Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors (original) (raw)

NMR solution conformation of an antitoxic analogue of alpha-conotoxin GI: identification of a common nicotinic acetylcholine receptor alpha 1-subunit binding surface for small ligands and alpha-conotoxins

K. Hun Mok

Biochemistry

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NMR Solution Conformation of an Antitoxic Analogue of α-Conotoxin GI: Identification of a Common Nicotinic Acetylcholine Receptor α 1 -Subunit Binding Surface for Small Ligands and α-Conotoxins † , ‡

K. Hun Mok

Biochemistry, 1999

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NMR structure determination of α-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold

Baldomero Olivera

Biochemical and Biophysical Research Communications, 2006

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Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors

Baldomero Olivera

Biochemical and Biophysical Research Communications, 2005

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Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist α-conotoxin OmIA that discriminates α3 vs. α6 nAChR subtypes

Baldomero Olivera

Biochemical and Biophysical Research Communications, 2006

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Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors

Baldomero Olivera

Biochemical Journal, 2004

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Three-Dimensional Solution Structure of α-Conotoxin MII, an α3β2 Neuronal Nicotinic Acetylcholine Receptor-Targeted Ligand

Baldomero Olivera

Biochemistry, 1997

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Nuclear Magnetic Resonance Solution Conformation of α-Conotoxin AuIB, an α3β4 Subtype-selective Neuronal Nicotinic Acetylcholine Receptor Antagonist

Baldomero Olivera

Journal of Biological Chemistry, 2000

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Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor

Lotten Ragnarsson

Scientific reports, 2017

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Alanine Scan of α-Conotoxin RegIIA Reveals a Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist

David J Adams

Journal of Biological Chemistry, 2014

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Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors

Todd Talley

Journal of Biological Chemistry, 2018

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A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from αD-Conotoxin GeXXA

David J Adams

Marine drugs, 2017

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alpha.-Conotoxin EI, A New Nicotinic Acetylcholine Receptor Antagonist with Novel Selectivity

Baldomero Olivera

Biochemistry, 1995

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Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant

Maxim Zhmak

Nature Structural & Molecular Biology, 2005

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NMR structure of alpha-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor

Ottavia Spiga

Biochemistry, 2002

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A New α-Conotoxin Which Targets α3β2 Nicotinic Acetylcholine Receptors

Baldomero Olivera

Journal of Biological Chemistry, 1996

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Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors

David J Adams

Scientific reports, 2015

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Differential Targeting of Nicotinic Acetylcholine Receptors by Novel αA-Conotoxins

Baldomero Olivera

Journal of Biological Chemistry, 1997

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Rational Design of α-Conotoxin Analogues Targeting a7 Nicotinic Acetylcholine Receptors : IMPROVED ANTAGONISTIC ACTIVITY BY INCORPORATION OF PROLINE DERIVATIVES

Kasper Harpsøe

The Journal of Biological Chemistry, 2009

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Solution Conformation of αA-conotoxin EIVA, a Potent Neuromuscular Nicotinic Acetylcholine Receptor Antagonist from Conus ermineus

Baldomero Olivera

Journal of Biological Chemistry, 2003

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NMR Structure of α-Bungarotoxin Free and Bound to a Mimotope of the Nicotinic Acetylcholine Receptor †

Ottavia Spiga

Biochemistry, 2002

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Rational Design of -Conotoxin Analogues Targeting 7 Nicotinic Acetylcholine Receptors: IMPROVED ANTAGONISTIC ACTIVITY BY INCORPORATION OF PROLINE DERIVATIVES

Christian Skonberg

Journal of Biological Chemistry, 2009

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α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition

David J Adams

British journal of pharmacology, 2017

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Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors

Owen McDougal

Toxins, 2019

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Determinants of Potency on α-Conotoxin MII, a Peptide Antagonist of Neuronal Nicotinic Receptors

Aldrin Gomes

Biochemistry, 2004

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Discovery of a Potent and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist from an α-Conotoxin Synthetic Combinatorial Library

Yi-Pin Chang

Journal of Medicinal Chemistry, 2014

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NMR-based binding screen and structural analysis of the complex formed between α-cobratoxin and an 18-mer cognate peptide derived from the α1 subunit of the nicotinic acetylcholine receptor from torpedo californica

Allison Zumberge

Journal of Biological Chemistry, 2002

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Analogs of -Conotoxin MII Are Selective for 6-Containing Nicotinic Acetylcholine Receptors

Layla Azam

Molecular Pharmacology, 2004

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Discovery, Synthesis, and Structure Activity of a Highly Selective α7 Nicotinic Acetylcholine Receptor Antagonist

Baldomero Olivera

Biochemistry, 2007

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Characterization and Three-Dimensional Structure Determination of ψ-Conotoxin Piiif, a Novel Noncompetitive Antagonist of Nicotinic Acetylcholine Receptors

Baldomero Olivera

Biochemistry, 2003

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α-Conotoxin Vc1.1 Structure–Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement

David J Adams

ACS Chemical Neuroscience, 2019

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Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB

David J Adams

Biochemical pharmacology, 2018

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alpha.-Conotoxins, small peptide probes of nicotinic acetylcholine receptors

Lourdes J Cruz

Biochemistry, 1991

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Towards structure determination of neurotoxin II bound to nicotinic acetylcholine receptor: a solid-state NMR approach

Alexander Arseniev

FEBS Letters, 2004

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