Isabel Fernaud | Universidad Politécnica de Madrid (original) (raw)
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Papers by Isabel Fernaud
Applied Sciences
The complexity of the human brain makes its understanding one of the biggest challenges that scie... more The complexity of the human brain makes its understanding one of the biggest challenges that science is currently confronting. Due to its complexity, the brain has been studied at many different levels and from many disciplines and points of view, using a diversity of techniques for getting meaningful data at each specific level and perspective, producing sometimes data that are difficult to integrate. In order to advance understanding of the brain, scientists need new tools that can speed up this analysis process and that can facilitate integrating research results from different disciplines and techniques. Visualization has proved to be useful in the analysis of complex data, and this paper focuses on the design of visualization solutions adapted to the specific problems posed by brain research. In this paper, we propose a unified framework that allows the integration of specific tools to work together in a coordinated manner in a multiview environment, displaying information at d...
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PLOS Computational Biology, 2018
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Cerebral cortex (New York, N.Y. : 1991), Oct 13, 2016
The Reelin pathway is essential for both neural migration and for the development and maturation ... more The Reelin pathway is essential for both neural migration and for the development and maturation of synaptic connections. However, its role in adult synaptic formation and remodeling is still being investigated. Here, we investigated the impact of the Reelin/Dab1 pathway on the synaptogenesis of newborn granule cells (GCs) in the young-adult mouse hippocampus. We show that neither Reelin overexpression nor the inactivation of its intracellular adapter, Dab1, substantially alters dendritic spine numbers in these neurons. In contrast, 3D-electron microscopy (focused ion beam milling/scanning electron microscope) revealed that dysregulation of the Reelin/Dab1 pathway leads to both transient and permanent changes in the types and morphology of dendritic spines, mainly altering mushroom, filopodial, and branched GC spines. We also found that the Reelin/Dab1 pathway controls synaptic configuration of presynaptic boutons in the dentate gyrus, with its dysregulation leading to a substantial...
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Frontiers in Neuroanatomy, 2015
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Brain Structure and Function, 2014
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The Journal of neuroscience : the official journal of the Society for Neuroscience, Jan 23, 2014
Dendritic spines establish most excitatory synapses in the brain and are located in Purkinje cell... more Dendritic spines establish most excitatory synapses in the brain and are located in Purkinje cell's dendrites along helical paths, perhaps maximizing the probability to contact different axons. To test whether spine helixes also occur in neocortex, we reconstructed >500 dendritic segments from adult human cortex obtained from autopsies. With Fourier analysis and spatial statistics, we analyzed spine position along apical and basal dendrites of layer 3 pyramidal neurons from frontal, temporal, and cingulate cortex. Although…
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Hippocampus, 2010
Why memory is a particular target for the pathological changes in Alzheimer's Disease (AD) ha... more Why memory is a particular target for the pathological changes in Alzheimer's Disease (AD) has long been a fundamental question when considering the mechanisms underlying this disease. It has been established from numerous biochemical and morphological studies that AD is, at least initially, a consequence of synaptic malfunction provoked by Amyloid β (Aβ) peptide. APP/PS1 transgenic mice accumulate Aβ throughout the brain, and they have therefore been employed to investigate the effects of Aβ overproduction on brain circuitry and cognition. Previous studies show that Aβ overproduction affects spine morphology in the hippocampus and amygdala, both within and outside plaques (Knafo et al., (2009) Cereb Cortex 19:586‐592; Knafo et al., (in press) J Pathol). Hence, we conducted a detailed analysis of dendritic spines located in the stratum oriens and stratum radiatum of the CA1 hippocampal subfield of APP/PS1 mice. Three‐dimensional analysis of 18,313 individual dendritic spines rev...
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Progress in Neurobiology, 2000
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Neuroinformatics, 2014
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Molecular Immunology, 1998
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The Journal of Pathology, 2009
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Applied Sciences
The complexity of the human brain makes its understanding one of the biggest challenges that scie... more The complexity of the human brain makes its understanding one of the biggest challenges that science is currently confronting. Due to its complexity, the brain has been studied at many different levels and from many disciplines and points of view, using a diversity of techniques for getting meaningful data at each specific level and perspective, producing sometimes data that are difficult to integrate. In order to advance understanding of the brain, scientists need new tools that can speed up this analysis process and that can facilitate integrating research results from different disciplines and techniques. Visualization has proved to be useful in the analysis of complex data, and this paper focuses on the design of visualization solutions adapted to the specific problems posed by brain research. In this paper, we propose a unified framework that allows the integration of specific tools to work together in a coordinated manner in a multiview environment, displaying information at d...
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
PLOS Computational Biology, 2018
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Cerebral cortex (New York, N.Y. : 1991), Oct 13, 2016
The Reelin pathway is essential for both neural migration and for the development and maturation ... more The Reelin pathway is essential for both neural migration and for the development and maturation of synaptic connections. However, its role in adult synaptic formation and remodeling is still being investigated. Here, we investigated the impact of the Reelin/Dab1 pathway on the synaptogenesis of newborn granule cells (GCs) in the young-adult mouse hippocampus. We show that neither Reelin overexpression nor the inactivation of its intracellular adapter, Dab1, substantially alters dendritic spine numbers in these neurons. In contrast, 3D-electron microscopy (focused ion beam milling/scanning electron microscope) revealed that dysregulation of the Reelin/Dab1 pathway leads to both transient and permanent changes in the types and morphology of dendritic spines, mainly altering mushroom, filopodial, and branched GC spines. We also found that the Reelin/Dab1 pathway controls synaptic configuration of presynaptic boutons in the dentate gyrus, with its dysregulation leading to a substantial...
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Frontiers in Neuroanatomy, 2015
Bookmarks Related papers MentionsView impact
Brain Structure and Function, 2014
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The Journal of neuroscience : the official journal of the Society for Neuroscience, Jan 23, 2014
Dendritic spines establish most excitatory synapses in the brain and are located in Purkinje cell... more Dendritic spines establish most excitatory synapses in the brain and are located in Purkinje cell's dendrites along helical paths, perhaps maximizing the probability to contact different axons. To test whether spine helixes also occur in neocortex, we reconstructed >500 dendritic segments from adult human cortex obtained from autopsies. With Fourier analysis and spatial statistics, we analyzed spine position along apical and basal dendrites of layer 3 pyramidal neurons from frontal, temporal, and cingulate cortex. Although…
Bookmarks Related papers MentionsView impact
Hippocampus, 2010
Why memory is a particular target for the pathological changes in Alzheimer's Disease (AD) ha... more Why memory is a particular target for the pathological changes in Alzheimer's Disease (AD) has long been a fundamental question when considering the mechanisms underlying this disease. It has been established from numerous biochemical and morphological studies that AD is, at least initially, a consequence of synaptic malfunction provoked by Amyloid β (Aβ) peptide. APP/PS1 transgenic mice accumulate Aβ throughout the brain, and they have therefore been employed to investigate the effects of Aβ overproduction on brain circuitry and cognition. Previous studies show that Aβ overproduction affects spine morphology in the hippocampus and amygdala, both within and outside plaques (Knafo et al., (2009) Cereb Cortex 19:586‐592; Knafo et al., (in press) J Pathol). Hence, we conducted a detailed analysis of dendritic spines located in the stratum oriens and stratum radiatum of the CA1 hippocampal subfield of APP/PS1 mice. Three‐dimensional analysis of 18,313 individual dendritic spines rev...
Bookmarks Related papers MentionsView impact
Progress in Neurobiology, 2000
Bookmarks Related papers MentionsView impact
Neuroinformatics, 2014
Bookmarks Related papers MentionsView impact
Molecular Immunology, 1998
Bookmarks Related papers MentionsView impact
The Journal of Pathology, 2009
Bookmarks Related papers MentionsView impact