Tenofovir-associated Fanconi syndrome and nephrotic syndrome in a patient with chronic hepatitis B monoinfection - PubMed (original) (raw)

Case Reports

. 2015 Oct;62(4):1318-20.

doi: 10.1002/hep.27730. Epub 2015 Mar 18.

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Case Reports

Tenofovir-associated Fanconi syndrome and nephrotic syndrome in a patient with chronic hepatitis B monoinfection

Hyeon Seok Hwang et al. Hepatology. 2015 Oct.

Abstract

Tenofovir disoproxil fumarate (TDF) is widely used as an effective first-line therapy for chronic hepatitis B (CHB) infection. While TDF demonstrates successful viral suppression, it has been linked to the development of renal proximal tubular (PT) dysfunction, leading to Fanconi syndrome. However, Fanconi syndrome has been rarely reported in CHB-monoinfected patients, and there were no reports of TDF-associated nephrotic syndrome. Here, we report a case of combined Fanconi and nephrotic syndrome in CHB patients after TDF exposure.

© 2015 by the American Association for the Study of Liver Diseases.

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