Total chemical synthesis of a functional interacting protein pair: The protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1 (original) (raw)

Design, total chemical synthesis, and binding properties of a [Leu-91-N1-methyl-7-azaTrp]Ras-binding domain of c-Raf-1

Jens Sydor, Martin Engelhard

Proceedings of the National Academy of Sciences, 1999

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A sensitive fluorescence monitor for the detection of activated Ras: total chemical synthesis of site-specifically labeled Ras binding domain of c-Raf1 immobilized on a surface

Christie Hunter

Chemistry & Biology, 2001

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Synthesis of Functional Ras Lipoproteins and Fluorescent Derivatives

Benjamin Bader

Journal of the American Chemical Society, 2001

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Synthesis of degenerated libraries of the ras-binding domain of raf and rapid selection of fast-folding and stable clones with the dihydrofolate reductase protein fragment complementation assay

François-xavier Campbell-valois

Methods in molecular biology (Clifton, N.J.), 2007

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Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins

Somasekhar Bondalapati

Nature Chemistry, 2016

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Chemical synthesis of proteins

Gregg Fields

Trends in Biotechnology, 2000

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Modification and Activation of Ras Proteins by Electrophilic Prostanoids with Different Structure are Site-Selective

Andrea Perez

Biochemistry, 2007

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Synthesis of the Rheb and K-Ras4B GTPases

Debapratim Das

Angewandte Chemie, 2010

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Introduction of unnatural amino acids into proteins using expressed protein ligationStandard IUPAC single- and triple-letter codes for amino acids are used throughout the article

Julio Camarero

Biopolymers, 1999

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Identification of ras/raf binding site and design of interfering peptide with potential clinical application

sylvain choquet

Integrative molecular medicine, 2016

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DNA-instructed acyl transfer reactions for the synthesis of bioactive peptides

Tom Grossmann

Bioorganic & Medicinal Chemistry Letters, 2011

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Protein and nucleic acid engineering. Recent French contributions. Part I

Alan Fersht

Biochimie, 1990

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Mutational analysis of a ras catalytic domain

Berthe Willumsen

Molecular and Cellular Biology, 1986

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Synthesis, characterization and solution properties of ras sequences modified by arylamine carcinogens at the first base of codon 61

Victor Day

Chemical Research in Toxicology, 1990

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Binding properties and biological characterization of new sugar-derived Ras ligands

Vadim Gaponenko, Alessandro Palmioli, Francesco Peri

MedChemComm, 2011

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Synthesis of novel proteins

Francesc Rabanal

Current Opinion in Chemical Biology, 1997

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Photoaffinity labeling of Ras converting enzyme 1 (Rcelp) using a benzophenone-containing peptide substrate

Kelly Kyro, Surya Manandhar

Bioorganic Medicinal Chemistry, 2010

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Through the looking glass - a new world of proteins enabled by chemical synthesis

Kalyaneswar Mandal

Journal of Peptide Science, 2012

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The C-Terminus of H-Ras as a Target for the Covalent Binding of Reactive Compounds Modulating Ras-Dependent Pathways

David Andreu

PLoS ONE, 2011

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Chemical Synthesis of Proteins Containing 300 Amino Acids

yulei li

Chemical Research in Chinese Universities, 2020

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Structure Determination and Dynamics of Peptides Overlapping the Catalytic Hairpin of the Ras-Specific GEF Cdc25 Mm †

Teresa Recca

Biochemistry, 2003

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Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery

Gyula Pálfy

Cancer and Metastasis Reviews

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Semisynthesis of Dimeric Proteins by Expressed Protein Ligation

Luca D'andrea

Organic Letters, 2008

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Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP

Kathleen Prinzo

Journal of Biological Chemistry, 1994

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Elucidating Structural Details of Ras-Effector Interactions

Saliha Ece Acuner Zorluuysal

International Journal of Advances in Engineering and Pure Sciences, 2019

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Targeting Ras with Macromolecules

Dehua Pei

Cold Spring Harbor Perspectives in Medicine, 2017

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Chemical synthesis of proteins: a tool for protein labeling

Lucia Rosa

2010

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Analysis of the Transforming Potential of the Human H-ras Gene by Random Mutagenesis

Mark Furth

Proceedings of The National Academy of Sciences, 1984

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Improved Binding of Raf to Ras·GDP Is Correlated with Biological Activity

Hans Kalbitzer

Journal of Biological Chemistry, 2009

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A High-throughput Approach to NRPS Domain Substitution for Generation of Novel Peptides

Sarah Messenger

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Synthesis of GTP-Derived Ras Ligands

Herbert Waldmann

ChemBioChem, 2004

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Editorial [Hot Topic: Polypeptide Chemical Ligation Tools in Protein Engineering (Guest Editor: Julio A. Camarero)]

Julio Camarero

Protein & Peptide Letters, 2005

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Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

Channing Der

Proceedings of the National Academy of Sciences, 1992

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Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

Juergen Feuerstein

Biochemistry, 1990

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