Prof. Mohamed Labib Salem | Tanta University (original) (raw)

Books by Prof. Mohamed Labib Salem

The objective of science is to find out the character, properties, and the laws governing the var... more The objective of science is to find out the character, properties,
and the laws governing the various things and phenomena that
we see in the natural world. Scientific research concerns the act
of knowingwhat mankind does not know yet. And science follows
very definite methods in trying to know what is yet unknown.
In the past various approaches have been proposed for finding
out the answers to the questionswe have about various events
and things. Some of these have proved to be useful, and some
have led people astray. Finally, after much trial and error, after
much groping in the dark, after many successes and failures,
science has found the proper methodological approach to find
truth about nature. This is what constitutes the philosophy of
science.

This section intends to present a conceptual analysis of basic terms in the history and philosoph... more This section intends to present a conceptual analysis of basic terms in the history and philosophy of science. The history and philosophy of science is a study of the gradual development of the entire series of human activities which has culminated in what is now termed science. As can be seen and expected, the terms, “History”, Philosophy” and “Science”, stare us in the face begging for explanations. We shall, therefore, analyze these terms in their nuances and ramifications. The question of science, what science is and what it exists for will be presented. There will be an attempt to analyze “scientific method” and distinguish it from “scientific technique”. The features and goals of science will also be discussed here. The notions of facts, hypothesis, scientific theory and scientific law will be briefly explained. With an analysis on the scientific method, we shall realize that the scientific process involves inductive reasoning in the most part and a quantum of deduction. There will be a cursory explanation of the nature and place of philosophy of science.

The Arab world covers a vast geographic area, comprising many different countries in Asia and Afr... more The Arab world covers a vast geographic area, comprising many different countries in Asia and Africa. The contemporary world owes much of its progress in all fields of human intellectual activity, including medicine, to Arabic culture, especially the advancements made during the Golden Age of Arabic-Islamic science (8th to 13th centuries C.E.). The glorious historic background of the Arabic world permits us to identify the debt that humanity owes to the Golden Age of Arabic science and to evaluate the research contributions made by Arab countries to biomedical sciences in our own day.

I would like to thank you for purchasing this book. “Critical Thinking: Practical strategies for ... more I would like to thank you for purchasing this book. “Critical Thinking:
Practical strategies for better decision making, problem solving and goal
setting.”
This book is an excellent introduction to the basic principles of critical
thinking. It will provide you with insightful tips, and easy steps that you can
follow to solve problems efficiently. The tips presented in this book aren’t
restricted to just one scenario and can be made use of in every aspect of life.
Critical thinking is the ability to think objectively and rationally about a
particular situation without letting your emotions rule you. This is an
important skill that’s quite important in life if you want to be successful. Like any other skill, this one can be easily learned! All it needs is a little bit of practice and patience.

In this book, you will learn about critical thinking, the skills essential for
critical thinking, strategies for better decision-making, and you will find tips for problem solving, and the learn the strategies needed for setting goals. The tips and various strategies mentioned in this book are not only easy to understand but can be followed quite easily as well. Let us get started without any further ado.

مشاعر آيلة للسقوط - مجموعة قصصية, 2021

المشاعر الطيبة لغة القلوب وأبخرة العقول برائحة العنبر والمسك، وكلما تأججت نيران المشاعر ازداد تصا... more المشاعر الطيبة لغة القلوب وأبخرة العقول برائحة العنبر والمسك، وكلما تأججت نيران المشاعر ازداد تصاعد أبخرة الأحاسيس الحُلوة من العقل وَرَقَّ القلب. ولكن هناك من المشاعر ما تظل تتأجج حتى تنضب شعلتها؛ فتخفت رويدًا رويدًا حتى تصير آيلة للسقوط، وتصبح من الذكريات ويحترق القلب. ولكن قد تتعافى المشاعر فجأة وتشتعل جذوة الأحاسيس الحُلوة مرة أخرى بفضل كلمة حب من أحدهم، أو اهتمام، أو نظرة بعيون حانية دامعة؛ أو قد تستمر في طريقها للسقوط كما تسقط أوراق الأشجار في الخريف.
وهكذا تحيا القلوب الرقيقة التي تبحث دائما عن يد تكفكف عليها أو كلمة تطبطب عليها. وعن تلك القلوب وعن تلك المشاعر تدور هذه المجموعة القصصية التي قد تجد نفسك فيها هنا أو هناك محاولا أن تمنع مشاعرك من السقوط

الكتاب مهم جدا للمشتغلين في البحث العلمي

Prof. Salem (Ph.D.) is the Prof. of Immunology, Faculty of Science, Tanta University, Egypt. He i... more Prof. Salem (Ph.D.) is the Prof. of Immunology, Faculty of Science, Tanta University, Egypt. He is an outstanding scholar in Immunology and Cancer Immunology based on his cutting-edge research in the USA, Japan, and Egypt. His main discoveries in the preclinical settings have been translated into clinics. Prof. Salem is the founding director of the Center of Excellence in Cancer Research, at Tanta University, President of the Egyptian Association of Cancer Research, Egypt. He won several Int., regional, and national prizes, awards, and recognition.

ARTICLE INFO Administration of olive oil optimizes the acetic acid induced colitis in CD1 mice, S... more ARTICLE INFO Administration of olive oil optimizes the acetic acid induced colitis in CD1 mice, Salem et al., 2017

Fibroblast growth factor (FGF) signaling has been implicated in the pathogenesis of pulmonary fib... more Fibroblast growth factor (FGF) signaling has been implicated in the pathogenesis of pulmonary fibrosis. Mice lacking FGF2 have increased mortality and impaired epithelial recovery after bleomycin exposure, supporting a protective or reparative function following lung injury. To determine whether FGF2 overexpression reduces bleomycin-induced injury, we developed an inducible genetic system to express FGF2 in type II pneumocytes. Double-transgenic (DTG) mice with doxycycline-inducible overexpression of human FGF2 (SPC-rtTA;TRE-hFGF2) or single-transgenic controls were administered intratracheal bleomycin and fed doxycycline chow, starting at either day 0 or day 7. In addition, wild-type mice received intratracheal or intravenous recombinant FGF2, starting at the time of bleomycin treatment. Compared to controls, doxycycline-induced DTG mice had decreased pulmonary fibrosis 21 days after bleomycin, as assessed by gene expression and histology. This beneficial effect was seen when FGF2 overexpression was induced at day 0 or day 7 after bleomycin. FGF2 overexpression did not alter epithelial gene expression, bronchoalveolar lavage cellularity or total protein. In vitro studies using primary mouse and human lung fibroblasts showed that FGF2 strongly inhibited baseline and TGF1-induced expression of alpha smooth muscle actin (SMA), collagen, and connective tissue growth factor. While FGF2 did not suppress phosphorylation of Smad2 or Smad-dependent gene expression, FGF2 inhibited TGF1-induced stress fiber formation and serum response factor-dependent gene expression. FGF2 inhibition of stress fiber formation and SMA requires FGF receptor 1 (FGFR1) and downstream MEK/ERK, but not AKT signaling. In summary, overexpression of FGF2 protects against bleomycin-induced pulmonary fibrosis in vivo and reverses TGF1-induced collagen and SMA expression and stress fiber formation in lung fibroblasts in vitro, without affecting either inflammation or epithelial gene expression. Our results suggest that in the lung, FGF2 is antifibrotic in part through decreased collagen expression and fibroblast to myofibroblast differentiation.

Aim of Study: Ovarian cancer (OC) leads to high mortality rate if diagnosed at late stage. The ai... more Aim of Study: Ovarian cancer (OC) leads to high mortality rate if diagnosed at late stage. The aim of the present study was to increase the survival rate by early disease diagnosis. Materials and Methods: A total of 21 females were divided into three groups. The control (n = 3), benign (n = 8), and malignant group (n = 10). We used flow cytometry to analyze cell cycle, caspase‑3, ‑8, and annexin V. Results: The results showed that the annexin V expressed in malignant group more than benign and normal groups with (P = 0.000 and P = 0.007), respectively. Caspase‑3 and 8 expression decreased in benign and malignant group than in normal group (P = 0.012 and P = 0.007), respectively. Furthermore, sub‑G1 apoptosis level decreased statistically significant in benign and malignant group than in normal group (P = 0.012 and P = 0.007), respectively. These data showed that (S phase) level had statistically significant increase in malignant group (P = 0.007) than the control group and marked statistically significant decrease (P = 0.000) in benign group than malignant group. This study explained changes in sub‑G1 apoptosis for benign group increase statistically significant (P = 0.003) than malignant group level. Conclusion: Caspase‑3 and ‑8 and annexin V may serve as diagnostic markers in OC, also explained that the decrement in control of the S phase in the cell cycle may considered one of the significant factors in the development of ovarian tumors.

Background: Management of alopecia areata (AA) and androgenetic alopecia (AGA) is often challengi... more Background: Management of alopecia areata (AA) and androgenetic alopecia (AGA) is often challenging as patients may be resistant to currently available modalities of treatment. The use of stem cells may be a novel option for resistant cases. Objective: To evaluate the safety and efficacy of the use of autologous bone marrow derived mono-nuclear cells (including stem cells) as compared to follicular stems cells for the management of resistant cases of AA and AGA. Methods: This study included 40 patients (20 AA patients and 20 AGA patients), all patients were treated with a single session of intradermal injection of autologous stem cells (SCs) therapy. They were divided into four groups according to the applied modality [either autologous bone marrow derived mononuclear cells (bone marrow mononuclear cells [BMMCs] or autologous follicular stem cells [FSC]). Results: Six months after stem cell therapy (SCT) injection, there was a significant improvement, confirmed by immunostaining and digital dermoscopy. The mean improvement in all groups was " very good ". There was no significant difference between both methods in either type of alopecia. No serious adverse events were reported. Conclusion: Autologous BMMCs and FSC seem to be a safe tolerable and effective treatment for the management of both resistant AA and AGA.

Dendritic cells (DCs) have been used in a number of clinical trials for cancer immunotherapy; how... more Dendritic cells (DCs) have been used in a number of clinical trials for cancer immunotherapy; however, they have achieved limited success in solid tumors. Consequently the aim of the present study was to identify a novel potential immunotherapeutic target for breast cancer patients through in vitro optimization of a viable DC-based vaccine. Immature DCs were primed by viable MCF-7 breast cancer cells and the activity and maturation of DCs were assessed through measuring CD83, CD86 and major histocompatibility complex (MHC)-II expression, in addition to different T cell subpopu-lations, namely CD4 + T cells, CD8 + T cells, and CD4 + CD25 + forkhead box protein 3 (Foxp3) + regulatory T cells (Tregs), by flow cytometric analysis. Foxp3 level was also measured by enzyme-linked immunosorbent assay (ELISA) in addition to reverse-transcription quantitative polymerase chain reaction. The levels of interleukin-12 (IL-12) and interferon-γ (IFN-γ) were determined by ELISA. Finally, the cytotoxicity of cytotoxic T lymphocytes (CTLs) was evaluated through measuring lactate dehydrogenase (LDH) release by ELISA. The results demonstrated that CD83 + , CD86 + and MHC-II + DCs were significantly elevated (P<0.001) following priming with breast cancer cells. In addition, there was increased activation of CD4 + and CD8 + T‑cells, with a significant decrease of CD4 + CD25 + Foxp3 + Tregs (P<0.001). Furthermore, a significant downregulation of FOXP3 gene expression (P<0.001) was identified, and a significant decrease in the level of its protein following activation (P<0.001) was demonstrated by ELISA. Additionally, significant increases in the secretion of IL‑12 and IFN-γ (P= 0.001) were observed. LDH release was significantly increased (P<0.001), indicating a marked cytotoxicity of CTLs against cancer cells. Therefore viable breast cancer cell-DC-based vaccines could expose an innovative avenue for a novel breast cancer immunotherapy.

مشاعر آيلة للسقوط - مجموعة قصصية, 2021

الكتاب مهم جدا للمشتغلين في البحث العلمي

International Immunopharmacology, Sep 1, 2023

International journal of dermatology, venereology and leprosy sciences, 2023

Mycosis fungoides is the most common type of cutaneous T cell lymphoma. The early diagnosis of MF... more Mycosis fungoides is the most common type of cutaneous T cell lymphoma. The early diagnosis of MF is still an area of debate and challenging issue due to its resemblance to chronic inflammatory dermatoses. Therefore, MF diagnosis is usually based on clinical-pathological correlation. Different lines of treatment are available for MF according to the disease staging.

Journal of Antivirals & Antiretrovirals, Dec 22, 2014

International Journal of Cancer and Biomedical Research (Print), Apr 17, 2021

IJCBR (jcbr.journals.ekb.eg) is published by Egyptian Society of Cancer Research (eacr.tanta.edu.... more IJCBR (jcbr.journals.ekb.eg) is published by Egyptian Society of Cancer Research (eacr.tanta.edu.eg) and sponsored by the Egyptian Knowledge Bank (www.ekb.eg)

Research Square (Research Square), Feb 8, 2023

International Journal of Cancer and Biomedical Research (Print), Apr 17, 2021

Background: Hepatitis C virus (HCV) is a major leading cause of pathogenesis of liver disease whi... more Background: Hepatitis C virus (HCV) is a major leading cause of pathogenesis of liver disease which was treated with IFN-based therapy and recently with Sovaldi®. There is a challenge to explore new drugs. Probiotics are the most common natural therapeutic that can ameliorate liver dysfunction. Aim: study the antiviral and antibacterial responses of the probiotics in patients with chronic (HCV). Materials and Methods: patients were treated with IFN/ribavirin, or both IFN and probiotics capsule that was containing L. acidophilus and Bifidobacterium spp. and administered as one capsule per day for a month. Blood and urine samples were collected before and after treatment strategies and were processed for quantitative determination of HCV PCR assay, identification of bacteria by VITEK2 system and 16S r RNA gene sequencing, estimation of probiotics antibacterial activity, as well as counts of leukocytes and CD3+ T cells and CD56+ natural killer cells. Results: Treatment of patients with L. acidophilus and Bifidobacteria spp. enhanced the responses of the patients to IFN-α and ribavirin treatment, as shown by the viral titter of HCV PCR assay that clarified the antiviral activity and also the antibacterial activity against the most common bacterial infections in patients with chronic HCV. Additionally, it increased the numbers of CD3+ and CD56+, Conclusions: Treatment with probiotics before IFN-α and ribavirin therapy can act as a supportive supplement with antiviral, positive immune response and antibacterial activities.

International Journal of Cancer and Biomedical Research (Print), Apr 17, 2021

Background: Using of experimental animal as models to mimic human pathological conditions has fac... more Background: Using of experimental animal as models to mimic human pathological conditions has facilitated understanding the mechanisms of different processes involved in these diseases. Among the experimental animals, mice are the mostly widely used animals in different experimental biology since it has a small size, easy breading, low cost, high fertility rate, and the extensive knowledge of its genome. The differences in the immune cell complements between young and adult mice, however, have not been well investigated. Aim: The present study aimed to compare aging on the immune cell components in outbreed and inbreed mice as well as to evaluate the their responses to the inflammatory stimuli Polyinosinic:polycytidylic acid (poly(I:C)). Results: The study investigated whether the aging or the poly(I:C) has the more damaging effect on the cell histology of the thymus gland and spleen. This study confirms that the alteration in the histology of the spleen of aged mice as compared to young mice. Furthermore, poly(I:C) had more tendency to induce alteration in the architecture and cellular components in the thymus and spleen of old mice than those in young mice. Conclusion: Immune compartments in old mice are more susceptible to inflammation than those in young mice.

International Journal of Cancer and Biomedical Research (Print), Jun 2, 2020

Background: Recurrence and metastasis are common in patients of breast cancer even after chemothe... more Background: Recurrence and metastasis are common in patients of breast cancer even after chemotherapy and radiotherapy. This recurrence may occur due to the emergence of immunoregulatory T (Treg) cells and the immune checkpoint molecules such as programmed cell death protein 1 (PD-1) which are known to suppress anti-tumor immunity. Aim: The aim of this study is to investigate the numbers of Treg cells and the expression of PD-1 molecule on T cells in the peripheral blood of breast cancer patients at different stages (II, III, and IV) compared to healthy individuals. Materials and Methods: Blood samples were collected from early diagnosed metastatic breast cancer patients before surgery. Leucocytes were stained with different antibodies including CD4, CD25, CD127, and PD1, and then were analyzed by multiparametric flow cytometry. Results: The results showed that the relative and absolute numbers of Treg cells were significantly increased in breast cancer patients. Interestingly, we found a correlation between the numbers and cancer progression from stages II to III and IV, as compared with healthy individuals. Furthermore, significant increases in PD-1 expression were observed on Treg cells and CD4 + T cells in cancer patients as compared to healthy controls. This profile of PD-1 expression was also correlated with the poor prognosis of the patients. Conclusion: The results provide a better understanding of the immunomodulatory role of Treg cells and PD-1 expression in breast cancer patients who are the target for immunotherapy using checkpoint inhibitors.

Journal of Nanoparticle Research, Jul 22, 2020

Super paramagnetic graphene oxide (GO)-Fe3O4 nanoparticle composites were prepared and characteri... more Super paramagnetic graphene oxide (GO)-Fe3O4 nanoparticle composites were prepared and characterized by conventional techniques such as XRD, SEM, EDX, FT-IR, Raman, XPS, DLS and zeta potential, etc. TEM studies have confirmed nanoparticle nature of the composites. The magnetic nanoparticle composites can be dispersed in mildly acidic aqueous solutions and get concentrated in a small volume under application of an external magnetic field. The composites were evaluated for the uptake of actinide ions such as Am 3+ , UO2 2+ , Th 4+ and Pu 4+ from mildly aqueous acidic solutions. Am 3+ sorption sharply increased with pH as the Kd values increased from about 10 at pH 1 to 10 5 at pH 3 beyond which a much less steeper decrease in the Kd values was seen. Eu 3+ displayed nearly comparable uptake behaviour to that of Am 3+ while the uptake of other metal ions followed the trend: Pu(IV) > Th(IV) >> UO2 2+. The adsorption behaviour of Am 3+ onto the graphene oxide-Fe3O4 nanoparticle composites fitted very well to the Langmuir as well as Temkin isotherm models. The desorption rate (using 1 M HNO3) was fast and reusability study results were highly encouraging. The very high uptake values suggest possible application of the magnetic nanoparticles in radioactive waste remediation in natural ground water.

Italian journal of dermatology and venereology, Mar 1, 2023

International Immunopharmacology, 2023

Journal of Clinical Oncology, May 20, 2016

e14579Background: Dendritic cells (DCs) shape the quantity and quality of anti-tumor immunity in ... more e14579Background: Dendritic cells (DCs) shape the quantity and quality of anti-tumor immunity in patients with cancer. We hypothesized that DC-based immunotherapy, in conjunction with a novel long-...

Biomedicine & Pharmacotherapy, May 1, 2017

Current Medicinal Chemistry, Feb 1, 2021

Flavonoids, commonly found in various plants, are a class of polyphenolic compounds having a basi... more Flavonoids, commonly found in various plants, are a class of polyphenolic compounds having a basic structural unit of 2-phenylchromone. Flavonoid compounds have attracted much attention due to their wide biological applications. In order to facilitate further research on the biomedical application of flavonoids, we surveyed the literature published on the use of flavonoids in medicine during the past decade, documented the commonly found structures in natural flavonoids, and summarized their pharmacological activities as well as associated mechanisms of action against a variety of health disorders including chronic inflammation, cancer, cardiovascular complications and hypoglycemia. In this mini-review, we provide suggestions for further research on the biomedical applications of flavonoids.

Medical Hypotheses, Jul 1, 2020

Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on ... more Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

International Journal of Immunopharmacology, Sep 1, 2000

In this study, antiviral eect of black seed oil (BSO) from Nigella sativa was investigated using ... more In this study, antiviral eect of black seed oil (BSO) from Nigella sativa was investigated using murine cytomegalovirus (MCMV) as a model. The viral load and innate immunity mediated by NK cells and Mf during early stage of the infection were analyzed. Intraperitoneal (i.p.) administration of BSO to BALB/c mice, a susceptible strain of MCMV infection, strikingly inhibited the virus titers in spleen and liver on day 3 of infection with 1 Â 10 5 PFU MCMV. This eect coincided with an increase in serum level of IFN-g. Although BSO treatment decreased both number and cytolytic function of NK cells on day 3 of infection, it increased numbers of Mf and CD4 + T cells. On day 10 of infection, the virus titer was undetectable in spleen and liver of BSO-treated mice, while it was detectable in control mice. Although spleen of both control and BSO-treated mice showed similar CTL activities on day 10 after infection, serum level of IFN-g in BSO-treated mice was higher. Furthermore, BSO treatment upregulated suppressor function of Mf in spleen. These results show that BSO exhibited a striking antiviral eect against MCMV infection which may be mediated by increasing of Mf number and function, and IFN-g production.

Journal of Immunology, Apr 1, 2007

We have reported that in vivo administration of the toll-like receptor 3 ligand (TLRL) poly (I:C)... more We have reported that in vivo administration of the toll-like receptor 3 ligand (TLRL) poly (I:C) induced rapid stimulation of the innate mediators, including NK cells, Mϕ, dendritic cells, and inflammatory cytokines. These effects strikingly augmented post vaccination CD8 T cells responses. It is not clear, however, whether poly (I:C) acts directly on CD8 T cells. Therefore, we analyzed the expression of TLRs on both CD4 and CD8 T cells and tested whether CD8 T cells respond directly to poly (I:C). Real-time PCR analysis revealed that TLRs (TLR1-TLR13) are expressed in the purified CD4 and CD8 T cells, and their in vitro treatment with 50 μg/ml poly 10 nM PMA, or with OVA peptide-pulsed splenocytes modulated the expression of the tested TLRs. Utilizing OT-1 TCR adoptive transfer transgenic mouse model, in vitro treatment of purified naïve OT-1 cells with 50 μg/ml poly (I:C) for 18 hours in the absence of antigen stimulation triggered their activation as evidenced by upregulation of the early activation markers CD69 and CD25, and downregulation of CD62L expression. Importantly, when these cells were adoptively transferred into naïve recipient followed by peptide vaccination, they showed superior expansion and activation to their naïve counterparts. These results clearly reveal a direct effect of poly (I:C) on CD8 T cells and supports the notion of direct involvement of TLRs in adaptive immune responses.

Journal of Immunology, Apr 1, 2009

Enhanced effector activity such as cytokine secretion, cell proliferation , cytolytic activity, e... more Enhanced effector activity such as cytokine secretion, cell proliferation , cytolytic activity, etc. in response to in vitro stimulation has been widely used as a means to predict in vivo activity after immune mediated interventions, such as adoptive transfer or systemic vaccination. Contrary to this, here we show that the enhanced in vivo survival and anti-tumor activity of cytokine conditioned early activated CD8+ T cells inversely correlates with their effector functions in vitro. When compared with late effector PmelIL-12, early effector showed decreased production of IFNγ and TNFα, and decreased expression of the degranulation marker CD107a in response to in vitro reactivation. However, after transfer into lymphodepleted hosts, early effector PmelIL-12 survived for at least 20 days and were able to effectively control the progression of B16 tumors in a superior manner than late effector PmelIL-12. Thus, effector activity in response to ex vivo antigenic restimulation does not necessarily predict in vivo activity. Other parameters such as surface expression of functional markers (CCR7, CD62L) and /or survival (CD127) could serve as better predictors of in vivo activity. Developing and validating accurate predictors of in vivo lymphocyte function would greatly facilitate our ability to rationally design novel immune based therapies for clinical trials that have significant anti-tumor activity.

Journal of Immunology, Apr 1, 2007

مقال , 2024

مع أنه كان من الممكن أن ينزل الوحي علي الرسول الكريم مُحمد بدون كتاب كما حدث مع كثير من الرسل، إل... more مع أنه كان من الممكن أن ينزل الوحي علي الرسول الكريم مُحمد بدون كتاب كما حدث مع كثير من الرسل، إلا أن الله أيده بنزول القرآن الكريم الذي تحتاج كل آية فيه إلي إعمال العقل لكي يطمئن القلب. فأول آية نزلت في غار حراء كانت عن القراءة (أعمال العقل: إقرأ) ثم العلم (إعمال العقل: خلق الإنسان من علق) ثم الكتابة (إعمال العقل: الذي علم بالقلم).

الفلسفة هي حالة من الرقي الفكري التي تعكس حضارة الشعوب المادية والمعنوية أشد ما يحزنني أثناء قرا... more الفلسفة هي حالة من الرقي الفكري التي تعكس حضارة الشعوب المادية والمعنوية

أشد ما يحزنني أثناء قراءتي في الفلسفة على وجه العموم وفلسفة العلم على وجه الخصوص أن معظم فلاسفة الغرب مثل هيجل يعتقدون بل ويصرحون أن الفلسفة إنتاج أوروبي مطلق تمتد جذوره في اليونان وسيقانه في أوروبا وخاصة ألمانيا (الجنس الآري الناطق باللغة الآرية) وينفون عن الحضارة المصرية القديمة التي سبقت الحضارة اليونانية بآلاف السنين والتي كانت معابدها وكهنتها (العلماء) تمثل مدارس يتعلم فيها الفلاسفة (العلماء) اليونانيين مثل "طاليس" و "فيثاغورث" وآخرهم "أرسطو". حتي أن العديد من الدراسات أثبتت أن "طاليس" نفسة أصله عربي كنعاني (فينيقي) . إنه الاستعلاء والاستقواء والغرور الذي أصاب فلاسفة أوروبا ما قبل وما بعد الحداثة (التي بدأت بعد عصر ديكارت).

2024

كل ما نفعله نحن العلماء يتراوح بين استقراء الجزيئات للوصول إلي الكليات أو استنباط الكليات للوصول ... more كل ما نفعله نحن العلماء يتراوح بين استقراء الجزيئات للوصول إلي الكليات أو استنباط الكليات للوصول إلي الجزيئات. وما هذا التفكير العلمي إلا محاولات للوصول إلي آليات خلق الله. فلم يكن هناك أحد ليشهد مراحل خلق السماوات والأرض، ولم يكن هناك أحد أثناء خلق النبات والحيوان ثم بعد ذلك الإنسان الأول ولا حتى الأخير. خلقنا ما هو إلا صندوق مغلق نحاول فك شفرته بالعلم ببطء منذ بدء الخليقة. وعندما بدأنا نفهم بعض أسرار الله في خلقه اكتشفنا أننا كالأطفال الذين لديهم سيارة أو طائرة يلعبون بها وهم لا يعرفون كيف صنعت حتى ولو كانوا يعلمون من الصانع. واذا حاولنا كيف صُنعت السيارة فعلينا فكها أولا لنتعرف علي أجزائها قطعة قطعة تم توصيلها وتركيبها مع بعضها البعض في هندسة شديدة التعقيد. ولكننا نفاجأ في النهاية أن إعادة تركيب العربة كما كانت ليس سهلا كحال تفكيكها .

الزوجة وراء اكتشاف فيتامين ج, 2024

الزوجة وراء اكتشاف فيتامين ج "شكرا للفلفل الأحمر" مقال بقلم د. محمد لبيب سالم من يحمي خلايانا وا... more الزوجة وراء اكتشاف فيتامين ج
"شكرا للفلفل الأحمر"
مقال بقلم د. محمد لبيب سالم
من يحمي خلايانا والخلايا في الحيوانات والنباتات من العطب والشيخوخة، بل وفي النهاية الموت المبرمج. فالخلية في حالة عمل دائما ولا تنام ولا تهدأ إلى قليلا أثناء النوم. وطالما الخلية تعمل وتكد وتجتهد فلابد من تكوين مخرجات نتيجة لعملية الأكسدة التي تتسبب في إيذائها أو موتها أو تحويلها إلى خلايا سرطانية.

"الحياة رواية يكتبها وينتجها صاحبها ويمثلها ويخرجها الناس ليشاهدها الجميع مجانًا على نفقة المنتج".

هناك اكتشافات فاصلة في الحياة ليس فقط على مستوى الفرد، ولكن أيضًا على مستوي المجتمع والدولة والعا... more هناك اكتشافات فاصلة في الحياة ليس فقط على مستوى الفرد، ولكن أيضًا على مستوي المجتمع والدولة والعالم أجمع. والتكنولوجيا هى أكثر الطرق التي يولد معها لحظات فاصلة تتسبب في تغيير ليس فقط في فكر وسلوك الشعوب، بل أيضًا في التركيب الديموجرافي وذلك بظهور طبقات اجتماعية جديدة تمامًا.

Resume, 2023

He is an outstanding scholar in Immunology and Cancer Immunology based on his cutting-edge resear... more He is an outstanding scholar in Immunology and Cancer Immunology based on his cutting-edge research in the USA, Japan, and Egypt. His main discoveries in the preclinical settings have been translated into clinic. Prof. Salem

"وكم أتمني أن يكون هناك يوم للتوصل بالخطابات"

My Biography السيرة الذاتية مختصرة

Mohamed L. Salem (PhD, 1995) is the Professor of Immunology at Tanta University, Egypt and was Vi... more Mohamed L. Salem (PhD, 1995) is the Professor of Immunology at Tanta University, Egypt and was Visiting Professor at Hollings Cancer Center and Department of Microbiology and Immunology, Medical University of South Carolina, USA. Dr. Salem is the Founder and Director of Center of Excellence in Cancer Research, Tanta University, Egypt and Founder and Chairman of Egyptian Association for Cancer Research. He is among the founding members of the Middle Eastern Association for Cancer Research, Canada. Dr Salem is also the Director of Delta Development Research Center which is a regional branch of Academy of Scientific Research and Technology (ASRT), Egypt; Director of the Grant, Innovation & Technology Transfer Center. Dr. Salem obtained his PhD in 1995 through a channel system between Tanta University, Egypt and Kyushu University, Japan. From 1997 -2001, he was a Postdoctoral Fellow at Kyushu University, Japan and from 2002-2010 as an Assistant Professor at Medical University of South Carolina, USA. Dr. Salem is member of several national committees including National Committee for Professorship Promotion, National Committee for the Biological Sciences, National Committee for Scientific Research Strategies, National Committee for Basic Sciences Sector at the Supreme Council of the Egyptian Universities, and National Committee of the Special Basic Science Sector at the Academy of Scientific Research and Technology, Egypt. Dr Salem won the State Incentive Award in 2004 in Biology, the State Excellence Award in 2010 in Basic Sciences from the Academy of Scientific Research and Technology, Egypt, and Tanta University Esteemed Award, Tanta University, Egypt in 2015. His h-index is 26 and published about 111 articles in peer-reviewed journals and attended more than 100 national and international workshops and conferences in Immunology. He supervised more than 69 Master and PhD students. He is a member of several editorial boards of peer-reviewed journals as well as ad hoc reviewer for more than 80 journals. He has been invited to give scientific talks in Egypt, UAE, Jordan, Saudi Arabia, USA, China and Canada. Dr Salem’s research focuses on understanding the cellular and molecular mechanisms underlying how cancer and virus escape from host immunity, in particular the rules of the immunosuppressive cells including lymphoid and myeloid lineages as well as developing effective anticancer immunotherapy strategies. His research projects have been funded by National Institute of Health, USA, Science and Technology Development Fund (STDF), Egypt, USA National Academy of Sciences, Tanta University, Egypt, private foundation and industry.

Research requires researchers and technicians. Researchers, however, are different than technicia... more Research requires researchers and technicians. Researchers, however, are different than technicians. Although their job description complements each other for generation of a standardized research, a researcher should be equipped with both intellectual and technical skills to deal with problem-based sciences. On the other hand, a technician needs to be equipped with technical skills, where intellectual skills are optional. IET A researcher needs the following 3 elements:

My Dear Immune System

My Dear Immune System is a poem by Prof. Mohamed Labib Salem, Tanta University, Egypt in celebrat... more My Dear Immune System is a poem by Prof. Mohamed Labib Salem, Tanta University, Egypt in celebration of the International Day of Immunology

Conference Presentation, 2024

Presentation Outlines - The 3 signal Model for Generation of Killer T cells Immunotherapy - Nega... more Presentation Outlines
- The 3 signal Model for Generation of Killer T cells Immunotherapy
- Negative Stimulatory PD-1 and PDL-1
- Nobel Prize winners: Allison and Honjo
- Clinical Applications of the scientific findings

عادة ما تراودني أسئلة مثل: لماذا لم يخلق الله عيوننا ميكروسكوبية لتري الميكروبات، أو لماذا لا يوج... more عادة ما تراودني أسئلة مثل: لماذا لم يخلق الله عيوننا ميكروسكوبية لتري الميكروبات، أو لماذا لا يوجد في أعيننا مخروط رابع كما هو في الطيور لنرى الأشعة فوق الحمراء والبنفسجية لنتمكن من رؤية الأشياء والكائنات غير المرئية. وعليك أن تتخيل الحال لو تحقق ذلك!

سألتني الباحثة بصوت يملأه القلق والتوتر عن هذا الخيط الرفيع الأسود وما إذا كان بسبب عدوي ميكروبية... more سألتني الباحثة بصوت يملأه القلق والتوتر عن هذا الخيط الرفيع الأسود وما إذا كان بسبب عدوي ميكروبية للخلايا التي زرعتها رغم حرصها الشديد على استخدام كل الأساليب المتبعة لعدم حدوث إصابة الخلايا بأي ميكروب أثناء عملية تحضير الخلايا وزراعتها تحت ظروف معملية محددة.