Parvin Mirmiran | Shahid Beheshti University of Medical Sciences (original) (raw)

Papers by Parvin Mirmiran

Research paper thumbnail of Effect of lentil sprouts on lipid profile and blood fasting glucose in overweight and obese patients with type 2 diabetes

Iranian Journal of Endocrinology and Metabolism

Introduction: The effects of lentil sprouts (LS) on lipid profiles and FBS among overweight and o... more Introduction: The effects of lentil sprouts (LS) on lipid profiles and FBS among overweight and obese patients with type 2 diabetes have not yet been examined. Considering the importance of legumes and cereal sprouts in traditional Iranian medicine, we conducted this trial to investigate the effects of LS on fasting blood glucose, and the atherogenic index of plasma (AIP), in overweight and obese patients with type 2 diabetes. Materials and Methods: Thirty-nine patients were randomly divided into two groups. For all individuals throughout the 8 weeks of the study period, the same drug treatment was given, with the intervention group patients consuming 60 g lentil sprouts in addition daily. Total cholesterol, triglycerides (TG), low-density lipoprotein (LDL-C), high density lipoprotein (HDL-C), fasting blood glucose (FBS) and atherogenic index of plasma (AIP) were measured at baseline and 8 weeks after intervention. Results: AIP decreased (P<0.07) in the LS group and their levels of HDL-C and LDL-C increased compared with baseline levels, whereas in the control group no significant change was seen. In this group a decrease in TG of 4.5% was seen, whereas this increase in the control group was 22%. Conclusions: Consumption of LS as supplementary treatment in type 2 diabetes could have favorable effects on lipid profiles, fasting blood glucose and reduce risk of coronary vascular diseases.

Research paper thumbnail of Snack consumption patterns and their associations with risk of incident metabolic syndrome: Tehran Lipid and Glucose Study

Aim: Few studies considered the association between snack patterns and metabolic abnormalities. H... more Aim: Few studies considered the association between snack patterns and metabolic abnormalities. Here we aimed to characterize the major snack patterns among Iranian adults and determine their association with the risk of metabolic syndrome (MetS) and its components.Methods: This study was conducted on 1713 MetS-free adults who participated in the third phase of the Tehran Lipid and Glucose Study (TLGS). At baseline, dietary intake of snack was assessed using a validated 168-items food frequency questionnaire, and snack patterns were obtained by principal component analysis (PCA). Adjusted Hazard Ratios (HRs) and 95% confidence intervals (CIs) were calculated for the association of incident MetS and its components with the extracted snack patterns.Results: PCA identified five major snack patterns, defined as "healthy pattern", "low-fructose pattern", "high-trans pattern", "high-caffeine pattern" and "high-fructose pattern". Participan...

Research paper thumbnail of High insulinemic potential of diet and lifestyle is associated with increased risk of chronic kidney disease incident in adults

BMC Nephrology

Background The role of higher insulinemic effects of dietary pattern and lifestyle factors on the... more Background The role of higher insulinemic effects of dietary pattern and lifestyle factors on the risk of chronic kidney disease (CKD) is not well-studied. In the current study, we aimed to investigate the relationship between the insulinemic potential of diet and lifestyle with the risk of CKD in adults. Methods A total of 6044 individuals without CKD, aged>18 years, were recruited from among participants of the Tehran Lipid and Glucose Study (third and fourth surveys) and followed a mean of 6.03 years(follow-up rate:94.95%). The dietary intake data were collected using a food frequency questionnaire. The insulinemic potential of diet and lifestyle was determined based on four empirical indices, including the empirical dietary index for hyperinsulinemia (EDIH), the empirical dietary index for insulin resistance (EDIR), the empirical lifestyle index for hyperinsulinemia (ELIH), and the empirical lifestyle index for insulin resistance (ELIR). Results Mean ± SD age of all study par...

Research paper thumbnail of Dietary patterns by reduced rank regression predicting changes in obesity indices in a cohort study: Tehran Lipid and Glucose Study

Asia Pacific journal of clinical nutrition, 2010

OBJECTIVE To examine the association between dietary patterns and obesity indices (BMI, WC, WHR) ... more OBJECTIVE To examine the association between dietary patterns and obesity indices (BMI, WC, WHR) among Tehranian adults in a 6-year follow-up study. METHODS Within frame of a cohort study in Tehran (mean follow up 6.6+/-0.9 years), 141 adults were recruited with: two 24 hour dietary recalls at the beginning, as well as obesity indices at the beginning and end of the study period. Dietary intakes were converted into grams of intakes of food items and categorized into 16 groups. Reduced rank regression analysis derived five patterns with total and polyunsaturated-to-saturated fat intake, cholesterol, fiber and calcium intake as response variables. Factors (dietary patterns) were generated retaining a corresponding factor loading > or = |0.17| on the food groups. Changes in obesity indices were scrutinized within quintiles of factor scores. RESULTS There were high loadings on refined carbohydrates, whole grain, starchy vegetables, other vegetables, red and refined meat, saturated/tr...

Research paper thumbnail of The association between dietary fats and the incidence risk of cardiovascular outcomes: Tehran Lipid and Glucose Study

Nutrition & Metabolism, 2021

Background The association between dietary fats and the risk of cardiovascular disease (CVD) is u... more Background The association between dietary fats and the risk of cardiovascular disease (CVD) is under debate. We aimed to determine the potential effects of dietary saturated fats (SFA), mono-unsaturated (MUFA) and poly-unsaturated (PUFA) fatty acids on the occurrence of CVD in an adult Asian population. Methods This study was conducted within the framework of the Tehran Lipid and Glucose Study on 2809 CVD-free adults, aged ≥ 19 years. Dietary intakes of fats were estimated using a validated 168-items semi-quantitative food frequency questionnaire, at baseline. Adjusted hazard ratios and 95% confidence intervals of CVD were calculated in tertile categories of dietary fats. The risk of CVD was estimated with multivariable Cox regression for the substitution of total fat or SFA with other macronutrients. Results During 10.6 years of follow up, the incidence rate of CVD events was 7.1%. Mean (± SD) age of the participants was 39 (± 14) years and 43.9% were men. Total fat, animal and pl...

Research paper thumbnail of Undesirable Cardiometabolic Outcomes of Fast-Food Patterns

Iranian journal of public health, 2015

Research paper thumbnail of Esmaillzadeh A, Mirmiran P, Azizi F. Whole-grain intake and the prevalence of hypertriglyceridemic waist phenotype in Tehranian adults. Am J Clin Nutr 81, 55-63

American Journal of Clinical Nutrition

ABSTRACT

Research paper thumbnail of Association of Dietary Proportions of Macronutrients with Visceral Adiposity Index: Non-Substitution and Iso-Energetic Substitution Models in a Prospective Study

Nutrients, 2015

We aimed to investigate associations between dietary macronutrient proportions and prospective vi... more We aimed to investigate associations between dietary macronutrient proportions and prospective visceral adiposity index changes (∆VAI). The study included 1254 adults (18-74 years), from the Tehran Lipid and Glucose Study (TLGS), who were followed for three years. Dietary intakes were assessed twice using food frequency questionnaires. Associations of dietary macronutrient with ∆VAI and risk of visceral adiposity dysfunction (VAD) after three years were investigated. The percentage of energy intake from protein in the total population, and from fat in women, were associated with higher increases in VAI. A 5% higher energy intake from protein substituted for carbohydrate, monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) was associated with higher ∆VAI. Higher energy intake from animal protein substituted for PUFAs was positively associated with ∆VAI. Substituting protein and PUFAs with MUFAs were related to higher ∆VAI. The associations were similar in men and women, but reached significance mostly among women. Risk of VAD was increased when 1% of energy from protein was replaced with MUFAs. Substituting protein for carbohydrate and fat, and fat for carbohydrate, resulted in increased risk of VAD in women. Higher dietary proportions of protein and animal-derived MUFA may be positively associated with ∆VAI and risk of VAD.

Research paper thumbnail of Relationship between dietary pattern and cardiometabolic risk factors in women with PCOS

Iranian Journal of Endocrinology and Metabolism

ABSTRACT

Research paper thumbnail of Patterns of food consumption and risk of type 2 diabetes in an Iranian population: A nested case-control study

Nutrition & Dietetics, 2015

Aim: To investigate the association between major dietary patterns and risk of type 2 diabetes me... more Aim: To investigate the association between major dietary patterns and risk of type 2 diabetes mellitus (T2DM) among an Iranian urban population. Methods: This is a nested case-control study involving 178 cases with T2DM and 520 controls matched for age, gender and the length of follow up who participated in the Tehran Lipid and Glucose Study (TLGS). A validated food frequency questionnaire, of 168 food items, was used to measure dietary intake, and principal component analysis was used to derive dietary pattern scores. Conditional logistic regression analysis was used to examine the association between dietary patterns scores and risk of T2DM. Results: The mean age of participants was 43.6 ± 12.0 years and 54% were women. Three dietary patterns, which explained 28.15% total variance, were identified: western, healthy and traditional Iranian patterns. Neither the western nor the healthy dietary patterns were significantly related to the risk of T2DM, but a higher score for the traditional dietary pattern (characterised by high intakes of whole grains, legumes, egg and red meat) was found to be associated with an 18% lower risk of T2DM, after adjustment for relevant confounders (odds ratio per 1-SD score 0.82 (95% CI 0.67-0.99)). Conclusions: Adherence to the traditional dietary pattern may be associated with reduced risk of T2DM in an Iranian population.

Research paper thumbnail of Association of B3-adrenoceptor gene polymorphism and obesity in Tehran lipid and glucose study population

Research paper thumbnail of Paper: THE EFFECTS OF IRAN-IRAQ WAR CIRCUMSTANCES ON ADOLESCENT'S ANTHROPOMETRIC AND BIOCHEMICAL INDICES AT THE AGE OF 11-18. TEHRAN LIPID AND GLUCOSE STUDY

Research paper thumbnail of Paper: HEALTHY EATING INDEX AND ITS RELATION WITH DIET QUALITY IN TEHRANI ADOLESCENTS: TEHRAN LIPID AND GLUCOSE STUDY

Research paper thumbnail of Paper: EFFECTS OF BROCCOLI SPROUT POWDER ON FASTING SERUM GLUCOSE AND LIPID PROFILES IN TYPE 2 DIABETIC PATIENTS

Research paper thumbnail of Transient Neonatal Hypothyroidism is Associated with Elevated Serum Anti-Thyroglobulin Antibody Levels in Newborns and Their Mothers

The Journal of Pediatrics, 2007

Transient congenital hypothyroidism (TCH) was detected in 6 of 35,067 newborns (1:5845 births) sc... more Transient congenital hypothyroidism (TCH) was detected in 6 of 35,067 newborns (1:5845 births) screened in Iran. Antithyroglobulin antibodies positivity was present in 4 of 6 (66.7%) of those with TCH and in 6 of 106 (5.7%) of those with &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;transient hyperthyrotropinemia and normal&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; diagnoses (P = .0005), but positivity was similar in newborns with transient hyperthyrotropinemia versus normal neonates (P = .397).

Research paper thumbnail of Metabolic Syndrome: Twenty Years of the Tehran Lipid and Glucose Study Findings

International Journal of Endocrinology and Metabolism, 2018

Context: In recent decades, investigations have been focused on the definition, incidence and pre... more Context: In recent decades, investigations have been focused on the definition, incidence and predictors of metabolic syndrome (MetS) in Iranians. This study aimed to review systematically investigations on MetS, conducted among the Tehran lipid and glucose study (TLGS) participants. Evidence Acquisition: Literature on MetS documented by TLGS studies published from 2000 to 2017 were searched using Pubmed and Scopus database in English language with a combination of following keywords: Metabolic syndrome, TLGS. Results: The harmonized definition of MetS was confirmed, based on the estimated cut point of waist circumference (WC) ≥ 95 cm for both genders in Iran. The incidence rate was 550.9/10000 person/years, lower among women (433.5/10000) than men (749.2/10000). The prevalence of abdominal obesity, high triglycerides (TG), low high density lipoprotein cholesterol (HDL-C), high blood pressure (BP), and high fasting blood glucose (FBG) was 30, 46, 69, 34, and 12%, respectively. The prevalence of MetS in adolescents was 10.1% with no significant difference between boys and girls (10.3% in boys and 9.9% in girls). A strong association of WC (OR: 2.32, CI: 2.06-2.59) and TGs (OR: 1.95, CI: 1.65-2.11) with development of MetS was found. In adolescent boys, WC had the highest OR for MetS risk. WHO-defined MetS was a significant predictor of total and cardiovascular mortality both in men (

Research paper thumbnail of Magnesium intake and prevalence of metabolic syndrome in adults: Tehran Lipid and Glucose Study

Public Health Nutrition, 2012

Objective: We examined the association of metabolic syndrome (MetS) and its components with dieta... more Objective: We examined the association of metabolic syndrome (MetS) and its components with dietary intakes of Mg in Tehran adults. Design: In a cross-sectional study, dietary intakes were assessed using a valid and reliable FFQ. MetS was defined according to the modified guidelines of the National Cholesterol Education Program Adult Treatment Panel III. Waist circumference (WC) was coded according to the newly introduced cut-off points for Iranian adults ($95 cm for both genders). Setting: Participants of the Tehran Lipid and Glucose Study (2006)(2007)(2008). Subjects: Adults (n 2504; 1120 men and 1384 women) aged 18-74 years. Results: The mean age of participants was 40?8 (SD 14?6) years and 38?2 (SD 13?5) years for men and women, respectively. The reported mean intake of Mg was 349 (SD 109) mg/d. After adjustment for confounding factors, dietary Mg intake was inversely associated with fasting blood glucose (b 5 20?08, P 5 0?006), TAG (b 5 20?058, P 5 0?009) and WC (b 5 20?013, P 5 0?006); however, there were no associations between dietary Mg and diastolic blood pressure, systolic blood pressure or HDL cholesterol. An association was observed between MetS Z-score and Mg intake (crude b 5 20?017, P 5 0?001), independent of age, gender, smoking, physical activity and BMI; this association was attenuated following further adjustment for dietary factors and menopausal status (b 5 20?034, P 5 0?061). Conclusions: Our findings suggest a significant inverse association between dietary Mg, MetS and its components.

Research paper thumbnail of Dietary intake of vitamin D and metabolic syndrome after 3 years follow up: Tehran Lipid and Glucose Study

The aim of this study was to examine the association between dietary intakes of vitamin D and the... more The aim of this study was to examine the association between dietary intakes of vitamin D and the metabolic syndrome (MetS) in Tehranian adults, Iran. Methods: In this population-based prospective study, a sample of 2357 subjects, aged 20-74 years, who had completed a validated food frequency questionnaire, were studied. MetS was defined according to the modified guidelines of the National Cholesterol Education Program Adults Treatment Panel III. Results: Median intakes of vitamin D were 1.5 and 1.6 µg/day in men and women respectively. After adjustment for confounding factors, dietary vitamin D intake was inversely associated with fasting blood glucose (β =-0.085, p = 0.004) and waist circumference (β =-0.065, p = 0.035); these associations were attenuated following further adjustment for demographics, body mass index (BMI) and dietary factors ((β =-0.066, p = 0.030) and (β =-0.065, p = 0.044), respectively. An association was observed between incidence of MetS and vitamin D intake (p trend = 0.040), independent of age, gender, smoking, physical activity; this association remained following further adjustment for BMI (p for trend = 0.044) and dietary factors (p for trend = 0.051). Conclusion: Our findings suggest a significant inverse association between dietary vitamin D intake, MetS, and some of its components after controlling for confounding factors.

Research paper thumbnail of Effect of dietary patterns on oxidative stress in Patiants with metabolic syndrome: Tehran Lipid and Glucose Study

Caspian Journal of Internal Medicine, 2018

Background: Metabolic syndrome is a prevalent condition with dramatic rising trend worldwide. Sin... more Background: Metabolic syndrome is a prevalent condition with dramatic rising trend worldwide. Single dietary factors, such as omega-3 fatty acids consumption protect body against oxidative damage by reinforcement of dietary total antioxidant capacity but the combination of all dietary components may be more effective when studied as integrated dietary patterns. This present study was designed to assess the association between different dietary patterns and oxidative stress in a population of Tehranian adults suffering from metabolic syndrome. Methods: Dietary data were collected using a validated 147-item semi-quantitative FFQ with a standard serving size. Factor analysis method was used to derive dietary patterns. Blood analysis and anthropometric measurements were also obtained. Oxidative stress was assesses using serum levels of Malondialdehyde (MDA) and total antioxidant capacity (TAC). Results: The regression coefficient for TAC and MDA with different quintiles of dietary patterns, adjusted for potential confounder in model 3 reveal a significant positive association between healthy pattern and serum TAC levels (β=0.244, p=0.008) and also between serum MDA levels and the unhealthy pattern (β=0.387, p=0.0001). On the other hand, a significant negative association found between serum TAC levels (β=-0.289, p=0.001) and the unhealthy pattern, a relationship also noted between serum MDA levels and the healthy dietary pattern (β=-0.273, p=0.002). Conclusions: Our findings suggest that following a healthy pattern filled with fruits and vegetables ameliorates oxidative stress status and on the contrary, attachment to an unhealthy pattern, characterized by higher intakes of fast foods and processed foods, aggravated the oxidative stress levels in Tehranian individuals suffering from metabolic syndrome.

Research paper thumbnail of Spinach consumption and nonalcoholic fatty liver disease among adults: a case–control study

BMC Gastroenterology

Background Spinach has high antioxidants and polyphenols and showed protective effects against li... more Background Spinach has high antioxidants and polyphenols and showed protective effects against liver diseases in experimental studies. We aimed to assess the association between dietary intake of spinach and odds of nonalcoholic fatty liver disease (NAFLD) in a case–control study among Iranian adults. Methods Totally 225 newly diagnosed NAFLD patients and 450 controls, aged 20–60 years, were recruited in this study. Participants’ dietary intakes were collected using a valid and reliable 168-item semi-quantitative food frequency questionnaire (FFQ). The logistic regression test was used for assessing the association between total, raw, and boiled dietary spinach with the odds of NAFLD. Results The mean (SD) age and BMI of participants (53% male) were 38.1 (8.8) years and 26.8 (4.3) kg/m2, respectively. In the final adjusted model for potential confounders, the odds (95% CI) of NAFLD in individuals in the highest tertile of daily total and raw spinach intake was [0.36 (0.19–0.71), P_t...

Research paper thumbnail of Effect of lentil sprouts on lipid profile and blood fasting glucose in overweight and obese patients with type 2 diabetes

Iranian Journal of Endocrinology and Metabolism

Introduction: The effects of lentil sprouts (LS) on lipid profiles and FBS among overweight and o... more Introduction: The effects of lentil sprouts (LS) on lipid profiles and FBS among overweight and obese patients with type 2 diabetes have not yet been examined. Considering the importance of legumes and cereal sprouts in traditional Iranian medicine, we conducted this trial to investigate the effects of LS on fasting blood glucose, and the atherogenic index of plasma (AIP), in overweight and obese patients with type 2 diabetes. Materials and Methods: Thirty-nine patients were randomly divided into two groups. For all individuals throughout the 8 weeks of the study period, the same drug treatment was given, with the intervention group patients consuming 60 g lentil sprouts in addition daily. Total cholesterol, triglycerides (TG), low-density lipoprotein (LDL-C), high density lipoprotein (HDL-C), fasting blood glucose (FBS) and atherogenic index of plasma (AIP) were measured at baseline and 8 weeks after intervention. Results: AIP decreased (P<0.07) in the LS group and their levels of HDL-C and LDL-C increased compared with baseline levels, whereas in the control group no significant change was seen. In this group a decrease in TG of 4.5% was seen, whereas this increase in the control group was 22%. Conclusions: Consumption of LS as supplementary treatment in type 2 diabetes could have favorable effects on lipid profiles, fasting blood glucose and reduce risk of coronary vascular diseases.

Research paper thumbnail of Snack consumption patterns and their associations with risk of incident metabolic syndrome: Tehran Lipid and Glucose Study

Aim: Few studies considered the association between snack patterns and metabolic abnormalities. H... more Aim: Few studies considered the association between snack patterns and metabolic abnormalities. Here we aimed to characterize the major snack patterns among Iranian adults and determine their association with the risk of metabolic syndrome (MetS) and its components.Methods: This study was conducted on 1713 MetS-free adults who participated in the third phase of the Tehran Lipid and Glucose Study (TLGS). At baseline, dietary intake of snack was assessed using a validated 168-items food frequency questionnaire, and snack patterns were obtained by principal component analysis (PCA). Adjusted Hazard Ratios (HRs) and 95% confidence intervals (CIs) were calculated for the association of incident MetS and its components with the extracted snack patterns.Results: PCA identified five major snack patterns, defined as "healthy pattern", "low-fructose pattern", "high-trans pattern", "high-caffeine pattern" and "high-fructose pattern". Participan...

Research paper thumbnail of High insulinemic potential of diet and lifestyle is associated with increased risk of chronic kidney disease incident in adults

BMC Nephrology

Background The role of higher insulinemic effects of dietary pattern and lifestyle factors on the... more Background The role of higher insulinemic effects of dietary pattern and lifestyle factors on the risk of chronic kidney disease (CKD) is not well-studied. In the current study, we aimed to investigate the relationship between the insulinemic potential of diet and lifestyle with the risk of CKD in adults. Methods A total of 6044 individuals without CKD, aged>18 years, were recruited from among participants of the Tehran Lipid and Glucose Study (third and fourth surveys) and followed a mean of 6.03 years(follow-up rate:94.95%). The dietary intake data were collected using a food frequency questionnaire. The insulinemic potential of diet and lifestyle was determined based on four empirical indices, including the empirical dietary index for hyperinsulinemia (EDIH), the empirical dietary index for insulin resistance (EDIR), the empirical lifestyle index for hyperinsulinemia (ELIH), and the empirical lifestyle index for insulin resistance (ELIR). Results Mean ± SD age of all study par...

Research paper thumbnail of Dietary patterns by reduced rank regression predicting changes in obesity indices in a cohort study: Tehran Lipid and Glucose Study

Asia Pacific journal of clinical nutrition, 2010

OBJECTIVE To examine the association between dietary patterns and obesity indices (BMI, WC, WHR) ... more OBJECTIVE To examine the association between dietary patterns and obesity indices (BMI, WC, WHR) among Tehranian adults in a 6-year follow-up study. METHODS Within frame of a cohort study in Tehran (mean follow up 6.6+/-0.9 years), 141 adults were recruited with: two 24 hour dietary recalls at the beginning, as well as obesity indices at the beginning and end of the study period. Dietary intakes were converted into grams of intakes of food items and categorized into 16 groups. Reduced rank regression analysis derived five patterns with total and polyunsaturated-to-saturated fat intake, cholesterol, fiber and calcium intake as response variables. Factors (dietary patterns) were generated retaining a corresponding factor loading > or = |0.17| on the food groups. Changes in obesity indices were scrutinized within quintiles of factor scores. RESULTS There were high loadings on refined carbohydrates, whole grain, starchy vegetables, other vegetables, red and refined meat, saturated/tr...

Research paper thumbnail of The association between dietary fats and the incidence risk of cardiovascular outcomes: Tehran Lipid and Glucose Study

Nutrition & Metabolism, 2021

Background The association between dietary fats and the risk of cardiovascular disease (CVD) is u... more Background The association between dietary fats and the risk of cardiovascular disease (CVD) is under debate. We aimed to determine the potential effects of dietary saturated fats (SFA), mono-unsaturated (MUFA) and poly-unsaturated (PUFA) fatty acids on the occurrence of CVD in an adult Asian population. Methods This study was conducted within the framework of the Tehran Lipid and Glucose Study on 2809 CVD-free adults, aged ≥ 19 years. Dietary intakes of fats were estimated using a validated 168-items semi-quantitative food frequency questionnaire, at baseline. Adjusted hazard ratios and 95% confidence intervals of CVD were calculated in tertile categories of dietary fats. The risk of CVD was estimated with multivariable Cox regression for the substitution of total fat or SFA with other macronutrients. Results During 10.6 years of follow up, the incidence rate of CVD events was 7.1%. Mean (± SD) age of the participants was 39 (± 14) years and 43.9% were men. Total fat, animal and pl...

Research paper thumbnail of Undesirable Cardiometabolic Outcomes of Fast-Food Patterns

Iranian journal of public health, 2015

Research paper thumbnail of Esmaillzadeh A, Mirmiran P, Azizi F. Whole-grain intake and the prevalence of hypertriglyceridemic waist phenotype in Tehranian adults. Am J Clin Nutr 81, 55-63

American Journal of Clinical Nutrition

ABSTRACT

Research paper thumbnail of Association of Dietary Proportions of Macronutrients with Visceral Adiposity Index: Non-Substitution and Iso-Energetic Substitution Models in a Prospective Study

Nutrients, 2015

We aimed to investigate associations between dietary macronutrient proportions and prospective vi... more We aimed to investigate associations between dietary macronutrient proportions and prospective visceral adiposity index changes (∆VAI). The study included 1254 adults (18-74 years), from the Tehran Lipid and Glucose Study (TLGS), who were followed for three years. Dietary intakes were assessed twice using food frequency questionnaires. Associations of dietary macronutrient with ∆VAI and risk of visceral adiposity dysfunction (VAD) after three years were investigated. The percentage of energy intake from protein in the total population, and from fat in women, were associated with higher increases in VAI. A 5% higher energy intake from protein substituted for carbohydrate, monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs) was associated with higher ∆VAI. Higher energy intake from animal protein substituted for PUFAs was positively associated with ∆VAI. Substituting protein and PUFAs with MUFAs were related to higher ∆VAI. The associations were similar in men and women, but reached significance mostly among women. Risk of VAD was increased when 1% of energy from protein was replaced with MUFAs. Substituting protein for carbohydrate and fat, and fat for carbohydrate, resulted in increased risk of VAD in women. Higher dietary proportions of protein and animal-derived MUFA may be positively associated with ∆VAI and risk of VAD.

Research paper thumbnail of Relationship between dietary pattern and cardiometabolic risk factors in women with PCOS

Iranian Journal of Endocrinology and Metabolism

ABSTRACT

Research paper thumbnail of Patterns of food consumption and risk of type 2 diabetes in an Iranian population: A nested case-control study

Nutrition & Dietetics, 2015

Aim: To investigate the association between major dietary patterns and risk of type 2 diabetes me... more Aim: To investigate the association between major dietary patterns and risk of type 2 diabetes mellitus (T2DM) among an Iranian urban population. Methods: This is a nested case-control study involving 178 cases with T2DM and 520 controls matched for age, gender and the length of follow up who participated in the Tehran Lipid and Glucose Study (TLGS). A validated food frequency questionnaire, of 168 food items, was used to measure dietary intake, and principal component analysis was used to derive dietary pattern scores. Conditional logistic regression analysis was used to examine the association between dietary patterns scores and risk of T2DM. Results: The mean age of participants was 43.6 ± 12.0 years and 54% were women. Three dietary patterns, which explained 28.15% total variance, were identified: western, healthy and traditional Iranian patterns. Neither the western nor the healthy dietary patterns were significantly related to the risk of T2DM, but a higher score for the traditional dietary pattern (characterised by high intakes of whole grains, legumes, egg and red meat) was found to be associated with an 18% lower risk of T2DM, after adjustment for relevant confounders (odds ratio per 1-SD score 0.82 (95% CI 0.67-0.99)). Conclusions: Adherence to the traditional dietary pattern may be associated with reduced risk of T2DM in an Iranian population.

Research paper thumbnail of Association of B3-adrenoceptor gene polymorphism and obesity in Tehran lipid and glucose study population

Research paper thumbnail of Paper: THE EFFECTS OF IRAN-IRAQ WAR CIRCUMSTANCES ON ADOLESCENT'S ANTHROPOMETRIC AND BIOCHEMICAL INDICES AT THE AGE OF 11-18. TEHRAN LIPID AND GLUCOSE STUDY

Research paper thumbnail of Paper: HEALTHY EATING INDEX AND ITS RELATION WITH DIET QUALITY IN TEHRANI ADOLESCENTS: TEHRAN LIPID AND GLUCOSE STUDY

Research paper thumbnail of Paper: EFFECTS OF BROCCOLI SPROUT POWDER ON FASTING SERUM GLUCOSE AND LIPID PROFILES IN TYPE 2 DIABETIC PATIENTS

Research paper thumbnail of Transient Neonatal Hypothyroidism is Associated with Elevated Serum Anti-Thyroglobulin Antibody Levels in Newborns and Their Mothers

The Journal of Pediatrics, 2007

Transient congenital hypothyroidism (TCH) was detected in 6 of 35,067 newborns (1:5845 births) sc... more Transient congenital hypothyroidism (TCH) was detected in 6 of 35,067 newborns (1:5845 births) screened in Iran. Antithyroglobulin antibodies positivity was present in 4 of 6 (66.7%) of those with TCH and in 6 of 106 (5.7%) of those with &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;transient hyperthyrotropinemia and normal&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; diagnoses (P = .0005), but positivity was similar in newborns with transient hyperthyrotropinemia versus normal neonates (P = .397).

Research paper thumbnail of Metabolic Syndrome: Twenty Years of the Tehran Lipid and Glucose Study Findings

International Journal of Endocrinology and Metabolism, 2018

Context: In recent decades, investigations have been focused on the definition, incidence and pre... more Context: In recent decades, investigations have been focused on the definition, incidence and predictors of metabolic syndrome (MetS) in Iranians. This study aimed to review systematically investigations on MetS, conducted among the Tehran lipid and glucose study (TLGS) participants. Evidence Acquisition: Literature on MetS documented by TLGS studies published from 2000 to 2017 were searched using Pubmed and Scopus database in English language with a combination of following keywords: Metabolic syndrome, TLGS. Results: The harmonized definition of MetS was confirmed, based on the estimated cut point of waist circumference (WC) ≥ 95 cm for both genders in Iran. The incidence rate was 550.9/10000 person/years, lower among women (433.5/10000) than men (749.2/10000). The prevalence of abdominal obesity, high triglycerides (TG), low high density lipoprotein cholesterol (HDL-C), high blood pressure (BP), and high fasting blood glucose (FBG) was 30, 46, 69, 34, and 12%, respectively. The prevalence of MetS in adolescents was 10.1% with no significant difference between boys and girls (10.3% in boys and 9.9% in girls). A strong association of WC (OR: 2.32, CI: 2.06-2.59) and TGs (OR: 1.95, CI: 1.65-2.11) with development of MetS was found. In adolescent boys, WC had the highest OR for MetS risk. WHO-defined MetS was a significant predictor of total and cardiovascular mortality both in men (

Research paper thumbnail of Magnesium intake and prevalence of metabolic syndrome in adults: Tehran Lipid and Glucose Study

Public Health Nutrition, 2012

Objective: We examined the association of metabolic syndrome (MetS) and its components with dieta... more Objective: We examined the association of metabolic syndrome (MetS) and its components with dietary intakes of Mg in Tehran adults. Design: In a cross-sectional study, dietary intakes were assessed using a valid and reliable FFQ. MetS was defined according to the modified guidelines of the National Cholesterol Education Program Adult Treatment Panel III. Waist circumference (WC) was coded according to the newly introduced cut-off points for Iranian adults ($95 cm for both genders). Setting: Participants of the Tehran Lipid and Glucose Study (2006)(2007)(2008). Subjects: Adults (n 2504; 1120 men and 1384 women) aged 18-74 years. Results: The mean age of participants was 40?8 (SD 14?6) years and 38?2 (SD 13?5) years for men and women, respectively. The reported mean intake of Mg was 349 (SD 109) mg/d. After adjustment for confounding factors, dietary Mg intake was inversely associated with fasting blood glucose (b 5 20?08, P 5 0?006), TAG (b 5 20?058, P 5 0?009) and WC (b 5 20?013, P 5 0?006); however, there were no associations between dietary Mg and diastolic blood pressure, systolic blood pressure or HDL cholesterol. An association was observed between MetS Z-score and Mg intake (crude b 5 20?017, P 5 0?001), independent of age, gender, smoking, physical activity and BMI; this association was attenuated following further adjustment for dietary factors and menopausal status (b 5 20?034, P 5 0?061). Conclusions: Our findings suggest a significant inverse association between dietary Mg, MetS and its components.

Research paper thumbnail of Dietary intake of vitamin D and metabolic syndrome after 3 years follow up: Tehran Lipid and Glucose Study

The aim of this study was to examine the association between dietary intakes of vitamin D and the... more The aim of this study was to examine the association between dietary intakes of vitamin D and the metabolic syndrome (MetS) in Tehranian adults, Iran. Methods: In this population-based prospective study, a sample of 2357 subjects, aged 20-74 years, who had completed a validated food frequency questionnaire, were studied. MetS was defined according to the modified guidelines of the National Cholesterol Education Program Adults Treatment Panel III. Results: Median intakes of vitamin D were 1.5 and 1.6 µg/day in men and women respectively. After adjustment for confounding factors, dietary vitamin D intake was inversely associated with fasting blood glucose (β =-0.085, p = 0.004) and waist circumference (β =-0.065, p = 0.035); these associations were attenuated following further adjustment for demographics, body mass index (BMI) and dietary factors ((β =-0.066, p = 0.030) and (β =-0.065, p = 0.044), respectively. An association was observed between incidence of MetS and vitamin D intake (p trend = 0.040), independent of age, gender, smoking, physical activity; this association remained following further adjustment for BMI (p for trend = 0.044) and dietary factors (p for trend = 0.051). Conclusion: Our findings suggest a significant inverse association between dietary vitamin D intake, MetS, and some of its components after controlling for confounding factors.

Research paper thumbnail of Effect of dietary patterns on oxidative stress in Patiants with metabolic syndrome: Tehran Lipid and Glucose Study

Caspian Journal of Internal Medicine, 2018

Background: Metabolic syndrome is a prevalent condition with dramatic rising trend worldwide. Sin... more Background: Metabolic syndrome is a prevalent condition with dramatic rising trend worldwide. Single dietary factors, such as omega-3 fatty acids consumption protect body against oxidative damage by reinforcement of dietary total antioxidant capacity but the combination of all dietary components may be more effective when studied as integrated dietary patterns. This present study was designed to assess the association between different dietary patterns and oxidative stress in a population of Tehranian adults suffering from metabolic syndrome. Methods: Dietary data were collected using a validated 147-item semi-quantitative FFQ with a standard serving size. Factor analysis method was used to derive dietary patterns. Blood analysis and anthropometric measurements were also obtained. Oxidative stress was assesses using serum levels of Malondialdehyde (MDA) and total antioxidant capacity (TAC). Results: The regression coefficient for TAC and MDA with different quintiles of dietary patterns, adjusted for potential confounder in model 3 reveal a significant positive association between healthy pattern and serum TAC levels (β=0.244, p=0.008) and also between serum MDA levels and the unhealthy pattern (β=0.387, p=0.0001). On the other hand, a significant negative association found between serum TAC levels (β=-0.289, p=0.001) and the unhealthy pattern, a relationship also noted between serum MDA levels and the healthy dietary pattern (β=-0.273, p=0.002). Conclusions: Our findings suggest that following a healthy pattern filled with fruits and vegetables ameliorates oxidative stress status and on the contrary, attachment to an unhealthy pattern, characterized by higher intakes of fast foods and processed foods, aggravated the oxidative stress levels in Tehranian individuals suffering from metabolic syndrome.

Research paper thumbnail of Spinach consumption and nonalcoholic fatty liver disease among adults: a case–control study

BMC Gastroenterology

Background Spinach has high antioxidants and polyphenols and showed protective effects against li... more Background Spinach has high antioxidants and polyphenols and showed protective effects against liver diseases in experimental studies. We aimed to assess the association between dietary intake of spinach and odds of nonalcoholic fatty liver disease (NAFLD) in a case–control study among Iranian adults. Methods Totally 225 newly diagnosed NAFLD patients and 450 controls, aged 20–60 years, were recruited in this study. Participants’ dietary intakes were collected using a valid and reliable 168-item semi-quantitative food frequency questionnaire (FFQ). The logistic regression test was used for assessing the association between total, raw, and boiled dietary spinach with the odds of NAFLD. Results The mean (SD) age and BMI of participants (53% male) were 38.1 (8.8) years and 26.8 (4.3) kg/m2, respectively. In the final adjusted model for potential confounders, the odds (95% CI) of NAFLD in individuals in the highest tertile of daily total and raw spinach intake was [0.36 (0.19–0.71), P_t...