Teresa Perra | Università di Sassari (original) (raw)

Papers by Teresa Perra

Research paper thumbnail of La tutela del derecho a la salud en cirugía en Italia: los desafíos de la pandemia de COVID-19

Convención Internacional de Salud, Cuba Salud 2022, 2022

El COVID-19 aparece en 2019 y rápidamente se convierte en pandemia. Cada país busca soluciones pa... more El COVID-19 aparece en 2019 y rápidamente se convierte en pandemia. Cada país busca soluciones para garantizar la salud de todos los ciudadanos. La cirugía juega un papel fundamental en el tratamiento de enfermedades agudas, crónicas y oncológicas que siguen avanzando aún en tiempos de pandemia. Objetivo: este trabajo tiene por objetivo analizar cómo se garantiza el derecho a la salud en cirugía durante la pandemia en Italia. Métodos: los autores analizan la respuesta italiana a la pandemia y principalmente la protección del derecho a la salud en la cirugía durante la pandemia. Resultados: El análisis de los resultados consta de dos partes. La primera analiza, desde el punto de vista jurídico, el derecho a la vida y a la salud en el ordenamiento jurídico italiano y la aplicación del derecho a la salud en cirugía durante la pandemia. La segunda se adentra en el mundo quirúrgico y examina cómo se garantiza concretamente el derecho a la salud de los pacientes COVID-19 positivos y negativos. En conclusión, se puede afirmar que el derecho a la salud coordinado con los principios constitucionales de dignidad, igualdad y solidaridad conduce necesariamente a encontrar la forma de proseguir la actividad quirúrgica.

Research paper thumbnail of Diritto alla salute e chirugia durante la pandemia di COVID-19

Revista de Estudos Constitucionais, Hermenêutica e Teoria do Direito (RECHTD), 2021

Riassunto: Nel presente articolo, gli autori concentrano la propria attenzione sul tema connesso ... more Riassunto: Nel presente articolo, gli autori concentrano la propria attenzione sul tema connesso al diritto alla salute e alla sua applicazione nel settore della chirurgia durante la pandemia di COVID-19. Ciascuno di essi approfondisce le questioni sottese all’argomento in base alle proprie competenze. L’emergenza sanitaria comporta numerose sfide e muoversi in questo scenario non è facile per coloro che svolgono le professioni sanitarie. Al fine di comprendere come possa essere gestita l’emergenza sanitaria senza sacrificare il diritto alla salute degli individui, sono analizzate le raccomandazioni elaborate nello specifico settore della chirurgia. Infine, gli autori rilevano come non si possa prescindere dalla ricerca scientifica che diviene il faro che illumina la strada da percorrere nel mezzo della pandemia di COVID-19.
Abstract: In this article, the authors focus their attention on the issue related to the right to health and its application in the field of surgery during the COVID-19 pandemic. Each of them explores the questions underlying the topic in accordance to their competences. The health emergency poses numerous challenges and moving in this scenario is not easy for health professionals. In order to understand how the health emergency can be managed without sacrificing individuals’ right to health, it is essential to analyse the recommendations developed in the specific sector of surgery. Finally, the authors underline the importance of the scientific research that becomes the beacon that illuminates the road ahead in the middle of the COVID-19 pandemic.

Research paper thumbnail of Elective cancer surgery in COVID-19 free surgical pathways during the SARS-CoV-2 pandemic: An international, multi-centre, comparative cohort study

European Journal of Surgical Oncology

Research paper thumbnail of Resilience of elective cancer surgery systems during COVID-19 lockdowns: an international, multicentre, prospective cohort study

The Lancet, 2021

Background Surgery is the main modality of cure for solid cancers and was prioritised to continue... more Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during SARS-CoV-2 outbreaks. This study aimed to identify areas for health system strengthening by comparing the delivery of elective cancer surgery during COVID-19 in periods of lockdown versus light restriction. Methods In this international, multicentre, prospective cohort study, we enrolled patients with 15 cancer types who had a decision for surgery during the SARS-CoV-2 pandemic (between Jan 21, 2020 and April 14, 2020) to Aug 31, 2020. Any hospital worldwide providing elective cancer surgery was eligible. The primary outcome was the non-operation rate (proportion of patients who did not undergo planned surgery). Reasons for non-operation were classified as COVID-19 related (societal, operational, or personal) or unrelated. Average national Oxford COVID-19 Stringency Index scores were calculated for each patient during their wait for surgery and classified into light restrictions (index <20), moderate lockdowns (20-60), and full lockdowns (>60). Cox proportional-hazards regression models were used to explore associations between lockdowns and non-operation. This study was registered at ClinicalTrials.gov, NCT04384926. Findings We enrolled 27 700 participants, of whom 20 006 patients (8526 men and 11480 women) from 466 hospitals and 61 countries did not receive surgery after a minimum of 3-months' follow up (median 23 weeks [IQR 16-30]). All patients had a COVID-19-related reason for non-operation. Light restrictions were associated with a 0•6% reference non-operation rate, moderate lockdowns with a 5•5% rate (HR 0•81, 95% CI 0•77-0•84, p<0•0001), and full lockdowns with a 15•0% rate (0•51, 0•50-0•53, p<0•0001). In sensitivity analyses, including adjustment for SARS-COV-2 case notification rates, moderate (0•84, 0•80-0•88; p<0•001), and full lockdowns (0•57, 0•54-0•60; p<0•001) remained independently associated with non-operation. Frail patients with advanced cancer, particularly those from low-income and middle-income countries and those requiring postoperative critical care, were more likely to not have an operation. Interpretation Cancer surgery systems worldwide were affected by lockdowns, including in the UK, with one in seven patients not undergoing planned surgery. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which could include protected elective surgical pathways and longterm investment in surge capacity for acute care during public health emergencies. In the UK, a whole-health system approach is required to mitigate against further harm for NHS patients.

Research paper thumbnail of Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery

Research paper thumbnail of Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic

British Journal of Surgery, 2021

Background: This study aimed to determine the impact of pulmonary complications on death after su... more Background: This study aimed to determine the impact of pulmonary complications on death after surgery both before and during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Methods: This was a patient-level, comparative analysis of two, international prospective cohort studies: one before the pandemic (January-October 2019) and the second during the SARS-CoV-2 pandemic (local emergence of COVID-19 up to 19 April 2020). Both included patients undergoing elective resection of an intra-abdominal cancer with curative intent across five surgical oncology disciplines. Patient selection and rates of 30-day postoperative pulmonary complications were compared. The primary outcome was 30-day postoperative mortality. Mediation analysis using a natural-effects model was used to estimate the proportion of deaths during the pandemic attributable to SARS-CoV-2 infection. Results: This study included 7402 patients from 50 countries; 3031 (40.9 per cent) underwent surgery before and 4371 (59.1 per cent) during the pandemic. Overall, 4.3 per cent (187 of 4371) developed postoperative SARS-CoV-2 in the pandemic cohort. The pulmonary complication rate was similar (7.1 per cent (216 of 3031) versus 6.3 per cent (274 of 4371); P ¼ 0.158) but the mortality rate was significantly higher (0.7 per cent (20 of 3031) versus 2.0 per cent (87 of 4371); P < 0.001) among patients who had surgery during the pandemic. The adjusted odds of death were higher during than before the pandemic (odds ratio (OR) 2.72, 95 per cent c.i. 1.58 to 4.67; P < 0.001). In mediation analysis, 54.8 per cent of excess postoperative deaths during the pandemic were estimated to be attributable to SARS-CoV-2 (OR 1.73, 1.40 to 2.13; P < 0.001). Conclusion: Although providers may have selected patients with a lower risk profile for surgery during the pandemic, this did not mitigate the likelihood of death through SARS-CoV-2 infection. Care providers must act urgently to protect surgical patients from SARS-CoV-2 infection.

Research paper thumbnail of The Impact of the COVID 19 Pandemic on Surgical Care in Italy

Junior Doctors Network Newsletter, 2021

Research paper thumbnail of BJS commission on surgery and perioperative care post-COVID-19

British Journal of Surgery, 2021

Background: Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 20... more Background: Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 2020 and global surgical practice was compromised. This Commission aimed to document and reflect on the changes seen in the surgical environment during the pandemic, by reviewing colleagues' experiences and published evidence.
Methods: In late 2020, BJS contacted colleagues across the global surgical community and asked them to describe how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had affected their practice. In addition to this, the Commission undertook a literature review on the impact of COVID-19 on surgery and perioperative care. A thematic analysis was performed to identify the issues most frequently encountered by the correspondents, as well as the solutions and ideas suggested to address them.
Results: BJS received communications for this Commission from leading clinicians and academics across a variety of surgical specialties in every inhabited continent. The responses from all over the world provided insights into multiple facets of surgical practice from a governmental level to individual clinical practice and training.
Conclusion: The COVID-19 pandemic has uncovered a variety of problems in healthcare systems, including negative impacts on surgical practice. Global surgical multidisciplinary teams are working collaboratively to address research questions about the future of surgery in the post-COVID-19 era. The COVID-19 pandemic is severely damaging surgical training. The establishment of a multidisciplinary ethics committee should be encouraged at all surgical oncology centres. Innovative leadership and collaboration is vital in the post-COVID-19 era.

Research paper thumbnail of Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study

The Lancet Oncology, 2021

Background: Surgery is the main modality of cure for solid cancers and was prioritised to continu... more Background: Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction.
Methods: This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index <20), moderate lockdowns (20-60), and full lockdowns (>60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926.
Findings: Of eligible patients awaiting surgery, 2003 (10•0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16-30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0•6% non-operation rate (26 of 4521), moderate lockdowns with a 5•5% rate (201 of 3646; adjusted hazard ratio [HR] 0•81, 95% CI 0•77-0•84; p<0•0001), and full lockdowns with a 15•0% rate (1775 of 11 827; HR 0•51, 0•50-0•53; p<0•0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0•84, 95% CI 0•80-0•88; p<0•001), and full lockdowns (0•57, 0•54-0•60; p<0•001), remained independently associated with non-operation. Surgery beyond 12 weeks from diagnosis in patients without neoadjuvant therapy increased during lockdowns (374 [9•1%] of 4521 in light restrictions, 317 [10•4%] of 3646 in moderate lockdowns, 2001 [23•8%] of 11 827 in full lockdowns), although there were no differences in resectability rates observed with longer delays.
Interpretation: Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and longterm investment in surge capacity for acute care during public health emergencies to protect elective staff and services.

Research paper thumbnail of Special Issue "State-of-the-Art in Pancreatic Surgery"

Journal of Clinical Medicine, 2021

https://www.mdpi.com/journal/jcm/special\_issues/pancreatic\_surgery Dear Colleagues, Pancreatic ... more https://www.mdpi.com/journal/jcm/special_issues/pancreatic_surgery

Dear Colleagues,

Pancreatic surgery (PS) is one of the most technically challenging kinds of surgery. Several surgical techniques and different anastomosis for the reconstruction of the digestive system have been performed over the years. PS has been adapted to treat different pancreatic diseases (e.g. cancer, acute or chronic pancreatitis, cysts). Various factors influence cancer recurrance, morbidity and mortality after PS, as scientific literature shows. The most common and clinically relevant complications are related to pancreaticojejunal anastomosis. The choice between neoadjuvant therapy and upfront surgery is dibated, in particular in case of vascular reconstruction. Resectability criteria, absolute and relative contraindications to PS are re-evaluated in the light of new scientific evidence. There are still many unanswered questions and further studies are needed to better manage and treat surgical patients with pancreatic disease. The scope of this Special Issue is to provide an overview of the global advancement of surgical research and clinical practice in the field of PS. Therefore, researchers in the field of PS are encouraged to share their experiences and discuss surgical approaches, submitting an original article or review to this Special Issue.

Guest editors:
Dr. Teresa Perra
Prof. Dr. Alberto Porcu

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 20 July 2022.

Research paper thumbnail of UK Head and neck cancer surgical capacity during the second wave of the COVID-19 pandemic: Have we learned the lessons? COVIDSurg collaborative

Clinical Otolaryngology, 2021

Objectives: The aim of this study was to evaluate the differences in surgical capacity for head a... more Objectives: The aim of this study was to evaluate the differences in surgical capacity for head and neck cancer in the UK between the first wave (March-June 2020) and the current wave (Jan-Feb 2021) of the COVID-19 pandemic.
Design: REDcap online-based survey of hospital capacity.
Setting: UK secondary and tertiary hospitals providing head and neck cancer surgery.
Participants: One representative per hospital was asked to report the capacity for head and neck cancer surgery in that institution.
Main outcome measures: The principal measures of interests were new patient referrals, capacity in outpatients, theatres and critical care; therapeutic compromises constituting delay to surgery, de-escalated surgery and therapeutic migration to non-surgical primary modality.
Results: Data were returned from approximately 95% of UK hospitals with a head and neck cancer surgery specialist service. 50% of UK head and neck cancer patients requiring surgery have significantly compromised treatments during the second wave: 28% delayed, 10% have received radiotherapy-based treatment instead of surgery, and 12% have received de-escalated surgery. Surgical capacity has been more severely constrained in the second wave (58% of pre-pandemic level) compared with the first wave (62%) despite the time to prepare.
Conclusions: Some hospitals are overwhelmed by COVID-19 and unable to offer essential cancer surgery, but all have neighbouring hospitals in their region retaining good (or even normal) capacity. It is noteworthy that very few patients have been appropriately redirected away from the hospitals most constrained by their burden of COVID-19. The paucity of an effective central or regional strategic response to this evident mismatch between demand and surgical capacity is to the detriment of our head and neck cancer patients.

Research paper thumbnail of SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

Anaesthesia, 2021

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill... more SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.

Research paper thumbnail of SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

Anaesthesia, 2021

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill... more SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.

Research paper thumbnail of Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study

The Journal of Thoracic and Cardiovascular Surgery, 2021

Research paper thumbnail of Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study

Anaesthesia, 2021

We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complicati... more We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined subgroup analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05-1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4-7 days or ≥ 8 days of 1.25 (1.04-1.48), p = 0.015 and 1.31 (1.11-1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care.

Research paper thumbnail of Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study

Anaesthesia, 2021

We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complicati... more We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined subgroup analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05-1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4-7 days or ≥ 8 days of 1.25 (1.04-1.48), p = 0.015 and 1.31 (1.11-1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care.

Research paper thumbnail of Appendectomy during the COVID-19 pandemic in Italy: a multicenter ambispective cohort study by the Italian Society of Endoscopic Surgery and new technologies (the CRAC study)

Updates in Surgery, 2021

Major surgical societies advised using non-operative management of appendicitis and suggested aga... more Major surgical societies advised using non-operative management of appendicitis and suggested against laparoscopy during the COVID-19 pandemic. The hypothesis is that a significant reduction in the number of emergent appendectomies was observed during the pandemic, restricted to complex cases. The study aimed to analyse emergent surgical appendectomies during pandemic on a national basis and compare it to the same period of the previous year. This is a multicentre, retrospective, observational study investigating the outcomes of patients undergoing emergent appendectomy in March-April 2019 vs March-April 2020. The primary outcome was the number of appendectomies performed, classified according to the American Association for the Surgery of Trauma (AAST) score. Secondary outcomes were the type of surgical technique employed (laparoscopic vs open) and the complication rates. One thousand five hundred forty one patients with acute appendicitis underwent surgery during the two study periods. 1337 (86.8%) patients met the inclusion criteria: 546 (40.8%) patients underwent surgery for acute appendicitis in 2020 and 791 (59.2%) in 2019. According to AAST, patients with complicated appendicitis operated in 2019 were 30.3% vs 39.9% in 2020 (p = 0.001). We observed an increase in the number of post-operative complications in 2020 (15.9%) compared to 2019 (9.6%) (p < 0.001). The following determinants increased the likelihood of complication occurrence: undergoing surgery during 2020 (+ 67%), the increase of a unit in the AAST score (+ 26%), surgery performed > 24 h after admission (+ 58%), open surgery (+ 112%) and conversion to open surgery (+ 166%). In Italian hospitals, in March and April 2020, the number of appendectomies has drastically dropped. During the first pandemic wave, patients undergoing surgery were more frequently affected by more severe appendicitis than the previous year's timeframe and experienced a higher number of complications. Trial registration number and date: Research Registry ID 5789, May 7th, 2020

Research paper thumbnail of SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

British Journal of Surgery, 2021

Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine num... more Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best-and worst-case scenarios were used to describe uncertainty. Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.

Research paper thumbnail of Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study

Anaesthesia, 2021

Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was ... more Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4-1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0-2 weeks, 3-4 weeks and 5-6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3-4.8), 3.9 (2.6-5.1) and 3.6 (2.0-5.2), respectively). Surgery performed ≥ 7 weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9-2.1)). After a ≥ 7 week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2-8.7) vs. 2.4% (95%CI 1.4-3.4) vs. 1.3% (95%CI 0.6-2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection. Patients with ongoing symptoms ≥ 7 weeks from diagnosis may benefit from further delay.

Research paper thumbnail of Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score

British Journal of Surgery, 2021

Research paper thumbnail of La tutela del derecho a la salud en cirugía en Italia: los desafíos de la pandemia de COVID-19

Convención Internacional de Salud, Cuba Salud 2022, 2022

El COVID-19 aparece en 2019 y rápidamente se convierte en pandemia. Cada país busca soluciones pa... more El COVID-19 aparece en 2019 y rápidamente se convierte en pandemia. Cada país busca soluciones para garantizar la salud de todos los ciudadanos. La cirugía juega un papel fundamental en el tratamiento de enfermedades agudas, crónicas y oncológicas que siguen avanzando aún en tiempos de pandemia. Objetivo: este trabajo tiene por objetivo analizar cómo se garantiza el derecho a la salud en cirugía durante la pandemia en Italia. Métodos: los autores analizan la respuesta italiana a la pandemia y principalmente la protección del derecho a la salud en la cirugía durante la pandemia. Resultados: El análisis de los resultados consta de dos partes. La primera analiza, desde el punto de vista jurídico, el derecho a la vida y a la salud en el ordenamiento jurídico italiano y la aplicación del derecho a la salud en cirugía durante la pandemia. La segunda se adentra en el mundo quirúrgico y examina cómo se garantiza concretamente el derecho a la salud de los pacientes COVID-19 positivos y negativos. En conclusión, se puede afirmar que el derecho a la salud coordinado con los principios constitucionales de dignidad, igualdad y solidaridad conduce necesariamente a encontrar la forma de proseguir la actividad quirúrgica.

Research paper thumbnail of Diritto alla salute e chirugia durante la pandemia di COVID-19

Revista de Estudos Constitucionais, Hermenêutica e Teoria do Direito (RECHTD), 2021

Riassunto: Nel presente articolo, gli autori concentrano la propria attenzione sul tema connesso ... more Riassunto: Nel presente articolo, gli autori concentrano la propria attenzione sul tema connesso al diritto alla salute e alla sua applicazione nel settore della chirurgia durante la pandemia di COVID-19. Ciascuno di essi approfondisce le questioni sottese all’argomento in base alle proprie competenze. L’emergenza sanitaria comporta numerose sfide e muoversi in questo scenario non è facile per coloro che svolgono le professioni sanitarie. Al fine di comprendere come possa essere gestita l’emergenza sanitaria senza sacrificare il diritto alla salute degli individui, sono analizzate le raccomandazioni elaborate nello specifico settore della chirurgia. Infine, gli autori rilevano come non si possa prescindere dalla ricerca scientifica che diviene il faro che illumina la strada da percorrere nel mezzo della pandemia di COVID-19.
Abstract: In this article, the authors focus their attention on the issue related to the right to health and its application in the field of surgery during the COVID-19 pandemic. Each of them explores the questions underlying the topic in accordance to their competences. The health emergency poses numerous challenges and moving in this scenario is not easy for health professionals. In order to understand how the health emergency can be managed without sacrificing individuals’ right to health, it is essential to analyse the recommendations developed in the specific sector of surgery. Finally, the authors underline the importance of the scientific research that becomes the beacon that illuminates the road ahead in the middle of the COVID-19 pandemic.

Research paper thumbnail of Elective cancer surgery in COVID-19 free surgical pathways during the SARS-CoV-2 pandemic: An international, multi-centre, comparative cohort study

European Journal of Surgical Oncology

Research paper thumbnail of Resilience of elective cancer surgery systems during COVID-19 lockdowns: an international, multicentre, prospective cohort study

The Lancet, 2021

Background Surgery is the main modality of cure for solid cancers and was prioritised to continue... more Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during SARS-CoV-2 outbreaks. This study aimed to identify areas for health system strengthening by comparing the delivery of elective cancer surgery during COVID-19 in periods of lockdown versus light restriction. Methods In this international, multicentre, prospective cohort study, we enrolled patients with 15 cancer types who had a decision for surgery during the SARS-CoV-2 pandemic (between Jan 21, 2020 and April 14, 2020) to Aug 31, 2020. Any hospital worldwide providing elective cancer surgery was eligible. The primary outcome was the non-operation rate (proportion of patients who did not undergo planned surgery). Reasons for non-operation were classified as COVID-19 related (societal, operational, or personal) or unrelated. Average national Oxford COVID-19 Stringency Index scores were calculated for each patient during their wait for surgery and classified into light restrictions (index <20), moderate lockdowns (20-60), and full lockdowns (>60). Cox proportional-hazards regression models were used to explore associations between lockdowns and non-operation. This study was registered at ClinicalTrials.gov, NCT04384926. Findings We enrolled 27 700 participants, of whom 20 006 patients (8526 men and 11480 women) from 466 hospitals and 61 countries did not receive surgery after a minimum of 3-months' follow up (median 23 weeks [IQR 16-30]). All patients had a COVID-19-related reason for non-operation. Light restrictions were associated with a 0•6% reference non-operation rate, moderate lockdowns with a 5•5% rate (HR 0•81, 95% CI 0•77-0•84, p<0•0001), and full lockdowns with a 15•0% rate (0•51, 0•50-0•53, p<0•0001). In sensitivity analyses, including adjustment for SARS-COV-2 case notification rates, moderate (0•84, 0•80-0•88; p<0•001), and full lockdowns (0•57, 0•54-0•60; p<0•001) remained independently associated with non-operation. Frail patients with advanced cancer, particularly those from low-income and middle-income countries and those requiring postoperative critical care, were more likely to not have an operation. Interpretation Cancer surgery systems worldwide were affected by lockdowns, including in the UK, with one in seven patients not undergoing planned surgery. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which could include protected elective surgical pathways and longterm investment in surge capacity for acute care during public health emergencies. In the UK, a whole-health system approach is required to mitigate against further harm for NHS patients.

Research paper thumbnail of Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery

Research paper thumbnail of Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic

British Journal of Surgery, 2021

Background: This study aimed to determine the impact of pulmonary complications on death after su... more Background: This study aimed to determine the impact of pulmonary complications on death after surgery both before and during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Methods: This was a patient-level, comparative analysis of two, international prospective cohort studies: one before the pandemic (January-October 2019) and the second during the SARS-CoV-2 pandemic (local emergence of COVID-19 up to 19 April 2020). Both included patients undergoing elective resection of an intra-abdominal cancer with curative intent across five surgical oncology disciplines. Patient selection and rates of 30-day postoperative pulmonary complications were compared. The primary outcome was 30-day postoperative mortality. Mediation analysis using a natural-effects model was used to estimate the proportion of deaths during the pandemic attributable to SARS-CoV-2 infection. Results: This study included 7402 patients from 50 countries; 3031 (40.9 per cent) underwent surgery before and 4371 (59.1 per cent) during the pandemic. Overall, 4.3 per cent (187 of 4371) developed postoperative SARS-CoV-2 in the pandemic cohort. The pulmonary complication rate was similar (7.1 per cent (216 of 3031) versus 6.3 per cent (274 of 4371); P ¼ 0.158) but the mortality rate was significantly higher (0.7 per cent (20 of 3031) versus 2.0 per cent (87 of 4371); P < 0.001) among patients who had surgery during the pandemic. The adjusted odds of death were higher during than before the pandemic (odds ratio (OR) 2.72, 95 per cent c.i. 1.58 to 4.67; P < 0.001). In mediation analysis, 54.8 per cent of excess postoperative deaths during the pandemic were estimated to be attributable to SARS-CoV-2 (OR 1.73, 1.40 to 2.13; P < 0.001). Conclusion: Although providers may have selected patients with a lower risk profile for surgery during the pandemic, this did not mitigate the likelihood of death through SARS-CoV-2 infection. Care providers must act urgently to protect surgical patients from SARS-CoV-2 infection.

Research paper thumbnail of The Impact of the COVID 19 Pandemic on Surgical Care in Italy

Junior Doctors Network Newsletter, 2021

Research paper thumbnail of BJS commission on surgery and perioperative care post-COVID-19

British Journal of Surgery, 2021

Background: Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 20... more Background: Coronavirus disease 2019 (COVID-19) was declared a pandemic by the WHO on 11 March 2020 and global surgical practice was compromised. This Commission aimed to document and reflect on the changes seen in the surgical environment during the pandemic, by reviewing colleagues' experiences and published evidence.
Methods: In late 2020, BJS contacted colleagues across the global surgical community and asked them to describe how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had affected their practice. In addition to this, the Commission undertook a literature review on the impact of COVID-19 on surgery and perioperative care. A thematic analysis was performed to identify the issues most frequently encountered by the correspondents, as well as the solutions and ideas suggested to address them.
Results: BJS received communications for this Commission from leading clinicians and academics across a variety of surgical specialties in every inhabited continent. The responses from all over the world provided insights into multiple facets of surgical practice from a governmental level to individual clinical practice and training.
Conclusion: The COVID-19 pandemic has uncovered a variety of problems in healthcare systems, including negative impacts on surgical practice. Global surgical multidisciplinary teams are working collaboratively to address research questions about the future of surgery in the post-COVID-19 era. The COVID-19 pandemic is severely damaging surgical training. The establishment of a multidisciplinary ethics committee should be encouraged at all surgical oncology centres. Innovative leadership and collaboration is vital in the post-COVID-19 era.

Research paper thumbnail of Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study

The Lancet Oncology, 2021

Background: Surgery is the main modality of cure for solid cancers and was prioritised to continu... more Background: Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction.
Methods: This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index <20), moderate lockdowns (20-60), and full lockdowns (>60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926.
Findings: Of eligible patients awaiting surgery, 2003 (10•0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16-30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0•6% non-operation rate (26 of 4521), moderate lockdowns with a 5•5% rate (201 of 3646; adjusted hazard ratio [HR] 0•81, 95% CI 0•77-0•84; p<0•0001), and full lockdowns with a 15•0% rate (1775 of 11 827; HR 0•51, 0•50-0•53; p<0•0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0•84, 95% CI 0•80-0•88; p<0•001), and full lockdowns (0•57, 0•54-0•60; p<0•001), remained independently associated with non-operation. Surgery beyond 12 weeks from diagnosis in patients without neoadjuvant therapy increased during lockdowns (374 [9•1%] of 4521 in light restrictions, 317 [10•4%] of 3646 in moderate lockdowns, 2001 [23•8%] of 11 827 in full lockdowns), although there were no differences in resectability rates observed with longer delays.
Interpretation: Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and longterm investment in surge capacity for acute care during public health emergencies to protect elective staff and services.

Research paper thumbnail of Special Issue "State-of-the-Art in Pancreatic Surgery"

Journal of Clinical Medicine, 2021

https://www.mdpi.com/journal/jcm/special\_issues/pancreatic\_surgery Dear Colleagues, Pancreatic ... more https://www.mdpi.com/journal/jcm/special_issues/pancreatic_surgery

Dear Colleagues,

Pancreatic surgery (PS) is one of the most technically challenging kinds of surgery. Several surgical techniques and different anastomosis for the reconstruction of the digestive system have been performed over the years. PS has been adapted to treat different pancreatic diseases (e.g. cancer, acute or chronic pancreatitis, cysts). Various factors influence cancer recurrance, morbidity and mortality after PS, as scientific literature shows. The most common and clinically relevant complications are related to pancreaticojejunal anastomosis. The choice between neoadjuvant therapy and upfront surgery is dibated, in particular in case of vascular reconstruction. Resectability criteria, absolute and relative contraindications to PS are re-evaluated in the light of new scientific evidence. There are still many unanswered questions and further studies are needed to better manage and treat surgical patients with pancreatic disease. The scope of this Special Issue is to provide an overview of the global advancement of surgical research and clinical practice in the field of PS. Therefore, researchers in the field of PS are encouraged to share their experiences and discuss surgical approaches, submitting an original article or review to this Special Issue.

Guest editors:
Dr. Teresa Perra
Prof. Dr. Alberto Porcu

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 20 July 2022.

Research paper thumbnail of UK Head and neck cancer surgical capacity during the second wave of the COVID-19 pandemic: Have we learned the lessons? COVIDSurg collaborative

Clinical Otolaryngology, 2021

Objectives: The aim of this study was to evaluate the differences in surgical capacity for head a... more Objectives: The aim of this study was to evaluate the differences in surgical capacity for head and neck cancer in the UK between the first wave (March-June 2020) and the current wave (Jan-Feb 2021) of the COVID-19 pandemic.
Design: REDcap online-based survey of hospital capacity.
Setting: UK secondary and tertiary hospitals providing head and neck cancer surgery.
Participants: One representative per hospital was asked to report the capacity for head and neck cancer surgery in that institution.
Main outcome measures: The principal measures of interests were new patient referrals, capacity in outpatients, theatres and critical care; therapeutic compromises constituting delay to surgery, de-escalated surgery and therapeutic migration to non-surgical primary modality.
Results: Data were returned from approximately 95% of UK hospitals with a head and neck cancer surgery specialist service. 50% of UK head and neck cancer patients requiring surgery have significantly compromised treatments during the second wave: 28% delayed, 10% have received radiotherapy-based treatment instead of surgery, and 12% have received de-escalated surgery. Surgical capacity has been more severely constrained in the second wave (58% of pre-pandemic level) compared with the first wave (62%) despite the time to prepare.
Conclusions: Some hospitals are overwhelmed by COVID-19 and unable to offer essential cancer surgery, but all have neighbouring hospitals in their region retaining good (or even normal) capacity. It is noteworthy that very few patients have been appropriately redirected away from the hospitals most constrained by their burden of COVID-19. The paucity of an effective central or regional strategic response to this evident mismatch between demand and surgical capacity is to the detriment of our head and neck cancer patients.

Research paper thumbnail of SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

Anaesthesia, 2021

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill... more SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.

Research paper thumbnail of SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study

Anaesthesia, 2021

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill... more SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We conducted a planned sub-study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS-CoV-2 diagnosis was defined as peri-operative (7 days before to 30 days after surgery); recent (1-6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre-operative anti-coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS-CoV-2; 2.2% (50/2317) in patients with peri-operative SARS-CoV-2; 1.6% (15/953) in patients with recent SARS-CoV-2; and 1.0% (11/1148) in patients with previous SARS-CoV-2. After adjustment for confounding factors, patients with peri-operative (adjusted odds ratio 1.5 (95%CI 1.1-2.0)) and recent SARS-CoV-2 (1.9 (95%CI 1.2-3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS-CoV-2 (1.7 (95%CI 0.9-3.0)). Overall, venous thromboembolism was independently associated with 30-day mortality (5.4 (95%CI 4.3-6.7)). In patients with SARS-CoV-2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri-operative or recent SARS-CoV-2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS-CoV-2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.

Research paper thumbnail of Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study

The Journal of Thoracic and Cardiovascular Surgery, 2021

Research paper thumbnail of Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study

Anaesthesia, 2021

We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complicati... more We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined subgroup analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05-1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4-7 days or ≥ 8 days of 1.25 (1.04-1.48), p = 0.015 and 1.31 (1.11-1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care.

Research paper thumbnail of Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study

Anaesthesia, 2021

We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complicati... more We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined subgroup analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05-1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4-7 days or ≥ 8 days of 1.25 (1.04-1.48), p = 0.015 and 1.31 (1.11-1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care.

Research paper thumbnail of Appendectomy during the COVID-19 pandemic in Italy: a multicenter ambispective cohort study by the Italian Society of Endoscopic Surgery and new technologies (the CRAC study)

Updates in Surgery, 2021

Major surgical societies advised using non-operative management of appendicitis and suggested aga... more Major surgical societies advised using non-operative management of appendicitis and suggested against laparoscopy during the COVID-19 pandemic. The hypothesis is that a significant reduction in the number of emergent appendectomies was observed during the pandemic, restricted to complex cases. The study aimed to analyse emergent surgical appendectomies during pandemic on a national basis and compare it to the same period of the previous year. This is a multicentre, retrospective, observational study investigating the outcomes of patients undergoing emergent appendectomy in March-April 2019 vs March-April 2020. The primary outcome was the number of appendectomies performed, classified according to the American Association for the Surgery of Trauma (AAST) score. Secondary outcomes were the type of surgical technique employed (laparoscopic vs open) and the complication rates. One thousand five hundred forty one patients with acute appendicitis underwent surgery during the two study periods. 1337 (86.8%) patients met the inclusion criteria: 546 (40.8%) patients underwent surgery for acute appendicitis in 2020 and 791 (59.2%) in 2019. According to AAST, patients with complicated appendicitis operated in 2019 were 30.3% vs 39.9% in 2020 (p = 0.001). We observed an increase in the number of post-operative complications in 2020 (15.9%) compared to 2019 (9.6%) (p < 0.001). The following determinants increased the likelihood of complication occurrence: undergoing surgery during 2020 (+ 67%), the increase of a unit in the AAST score (+ 26%), surgery performed > 24 h after admission (+ 58%), open surgery (+ 112%) and conversion to open surgery (+ 166%). In Italian hospitals, in March and April 2020, the number of appendectomies has drastically dropped. During the first pandemic wave, patients undergoing surgery were more frequently affected by more severe appendicitis than the previous year's timeframe and experienced a higher number of complications. Trial registration number and date: Research Registry ID 5789, May 7th, 2020

Research paper thumbnail of SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

British Journal of Surgery, 2021

Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine num... more Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best-and worst-case scenarios were used to describe uncertainty. Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.

Research paper thumbnail of Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study

Anaesthesia, 2021

Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was ... more Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4-1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0-2 weeks, 3-4 weeks and 5-6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3-4.8), 3.9 (2.6-5.1) and 3.6 (2.0-5.2), respectively). Surgery performed ≥ 7 weeks after SARS-CoV-2 diagnosis was associated with a similar mortality risk to baseline (odds ratio (95%CI) 1.5 (0.9-2.1)). After a ≥ 7 week delay in undertaking surgery following SARS-CoV-2 infection, patients with ongoing symptoms had a higher mortality than patients whose symptoms had resolved or who had been asymptomatic (6.0% (95%CI 3.2-8.7) vs. 2.4% (95%CI 1.4-3.4) vs. 1.3% (95%CI 0.6-2.0), respectively). Where possible, surgery should be delayed for at least 7 weeks following SARS-CoV-2 infection. Patients with ongoing symptoms ≥ 7 weeks from diagnosis may benefit from further delay.

Research paper thumbnail of Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score

British Journal of Surgery, 2021

Research paper thumbnail of La tutela del derecho a la salud en cirugía en Italia: los desafíos de la pandemia de COVID-19

Evento: IV Convención Internacional “Cuba-Salud 2022”, 17-21 de octubre de 2022, Palacio de Conv... more Evento: IV Convención Internacional “Cuba-Salud 2022”, 17-21 de octubre de 2022, Palacio de Convenciones de La Habana, Cuba;
Organizan y Auspician: Ministerio de Salud Pública de la República de Cuba, Organización Mundial de la Salud/Organización Panamericana de la Salud, Consejo Nacional de Sociedades Científicas de la Salud de Cuba, Escuela Nacional de Salud Pública de Cuba, Academia de Ciencias de Cuba, Sindicato Nacional de Trabajadores de la Salud, Cámara de Comercio de la República de Cuba, Ministerio de Relaciones Exteriores, Ministerio de Comercio Exterior y la Inversión Extranjera, Ministerio de Turismo, Universidad de Ciencias Médicas de La Habana, Sociedad Cubana de Salud Pública, Sociedad Cubana de Higiene y Epidemiología, Sociedad Cubana de Informática Médica, Sociedad Cubana de Geriatría y Gerontología, Sociedad Cubana de Educadores en Ciencias de la Salud, Sociedad Cubana de Medicina Familiar, Organización Superior de Dirección Empresarial BioCubaFarma,
Palacio de Convenciones de La Habana, Unión de Universidades de América Latina,
Alianza de Sociedades de Salud Pública para Las Américas, Fondo de Población de las Naciones Unidas (UNFPA) Cuba.

Nell’ambito della IV Convención Internacional “Cuba-Salud 2022”, tenutasi dal 17 al 21 ottobre 2022, nel Palacio de Convenciones de La Habana, Cuba, si è svolto l'Encuentro Internacional “Sistemas y Servicios de Salud”, Simposio Determinantes Sociales de la Salud y Políticas Públicas;

Ponentes: Livio Perra e Teresa Perra;
Titolo ponencia: “La tutela del derecho a la salud en cirugía en Italia: los desafíos de la pandemia de COVID-19”,
Viernes 21, h. 12:50, SESIÓN DE LA MAÑANA, SALA 13.

Il Programa Científico è disponibile al seguente link: https://convencionsalud.sld.cu/index.php/convencionsalud22/2022/pages/view/programa Si veda: p. 93.

Research paper thumbnail of The impact of sarcopenia on the risk of postoperative  pancreatic fistula after pancreatoduodenectomy

41st Annual Meeting German Pancreas Club, Lübeck, Germany, February 10 - 12, 2022, 2022

FRIDAY, FEB 11, 2022 h 12:00 Lecture Hall (Live stream) Flash-Talks of selected posters Flash Tal... more FRIDAY, FEB 11, 2022 h 12:00 Lecture Hall (Live stream)
Flash-Talks of selected posters
Flash Talk: The impact of sarcopenia on the risk of postoperative pancreatic fistula after pancreatoduodenectomy (ID 279 | P76)
Teresa Perra, Alberto Porcu

FRIDAY, FEB 11, 2022 h 12:35 Poster Lounge 8
Poster presentations
The impact of sarcopenia on the risk of postoperative pancreatic fistula after pancreatoduodenectomy (P76 | ID 279)
Teresa Perra, Alberto Porcu

Research paper thumbnail of Presentazione del volume "Global Threats in the Anthropocene: from Covid-19 to the future"

Presentazione del volume “Global Threats in the Anthropocene: from Covid-19 to the future” a cura... more Presentazione del volume “Global Threats in the Anthropocene: from Covid-19 to the future” a cura di Leonardo Mercatanti e Stefano Montes (Dipartimento di Culture e Società, Università degli Studi di Palermo)
Mercoledì 1 dicembre 2021 Ore 17:30

Research paper thumbnail of La medicina personalizada en la cirugía hepatobiliopancreática: Anomalías y variantes anatómicas del sistema hepático arterial

XI Congreso Internacional de Salud, Bienestar y Sociedad, Sorbonne Université, París, Francia, 2 - 3 de septiembre de 2021, 2021

Cada procedimiento quirúrgico se caracteriza por tiempos y pasos que se han establecidos por acci... more Cada procedimiento quirúrgico se caracteriza por tiempos y pasos que se han establecidos por acciones repetidas una y otra vez, con el aporte de mejorías que han permitido la evolución técnica. Cada paciente es diferente. En particular, respecto a la cirugía hepatobiliopancreática, no es raro incurrir en variantes y anomalías anatómicas del árbol vascular o biliar. El enfoque de este trabajo es el análisis de las anomalías y variantes del sistema hepático arterial. Realizamos una búsqueda bibliográfica, dirigida hacia anomalías y variantes anatómicas del sistema hepático arterial, en la base de datos PubMed y las listas de referencias de los artículos más relevantes. Las variantes y anomalías anatómicas del sistema hepático arterial son heterogéneas. No es raro detectar la presencia de arterias hepáticas aberrantes accesorias o reemplazantes. Dos son los sitios de origen de arterias hepáticas aberrantes más frecuentes. Las arterias hepáticas izquierdas aberrantes pueden originarse de la arteria gástrica izquierda. Las arterias hepáticas derechas aberrantes pueden tener origen en la arteria mesentérica superior y suelen tener un trayecto retroduodenoportal. Las imágenes radiológicas preoperatorias pueden ayudar a detectar anomalías y variantes anatómicas vasculares y planear el abordaje resectivo más adecuado en la cirugía hepatobiliopancreática. Los vasos pueden ser afectados por tumores o tener trayectos que aumentan el riesgo de lesión vascular. Una cuidadosa evaluación de los patrones arteriales del paciente puede permitir seleccionar los pasos técnicos más adecuados para cada paciente en función de sus peculiares características, realizando procedimientos quirúrgicos de forma personalizada.

Research paper thumbnail of Scienza in Piazza 2021

L’ateneo di Sassari, le scuole secondarie superiori di città e provincia, la rete di associazioni... more L’ateneo di Sassari, le scuole secondarie superiori di città e provincia, la rete di associazioni scientifiche Scienza in Movimento, insieme come una unica squadra, si sono preparati a vincere la sfida che la situazione di pandemia ha proposto organizzando la versione online dell’atteso evento di Public Engagement Scienza in Piazza, arrivato quest’anno alla sua quindicesima edizione, la prima a distanza. La mostra come sempre costituita da exhibit animati da ragazzi e docenti della scuola e dell’università, insieme a esperti della rete Scienza in Movimento rappresenta quest’anno il primo evento online che fa seguito a una fase preparatoria avviata nelle scuole e nei dipartimenti aderenti, coinvolgendo studenti e docenti sia delle scuole sia dell’Ateneo, in una serie d’iniziative e attività di laboratorio a sostegno della formazione scientifica e non solo, usufruibili a distanza. Attraverso un coinvolgimento diretto di tutti gli animatori, si punta a promuovere in essi la curiosità e l’interesse verso le discipline scientifiche, verso i diversi aspetti della comunicazione, in un quadro atto a far crescere la socialità nei ragazzi, l’innovazione della didattica nei docenti, infine ma non da meno il coinvolgimento delle Famiglie nell’educazione dei propri figli. Parlare dell'argomento scientifico che ci appassiona: incontro con FameLab Sassari 2021 Tre minuti per raccontare la scienza! FameLab è il contest internazionale di comunicazione scientifica dedicato agli studenti universitari e ai giovani ricercatori che vogliono condividere una grande passione scientifica. La loro missione è coinvolgere giuria e pubblico, parlando con competenza, chiarezza e carisma.

Titoli interventi:
Livio Perra, I diritti della natura
Teresa Perra, Chirurgia generale durante la pandemia di COVID-19

Research paper thumbnail of ScienzArena - SHARPER Night - Università degli Studi di Sassari

ScienzArena - SHARPER Night - Università degli Studi di Sassari 17:00 - 19:00: ScienzArena Talks ... more ScienzArena - SHARPER Night - Università degli Studi di Sassari 17:00 - 19:00: ScienzArena Talks brevi talk divulgativi a cura dei ricercatori dell’Università di Sassari
Valentina Talu (DADU): Verso la costruzione di città autism-friendly
Antonio Brunetti (Dip. Scienze CC.FF.MM.NN.): Una nuova visione sulla metallurgia nuragica
Vanessa Lozano (Dip. Agraria): Utilizzo della Citizen Science per migliorare le conoscenze sulla distribuzione di specie invasive
Matteo Garau (Dip. Agraria): Scelte etiche per la Salute del Suolo: valorizzazione delle filiere agro-alimentari per un’agricoltura eco-sostenibile
Livio Perra (DISSUF): Il genocidio culturale
Teresa Perra (Dip. Sc. Mediche Chirurgiche e Sperim.): I progressi della chirurgia oncologica
Beatrice Groppa (studentessa DISSUF): “Le Orecchie a cotoletta”: divagazione sul pipistrello sardo

Programma disponibile al seguente link: https://www.uniss.it/node/13667

Research paper thumbnail of ScienzArena Talks - SHARPER Night - Università degli Studi di Sassari

Brevi talk divulgativi con i ricercatori Uniss Teresa Perra, Vanessa Lozano, Livio Perra. Talk: T... more Brevi talk divulgativi con i ricercatori Uniss Teresa Perra, Vanessa Lozano, Livio Perra.
Talk:
Teresa Perra, La chirurgia oncologica;
Vanessa Lozano, Le specie aliene invasive;
Livio Perra, I diritti della natura.

Sassari, 24/09/2021 h. 16:30 – 17:00
Spazio ScienzArena, atrio del Palazzo dell’Università degli Studi di Sassari

Research paper thumbnail of FameLab OFF - Ricercatori alla spina - SHARPER Night - Università degli Studi di Sassari

FameLab OFF - Ricercatori alla spina - SHARPER Night - Università degli Studi di Sassari Brevi t... more FameLab OFF - Ricercatori alla spina - SHARPER Night - Università degli Studi di Sassari
Brevi talk divulgativi da parte dei partecipanti a FameLab 2021.
Talk:
1. Le piante aliene di Vanessa;
2. Nicola e l'apprendimento da fenomeni;
3. Lucia e i suoi studi sulla fatica;
4. Livio e i diritti della natura;
5. La fisiologia del sorriso di Francesca;
6. Luigi e la ricerca in pandemia;
7. Teresa e la chirurgia oncologica.

Sassari, 23/09/2021 h. 19:30 - 21:30