α-Conotoxin Vc1.1 Structure–Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement (original) (raw)

Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor

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Scientific reports, 2017

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Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins

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The Journal of biological chemistry, 2016

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Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor Subtype

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Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors

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Biochemical and Biophysical Research Communications, 2005

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Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist α-conotoxin OmIA that discriminates α3 vs. α6 nAChR subtypes

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Biochemical and Biophysical Research Communications, 2006

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α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition

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British journal of pharmacology, 2017

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Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models

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Marine Drugs, 2018

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Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors

Todd Talley

Journal of Biological Chemistry, 2018

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Positional Scanning Mutagenesis of -Conotoxin PeIA Identifies Critical Residues That Confer Potency and Selectivity for 6/ 3 2 3 and 3 2 Nicotinic Acetylcholine Receptors

Layla Azam

Journal of Biological Chemistry, 2013

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Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors

Owen McDougal

Marine Drugs, 2019

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α-Conotoxin PIA Is Selective for α6 Subunit-Containing Nicotinic Acetylcholine Receptors

Baldomero Olivera

The Journal of Neuroscience, 2003

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Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors

Owen McDougal

Toxins, 2019

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A New α-Conotoxin Which Targets α3β2 Nicotinic Acetylcholine Receptors

Baldomero Olivera

Journal of Biological Chemistry, 1996

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Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors

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Biochemical Journal, 2004

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αS-Conotoxin RVIIIA: A Structurally Unique Conotoxin That Broadly Targets Nicotinic Acetylcholine Receptors

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alpha.-Conotoxin EI, A New Nicotinic Acetylcholine Receptor Antagonist with Novel Selectivity

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Biochemistry, 1995

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Novel ?-conotoxins from Conus spurius and the ?-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors

Francesco Peri

Febs Journal, 2007

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Alanine Scan of α-Conotoxin RegIIA Reveals a Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist

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Journal of Biological Chemistry, 2014

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Differential Targeting of Nicotinic Acetylcholine Receptors by Novel αA-Conotoxins

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Journal of Biological Chemistry, 1997

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Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors

Michael McIntosh

Acta Pharmacologica Sinica, 2009

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Amino Acid Residues That Confer High Selectivity of the 6 Nicotinic Acetylcholine Receptor Subunit to -Conotoxin MII[S4A,E11A,L15A]

Layla Azam

Journal of Biological Chemistry, 2008

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Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors

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Scientific reports, 2015

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α4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors

Tanya Sanders

Peptides, 2008

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Single amino acid substitutions in α-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor

David J Adams

1999

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Solution Conformation of αA-conotoxin EIVA, a Potent Neuromuscular Nicotinic Acetylcholine Receptor Antagonist from Conus ermineus

Baldomero Olivera

Journal of Biological Chemistry, 2003

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alpha.-Conotoxins, small peptide probes of nicotinic acetylcholine receptors

Lourdes J Cruz

Biochemistry, 1991

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αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors

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Biochemical pharmacology, 2015

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Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant

Maxim Zhmak

Nature Structural & Molecular Biology, 2005

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α-Conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors

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FEBS Letters, 2003

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α-Conotoxin OmIA Is a Potent Ligand for the Acetylcholine-binding Protein as Well as α3β2 and α7 Nicotinic Acetylcholine Receptors

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Journal of Biological Chemistry, 2006

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Atypical -Conotoxin LtIA from Conus litteratus Targets a Novel Microsite of the 3 2 Nicotinic Receptor

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Journal of Biological Chemistry, 2010

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α-Conotoxins PnIA and [A10L]PnIA Stabilize Different States of the α7-L247T Nicotinic Acetylcholine Receptor

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Journal of Biological Chemistry, 2003

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