Devanand Venkatasubbu | SRM UNIVERSITY (original) (raw)

Papers by Devanand Venkatasubbu

Electronic Materials Letters

X-rays are widely used in many domains such as clinical diagnostic, imaging, industrial inspectio... more X-rays are widely used in many domains such as clinical diagnostic, imaging, industrial inspection, and environmental safety, allowing researchers for innoviative superior low-dose sensor development. In direct detection type of X-ray, X-ray photons are directly absorbed by photoconductors such as HgI2, PbI2, and BiI3 that are the available X-ray semiconductor detectors. This study analyzes the properties of micro and nanocrystalline PbWO4 prepared as thick film above the interdigitated electrode for direct photon detection. PbWO4 was found to have a better attenuation value of ~ 6.13 cm2/g at 70 keV as compared with the existing semiconductor detectors. The X-ray-instigated photocurrent behavior of PbWO4 was measured at various low doses by an intra-oral 70 keV machine connected with a Keithley model 2450 measuring source meter. Maximum sensitivity was found to be about 0.40 and 9.80 nC/mGycm3, respectively, for micro and nanocrystalline PbWO4, obtained at 7.97 mGy dose. The nanocrystalline PbWO4 thick film displayed more than twenty-four times sensitivity as compared with the microcrystalline PbWO4 film by virtue of the nanocrystalline size effect on X-ray detection.

Materials Today: Proceedings

Diamond and Related Materials

New Journal of Chemistry

GO/TiO2(V–N) is fabricated as a visible light driven efficient antimicrobial material. In the pre... more GO/TiO2(V–N) is fabricated as a visible light driven efficient antimicrobial material. In the presence of light, GO/TiO2(V–N) was employed as a photocatalytic active material against wound pathogens.

Materials Science and Engineering: C, 2017

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021

Abstract Targeted drug delivery is an advanced method that increases the concentration of drug in... more Abstract Targeted drug delivery is an advanced method that increases the concentration of drug in the specific targeted area in the body. It improves efficacy of treatment and reduces the side effects in drug administration. The use of nanoparticles enhances the bioavailability, in vivo stability, intestinal absorption, solubility, sustained and targeted delivery. Quercetin (Q) is an anticancer agent used in cancer models due to its antioxidant and antitumor properties. Folic acid (FA) is the ligand used to activate receptor mediated endocytosis for targeted delivery of Quercetin. Polydopamine (PD) is pH sensitive and also inhibits angiogenesis. The quinones of PD serves as anchoring points for FA conjugation. In this work, honeycomb structured Nickel oxide (NiO) nanoparticles loaded with quercetin, surface modified with FA and PD was synthesized to target triple negative breast cancer cells. NiO was characterized by XRD, FTIR, Raman Spectroscopy, BET analysis and Zeta Potential. The honeycomb structure was confirmed by SEM. NiO size and morphology was analyzed by TEM. The porous structure of NiO enabled the efficient loading of Quercetin. Hemolysis analysis showed NiO has good hemocompatibility. The drug release profile confirmed a pH sensitive and controlled delivery of Quercetin. The drug release profile expressed higher release at lower pH. The drug release kinetic profile unveils the primary release mechanism to be diffusion controlled. MTT assay were performed against Vero cell line and MDA-MB-231 breast cancer cell line. The nanoformulation showed reduced cytotoxicity and good biocompatibility on Vero cells and appreciable anti-cancer activity on MDA-MB-231 breast cancer cell line.

Environmental Pollution, 2021

The synergistic photoelectrochemical (PEC) technology is a robust process for the conversion of C... more The synergistic photoelectrochemical (PEC) technology is a robust process for the conversion of CO2 into fuels. However, designing a highly efficient UV-visible driven photoelectrocatalyst is still challenging. Herein, a plasmonic Ag NPs modified TiO2/RGO photoelectrocatalyst (Ag-TiO2/RGO) has been designed for the PEC CO2 reduction into selective production of CH3OH. HR-TEM analysis revealed that Ag and TiO2 NPs with average sizes of 4 and 7 nm, respectively, were densely grown on the few-micron-sized 2D RGO nanosheets. The physicochemical analysis was used to determine the optical and textural properties of the Ag-TiO2/RGO nanohybrids. Under VU-Vis light illumination, Ag-TiO2/RGO photocathode possessed a current density of 23.5 mA cm-2 and a lower electrode resistance value of 125 Ω in CO2-saturated 1.0 M KOH-aqueous electrolyte solution. Catalytic studies showed that the Ag-TiO2/RGO photocathode possessed a remarkable PEC CO2 reduction activity and selective production of CH3OH with a yield of 85 μmol L-1 cm-2, the quantum efficiency of 20% and Faradic efficiency of 60.5% at onset potential of -0.7 V. A plausible PEC CO2 reduction mechanism over Ag-TiO2/RGO photocathode is schematically demonstrated. The present work gives a new avenue to develop high-performance and stable photoelectrocatalyst for PEC CO2 reduction towards sustainable liquid fuels production.

Journal of Fluorescence, 2020

Semiconducting nanoparticles with luminescent properties are used as detection probes and drug ca... more Semiconducting nanoparticles with luminescent properties are used as detection probes and drug carriers in in-vitro and in-vivo analysis. ZnO nanoparticles, due to its biocompatibility and low cost, have shown potential application in bioimaging and drug delivery. Thus, ZnO/SiO 2 core/shell nanoparticle was synthesised by wet chemical method for fluorescent probing and drug delivery application. The synthesised core/shell nanomaterial was characterized using XRD, FTIR, UV-VIS spectroscopy, Raman spectroscopy, TEM and PL analysis. The silicon shell enhances the photoluminescence and aqueous stability of the pure ZnO nanoparticles. The porous surface of the shell acts as a carrier for sustained release of curcumin. The synthesized core/shell particle shows high cell viability, hemocompatibility and promising florescent property.

Applied Surface Science, 2019

Abstract Zinc Oxide (ZnO) nanoparticles are used in the field of nanomedicine. ZnO is non-toxic a... more Abstract Zinc Oxide (ZnO) nanoparticles are used in the field of nanomedicine. ZnO is non-toxic and compatible with biological system. The major problem of wound is infections. The infections delays wound healing. Usage of Nanomaterials like ZnO nanoparticles for wound healing is promising. ZnO nanoparticles are synthesised by wet chemical method. It is annealed at 300, 500, 700, and 900 °C for 3 h. ZnO nanoparticle morphology and size distribution are analysed by XRD, FTIR and TEM. The influences of particle size on fibroblast cell growth (NIH3T3) and on antimicrobial activity are analysed. The growth of fibroblast cell is higher with ZnO nanoparticles of larger particle size. Further the MTT analysis, fluorescence calcein AM cell staining and F-actin analysis confirms the growth of fibroblast cells with improved biocompatibility behaviour. The antimicrobial activity is higher for ZnO nanoparticles of lower particle size. Confocal microscope analysis and Zone of inhibition analysis confirms the antimicrobial activity of ZnO nanoparticles.

International Journal of Biological Macromolecules, 2019

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Materials Science in Semiconductor Processing, 2019

Materials such as PbI 2 , HgI 2 and PbO are widely used to fabricate flat panel X-ray imaging det... more Materials such as PbI 2 , HgI 2 and PbO are widely used to fabricate flat panel X-ray imaging detector because of high X-ray stopping power (attenuation coefficient). In general, the stopping power (Z 4 /E 3) depends on high atomic number (Z) of the material and energy (E) of the X-ray radiation. In the present study, high atomic numbered bismuth oxyiodides such as BiOI and Bi 5 O 7 I nanocrystals were synthesized using a novel process and used in the device fabrication. Thick films of both the samples were coated on the top of patterned metal electrode and interfaced with a source meter to readout the electrical variation for 3.2 s illumination of X-ray using 70 kV real-time dental X-ray imaging machine. The observed result reveals that, the sensitivity increases with the increase of Z value. Also the possibility of utilizing both the nanocrystalline bismuth oxyiodides for the low-dose X-ray detector was explored.

Sensors and Actuators A: Physical, 2019

Colloids and Surfaces A: Physicochemical and Engineering Aspects

Journal of Pharmacy & Bioallied Sciences, 2021

Bone is an amazing nanocomposite tissue made of both organic (primarily collagen) and inorganic (... more Bone is an amazing nanocomposite tissue made of both organic (primarily collagen) and inorganic (primarily nano-hydroxyapatite [n-HA]) elements. Bone grafting is a widely used surgical technique in dental and orthopedic surgeries to enhance bone regeneration. In view of the significant drawbacks of traditional treatments, nanomaterials offer new strategies for bone regeneration. The HA with the chemical formula of Ca10(OH)2(PO4)6 is very identical to the inorganic portion of bone. Due to its high stability and minimal solubility, it is often used in orthopedic and dental procedures. Currently, n-HA, which facilitates the growth of new bone, has garnered considerable attention because of better bioactivity and bone integration ability when compared to porous HA. This review gives comprehensive insights related to n-HA structure, chemical composition, surface modification techniques, and their application in bone tissue engineering.

The present investigation was carried out to screen various extracts of Clausena dentata and Dodo... more The present investigation was carried out to screen various extracts of Clausena dentata and Dodonea viscosa and cultivated plants like Anacardium occidentale and Nicotiana tobacum. Among the various extracts tested, 5% concentration of extract gave 100% of FDI (Feeding Deterrence Index). Comparing the antifeedent activity of the plants mentioned above, pet ether extracts have D. viscosa (83.4%) and seed oil of A. occidentale (87.4%) showed greater antifeedent activity at 3% concentration.

Photodiagnosis and Photodynamic Therapy, 2021

Treating infection causing microorganisms is one of the major challenges in wound healing. They g... more Treating infection causing microorganisms is one of the major challenges in wound healing. They gain resistance due to the overuse of conventional antibiotics. Biocompatible nanomaterials with enhanced antibacterial activity are developed to overcome the bacterial resistance. Another promising technique called antimicrobial photodynamic therapy (aPDT) was used to selectively to cause damage infectious pathogenic cells via more generation of reactive oxygen species (ROS). GO/Zn(Cu)O nanocomposite was synthesized by co-precipitation method. Graphene Oxide (GO) is known for its high surface to volume ratio, excellent surface functionality and enhanced antimicrobial property. ZnO nanoparticle induces the generation of reactive oxygen species (ROS) under light irradiation and it leads to recombination of electron-hole pair. Nanocomposites of GO and Cu doped ZnO increases visible light absorption and enhances the photocatalytic property. It generates more ROS and increases the bacterial inhibition. GO/Zn(Cu)O nanocomposite is tested against Staphylococcus aureus (S. aureus), Enterococcus faecium (E. faecium), Escherichia coli (E. coli), Salmonella typhi (S. typhi), Shigella flexneri (S. flexneri) and Pseudomonas aeruginosa (P. aeruginosa) by well diffusion method, growth curve, colony count, biofilm formation under both dark and visible light condition. Reactive Oxygen Species assay (ROS), Lactate dehydrogenase leakage (LDH) assay, Protein estimation assay and membrane integrity study proves the mechanism of inhibition of bacteria. Inhibition kinetics shows the sensitivity between bacteria and GO/Zn(Cu)O nanocomposite.

MOJ Proteomics & Bioinformatics, 2017

| http://medcraveonline.com motility, protein translation, protein turnover, cellular signaling a... more | http://medcraveonline.com motility, protein translation, protein turnover, cellular signaling and apoptosis. 3 Often times they regulate cellular processes through a highly controlled series of phosphorylation reactions wherein activity of a downstream protein kinase is regulated by phosphorylation by another upstream protein kinase. Deregulated kinase activity is a frequent cause of disease, particularly cancer, where they regulate many aspects important in tumor progression and metastasis. In several instances protein kinases regulates cancer progression by phosphorylating ontogenesis and tumor suppressor proteins thereby regulating the activity, stability, and function. 4-8 Interestingly, many of the tumor suppressor genes and dominant oncogenes identified so far are also protein kinases. Kinases such as c-Src, c-Abl, mitogen activated protein (MAP) kinase, phosphotidylinositol-3-kinase (PI3K) AKT, and the epidermal growth factor (EGF) receptor are commonly activated in cancer cells, and are known to contribute to tumor genesis. 9-13 Given their importance in human diseases such as cancer, protein kinases have emerged as attractive therapeutic targets.

Applied Nanoscience, 2021

In this present investigation, synthesis and characterization of mesoporous SiO2 was prepared and... more In this present investigation, synthesis and characterization of mesoporous SiO2 was prepared and the curcumin drug was loaded into the nanoparticles. The haemolytic study and antibacterial activity were investigated. The work is focused on the synthesis of silica by sol–gel methods from precursor of silica tetraethyl orthosilicate (TEOS), NaOH, pore generating agent cetyltrimethylammonium bromide (CTAB). The morphology analysis of the particles was carried out using field-emission scanning electron microscopy techniques (FESEM), Silica dioxide were confirmed by XRD and FTIR analysis. The Mesoporous analysis, surface area, pore size and pore volumes N2 adsorption/desorption are carried out by BET analysis.