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Differential Azole Antifungal Efficacies Contrasted Using a Saccharomyces cerevisiae Strain Humanized for Sterol 14α-Demethylase at the Homologous Locus
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Bioorganic & Medicinal Chemistry Letters, 2010
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The Antifungal Activity of 2,2 -Diamino-4,4 -Dithiazole Derivatives is Due to the Possible Inhibition of Lanosterol-14–α-Demethylase
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The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans, Trichophyton spp., and Microsporum canis
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Antimicrobial Agents and Chemotherapy, 2004
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Synthesis and In Vitro Evaluation of Novel 1, 2, 4-Triazole Derivatives as Antifungal Agents
atin Kalra
Letters in Drug Design & Discovery, 2010
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Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161
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Multiple resistance mechanisms to azole antifungals in yeast clinical isolates
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Mode of Action Studies: Basis for the Search of New Antifungal Drugs
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Annals of the New York Academy of Sciences, 1988
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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase
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Antimicrobial Agents and Chemotherapy, 2015
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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14-Demethylase
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Repurposing approach identifies phenylpentanol derivatives as potent azole chemosensitizing agents effective against azole-resistant Candida species
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Prothioconazole and Prothioconazole-Desthio Activities against Candida albicans Sterol 14-α-Demethylase
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Applied and Environmental Microbiology, 2012
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Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14a-demethylase Inhibitors
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Amino Acid Substitutions in the Cytochrome P-450 Lanosterol 14α-Demethylase (CYP51A1) from Azole-Resistant Candida albicans Clinical Isolates Contribute to Resistance to Azole Antifungal Agents
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Antimicrobial Agents and Chemotherapy, 1998
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Rational Design of New Monoterpene-Containing Azoles and Their Antifungal Activity
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Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs
Rajini Rao
PLoS Pathog, 2010
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European Journal of Medicinal Chemistry, 2019
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Design, synthesis and evaluation of 1, 2, 4-triazole derivatives as antifungal
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Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals
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Potentiation of Azole Antifungals by 2-Adamantanamine
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Antimicrobial Agents and Chemotherapy, 2013
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Sterol 14α-Demethylase Structure-Based Design of VNI ((R)-N-(1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis
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PF1163A, a Novel Antifungal Agent, Inhibit Ergosterol Biosynthesis at C-4 Sterol Methyl Oxidase
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The Journal of Antibiotics, 2002
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Thiazolyl-Oxadiazole Derivatives Targeting Lanosterol 14Α-DEMETHYLASE as Potential Antifungal Agents: Design, Synthesis and Molecular Docking Studies
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2016
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Molecular design of two sterol 14α-demethylase homology models and their interactions with the azole antifungals ketoconazole and bifonazole
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Journal of Computer-Aided Molecular Design, 2005
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Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones
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Journal of Medicinal Chemistry, 1984
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Heterologous expression of full-length lanosterol 14α-demethylases of prominent fungal pathogens Candida albicans and Candida glabrata provides tools for antifungal discovery
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Antimicrobial Agents and Chemotherapy, 2018
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elham Assadpour
European Journal of Medicinal Chemistry, 2009
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Sterol 14α-Demethylase as a Potential Target for Antitrypanosomal Therapy: Enzyme Inhibition and Parasite Cell Growth
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Chemistry & Biology, 2007
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