Efficacy of Extrapleural Plombage with Silicone Plug in Destructive Pulmonary Tuberculosis Patients and Its Impact on Pulmonary Functions and Blood Gases (original) (raw)
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The Bulletin of Contemporary Clinical Medicine, 2021
Abstract. Pulmonary tuberculosis (TBL), as well as chronic obstructive pulmonary disease (COPD), have a diverse negative impact on the quality of life (QOL) of patients. In this regard, a detailed study of the quality of life of patients with pulmonary tuberculosis in combination with chronic obstructive pulmonary disease retains its importance and relevance. Aim. The aim of the study was to determine the orientation and degree of influence of clinical and functional features of pulmonary tuberculosis and concomitant chronic obstructive pulmonary disease on patients’ quality of life and their interrelation with each other. Material and methods. Two groups of patients were studied: patients with pulmonary tuberculosis without chronic obstructive pulmonary disease (49 people), and pulmonary tuberculosis combined with chronic obstructive pulmonary disease (37 people), who were hospitalized at the tuberculosis dispensary. Male patients prevailed in both groups, infiltrative pulmonary tuberculosis was diagnosed more frequently, first-time pulmonary tuberculosis was detected, and the mean age was over 45 years. Patients’ quality of life was assessed using the MOS SF-36 questionnaire. External respiratory function was examined by spirometry. Statistical analysis was performed using Statistica 10.0 package, variance and correlation analysis of the obtained data was performed. Results and discussion. In both groups, pulmonary tuberculosis with and without chronic obstructive pulmonary disease was associated with decreased physical activity (PF 63,91 and 67,55, respectively), and recurrence of chronic obstructive pulmonary disease was associated with decreased perception of general health (GH 53,0), and had a negative effect on daily activities (RP 48,64), including through impairment of the emotional sphere (RE 43,24). In the group of patients with pulmonary tuberculosis without chronic obstructive pulmonary disease compared to the general population in the Russian Federation, there was a decrease in social activity (SF 62,75) and physical activity (PF 67,55). Conclusion. The study showed that for the majority of domains, the decrease in quality of life in both groups - pulmonary tuberculosis with chronic obstructive pulmonary disease and pulmonary tuberculosis without chronic obstructive pulmonary disease – was noted in older age groups. The most significant decrease in the quality of life in both groups was in the domain of physical functioning (PF). In the group of patients with pulmonary tuberculosis with chronic obstructive pulmonary disease there was a more pronounced negative effect of emotional background (RE) on the performance of daily activities and a lower perception of the physical component of health (PH). In the group of patients with pulmonary tuberculosis without chronic obstructive pulmonary disease, social functioning (SF) was affected more frequently, and there was a more pronounced sensation of pain (BP). Key words: lung tuberculosis, COPD, quality of life, SF-36.
Extrapulmonary tuberculosis: risk factors
Health and Ecology Issues, 2021
Objective. To identify the main demographic and clinical risk factors for the development of extrapulmonary tuberculosis (EPTB).Materials and methods. A retrospective study of tuberculosis cases registered from 2016 to 2020 in the Gomel region was conducted (330 patients with EPTB and 2,505 patients with pulmonary tuberculosis). The odds ratios were calculated to assess the risk factors for the development of EPTB.Results. The prevalence of EPTB was studied over the course of five years. The most significant risk factors for the development of tuberculosis in extrapulmonary localizations have been identified.Conclusion. The risk factors for the development of EPTB are age (EPTB often develops in children and older persons), females, and in those who have had an episode of tuberculosis previously. Awareness of the predisposing factors may help physicians maintain a high index of suspicion regarding the development of EPTB.
Grekov's Bulletin of Surgery, 2016
The article presents the results of thoracoscopic surgeries in case of bullous emphysema of the lung in 88 patients. The patients have been divided into 2 groups according to the method of treatment: 1) destruction of pulmonary bullas and pleurodesis using diathermic electrocoagulation (42 people); 2) destruction of pulmonary bullas and subtotal pleurectomy (47 people). The operative periods weren’t statistically differentiated in patient’s groups. The volume of hemorrhage and exudation period from the pleural cavity were significantly higher in patient’s group, where patients underwent pleurectomy. However, lung spreading terms and ending of air leakage, periods of drains removal from the pleural cavity, hospital stay and rate of pneumothorax recurrence were considerably smaller in the group without application of pleurodesis.
Russian Journal of Infection and Immunity
The effectiveness of chemotherapy for infiltrative pulmonary tuberculosis (ITL) is determined by proper timing and adequacy of treatment. The speed of reparative changes in the pulmonary parenchyma is associated with the effectiveness of therapy. Different classes of proteinases are involved in extracellular matrix remodeling. Aim. To evaluate a potential of using the markers of proteinase /inhibitors axis for predicting effectiveness of therapy in patients with ITL due to varying resistance of Mycobacterium tuberculosis to anti-tuberculosis drugs (PTP). Material and methods. A retrospective study included 60 and 55 ITL patients with the drug sensitive (DS) and drug resistance (DR) Mtb strains, respectively. Patients were divided into two groups according to therapy effectiveness. The levels of blood serum matrix metalloproteinase MMP-1, -3, -8, -9 and their TIMP-1 inhibitor, neutrophil elastase (NE), alpha-2 macroplobulin (MG) and proteinase inhibitor (PI) were determined. Statisti...
Vacuum Therapy in Treatment of the Pilonidal Sinus Disease
Koloproktologia, 2016
AIM. To improve results of complex treatment of the pilonidal disease (PD). PATIENTSS AND METHODS. 31 patients with the PD were included into study. Of them in 16 patients postoperative wound was left open and vacuum therapy was applied. In 15 patients postoperative wound was left open and managed by ointment dressing. Groups of patients were well matched in terms of age, gender, degree of inflammation and co-morbidity RESULTS. Application ofvacuum therapy reduced the time of wound healing to 27,5±3,6 days comparing to 79±6,6 days of wounds managed routinely. The mean decrease of wounds' area at POD14 treated by vacuum therapy and without was 60 % vs. 20 % correspondingly. Reduction of pain intensity according to a visual analog scale in group with vacuum therapy (1,5/2,2 vs. 1,8/2,8) and earlier return to original occupation (31±3,9 vs. 39±5,7) was noted. Wound infection developed only in 3/15 (20 %) patients managed by ointment dressing. There was no recurrence of the disease ...
Bactericidal Activity of Leukocytes in Pulmonary Tuberculosis Patients
Туберкулез и болезни лёгких, 2017
Бактерицидная активность лейкоцитов изучена у 63 больных впервые выявленным инфильтративным туберкулезом легких (ИТЛ) и 28-фиброзно-кавернозным туберкулезом легких (ФКТ)� Для больных с обеими клиническими формами туберкулеза характерна разнонаправленная кислородзависимая бактерицидная активность фагоцитирующих клеток: снижение показателей нитрозилирующего стресса, в большей степени характерное для больных ФКТ, и рост показателей оксидативного стресса, больше выраженного при ФКТ� Выявлена сопряженность функционирования иммунокомпетентных клеток, участвующих в бактерицидной функции: при ФКТ-между показателями оксидативного стресса, при ИТЛ-нитрозилирующего; отмечен синергический эффект респираторного взрыва� Если при хронической форме туберкулеза легких за бактерицидную функцию одинаково «отвечают» оба типа клеток, то при впервые выявленном нелеченном ИТЛ доминирующая роль отводится нейтрофилам как клеткам первой линии защиты� Полученные результаты дают основание полагать, что при впервые выявленном нелеченном туберкулезе легких важная роль в подавлении микобактерий туберкулеза отводится нитрозилирующему стрессу, а при хронической форме туберкулеза-оксидативному� Ключевые слова: туберкулез, бактерицидная активность, нитрозилирующий и оксидативный стресс