
Response to Intravenous Fructose Challenge, by Fructose Intake
Figure 2
Response to Intravenous Fructose Challenge, by Uric Acid Level
Figure 3
Median (IQR) Changes After I.V. Fructose, by Uric Acid Status
Similar articles
- Investigating the effects of an oral fructose challenge on hepatic ATP reserves in healthy volunteers: A (31)P MRS study.
Bawden SJ, Stephenson MC, Ciampi E, Hunter K, Marciani L, Macdonald IA, Aithal GP, Morris PG, Gowland PA. Bawden SJ, et al. Clin Nutr. 2016 Jun;35(3):645-9. doi: 10.1016/j.clnu.2015.04.001. Epub 2015 Apr 14. Clin Nutr. 2016. PMID: 25935852 - Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study.
Cortez-Pinto H, Chatham J, Chacko VP, Arnold C, Rashid A, Diehl AM. Cortez-Pinto H, et al. JAMA. 1999 Nov 3;282(17):1659-64. doi: 10.1001/jama.282.17.1659. JAMA. 1999. PMID: 10553793 - No difference between high-fructose and high-glucose diets on liver triacylglycerol or biochemistry in healthy overweight men.
Johnston RD, Stephenson MC, Crossland H, Cordon SM, Palcidi E, Cox EF, Taylor MA, Aithal GP, Macdonald IA. Johnston RD, et al. Gastroenterology. 2013 Nov;145(5):1016-1025.e2. doi: 10.1053/j.gastro.2013.07.012. Epub 2013 Jul 19. Gastroenterology. 2013. PMID: 23872500 Clinical Trial. - Fructose as a key player in the development of fatty liver disease.
Basaranoglu M, Basaranoglu G, Sabuncu T, Sentürk H. Basaranoglu M, et al. World J Gastroenterol. 2013 Feb 28;19(8):1166-72. doi: 10.3748/wjg.v19.i8.1166. World J Gastroenterol. 2013. PMID: 23482247 Free PMC article. Review. - Sugar, uric acid, and the etiology of diabetes and obesity.
Johnson RJ, Nakagawa T, Sanchez-Lozada LG, Shafiu M, Sundaram S, Le M, Ishimoto T, Sautin YY, Lanaspa MA. Johnson RJ, et al. Diabetes. 2013 Oct;62(10):3307-15. doi: 10.2337/db12-1814. Diabetes. 2013. PMID: 24065788 Free PMC article. Review.
Cited by
- Exosome prospects in the diagnosis and treatment of non-alcoholic fatty liver disease.
Tamimi A, Javid M, Sedighi-Pirsaraei N, Mirdamadi A. Tamimi A, et al. Front Med (Lausanne). 2024 Jul 31;11:1420281. doi: 10.3389/fmed.2024.1420281. eCollection 2024. Front Med (Lausanne). 2024. PMID: 39144666 Free PMC article. Review. - Myosteatosis: Diagnosis, pathophysiology and consequences in metabolic dysfunction-associated steatotic liver disease.
Henin G, Loumaye A, Leclercq IA, Lanthier N. Henin G, et al. JHEP Rep. 2023 Nov 14;6(2):100963. doi: 10.1016/j.jhepr.2023.100963. eCollection 2024 Feb. JHEP Rep. 2023. PMID: 38322420 Free PMC article. Review. - Dietary Patterns, Foods, and Nutrients to Ameliorate Non-Alcoholic Fatty Liver Disease: A Scoping Review.
Montemayor S, García S, Monserrat-Mesquida M, Tur JA, Bouzas C. Montemayor S, et al. Nutrients. 2023 Sep 14;15(18):3987. doi: 10.3390/nu15183987. Nutrients. 2023. PMID: 37764771 Free PMC article. Review. - Fructose: a modulator of intestinal barrier function and hepatic health?
Staltner R, Burger K, Baumann A, Bergheim I. Staltner R, et al. Eur J Nutr. 2023 Dec;62(8):3113-3124. doi: 10.1007/s00394-023-03232-7. Epub 2023 Aug 18. Eur J Nutr. 2023. PMID: 37596353 Free PMC article. Review. - The fructose survival hypothesis for obesity.
Johnson RJ, Lanaspa MA, Sanchez-Lozada LG, Tolan D, Nakagawa T, Ishimoto T, Andres-Hernando A, Rodriguez-Iturbe B, Stenvinkel P. Johnson RJ, et al. Philos Trans R Soc Lond B Biol Sci. 2023 Sep 11;378(1885):20220230. doi: 10.1098/rstb.2022.0230. Epub 2023 Jul 24. Philos Trans R Soc Lond B Biol Sci. 2023. PMID: 37482773 Free PMC article. Review.
References
- Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006;43:S99–S112. - PubMed
- Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr. 2004;79:537–543. - PubMed
- Putnam J, Alshouse JE. Food Consumption, Prices and Expenditures. 1970–1997. Washington, DC: Food and Rural Economics Division, Economics Research Service, US Dept of Agriculture; 1999. Statistical Bulletin No. 965.
- French SA, Lin BH, Guthrie JF. National trends in soft drink consumption among children and adolescents age 6 to 17 years: prevalence, amounts, and sources, 1977/1978 to 1994/1998. J Am Diet Assoc. 2003;103:1326–1331. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
- R01-DK060427/DK/NIDDK NIH HHS/United States
- HL-68607/HL/NHLBI NIH HHS/United States
- K23-DK062116/DK/NIDDK NIH HHS/United States
- M01-RR00052/RR/NCRR NIH HHS/United States
- K23 DK062116-05/DK/NIDDK NIH HHS/United States
- U01 DK057149/DK/NIDDK NIH HHS/United States
- UO1-DK57149/DK/NIDDK NIH HHS/United States
- R01 HL068607/HL/NHLBI NIH HHS/United States
- R01 DK060427/DK/NIDDK NIH HHS/United States
- M01 RR000052/RR/NCRR NIH HHS/United States
- K23 DK062116/DK/NIDDK NIH HHS/United States
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous