Selenium in thyroid disorders - essential knowledge for clinicians - PubMed (original) (raw)

Review

. 2020 Mar;16(3):165-176.

doi: 10.1038/s41574-019-0311-6. Epub 2020 Jan 30.

Affiliations

• PMID: 32001830
• DOI: 10.1038/s41574-019-0311-6

Review

Selenium in thyroid disorders - essential knowledge for clinicians

Kristian Hillert Winther et al. Nat Rev Endocrinol. 2020 Mar.

Abstract

In the 1990s, selenium was identified as a component of an enzyme that activates thyroid hormone; since this discovery, the relevance of selenium to thyroid health has been widely studied. Selenium, known primarily for the antioxidant properties of selenoenzymes, is obtained mainly from meat, seafood and grains. Intake levels vary across the world owing largely to differences in soil content and factors affecting its bioavailability to plants. Adverse health effects have been observed at both extremes of intake, with a narrow optimum range. Epidemiological studies have linked an increased risk of autoimmune thyroiditis, Graves disease and goitre to low selenium status. Trials of selenium supplementation in patients with chronic autoimmune thyroiditis have generally resulted in reduced thyroid autoantibody titre without apparent improvements in the clinical course of the disease. In Graves disease, selenium supplementation might lead to faster remission of hyperthyroidism and improved quality of life and eye involvement in patients with mild thyroid eye disease. Despite recommendations only extending to patients with Graves ophthalmopathy, selenium supplementation is widely used by clinicians for other thyroid phenotypes. Ongoing and future trials might help identify individuals who can benefit from selenium supplementation, based, for instance, on individual selenium status or genetic profile.

PubMed Disclaimer

Similar articles

• The chronic autoimmune thyroiditis quality of life selenium trial (CATALYST): study protocol for a randomized controlled trial.
  Winther KH, Watt T, Bjørner JB, Cramon P, Feldt-Rasmussen U, Gluud C, Gram J, Groenvold M, Hegedüs L, Knudsen N, Rasmussen ÅK, Bonnema SJ. Winther KH, et al. Trials. 2014 Apr 9;15:115. doi: 10.1186/1745-6215-15-115. Trials. 2014. PMID: 24716668 Free PMC article. Clinical Trial.
• Insufficient documentation for clinical efficacy of selenium supplementation in chronic autoimmune thyroiditis, based on a systematic review and meta-analysis.
  Winther KH, Wichman JE, Bonnema SJ, Hegedüs L. Winther KH, et al. Endocrine. 2017 Feb;55(2):376-385. doi: 10.1007/s12020-016-1098-z. Epub 2016 Sep 28. Endocrine. 2017. PMID: 27683225 Free PMC article. Review.
• Is selenium supplementation in autoimmune thyroid diseases justified?
  Winther KH, Bonnema SJ, Hegedüs L. Winther KH, et al. Curr Opin Endocrinol Diabetes Obes. 2017 Oct;24(5):348-355. doi: 10.1097/MED.0000000000000356. Curr Opin Endocrinol Diabetes Obes. 2017. PMID: 28639965 Review.
• Search for relevant indications for selenium supplementation in thyroid diseases.
  Wojciechowska-Durczynska K, Lewinski A. Wojciechowska-Durczynska K, et al. Neuro Endocrinol Lett. 2017 Aug;38(4):237-241. Neuro Endocrinol Lett. 2017. PMID: 28871707 Review.
• Decline in thyroid (18)fluorodeoxyglucose uptake associated with selenium supplementation in a patient with autoimmune thyroiditis.
  Giovanella L, Suriano S, Ceriani L. Giovanella L, et al. Thyroid. 2009 Nov;19(11):1291-2. doi: 10.1089/thy.2009.0231. Thyroid. 2009. PMID: 19785520 No abstract available.

Cited by

• Valuable Data "Gain" and "Loss": The Quantitative Impact of Information Choice on Consumers' Decision to Buy Selenium-Rich Agricultural Products.
  Zhou B, Wu H, Wu B, Song Z. Zhou B, et al. Foods. 2024 Oct 13;13(20):3256. doi: 10.3390/foods13203256. Foods. 2024. PMID: 39456317 Free PMC article.
• Diet in Thyroid Disorders: A Survey among Clinicians and a Review of the Current Perspective.
  Singh AK, Chatterjee S, Singh A, Bhattacharjee R. Singh AK, et al. Indian J Endocrinol Metab. 2024 Jul-Aug;28(4):378-384. doi: 10.4103/ijem.ijem_68_24. Epub 2024 May 29. Indian J Endocrinol Metab. 2024. PMID: 39371648 Free PMC article.
• A comprehensive review on potential role of selenium, selenoproteins and selenium nanoparticles in male fertility.
  Yuan S, Zhang Y, Dong PY, Chen Yan YM, Liu J, Zhang BQ, Chen MM, Zhang SE, Zhang XF. Yuan S, et al. Heliyon. 2024 Jul 19;10(15):e34975. doi: 10.1016/j.heliyon.2024.e34975. eCollection 2024 Aug 15. Heliyon. 2024. PMID: 39144956 Free PMC article. Review.
• Effects of Selenium Content on Growth, Antioxidant Activity, and Key Selenium-Enriched Gene Expression in Alfalfa Sprouts.
  Ren Y, Zhang Q, Li X, Zhang T, Tian D, Liu L, Dong X, Wang ZY, Chai M. Ren Y, et al. Foods. 2024 Jul 18;13(14):2261. doi: 10.3390/foods13142261. Foods. 2024. PMID: 39063347 Free PMC article.

References

1. 1. Schwarz, K. & Foltz, C. M. Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. J. Am. Chem. Soc. 79, 3292–3293 (1957).
2. 1. Hatfield, D. L. & Gladyshev, V. N. How selenium has altered our understanding of the genetic code. Mol. Cell Biol. 22, 3565–3576 (2002). - PubMed - PMC
3. 1. Rayman, M. P. Selenium and human health. Lancet 379, 1256–1268 (2012). This article presents an overview of the different roles of selenium in relation to human health. - PubMed - PMC
4. 1. Clark, L. C. et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 276, 1957–1963 (1996). - PubMed
5. 1. Lippman, S. M. et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 301, 39–51 (2009). - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information