Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets - PubMed (original) (raw)

Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets

D E MacIntyre et al. Biochem J. 1983.

Abstract

Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets as indicated by [32P]phosphatidate accumulation in platelets pre-labelled with [32P]Pi, and by [3H]phosphatidate accumulation and [3H]phosphatidylinositol loss in platelets pre-labelled with [3H]arachidonate. These effects of platelet-activating factor are direct and are independent of the production and/or release of endogenous platelet agonists such as ADP, 5-hydroxytryptamine and thromboxane A2.

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