Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance - PubMed (original) (raw)

Comparative Study

doi: 10.1007/BF00400733.

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Comparative Study

Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance

M Laakso et al. Diabetologia. 1995 May.

Abstract

Skeletal muscle and adipose tissue hexokinase II is a promising candidate gene for non-insulin-dependent diabetes mellitus (NIDDM) and insulin resistance. Therefore, we investigated the association of alleles at four polymorphic loci in this gene with NIDDM and insulin resistance in 110 Finnish diabetic patients with NIDDM and in 97 Finnish control subjects with normal glucose tolerance and a negative family history of diabetes. The four polymorphic nucleotide substitutions (silent) in the coding region of the hexokinase II gene were: GAC 251 GAT (exon 7), AAC 692 AAT and CCG 736 CCC (exon 15), and CTG 766 CTA (exon 16). Allele frequencies of each of these polymorphisms did not differ between patients with NIDDM and control subjects. In addition, subjects who were homozygous for the less frequent allele of each of the four polymorphisms had a similar degree of insulin resistance, as determined by the euglycaemic clamp technique, as did the subjects who were homozygous for the common allele in both control subjects and in patients with NIDDM. In conclusion, polymorphisms in the hexokinase II gene are not associated with the risk of NIDDM or insulin resistance in the Finnish population.

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References

    1. Clin Pharmacol Ther. 1992 Dec;52(6):620-6 - PubMed
    1. Diabetes. 1992 Nov;41(11):1473-90 - PubMed
    1. Endocr Rev. 1985 Winter;6(1):45-86 - PubMed
    1. Genomics. 1989 Nov;5(4):874-9 - PubMed
    1. Diabetes Care. 1990 Jun;13(6):600-9 - PubMed

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