Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation - PubMed (original) (raw)
. 1993 May 6;363(6424):45-51.
doi: 10.1038/363045a0.
Affiliations
- PMID: 8479536
- DOI: 10.1038/363045a0
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
S E Egan et al. Nature. 1993.
Abstract
The proteins Grb2-Sem-5, Shc and Sos have been implicated in the signalling pathway from tyrosine kinase receptors to Ras. Grb2-Sem-5 binds directly to murine Sos1, a Ras exchange factor, through two SH3 domains. Sos is also associated with ligand-activated tyrosine kinase receptors which bind Grb2-Sem-5, and with the Grb2-Sem-5 binding protein, Shc. Ectopic expression of Drosophila Sos stimulates morphological transformation of rodent fibroblasts. These data define a pathway by which tyrosine kinases act through Ras to control cell growth and differentiation.
Comment in
- Signal transduction. How receptors turn Ras on.
McCormick F. McCormick F. Nature. 1993 May 6;363(6424):15-6. doi: 10.1038/363015a0. Nature. 1993. PMID: 8479530 No abstract available.
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