Pre-TCR signaling intensity shapes the TCRβ repertoire (original) (raw)
Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development
Makio Tokunaga
Nature Immunology, 2006
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Early Molecular Events Induced by T Cell Receptor (TCR) Signaling in Immature CD4 + CD8 + Thymocytes: Increased Synthesis of TCR-c~ Protein Is an Early Response to TCR Signaling That Compensates for TCR-c~ Instability, Improves TCR Assembly, and Parallels Other Indicators of Positive Selection
Kelly Kearse
2000
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Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection
Kelly Kearse
The Journal of experimental medicine, 1995
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Premature TCR Expression and Signaling in Early Thymocytes Impair Thymocyte Expansion and Partially Block Their Development
Ljiljana Vasovic
The Journal of Immunology, 2001
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Pre-TCR ligand binding impacts thymocyte development before αβTCR expression
Jia-huai Wang
Proceedings of the National Academy of Sciences of the United States of America, 2015
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Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation
Cameron Messier
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Constitutive expression of the pre-TCR enables development of mature T cells
Paul C M van den Berk
International Immunology, 2006
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Identification of a Late Stage of Small Noncycling pT - Pre-T Cells as Immediate Precursors of T Cell Receptor / + Thymocytes
Maria Toribio
Journal of Experimental Medicine, 1998
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Early molecular events induced by TCR signaling in immature CD4+ CD8+ thymocytes
Kelly Kearse
1995
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The timing of TCR expression critically influences T cell development and selection
M. Sandau
Journal of Experimental Medicine, 2005
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Regulation of pre-T cell receptor (pTα-TCRβ) gene expression during human thymic development
Maria Toribio
Journal of Experimental Medicine
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Stable interactions and sustained TCR signaling characterize thymocyte-thymocyte interactions that support negative selection
Ellen Robey
Journal of immunology (Baltimore, Md. : 1950), 2015
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Role of oligometric TCR complexes and TCR-interacting molecules in T cell develoment and activation
Rashmi Kumar
2011
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The early proximal TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network
Kevin D Pavelko
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Selective Expression of the 21-Kilodalton Tyrosine-Phosphorylated Form of TCR Promotes the Emergence of T Cells with Autoreactive Potential
Nicolai van Oers
The Journal of Immunology, 2005
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Precursor Thymocyte Proliferation and Differentiation Are Controlled by Signals Unrelated to the Pre-TCR
Michelle Tourigny
The Journal of Immunology, 2000
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Expression of fully assembled TCR-CD3 complex on double positive thymocytes: synergistic role for the PRS and ER retention motifs in the intra-cytoplasmic tail of CD3
Samantha Li
International Immunology, 2009
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TCR Signal Strength and T Cell Development
Joanna Brzostek
Annual Review of Cell and Developmental Biology, 2016
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Premature TCRab Expression and Signaling in Early Thymocytes Impair Thymocyte Expansion and Partially Block Their Development
Ljiljana Vasovic
The Journal of Immunology, 2001
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Is TCR β expression an essential event in early thymocyte development?
Donald Palmer
Immunology Today, 1993
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TCRA Gene Rearrangement in Immature Thymocytes in Absence of CD3, Pre-TCR, and TCR Signaling
Pierre Ferrier
The Journal of Immunology, 2001
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In vivo fate mapping identifies pre-TCR expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis
H. Luche
Journal of Experimental Medicine, 2013
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T cell self-reactivity during thymic development dictates the timing of positive selection
Ellen Robey
eLife
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Developmental regulation of ?? T cell antigen receptor assembly in immature CD4+CD8+ thymocytes
Kelly Kearse
BioEssays, 1995
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Molecular mechanisms that control mouse and human TCR-αβ and TCR-γδ T cell development
Tom Taghon
Seminars in Immunopathology, 2008
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Defined T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation
B. Erman
Journal of Experimental Medicine, 2004
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Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development
Maria Toribio
Journal of Experimental Medicine, 1996
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Different initiation of pre-TCR and γδTCR signalling
Claude Saint-Ruf
Nature, 2000
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Regulation of T cell receptor (TCR) gene expression by CD3 complex signaling in immature thymocytes: Implications for TCR allelic exclusion
Alexandre Potocnik
Proceedings of the National Academy of Sciences, 1999
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Visualization of the earliest steps of γδ T cell development in the adult thymus
Immo Prinz
Nature Immunology, 2006
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In vivo fate mapping identifies pre-TCRα expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis
Hervé LUCHE
Journal of Experimental Medicine, 2013
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Allelic exclusion of mouse T cell receptor α chains occurs at the time of thymocyte TCR up-regulation
Nicholas Gascoigne
Immunity, 1995
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TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-cell differentiation
Arjen Bakker
Blood, 1999
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Critical and Multiple Roles for the CD3 Intracytoplasmic Tail in Double Negative to Double Positive Thymocyte Differentiation
Samantha Li
The Journal of Immunology, 2009
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Development of T cells expressing an altered TCR complex
Thomas Ramos
European Journal of Immunology, 2003
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