Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor (original) (raw)

The Journal of biological chemistry, 2016

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant

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Nature Structural & Molecular Biology, 2005

Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors

Biochemical and Biophysical Research Communications, 2005

Alanine Scan of α-Conotoxin RegIIA Reveals a Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist

Journal of Biological Chemistry, 2014

Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors

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Journal of Biological Chemistry, 2018

α-Conotoxin Vc1.1 Structure–Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement

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Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors

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Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist α-conotoxin OmIA that discriminates α3 vs. α6 nAChR subtypes

Biochemical and Biophysical Research Communications, 2006

Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors

Scientific reports, 2015

Identifying Key Amino Acid Residues That Affect α-Conotoxin AuIB Inhibition of α3β4 Nicotinic Acetylcholine Receptors

Journal of Biological Chemistry, 2013

Discovery of a Potent and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist from an α-Conotoxin Synthetic Combinatorial Library

Yi-Pin Chang

Journal of Medicinal Chemistry, 2014

Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor Subtype

Journal of medicinal chemistry, 2018

α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition

British journal of pharmacology, 2017

Nuclear Magnetic Resonance Solution Conformation of α-Conotoxin AuIB, an α3β4 Subtype-selective Neuronal Nicotinic Acetylcholine Receptor Antagonist

Journal of Biological Chemistry, 2000

alpha.-Conotoxin EI, A New Nicotinic Acetylcholine Receptor Antagonist with Novel Selectivity

Biochemistry, 1995

Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors

Petros Giastas

Frontiers in Pharmacology

Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors

Owen McDougal

Toxins, 2019

Identifying Key Amino Acid Residues That Affect -Conotoxin AuIB Inhibition of 3 4 Nicotinic Acetylcholine Receptors

Hartmut Cuny

Journal of Biological Chemistry, 2013

Three-Dimensional Solution Structure of α-Conotoxin MII, an α3β2 Neuronal Nicotinic Acetylcholine Receptor-Targeted Ligand

Biochemistry, 1997

Positional Scanning Mutagenesis of -Conotoxin PeIA Identifies Critical Residues That Confer Potency and Selectivity for 6/ 3 2 3 and 3 2 Nicotinic Acetylcholine Receptors

Layla Azam

Journal of Biological Chemistry, 2013

Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors

Irina Vetter

Biochemical Pharmacology, 2013

Atypical -Conotoxin LtIA from Conus litteratus Targets a Novel Microsite of the 3 2 Nicotinic Receptor

Cheryl Dowell

Journal of Biological Chemistry, 2010

Solution Conformation of αA-conotoxin EIVA, a Potent Neuromuscular Nicotinic Acetylcholine Receptor Antagonist from Conus ermineus

Journal of Biological Chemistry, 2003

Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors

Biochemical pharmacology, 2014

α4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors

Tanya Sanders

Peptides, 2008

A New α-Conotoxin Which Targets α3β2 Nicotinic Acetylcholine Receptors

Journal of Biological Chemistry, 1996

Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors

Owen McDougal

Marine Drugs, 2019

Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations

Marine Drugs, 2020

NMR solution conformation of an antitoxic analogue of alpha-conotoxin GI: identification of a common nicotinic acetylcholine receptor alpha 1-subunit binding surface for small ligands and alpha-conotoxins

K. Hun Mok

Biochemistry

Rational design of new ligands for nicotinic receptors on the basis of α-conotoxin PnIA

Anton O Chugunov

Doklady Biochemistry and Biophysics, 2015

Rational Design of α-Conotoxin Analogues Targeting a7 Nicotinic Acetylcholine Receptors : IMPROVED ANTAGONISTIC ACTIVITY BY INCORPORATION OF PROLINE DERIVATIVES

Kasper Harpsøe

The Journal of Biological Chemistry, 2009

αS-Conotoxin RVIIIA: A Structurally Unique Conotoxin That Broadly Targets Nicotinic Acetylcholine Receptors

Biochemistry

NMR structure determination of α-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold

Biochemical and Biophysical Research Communications, 2006