Point Mutations in the 14-α Sterol Demethylase Cyp51A or Cyp51C Could Contribute to Azole Resistance in Aspergillus flavus
Emilia Mellado
Genes, 2020
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Targeted Gene Disruption of the 14-α Sterol Demethylase ( cyp51A ) in Aspergillus fumigatus and Its Role in Azole Drug Susceptibility
Buitrago Serna
Antimicrobial Agents and Chemotherapy, 2005
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Targeted Gene Disruption of the 14- Sterol Demethylase (cyp51A) in Aspergillus fumigatus and Its Role in Azole Drug Susceptibility
Laura Buitrago
Antimicrobial Agents and Chemotherapy, 2005
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Substitutions at Methionine 220 in the 14 -Sterol Demethylase (Cyp51A) of Aspergillus fumigatus Are Responsible for Resistance In Vitro to Azole Antifungal Drugs
G. Garcia-Effron
Antimicrobial Agents and Chemotherapy, 2004
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Sterol Content Analysis Suggests Altered Eburicol 14α-Demethylase (CYP51) Activity In Isolates of Mycosphaerella Graminicola Adapted to Azole Fungicides
Nathan Hawkins
FEMS …, 2009
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Sterol content analysis suggests altered eburicol 14α-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides
Jane Ward
FEMS Microbiology Letters, 2009
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The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus
Gustavo Henrique
Medical Mycology, 2005
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Plant Sterol 14α-Demethylase Affinity for Azole Fungicides
Soren Bak
Biochemical and Biophysical Research Communications, 2001
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Differential Azole Antifungal Efficacies Contrasted Using a Saccharomyces cerevisiae Strain Humanized for Sterol 14α-Demethylase at the Homologous Locus
Denis POMPON
Antimicrobial Agents and Chemotherapy, 2008
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Differences in Interactions between Azole Drugs Related to Modifications in the 14- Sterol Demethylase Gene (cyp51A) of Aspergillus fumigatus
G. Garcia-Effron
Antimicrobial Agents and Chemotherapy, 2005
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The amino acid substitution N136Y in Candida albicans sterol 14alpha-demethylase is involved in fluconazole resistance
Audrey FLEURY
Medical mycology, 2016
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Differences in interactions between azole drugs related to modifications in the 14-α sterol demethylase gene (cyp51A) of Aspergillus fumigatus
Emilia Mellado
Antimicrobial agents …, 2005
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Three-dimensional models of 14α-sterol demethylase (Cyp51A) from Aspergillus lentulus and Aspergillus fumigatus: an insight into differences in voriconazole interaction
Dominique Sanglard
International Journal of Antimicrobial Agents, 2011
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Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450
Osamu Gotoh
Antimicrobial Agents and Chemotherapy, 1999
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Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans
Marcel Borgers, Hugo Vanden Bossche
Microbiology (Reading, England), 1999
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Understanding the environmental drivers of clinical azole resistance in Aspergillus species
pooja sen
Drug Target Insights
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Structural alterations to counter multi-drug resistance in azoles
Tapan Mukherjee, Parth Malik
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The Mutation T315A in Candida albicans Sterol 14α-Demethylase Causes Reduced Enzyme Activity and Fluconazole Resistance through Reduced Affinity
muhammad saeed Akhtar
Journal of Biological Chemistry, 1997
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Relationship of Azole Resistance with the Structural Alteration of the Target Sites: Novel Synthetic Compounds for Better Antifungal Activities
Ram Kumar, Tapan Mukherjee, Parth Malik
The Natural Products Journal, 2014
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Amino Acid Substitutions in the Cytochrome P-450 Lanosterol 14α-Demethylase (CYP51A1) from Azole-Resistant Candida albicans Clinical Isolates Contribute to Resistance to Azole Antifungal Agents
Dominique Sanglard
Antimicrobial Agents and Chemotherapy, 1998
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In Vitro Evolution of Itraconazole Resistance in Aspergillus fumigatus Involves Multiple Mechanisms of Resistance
Gustavo Henrique
Antimicrobial Agents and Chemotherapy, 2004
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Amino Acid Substitutions at the Major Insertion Loop of Candida albicans Sterol 14alpha-Demethylase Are Involved in Fluconazole Resistance
Florent Morio
PLoS ONE, 2011
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Multiple resistance mechanisms to azole antifungals in yeast clinical isolates
David Calabrese
Drug Resistance Updates, 1998
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Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161
Mikhail Keniya
Antimicrobial Agents and Chemotherapy
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Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450
Osamu Gotoh
Antimicrobial agents and chemotherapy, 1999
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Stereoselective interaction of SCH 39304, a triazole, with sterol 14alpha-demethylase of Aspergillus fumigatus
Venkateswarlu Kanamarlapudi
Journal of Antimicrobial Chemotherapy, 1997
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Reversal of Fluconazole Resistance in Multidrug Efflux-Resistant Fungi by the Dysidea a renaria Sponge Sterol 9α, 11α-Epoxycholest-7-ene-3β, 5α, 6α, 19-tetrol 6- …
Chowdhury Hossain
Journal of natural …, 2003
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Biochemical Mechanisms Involved in Selective Fungitoxicity of Two Sterol 14α-Demethylation Inhibitors, Prochloraz and Quinconazole: Accumulation and Metabolism Studies
Maarten A De Waard
Pesticide Science, 1992
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Transcriptomics analysis of propiconazole-treated Cochliobolus sativus reveals new putative azole targets in the plant pathogen
Deepika Somani
Functional & Integrative Genomics
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Molecular Modelling of the Emergence of Azole Resistance in Mycosphaerella graminicola
Hans Cools
PLoS ONE, 2011
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Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B
nadja ferreira rabelo de melo
Antimicrobial Agents and Chemotherapy, 2010
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Contributions of both ATP-Binding Cassette Transporter and Cyp51A Proteins Are Essential for Azole Resistance in Aspergillus fumigatus
Sanjoy Paul
Antimicrobial agents and chemotherapy, 2017
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Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase
Yongju Huang
Scientific Reports
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