Mahendra Khyade | Sangamner College, Sangamner (original) (raw)

Papers by Mahendra Khyade

Pharmacognosy Research, 2023

Background: In traditional medicine, Abelmoschus manihot (L.) Medik, which belongs to the Malvace... more Background: In traditional medicine, Abelmoschus manihot (L.) Medik, which belongs to the Malvaceae family, has been used to treat boils, sores, sprains, inflammations, tuberculosis, and leucoderma. Objectives: The objective of this study was to establish identification and quality control standards. Materials and Methods: For pharmacognostic evaluation, macroscopy, micromorphology and physicochemical constants have been used. Microchemical colour reaction tests and HPTLC studies were performed for qualitative phytochemistry. Results: Externally the root is yellowish-brown to yellowish-white and has a distinct odour, bitter taste, wavy shape, and smooth texture. The periderm was composed of 4-5 thin-walled cells. The secondary phloem has dilated rays and broad pyramid-shaped mucilage-packed rays. The fibres have thin walls and are narrow, and the secondary xylem is a compact circular cylinder with eight to eight radial lines of vessel chains. Prismatic calcium oxalate crystals, lignified long, narrow, thick-walled fibres with parenchyma cells, lignified cork cells, and cylindrical vessel elements were discovered in powdered samples. Physicochemically, the ash value was found above 8% which shows more than 75% solubility in acid whereas water and methanol extractive values were found to be just above and below 8% respectively. In UV-fluorescence study, very distinctive colour changes of the powdered root have been recorded. The phytochemical analysis reveals the presence of glycosides, saponins, flavonoids, tannins, and steroids. GC-MS and HPTLC are also used to characterize lipid and phenolic molecules. Conclusion: These findings will help in the future identification and quality control of A. manihot as reference standards.

Journal of Natural Remedies, Jun 1, 2011

Ethnobotanical survey was conducted during 2006-2008 in Akole Taluka of Ahmednagar district in We... more Ethnobotanical survey was conducted during 2006-2008 in Akole Taluka of Ahmednagar district in Western Ghats of Maharashtra State. The tribes such as Mahadev Koli, Ramoshi, Thakar and Bhills are dwelling in the study area, apart from other rural people. Information on 40 angiospermic species belonging to 38 genera of 24 families was gathered, as used as an antidote against snakebite by those people. The present paper reports botanical names, family, local names, parts used, preparation and mode of administration. Also a discussion on present data compared with already published reports on snakebite is included.

The present work was carried out to evaluate the free radical scavenging potential of Oxalis cori... more The present work was carried out to evaluate the free radical scavenging potential of Oxalis coriculata. The ethanol (80%) extract was tested for free radical scavenging assay using DPPH, Nitric oxide and ABTS assay. Furthermore, qualitative along with quantitative estimation of flavonoids and phenolic contents were also carried out using aluminium chloride and Folin–Ciocalteu reagent method respectively. Preliminary phytochemical screening of the extract revealed the presence of various bioactive compounds such as steroids, phenolic groups, saponins, tannin, flavonoids, carbohydrates, coumarins, alkaloids and terpenoids. The total phenolic and flavonoid contents were found to be 2.11± 0.08 mg/100mg dry weight equivalents to gallic acid (GAE)/ 100mg dry weight and 4.45±0.15 mg/100mg dry weight equivalents to quercetin (QE), respectively. The extract revealed significant antiradical activity in a dose-dependent manner in all the assays. The IC 50 values of all parameters were also determined using ascorbic acid as a standard. HPLC analysis further confirmed the presence of rutin, salicylic acid and benzoic acid. The results obtained in the present work indicated that O. corniculata could be a potential source of natural antioxidant.

In the present investigation antioxidant and salivary alpha-amylase inhibitory activity of methan... more In the present investigation antioxidant and salivary alpha-amylase inhibitory activity of methanol extract of Colocasia esculenta corm was evaluated. The antioxidant activity of methanol extract of C .esculenta (CME) was evaluated by FRAP, DPPH, and ferric reducing power assay. Similarly, total phenol content and salivary alpha-amylase inhibitory activity of CME was evaluated by Folin-Ciocalteau and DNS method respectively. The result of total phenolic content assay reveals that CME containing 0.0137 + 1.33 mg GAE/g dw of CME. The observed resultant antioxidant activity of CME in all studied models was moderate as compared with reference standard BHT and BHA. At 1 mg/ml, CME showed salivary alpha-amylase inhibitory activity with IC50 value of 0.94 mg/ml. In conclusion, from the results of present study it is confirmed that antioxidant and alpha-amylase inhibitory activity of methanol extract of C .esculenta may contribute in its earlier observed antidiabetic potential.

In Indian medicinal plant literature, leaves of Annona squamosa, Annona reticulata Balanites aegy... more In Indian medicinal plant literature, leaves of Annona squamosa, Annona reticulata Balanites aegyptica Caesalpinia bonducella, Cleome gynandra and Diplocyclos palmatus have been traditionally reported to be used as anthelmintics. Hence, it is essential to examine these plant species for anthelmintic potential to support traditional claim. The present study was carried out to determine and compare anthelmintic efficacies of these plants against the commercially available anthelmintic drug, nitazoxamide. Ethanol extracts of leaves of all studied plants were examined for anthelmintic activity against Indian adult earthworm. All extracts demonstrated highly significant dose-dependent anthelmintic activity at tested concentrations of 10, 20, 50 mg/ml, compared with reference standard nitazoxamide. In conclusion, all studied plants have potential application in the treatment of helminthes infections. The results of this study also validated the basis for the traditional use of these plant...

Current Nutrition & Food Science, 2020

Background: Seeds of Cassia auriculata are reported to be used for varying medicinal purposes; ho... more Background: Seeds of Cassia auriculata are reported to be used for varying medicinal purposes; however, information on nutritive value and physical properties of seeds remains unexplored. Hence, this study is carried out to investigate the proximate, minerals, fatty acid profile, functional properties, phenolic profiling as well as antioxidant activities of seed in order to give adequate information on its suitability as a possible future food source. Methods: The proximate compositions were evaluated by AOAC, and other standard prescribed methods. Minerals and fatty acids compositions were determined using Atomic Absorption Spectrophotometer and UV-visible spectrophotometers, while anti-nutrient determinations were carried out using standard procedures. Antioxidant activity and phenolic profiles were also analyzed using UV-visible spectrophotometers and HPLC. Results: The results obtained from proximate analysis were: moisture content (9.74%), ash content (4.95%), protein (23.83%),...

Journal of Ethnopharmacology, 2017

Asian Journal of Biomedical and Pharmaceutical Sciences, Oct 10, 2012

In Indian medicinal plant literature, leaves of Annona squamosa, Annona reticulata Balanites aegy... more In Indian medicinal plant literature, leaves of Annona squamosa, Annona reticulata Balanites aegyptica Caesalpinia bonducella, Cleome gynandra and Diplocyclos palmatus have been traditionally reported to be used as anthelmintics. Hence, it is essential to examine these plant species for anthelmintic potential to support traditional claim. The present study was carried out to determine and compare anthelmintic efficacies of these plants against the commercially available anthelmintic drug, nitazoxamide. Ethanol extracts of leaves of all studied plants were examined for anthelmintic activity against Indian adult earthworm. All extracts demonstrated highly significant dose-dependent anthelmintic activity at tested concentrations of 10, 20, 50 mg/ml, compared with reference standard nitazoxamide. In conclusion, all studied plants have potential application in the treatment of helminthes infections. The results of this study also validated the basis for the traditional use of these plants as anthelmintics in Indian medicine.

Pharmacologyonline

In the present investigation antioxidant and salivary alpha-amylase inhibitory activity of methan... more In the present investigation antioxidant and salivary alpha-amylase inhibitory activity of methanol extract of Colocasia esculenta corm was evaluated. The antioxidant activity of methanol extract of C .esculenta (CME) was evaluated by FRAP, DPPH, and ferric reducing power assay. Similarly, total phenol content and salivary alpha-amylase inhibitory activity of CME was evaluated by Folin-Ciocalteau and DNS method respectively. The result of total phenolic content assay reveals that CME containing 0.0137 + 1.33 mg GAE/g dw of CME. The observed resultant antioxidant activity of CME in all studied models was moderate as compared with reference standard BHT and BHA. At 1 mg/ml, CME showed salivary alphaamylase inhibitory activity with IC50 value of 0.94 mg/ml. In conclusion, from the results of present study it is confirmed that antioxidant and alpha-amylase inhibitory activity of methanol extract of C .esculenta may contribute in its earlier observed antidiabetic potential.

Journal of Coastal Life Medicine, 2014

Different parts of Wrightia tinctoria R. Br. (Apocynaceae) (W. tinctoria), have been extensively ... more Different parts of Wrightia tinctoria R. Br. (Apocynaceae) (W. tinctoria), have been extensively used in Indian systems of medicine such as Ayurveda, Siddha and Unani for the treatment of jaundice, malaria, psoriasis and many other ailments. The present review has been primed to describe the existing data on the information on the traditional uses, botany, pharmacognosy, phytochemical constituents, pharmacological activities and toxicology of W. tinctoria. The information was gathered via electronic search (using Google Scholar, NOPR, Pubmed, Elsevier, Medline Plus and Web of Science) and library search for the books on traditional medicine as well as the articles published in peer-reviewed journals. The plant is rich in compounds containing alkaloids, saponins, indoxy yielding O-glycoside(s), phenolics, flavonoids, isatin tryptanthrin, anthranillate, rutin, β-isatin, tryptophan, indigotin, indirubin, wrightial and sterols. The vast number of literature found in database revealed that the extracts of different parts of W. tinctoria showed significant pharmacological actions. Clinical studies indicated a broad range of applications in the treatment of psoriasis and other skin diseases. We suggest that there is a need for further investigations to isolate active principles that confer pharmacological action. Therefore, identification of such active compound is useful for producing safer drugs in the treatments of various ailments.

Our present study was aimed to detect the medicinal uses of the plant Murraya koenigii (L) Spreng... more Our present study was aimed to detect the medicinal uses of the plant Murraya koenigii (L) Spreng belonging to the family Rutaceae by performing various studies such as Pharmacognostical, phytochemical and antibacterial activity, using seven different bacterial strains, which are harmful to human beings. The Murraya koenigii commonly known as "Curry leaf" has been recognized in different systems of traditional medicines for the treatment of different diseases and ailments of human beings. The leaves of the plant are said to be cooling and stomachache. The study includes macroscopy, microscopy, preliminary phytochemical screening and antibacterial evaluation.

INTERNATIONAL JOURNAL OF RESEARCH IN AYURVEDA & PHARMACY, 2014

Wrightia arborea (Densst.) Mabb. belonging to the family Apocynaceae, is a small deciduous tree, ... more Wrightia arborea (Densst.) Mabb. belonging to the family Apocynaceae, is a small deciduous tree, distributed throughout the warmer parts of India. Different organs (root, bark and leaf) have been used in traditional medicine for many years. The present study was undertaken to investigate the pharmacognostic characters of root, bark and leaf, which were carried out in terms of organoleptic, macroscopic, microscopic, physiochemical analysis and phytochemical testing as per WHO recommended methods for standardization of different organs of the plant. In quantitative microscopy, the average stomatal index was found to be 23.0, vein islet number 25.14 and vein termination number 20.0. Physico-chemically, the moisture content was comparatively more in bark, while it was less in the root; extractive values of chloroform, ethanol and water soluble extractive were 8.8 % w/w, 21.4 % w/w and 23.68 % w/w respectively. The total ash value was less in root, than that of the leaves; whereas acid insoluble ash value was more in leaves than root. The preliminary phytochemical screening revealed the presence of alkaloids, flavonoides, phlobatannin in bark and leaves; phenolics, reducing sugars, saponins, tannins found in all studied organs, while leucoanthocyanins, iridoids, steroids and terpenoid revealed in the leaves only. Of the various phytochemicals and minerals estimated, saponin and tannins were found in larger amounts in leaves than others, whereas the minerals, calcium were more in leaf. The present pharmacognostic parameters reported on this plant can serve as a valuable source of identification and provide a suitable diagnostic tool for standardization besides adulterant identification in related species or weeds.

Journal of Ethnopharmacology, 2014

Ethnopharmacological relevance: Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex ... more Ethnopharmacological relevance: Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don are two vital medicinal plant species (family: Apocynaceae). In India, the therapeutic use of Alstonia scholaris has been described in both codified and non-codified drug systems for the treatment of malaria, jaundice, gastrointestinal troubles, cancer and in many other ailments. Other species, Alstonia macrophylla has been used in conventional medicines in Thailand, Malaysia and Philippines as a general tonic, aphrodisiac, anticholeric, antidysentery, antipyretic, emmenagogue, and vulnerary agents. In India, Alstonia macrophylla is used as a substitute for Alstonia scholaris in various herbal pharmaceutical preparations. However, one certainly cannot evaluate the truthfulness of a practice (i.e. in scientific terms). In this article we discuss and summarize comparative data about traditional uses, phytochemistry, pharmacology and toxicity of Alstonia scholaris and Alstonia macrophylla. Moreover, in order to unfold future research opportunities, lacunae in the present knowledge are also highlighted. Materials and methods: Literature about Alstonia scholaris and Alstonia macrophylla was collected by using electronic and library search. Additionally, referred books on traditional medicine and ethnopharmacology were also utilized for receiving traditional records about both the plant species. Results: Both Alstonia scholaris and Alstonia macrophylla are rich in different types of bioactive alkaloids. So far, broad spectrum of in vitro and in vivo biological and pharmacological activities have been reported to both the species. Amongst them, antimicrobial and anticancer activities were promising. Conclusions: The use of Alstonia macrophylla as a substitute for Alstonia scholaris is not at all justifiable as both the species are distinct from each other in their phytochemistry and pharmacology. Further detail chemical fingerprinting and metabolic studies of these two species are warranted to prevent their mutual adulteration most importantly in the context of commercial preparations.

ajebs.com

... during the study. During the ethnobotanical exploration (2006-2008), observations on the four... more ... during the study. During the ethnobotanical exploration (2006-2008), observations on the four important ailments like jaundice, asthma, mouth ulcer ant teeth disorders among the tribal communities were recorded. Due to strong ...

Ethnobotanical Leaflets, 2009

The present communication deals with the ethnobotanical exploration,identification,concerns and f... more The present communication deals with the ethnobotanical exploration,identification,concerns and future potentialities of the wild edible plant species consumed by the tribal communities inhabiting in the hilly areas of akole tahasil of Ahmednagar district fall in Maharashtra state-India. A total of 31 plant species belonging to 23 families were reported from the study area. Amaranthaceae was the dominant family with 4 taxa,while Papilionaceae followed with 3 taxa. Ascplepidaceae and Bignoniaceae represented by 2 taxa each. The four major life forms were climbers, herbs, shrubs and trees. Herb makes up the highest proportion of the edible species followed by trees, shrubs and climbers. The plant species are divided into two class-vegetables and raw. Also the present finding support further investigation into nutritional profits, pharmacological prospects and conservational studies.

Plant and Human Health, Volume 1, 2018

Pharmacognosy Research, 2023

Background: In traditional medicine, Abelmoschus manihot (L.) Medik, which belongs to the Malvace... more Background: In traditional medicine, Abelmoschus manihot (L.) Medik, which belongs to the Malvaceae family, has been used to treat boils, sores, sprains, inflammations, tuberculosis, and leucoderma. Objectives: The objective of this study was to establish identification and quality control standards. Materials and Methods: For pharmacognostic evaluation, macroscopy, micromorphology and physicochemical constants have been used. Microchemical colour reaction tests and HPTLC studies were performed for qualitative phytochemistry. Results: Externally the root is yellowish-brown to yellowish-white and has a distinct odour, bitter taste, wavy shape, and smooth texture. The periderm was composed of 4-5 thin-walled cells. The secondary phloem has dilated rays and broad pyramid-shaped mucilage-packed rays. The fibres have thin walls and are narrow, and the secondary xylem is a compact circular cylinder with eight to eight radial lines of vessel chains. Prismatic calcium oxalate crystals, lignified long, narrow, thick-walled fibres with parenchyma cells, lignified cork cells, and cylindrical vessel elements were discovered in powdered samples. Physicochemically, the ash value was found above 8% which shows more than 75% solubility in acid whereas water and methanol extractive values were found to be just above and below 8% respectively. In UV-fluorescence study, very distinctive colour changes of the powdered root have been recorded. The phytochemical analysis reveals the presence of glycosides, saponins, flavonoids, tannins, and steroids. GC-MS and HPTLC are also used to characterize lipid and phenolic molecules. Conclusion: These findings will help in the future identification and quality control of A. manihot as reference standards.

Journal of Natural Remedies, Jun 1, 2011

Ethnobotanical survey was conducted during 2006-2008 in Akole Taluka of Ahmednagar district in We... more Ethnobotanical survey was conducted during 2006-2008 in Akole Taluka of Ahmednagar district in Western Ghats of Maharashtra State. The tribes such as Mahadev Koli, Ramoshi, Thakar and Bhills are dwelling in the study area, apart from other rural people. Information on 40 angiospermic species belonging to 38 genera of 24 families was gathered, as used as an antidote against snakebite by those people. The present paper reports botanical names, family, local names, parts used, preparation and mode of administration. Also a discussion on present data compared with already published reports on snakebite is included.

The present work was carried out to evaluate the free radical scavenging potential of Oxalis cori... more The present work was carried out to evaluate the free radical scavenging potential of Oxalis coriculata. The ethanol (80%) extract was tested for free radical scavenging assay using DPPH, Nitric oxide and ABTS assay. Furthermore, qualitative along with quantitative estimation of flavonoids and phenolic contents were also carried out using aluminium chloride and Folin–Ciocalteu reagent method respectively. Preliminary phytochemical screening of the extract revealed the presence of various bioactive compounds such as steroids, phenolic groups, saponins, tannin, flavonoids, carbohydrates, coumarins, alkaloids and terpenoids. The total phenolic and flavonoid contents were found to be 2.11± 0.08 mg/100mg dry weight equivalents to gallic acid (GAE)/ 100mg dry weight and 4.45±0.15 mg/100mg dry weight equivalents to quercetin (QE), respectively. The extract revealed significant antiradical activity in a dose-dependent manner in all the assays. The IC 50 values of all parameters were also determined using ascorbic acid as a standard. HPLC analysis further confirmed the presence of rutin, salicylic acid and benzoic acid. The results obtained in the present work indicated that O. corniculata could be a potential source of natural antioxidant.

In the present investigation antioxidant and salivary alpha-amylase inhibitory activity of methan... more In the present investigation antioxidant and salivary alpha-amylase inhibitory activity of methanol extract of Colocasia esculenta corm was evaluated. The antioxidant activity of methanol extract of C .esculenta (CME) was evaluated by FRAP, DPPH, and ferric reducing power assay. Similarly, total phenol content and salivary alpha-amylase inhibitory activity of CME was evaluated by Folin-Ciocalteau and DNS method respectively. The result of total phenolic content assay reveals that CME containing 0.0137 + 1.33 mg GAE/g dw of CME. The observed resultant antioxidant activity of CME in all studied models was moderate as compared with reference standard BHT and BHA. At 1 mg/ml, CME showed salivary alpha-amylase inhibitory activity with IC50 value of 0.94 mg/ml. In conclusion, from the results of present study it is confirmed that antioxidant and alpha-amylase inhibitory activity of methanol extract of C .esculenta may contribute in its earlier observed antidiabetic potential.

In Indian medicinal plant literature, leaves of Annona squamosa, Annona reticulata Balanites aegy... more In Indian medicinal plant literature, leaves of Annona squamosa, Annona reticulata Balanites aegyptica Caesalpinia bonducella, Cleome gynandra and Diplocyclos palmatus have been traditionally reported to be used as anthelmintics. Hence, it is essential to examine these plant species for anthelmintic potential to support traditional claim. The present study was carried out to determine and compare anthelmintic efficacies of these plants against the commercially available anthelmintic drug, nitazoxamide. Ethanol extracts of leaves of all studied plants were examined for anthelmintic activity against Indian adult earthworm. All extracts demonstrated highly significant dose-dependent anthelmintic activity at tested concentrations of 10, 20, 50 mg/ml, compared with reference standard nitazoxamide. In conclusion, all studied plants have potential application in the treatment of helminthes infections. The results of this study also validated the basis for the traditional use of these plant...

Current Nutrition & Food Science, 2020

Background: Seeds of Cassia auriculata are reported to be used for varying medicinal purposes; ho... more Background: Seeds of Cassia auriculata are reported to be used for varying medicinal purposes; however, information on nutritive value and physical properties of seeds remains unexplored. Hence, this study is carried out to investigate the proximate, minerals, fatty acid profile, functional properties, phenolic profiling as well as antioxidant activities of seed in order to give adequate information on its suitability as a possible future food source. Methods: The proximate compositions were evaluated by AOAC, and other standard prescribed methods. Minerals and fatty acids compositions were determined using Atomic Absorption Spectrophotometer and UV-visible spectrophotometers, while anti-nutrient determinations were carried out using standard procedures. Antioxidant activity and phenolic profiles were also analyzed using UV-visible spectrophotometers and HPLC. Results: The results obtained from proximate analysis were: moisture content (9.74%), ash content (4.95%), protein (23.83%),...

Journal of Ethnopharmacology, 2017

Asian Journal of Biomedical and Pharmaceutical Sciences, Oct 10, 2012

In Indian medicinal plant literature, leaves of Annona squamosa, Annona reticulata Balanites aegy... more In Indian medicinal plant literature, leaves of Annona squamosa, Annona reticulata Balanites aegyptica Caesalpinia bonducella, Cleome gynandra and Diplocyclos palmatus have been traditionally reported to be used as anthelmintics. Hence, it is essential to examine these plant species for anthelmintic potential to support traditional claim. The present study was carried out to determine and compare anthelmintic efficacies of these plants against the commercially available anthelmintic drug, nitazoxamide. Ethanol extracts of leaves of all studied plants were examined for anthelmintic activity against Indian adult earthworm. All extracts demonstrated highly significant dose-dependent anthelmintic activity at tested concentrations of 10, 20, 50 mg/ml, compared with reference standard nitazoxamide. In conclusion, all studied plants have potential application in the treatment of helminthes infections. The results of this study also validated the basis for the traditional use of these plants as anthelmintics in Indian medicine.

Pharmacologyonline

In the present investigation antioxidant and salivary alpha-amylase inhibitory activity of methan... more In the present investigation antioxidant and salivary alpha-amylase inhibitory activity of methanol extract of Colocasia esculenta corm was evaluated. The antioxidant activity of methanol extract of C .esculenta (CME) was evaluated by FRAP, DPPH, and ferric reducing power assay. Similarly, total phenol content and salivary alpha-amylase inhibitory activity of CME was evaluated by Folin-Ciocalteau and DNS method respectively. The result of total phenolic content assay reveals that CME containing 0.0137 + 1.33 mg GAE/g dw of CME. The observed resultant antioxidant activity of CME in all studied models was moderate as compared with reference standard BHT and BHA. At 1 mg/ml, CME showed salivary alphaamylase inhibitory activity with IC50 value of 0.94 mg/ml. In conclusion, from the results of present study it is confirmed that antioxidant and alpha-amylase inhibitory activity of methanol extract of C .esculenta may contribute in its earlier observed antidiabetic potential.

Journal of Coastal Life Medicine, 2014

Different parts of Wrightia tinctoria R. Br. (Apocynaceae) (W. tinctoria), have been extensively ... more Different parts of Wrightia tinctoria R. Br. (Apocynaceae) (W. tinctoria), have been extensively used in Indian systems of medicine such as Ayurveda, Siddha and Unani for the treatment of jaundice, malaria, psoriasis and many other ailments. The present review has been primed to describe the existing data on the information on the traditional uses, botany, pharmacognosy, phytochemical constituents, pharmacological activities and toxicology of W. tinctoria. The information was gathered via electronic search (using Google Scholar, NOPR, Pubmed, Elsevier, Medline Plus and Web of Science) and library search for the books on traditional medicine as well as the articles published in peer-reviewed journals. The plant is rich in compounds containing alkaloids, saponins, indoxy yielding O-glycoside(s), phenolics, flavonoids, isatin tryptanthrin, anthranillate, rutin, β-isatin, tryptophan, indigotin, indirubin, wrightial and sterols. The vast number of literature found in database revealed that the extracts of different parts of W. tinctoria showed significant pharmacological actions. Clinical studies indicated a broad range of applications in the treatment of psoriasis and other skin diseases. We suggest that there is a need for further investigations to isolate active principles that confer pharmacological action. Therefore, identification of such active compound is useful for producing safer drugs in the treatments of various ailments.

Our present study was aimed to detect the medicinal uses of the plant Murraya koenigii (L) Spreng... more Our present study was aimed to detect the medicinal uses of the plant Murraya koenigii (L) Spreng belonging to the family Rutaceae by performing various studies such as Pharmacognostical, phytochemical and antibacterial activity, using seven different bacterial strains, which are harmful to human beings. The Murraya koenigii commonly known as "Curry leaf" has been recognized in different systems of traditional medicines for the treatment of different diseases and ailments of human beings. The leaves of the plant are said to be cooling and stomachache. The study includes macroscopy, microscopy, preliminary phytochemical screening and antibacterial evaluation.

INTERNATIONAL JOURNAL OF RESEARCH IN AYURVEDA & PHARMACY, 2014

Wrightia arborea (Densst.) Mabb. belonging to the family Apocynaceae, is a small deciduous tree, ... more Wrightia arborea (Densst.) Mabb. belonging to the family Apocynaceae, is a small deciduous tree, distributed throughout the warmer parts of India. Different organs (root, bark and leaf) have been used in traditional medicine for many years. The present study was undertaken to investigate the pharmacognostic characters of root, bark and leaf, which were carried out in terms of organoleptic, macroscopic, microscopic, physiochemical analysis and phytochemical testing as per WHO recommended methods for standardization of different organs of the plant. In quantitative microscopy, the average stomatal index was found to be 23.0, vein islet number 25.14 and vein termination number 20.0. Physico-chemically, the moisture content was comparatively more in bark, while it was less in the root; extractive values of chloroform, ethanol and water soluble extractive were 8.8 % w/w, 21.4 % w/w and 23.68 % w/w respectively. The total ash value was less in root, than that of the leaves; whereas acid insoluble ash value was more in leaves than root. The preliminary phytochemical screening revealed the presence of alkaloids, flavonoides, phlobatannin in bark and leaves; phenolics, reducing sugars, saponins, tannins found in all studied organs, while leucoanthocyanins, iridoids, steroids and terpenoid revealed in the leaves only. Of the various phytochemicals and minerals estimated, saponin and tannins were found in larger amounts in leaves than others, whereas the minerals, calcium were more in leaf. The present pharmacognostic parameters reported on this plant can serve as a valuable source of identification and provide a suitable diagnostic tool for standardization besides adulterant identification in related species or weeds.

Journal of Ethnopharmacology, 2014

Ethnopharmacological relevance: Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex ... more Ethnopharmacological relevance: Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don are two vital medicinal plant species (family: Apocynaceae). In India, the therapeutic use of Alstonia scholaris has been described in both codified and non-codified drug systems for the treatment of malaria, jaundice, gastrointestinal troubles, cancer and in many other ailments. Other species, Alstonia macrophylla has been used in conventional medicines in Thailand, Malaysia and Philippines as a general tonic, aphrodisiac, anticholeric, antidysentery, antipyretic, emmenagogue, and vulnerary agents. In India, Alstonia macrophylla is used as a substitute for Alstonia scholaris in various herbal pharmaceutical preparations. However, one certainly cannot evaluate the truthfulness of a practice (i.e. in scientific terms). In this article we discuss and summarize comparative data about traditional uses, phytochemistry, pharmacology and toxicity of Alstonia scholaris and Alstonia macrophylla. Moreover, in order to unfold future research opportunities, lacunae in the present knowledge are also highlighted. Materials and methods: Literature about Alstonia scholaris and Alstonia macrophylla was collected by using electronic and library search. Additionally, referred books on traditional medicine and ethnopharmacology were also utilized for receiving traditional records about both the plant species. Results: Both Alstonia scholaris and Alstonia macrophylla are rich in different types of bioactive alkaloids. So far, broad spectrum of in vitro and in vivo biological and pharmacological activities have been reported to both the species. Amongst them, antimicrobial and anticancer activities were promising. Conclusions: The use of Alstonia macrophylla as a substitute for Alstonia scholaris is not at all justifiable as both the species are distinct from each other in their phytochemistry and pharmacology. Further detail chemical fingerprinting and metabolic studies of these two species are warranted to prevent their mutual adulteration most importantly in the context of commercial preparations.

ajebs.com

... during the study. During the ethnobotanical exploration (2006-2008), observations on the four... more ... during the study. During the ethnobotanical exploration (2006-2008), observations on the four important ailments like jaundice, asthma, mouth ulcer ant teeth disorders among the tribal communities were recorded. Due to strong ...

Ethnobotanical Leaflets, 2009

The present communication deals with the ethnobotanical exploration,identification,concerns and f... more The present communication deals with the ethnobotanical exploration,identification,concerns and future potentialities of the wild edible plant species consumed by the tribal communities inhabiting in the hilly areas of akole tahasil of Ahmednagar district fall in Maharashtra state-India. A total of 31 plant species belonging to 23 families were reported from the study area. Amaranthaceae was the dominant family with 4 taxa,while Papilionaceae followed with 3 taxa. Ascplepidaceae and Bignoniaceae represented by 2 taxa each. The four major life forms were climbers, herbs, shrubs and trees. Herb makes up the highest proportion of the edible species followed by trees, shrubs and climbers. The plant species are divided into two class-vegetables and raw. Also the present finding support further investigation into nutritional profits, pharmacological prospects and conservational studies.

Plant and Human Health, Volume 1, 2018