Crystal structure of the Src family tyrosine kinase Hck - PubMed (original) (raw)

. 1997 Feb 13;385(6617):602-9.

doi: 10.1038/385602a0.

Affiliations

• PMID: 9024658
• DOI: 10.1038/385602a0

Crystal structure of the Src family tyrosine kinase Hck

F Sicheri et al. Nature. 1997.

Abstract

The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

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Comment in

• New impressions of Src and Hck.
  Pawson T. Pawson T. Nature. 1997 Feb 13;385(6617):582-3, 585. doi: 10.1038/385582b0. Nature. 1997. PMID: 9024653 No abstract available.

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