Probing the Inhibitor versus Chaperone Properties of sp²-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease (original ) (raw )Glucocerebrosidase Enhancers for Selected Gaucher Disease Genotypes by Modification of α-1-C -Substituted Imino-D-xylitols (DIXs) by Click Chemistry
Camille Decroocq
ChemMedChem, 2014
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Glucocerebrosidase Enhancers for Selected Gaucher Disease Genotypes by Modification of α-1- C -Substituted Imino- D -xylitols (DIXs) by Click Chemistry
Antonio Afonso Delgado
ChemMedChem, 2014
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Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease-Chemotype 2
Noel Southall
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Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease
raymond dwek
Tetrahedron: Asymmetry, 2005
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Use of the L-idonojirimycin derivatives as pharmacological chaperones for the treatment of Gaucher disease
Pilar Giraldo
Molecular Genetics and Metabolism, 2013
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Amphiphilic 1-Deoxynojirimycin Derivatives through Click Strategies for Chemical Chaperoning in N370S Gaucher Cells
K. Haupt
The Journal of Organic Chemistry, 2011
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pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases
Eiji Nanba
Angewandte Chemie, 2015
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Synthesis and evaluation of a bicyclic deo×ymannojirimycin derivative as a potential glycosidase inhibitor
Kelly Tanaka
Canadian Journal of Chemistry-revue Canadienne De Chimie, 1998
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Crystal Structures of Complexes of N-Butyl- and N-Nonyl-Deoxynojirimycin Bound to Acid beta-Glucosidase: INSIGHTS INTO THE MECHANISM OF CHEMICAL CHAPERONE ACTION IN GAUCHER DISEASE
Yoseph Shaaltiel
Journal of Biological Chemistry, 2007
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Improved cellular inhibitors for glycoprotein processing α-glucosidases: biological characterisation of alkyl- and arylalkyl-N-substituted deoxynojirimycins
raymond dwek
Tetrahedron: Asymmetry, 2009
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Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid b-Glucosidase
David Aviezer
2000
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α- and β-Glucosidase Inhibitors: Chemical Structure and Biological Activity
Ivone Carvalho
ChemInform, 2007
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and β-Glucosidase inhibitors: chemical structure and biological activity
Eduardo Melo
Tetrahedron, 2006
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Synthesis of Hybrids of D‐Glucose and D‐Galactose with Pyrrolidine‐Based Iminosugars as Glycosidase Inhibitors
Girish Rawal
European Journal of …, 2008
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Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease
J. Inglese , Douglas Auld
Proceedings of the National Academy of Sciences, 2007
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α-Geminal Dihydroxymethyl Piperidine and Pyrrolidine Iminosugars: Synthesis, Conformational Analysis, Glycosidase Inhibitory Activity, and Molecular Docking Studies
Nitin Pawar , Vedavati G Puranik
The Journal of Organic Chemistry, 2012
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3,4,5‐Trihydroxypiperidine Based Multivalent Glucocerebrosidase (GCase) Enhancers
Paolo Paoli
ChemBioChem, 2022
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Selective glycosidase inhibitors: A patent review (2012-present)
Reaz Uddin
International journal of biological macromolecules, 2018
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Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars
Richard van den Berg
ACS Medicinal Chemistry Letters, 2011
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Back to (non)-Basics: Recent Developments in Neutral and Charge- Balanced Glycosidase Inhibitors
Todd Houston
Mini-Reviews in Medicinal Chemistry, 2003
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Tetrahedron report number 773 a-and b-Glucosidase inhibitors: chemical structure and biological activity
man U
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Back to (non-)Basics: An Update on Neutral and Charge-Balanced Glycosidase Inhibitors
Todd Houston
Mini reviews in medicinal chemistry, 2017
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C 1-/C 2-aromatic-imino-glyco-conjugates: experimental and computational studies of binding, inhibition and docking aspects towards glycosidases isolated from …
Atanu Mitra
Glycoconjugate …, 2009
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General Approach to Glycosidase Inhibitors. Enantioselective Synthesis of Deoxymannojirimycin and Swainsonine
Miquel Pericàs
The Journal of Organic Chemistry, 2005
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c-Hydroxyethyl piperidine iminosugar and N-alkylated derivatives: A study of their activity as glycosidase inhibitors and as immunosuppressive agents
Sougata Ghosh
2014
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Structural, Kinetic, and Thermodynamic Analysis of Glucoimidazole-Derived Glycosidase Inhibitors
Andrea Vasella
Biochemistry, 2006
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Synthesis of a New β-Galactosidase Inhibitor Displaying Pharmacological Chaperone Properties for GM1 Gangliosidosis
Paolo Paoli
Molecules
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N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors
Yves Blériot
Organic & biomolecular chemistry, 2014
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Synthesis and Evaluation of Eight- and Four-Membered Iminosugar Analogues as Inhibitors of Testicular Ceramide-Specific Glucosyltransferase, Testicular β-Glucosidase 2, and Other Glycosidases
Ernst Schonbrunn
The Journal of Organic Chemistry, 2012
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Synthesis and evaluation of d-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors
Martijn D P Risseeuw
Bioorganic & Medicinal Chemistry Letters, 2009
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