Secretion of alpha 1-antitrypsin by alveolar epithelial cells - PubMed (original) (raw)

Comparative Study

. 1994 Jun 13;346(2-3):171-4.

doi: 10.1016/0014-5793(94)80695-0.

Affiliations

• PMID: 8013628
• DOI: 10.1016/0014-5793(94)80695-0

Free article

Comparative Study

Secretion of alpha 1-antitrypsin by alveolar epithelial cells

P Venembre et al. FEBS Lett. 1994.

Free article

Abstract

We have investigated the ability of alveolar epithelial cells (human A549 cell line and rat type-II pneumocytes) to produce alpha 1-antitrypsin (AAT). Northern blot analysis demonstrated the presence of an AAT-specific mRNA transcript in A549 cells. Unstimulated A549 cells secreted immunoreactive AAT at a rate of 0.51 +/- 0.04 ng/10(6) cells/h, with a modified glycosylation compared to serum AAT. AAT formed a complex with neutrophil elastase. Rat type-II pneumocytes secreted immunoreactive AAT. Our results suggest that alveolar epithelial cells could participate in antiprotease defense within the lung through local AAT production.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal