Yasser Serag | Tanta University (original) (raw)
Papers by Yasser Serag
International journal of medical ophthalmology, Dec 31, 2022
Background: Silicone oil (SO) is commonly employed as a durable replacement for the vitreous subs... more Background: Silicone oil (SO) is commonly employed as a durable replacement for the vitreous substitute following vitreoretinal surgery to treat retinal detachment accompanied by significant proliferative vitreoretinopathy. The aim of the work was to correlate macular optical coherence tomography (OCT) pattern and visual recovery after vitrectomy with SO for retinal detachment. Methods: This interventional, prospective, comparative study included 60 patients aged up to 18 years old, both sexes, with retinal detachment and had done pars plana vitrectomy (PPV) and used SO as tamponade. Al participants were distributed into two equal groups: The first group presented with rhegmatogenous retinal detachment (RRD), up to eighteen participants were macula On, while the remaining twelve were macula Off and Group II: presented with tractional retinal detachment involving the macular area. Results: Correlation between multifocal electroretinography (MFERG) and OCT signs there is marked depression in conduction of MFERG because of silicone filled eye. In comparison between central foveal thickness at postoperative month-3 and MFERG, there was no statistically variation among both groups since there was marked depression of amplitude and prolonged latency of P1in both groups. In group I all patients postoperative by 3 months gained improvement in the acuity of vision over 20/200, group II P1 latency in patients with visual acuity (VA) better than 20/200, there was no marked variation between both groups. Conclusions: Performing non-contact OCT before the removal of SO is important. OCT is very helpful in decision making of timing of SO removal. The condition of the macula whether macula on or off preoperatively is the most important factor in predicting visual outcome.
International Journal of Medical Ophthalmology
Background: The measurement of retinal nerve fibre layer (RNFL) thickness is widely recognized as... more Background: The measurement of retinal nerve fibre layer (RNFL) thickness is widely recognized as a very delicate tool of optic nerve damage, since it manifests before the manifestation of visual field impairment. Aim of the work: The aim of this study was to evaluate the effect of refractive status and axial length of the eye on the thickness of the peripapillary RNFL in individuals with and without glaucoma. This was achieved via the use of optical coherence tomography. Methods: This research was carried on 54 eyes of 27 glaucomatous patients and 54 eyes of 27 healthy. Inclusion criteria were participants aged 20-60 years old, with clear ocular media and Glaucomatous patients were previously diagnosed by fundus examination, IOP measurement and visual field. Results: The thickness of the RNFL in different quadrants is influenced by factors such as axial length, refractive error, and age. However, it has been discovered that changes in axial length or age do not have an impact on the thickness of the RNFL in the temporal quadrant, unlike the other quadrants. Multivariate analysis show that axial length and age are the main factors affecting RNFL thickness in myopic eyes either normal or glaucomatous. Conclusions: The diagnosis of glaucoma with myopia is a controversy due to the alterations in the optic disc. This research used an OCT technology to evaluate the effect of axial length and refractive error on RNFL thickness. The findings revealed that changes in axial length had a differential effect, with the exception of the temporal quadrant. The presence or severity of changes in the temporal quadrant is often minimal or nonexistent. The thinning in the temporal quadrant may indicate the glaucoma.
Journal of advances in medicine and medical research, Jul 27, 2022
Background: In the non-proliferative stage, diabetic retinopathy (DR) is a retinal vascular disea... more Background: In the non-proliferative stage, diabetic retinopathy (DR) is a retinal vascular disease. Characterised by the formation of micro aneurysms, retinal haemorrhages, exudates, venous alterations, and capillary non-perfusion. With the usage of optical coherence tomography angiography (OCTA), the purpose of this study was to determine the correlation between vessel density and best corrected visual acuity (BCVA) in DR patients. Methods: This prospective observational research was done on 50 eyes of 35 consecutive diabetic patients who were diagnosed with mild, moderate or severe non-proliferative diabetic retinopathy (NPDR) and patients with proliferative diabetic changes (as NVD and neovascularization elsewhere (NVE)) as well as a control group consisting of 20 eyes of 10 healthy age-matched participants. Participants were divided into two groups: group A (diabetic patients): sub divided group A1: 40 eyes diagnosed with NPDR and A2: 10 eyes diagnosed with proliferative diabetic retinopathy (PDR) and group B (control group): 20 healthy eyes of age matched participants as a control group. All the eyes were subjected to fund us fluoresce in angiography (FFA) and OCTA. Comparison was made between the vascular density index (VD) in the different slaps between NPDR and PDR group, as well as correlation between the VD and BCVA. Results: Significant positive correlation was observed between visual acuity (Log MAR) and vascular density index of superficial layer, deep layer in NPDR group and PDR group. Significant positive correlation was observed between vascular density index of superficial, deep layer and best corrected visual acuity (BCVA) (Log MAR) in NPDR group and PDR group.
Journal of advances in medicine and medical research, Nov 22, 2022
Background: Central serous Chorioretinopathy (CSC) is characterized by serous subretinal fluid (S... more Background: Central serous Chorioretinopathy (CSC) is characterized by serous subretinal fluid (SRF)leakage and accumulation with subsequent serous retinal detachment We conducted this study to study the predictive factors associated with resolution of the non-treated, first episode of acute CSC including systemic factors and ocular factors using different imaging modalities. Methods: This prospective, observational study of 30 affected eyes and 30 fellow eyes of 30 consecutive patients with non-treated, first episode of acute CSC and age and sex matched control group of 30 eyes were also studied. Detailed history taking including: name, age, residence, previous and present ocular or systemic diseases, previous ocular trauma, previous ocular surgery, assessment of systemic factors including, smoking, hypertension, Helicobacter pylori infection, pregnancy, sleeping disturbance, autoimmune diseases and psychological factors, history of intake of ocular or systemic medications especially corticosteroid and psychopharmacological medications, best corrected visual acuity (BCVA). Results: The baseline BCVA of the "Improvement" group was lower than that of "No Improvement" group and the difference was statistically significant (p. value 0.014*). On the other hand, the final BCVA of the "Improvement" group was higher than that of "No Improvement" group and the difference was also statistically significant (p. value 0.005*). There was a statistically significant decrease of the mean automated central retinal thickness (ACRT) (P-value 0.004*), mean vertical Original Research Article
Clinical Ophthalmology
Background and Aim: COVID-19 infection is a respiratory disease but it can have ophthalmological ... more Background and Aim: COVID-19 infection is a respiratory disease but it can have ophthalmological manifestations as well. This study aimed to investigate the ophthalmological implications of COVID-19 either during the course of the disease or after recovery. Methods: A retrospective study included the records of 425 COVID-19 patients, proved by positive PCR swabs. The records were collected from three isolation hospitals in Gharbeya Governorate, Egypt. Results: The mean age of the studied group was 41.73 ± 13.59, and 216 (50.8%) of them were males. One hundred and thirty one (30.8%) patients had ophthalmological manifestations. Among the entire patients, the most common ophthalmological presentation was conjunctivitis in 111 patients (26.1%), followed by neuro-retinal affection in 9 (2.1%), secondary fungal orbital cellulitis in 6 (1.4%), episcleritis in 3 (0.7%) and keratitis in 2 (0.5%) patients. All of the observed ophthalmological implications occurred either during the course of the disease (concurrent) or after recovery, except for the fungal orbital cellulitis which occurred only after recovery. Conclusion: COVID-19 could cause different eye manifestations. Recovery from the main disease does not guarantee eye safety, especially in high-risk patients.
Journal of Clinical & Experimental Ophthalmology
Background: Cataract extraction affects some of the anterior chamber (AC) parameters like AC dept... more Background: Cataract extraction affects some of the anterior chamber (AC) parameters like AC depth (ACD) and the width of the AC angle. Different techniques are used to evaluate these effects before and after cataract extraction. Purpose: To evaluate the results of Anterior Segment Optical Coherence Tomography (AS-OCT), Ultrasound Biomicroscopy (UBM) & Pentacam in evaluating the changes of the anterior segment parameters after cataract extraction. Methods: Prospective non-randomized study including 40 cataractous eyes. AS-OCT, UBM and Pentacam were done 1 week before, 1 week and 1 month after phacoemulsification with intraocular lens (IOL) implantation, to measure ACD, AC angle width, and central corneal thickness (CCT). Results: ACD depth, AC angle width and CCT increased significantly 1 week and 1 month after surgery than the preoperative level (p<0.001), with no significant difference between 1 week and 1 month after surgery (p>0.05). No significant difference between the 3 techniques in most measures either pre-or postoperatively. Conclusion: ACD, AC angle width and CCT are significantly increased after uneventful phacoemulsification surgery and Foldable IOL implantation, which have become stabilized after 1 month of surgery with no significant difference in the measures given by AS-OCT, UBM or Pentacam.
Toxicology and industrial health, 2017
Organic solvents are widely used in many industries, and usually, exposure occurs with mixtures o... more Organic solvents are widely used in many industries, and usually, exposure occurs with mixtures of solvents. Organic solvent mixtures are known for their ability to affect tissues of high lipid content including the myelin sheath in the nervous system. The purpose of this work was to study the evidence that long-term (more than 10 years) exposure to organic solvent mixtures among painters can induce neuro-ophthalmological effects on the function of retinal ganglion cells and the optic tract. Twenty workers with long-term occupational exposure to mixed organic solvents were compared to 40 control subjects. The controls were matched for age, gender, and demographic characteristics but were not occupationally exposed to any known organic solvents, using the following comparators: visual evoked potential (VEP), electroretinogram (ERG), color vision (CV), and contrast sensitivity (CS) testing. Environmental monitoring was done in the work environment with consideration to the American Co...
International journal of medical ophthalmology, Dec 31, 2022
Background: Silicone oil (SO) is commonly employed as a durable replacement for the vitreous subs... more Background: Silicone oil (SO) is commonly employed as a durable replacement for the vitreous substitute following vitreoretinal surgery to treat retinal detachment accompanied by significant proliferative vitreoretinopathy. The aim of the work was to correlate macular optical coherence tomography (OCT) pattern and visual recovery after vitrectomy with SO for retinal detachment. Methods: This interventional, prospective, comparative study included 60 patients aged up to 18 years old, both sexes, with retinal detachment and had done pars plana vitrectomy (PPV) and used SO as tamponade. Al participants were distributed into two equal groups: The first group presented with rhegmatogenous retinal detachment (RRD), up to eighteen participants were macula On, while the remaining twelve were macula Off and Group II: presented with tractional retinal detachment involving the macular area. Results: Correlation between multifocal electroretinography (MFERG) and OCT signs there is marked depression in conduction of MFERG because of silicone filled eye. In comparison between central foveal thickness at postoperative month-3 and MFERG, there was no statistically variation among both groups since there was marked depression of amplitude and prolonged latency of P1in both groups. In group I all patients postoperative by 3 months gained improvement in the acuity of vision over 20/200, group II P1 latency in patients with visual acuity (VA) better than 20/200, there was no marked variation between both groups. Conclusions: Performing non-contact OCT before the removal of SO is important. OCT is very helpful in decision making of timing of SO removal. The condition of the macula whether macula on or off preoperatively is the most important factor in predicting visual outcome.
International Journal of Medical Ophthalmology
Background: The measurement of retinal nerve fibre layer (RNFL) thickness is widely recognized as... more Background: The measurement of retinal nerve fibre layer (RNFL) thickness is widely recognized as a very delicate tool of optic nerve damage, since it manifests before the manifestation of visual field impairment. Aim of the work: The aim of this study was to evaluate the effect of refractive status and axial length of the eye on the thickness of the peripapillary RNFL in individuals with and without glaucoma. This was achieved via the use of optical coherence tomography. Methods: This research was carried on 54 eyes of 27 glaucomatous patients and 54 eyes of 27 healthy. Inclusion criteria were participants aged 20-60 years old, with clear ocular media and Glaucomatous patients were previously diagnosed by fundus examination, IOP measurement and visual field. Results: The thickness of the RNFL in different quadrants is influenced by factors such as axial length, refractive error, and age. However, it has been discovered that changes in axial length or age do not have an impact on the thickness of the RNFL in the temporal quadrant, unlike the other quadrants. Multivariate analysis show that axial length and age are the main factors affecting RNFL thickness in myopic eyes either normal or glaucomatous. Conclusions: The diagnosis of glaucoma with myopia is a controversy due to the alterations in the optic disc. This research used an OCT technology to evaluate the effect of axial length and refractive error on RNFL thickness. The findings revealed that changes in axial length had a differential effect, with the exception of the temporal quadrant. The presence or severity of changes in the temporal quadrant is often minimal or nonexistent. The thinning in the temporal quadrant may indicate the glaucoma.
Journal of advances in medicine and medical research, Jul 27, 2022
Background: In the non-proliferative stage, diabetic retinopathy (DR) is a retinal vascular disea... more Background: In the non-proliferative stage, diabetic retinopathy (DR) is a retinal vascular disease. Characterised by the formation of micro aneurysms, retinal haemorrhages, exudates, venous alterations, and capillary non-perfusion. With the usage of optical coherence tomography angiography (OCTA), the purpose of this study was to determine the correlation between vessel density and best corrected visual acuity (BCVA) in DR patients. Methods: This prospective observational research was done on 50 eyes of 35 consecutive diabetic patients who were diagnosed with mild, moderate or severe non-proliferative diabetic retinopathy (NPDR) and patients with proliferative diabetic changes (as NVD and neovascularization elsewhere (NVE)) as well as a control group consisting of 20 eyes of 10 healthy age-matched participants. Participants were divided into two groups: group A (diabetic patients): sub divided group A1: 40 eyes diagnosed with NPDR and A2: 10 eyes diagnosed with proliferative diabetic retinopathy (PDR) and group B (control group): 20 healthy eyes of age matched participants as a control group. All the eyes were subjected to fund us fluoresce in angiography (FFA) and OCTA. Comparison was made between the vascular density index (VD) in the different slaps between NPDR and PDR group, as well as correlation between the VD and BCVA. Results: Significant positive correlation was observed between visual acuity (Log MAR) and vascular density index of superficial layer, deep layer in NPDR group and PDR group. Significant positive correlation was observed between vascular density index of superficial, deep layer and best corrected visual acuity (BCVA) (Log MAR) in NPDR group and PDR group.
Journal of advances in medicine and medical research, Nov 22, 2022
Background: Central serous Chorioretinopathy (CSC) is characterized by serous subretinal fluid (S... more Background: Central serous Chorioretinopathy (CSC) is characterized by serous subretinal fluid (SRF)leakage and accumulation with subsequent serous retinal detachment We conducted this study to study the predictive factors associated with resolution of the non-treated, first episode of acute CSC including systemic factors and ocular factors using different imaging modalities. Methods: This prospective, observational study of 30 affected eyes and 30 fellow eyes of 30 consecutive patients with non-treated, first episode of acute CSC and age and sex matched control group of 30 eyes were also studied. Detailed history taking including: name, age, residence, previous and present ocular or systemic diseases, previous ocular trauma, previous ocular surgery, assessment of systemic factors including, smoking, hypertension, Helicobacter pylori infection, pregnancy, sleeping disturbance, autoimmune diseases and psychological factors, history of intake of ocular or systemic medications especially corticosteroid and psychopharmacological medications, best corrected visual acuity (BCVA). Results: The baseline BCVA of the "Improvement" group was lower than that of "No Improvement" group and the difference was statistically significant (p. value 0.014*). On the other hand, the final BCVA of the "Improvement" group was higher than that of "No Improvement" group and the difference was also statistically significant (p. value 0.005*). There was a statistically significant decrease of the mean automated central retinal thickness (ACRT) (P-value 0.004*), mean vertical Original Research Article
Clinical Ophthalmology
Background and Aim: COVID-19 infection is a respiratory disease but it can have ophthalmological ... more Background and Aim: COVID-19 infection is a respiratory disease but it can have ophthalmological manifestations as well. This study aimed to investigate the ophthalmological implications of COVID-19 either during the course of the disease or after recovery. Methods: A retrospective study included the records of 425 COVID-19 patients, proved by positive PCR swabs. The records were collected from three isolation hospitals in Gharbeya Governorate, Egypt. Results: The mean age of the studied group was 41.73 ± 13.59, and 216 (50.8%) of them were males. One hundred and thirty one (30.8%) patients had ophthalmological manifestations. Among the entire patients, the most common ophthalmological presentation was conjunctivitis in 111 patients (26.1%), followed by neuro-retinal affection in 9 (2.1%), secondary fungal orbital cellulitis in 6 (1.4%), episcleritis in 3 (0.7%) and keratitis in 2 (0.5%) patients. All of the observed ophthalmological implications occurred either during the course of the disease (concurrent) or after recovery, except for the fungal orbital cellulitis which occurred only after recovery. Conclusion: COVID-19 could cause different eye manifestations. Recovery from the main disease does not guarantee eye safety, especially in high-risk patients.
Journal of Clinical & Experimental Ophthalmology
Background: Cataract extraction affects some of the anterior chamber (AC) parameters like AC dept... more Background: Cataract extraction affects some of the anterior chamber (AC) parameters like AC depth (ACD) and the width of the AC angle. Different techniques are used to evaluate these effects before and after cataract extraction. Purpose: To evaluate the results of Anterior Segment Optical Coherence Tomography (AS-OCT), Ultrasound Biomicroscopy (UBM) & Pentacam in evaluating the changes of the anterior segment parameters after cataract extraction. Methods: Prospective non-randomized study including 40 cataractous eyes. AS-OCT, UBM and Pentacam were done 1 week before, 1 week and 1 month after phacoemulsification with intraocular lens (IOL) implantation, to measure ACD, AC angle width, and central corneal thickness (CCT). Results: ACD depth, AC angle width and CCT increased significantly 1 week and 1 month after surgery than the preoperative level (p<0.001), with no significant difference between 1 week and 1 month after surgery (p>0.05). No significant difference between the 3 techniques in most measures either pre-or postoperatively. Conclusion: ACD, AC angle width and CCT are significantly increased after uneventful phacoemulsification surgery and Foldable IOL implantation, which have become stabilized after 1 month of surgery with no significant difference in the measures given by AS-OCT, UBM or Pentacam.
Toxicology and industrial health, 2017
Organic solvents are widely used in many industries, and usually, exposure occurs with mixtures o... more Organic solvents are widely used in many industries, and usually, exposure occurs with mixtures of solvents. Organic solvent mixtures are known for their ability to affect tissues of high lipid content including the myelin sheath in the nervous system. The purpose of this work was to study the evidence that long-term (more than 10 years) exposure to organic solvent mixtures among painters can induce neuro-ophthalmological effects on the function of retinal ganglion cells and the optic tract. Twenty workers with long-term occupational exposure to mixed organic solvents were compared to 40 control subjects. The controls were matched for age, gender, and demographic characteristics but were not occupationally exposed to any known organic solvents, using the following comparators: visual evoked potential (VEP), electroretinogram (ERG), color vision (CV), and contrast sensitivity (CS) testing. Environmental monitoring was done in the work environment with consideration to the American Co...