A Retrospective Study of Primary Brain Tumors in Children under 14 Years of Age at PIMS, Islamabad. (original) (raw)
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2021
Objective: To analyze the histological spectrum of pediatric brain tumors (PBT) in Pakistani population and to compare the results with international data. Study Design: Retrospective observational study. Place and Duration of Study: Armed Forces Institute of Pathology, Rawalpindi, from Jan 2015 and Dec 2019. Methodology: This data was analyzed using the latest World Health Organization (WHO) classification of Tumors of Central Nervous System 2016. The cases were divided in 5 categories according to age (0-2, 3-5, 6-8, 9-11 & 12-14 years). Results: A total of 43 cases were included in the study. Of these cases, 26 (60.46%) were male and 17 (39.5%) were female. Male to female ratio was 1.5-1. The 6-8 year age group had the highest number of tumors while 0-2 year age group had the least. Mean age of diagnosis was 7.6 years. Ependymoma wasthe most common morphological type with 12 cases (28%) followed by pilocytic astrocytoma, diffuse glioma with 10 cases each (23%) and medulloblastoma...
Annals of Pathology and Laboratory Medicine, 2016
Background: The primary pediatric brain tumors (PBT) are the second most common cause of death due to malignancies in children. This study was done to analyze the histological spectrum of primary brain tumors in children and also to find out the epidemiology of the common pediatric brain tumors. Methods: Data regarding age, gender, topography, and histopathology of 239 pediatric patients (0–18 years) with brain tumors operated over a period of 15 years (January-2001 to December-2015) was collected and analyzed according to World Health Organization 2007 classification Result: PBTs were more common in males (54.8%) as compared to females (45.2%) with male to female ratio of 1.21:1. Frequency of tumors was higher in childhood age group (>5-<15 years) i.e. (55.6%) when compared to adolescent age group (15.9%). The most common anatomical site was cerebellum (40.5%), followed by hemispheres (21.4%). Supratentorial tumors (51.9%) were predominant than infratentorial tumors (45.2%) a...
Spectrum of pediatric brain tumors: a report of 341 cases from a tertiary cancer center in India
Indian journal of pediatrics, 2014
Brain tumors are the second most common cancers after hematological malignancies accounting for approximate 21% of all childhood malignancies in children between ages of 0 and 14 y. The present study was undertaken to determine the spectrum of the brain tumors diagnosed in a tertiary cancer center in South India. A retrospective analysis of the data of pediatric brain tumors diagnosed between 2003 and 2009 was done and data was classified according to the age, gender and histology types. Out of 2,844 pediatric patients, 341 (11.99%) were diagnosed as having brain tumors. Most of the patients were in the age group of >5-14 y. Male to female ratio was 1.58:1. The most common pediatric brain tumor was medulloblastoma followed by astrocytoma and ependymoma. Glioblastoma multiforme was the most common subtype of astrocytoma. Other common tumors were glioma, oligodendroglioma, periphereral neuroectodermal tumor and germ cell tumor. As compared to western data, incidence of brain tumors...
Intracranial tumors in children: a 10-year review from a single tertiary health-care center
Child's Nervous System, 2019
Objective Brain tumors are the second most common pediatric malignancy and the most common cause of cancer-related mortality and morbidities. Major advances in terms of surgery, radiation, and chemotherapy have led to better outcomes in developed countries. Delayed diagnosis, advanced disease at presentation, late referrals, nosocomial infections, delays to radiotherapy, and poor support services are the major reasons for poorer outcomes in developing countries. Little is known about the profile of brain tumors in Pakistan. This study aims to evaluate the epidemiology, management, and clinical outcomes of children with brain tumors in Pakistan in a single tertiary care center. Methods/materials All children (0-16 years) with primary CNS tumors from 2004 to 2014 at Aga Khan University Hospital were reviewed retrospectively for clinical data, demographics, radiological findings, management, and outcome. Results One hundred seventy-five children were included in the study. Male to female ratio was 1.4:1. Most of the patients were in 5-10 years age group (38.9%). Most common presenting complains were headache 115 (65.7%) and vomiting 100 (57.1%). Predominant site was infratentorial 93 (53%). Glial tumors were 105 (60%) followed by embryonal 40(22.9%), craniopharyngiomas 25 (14.3%), and germ cell 1 (0.6%). Astrocytomas (25.7%) were the most common glial tumors while medulloblastoma (15.4%) was the most common embryonal tumor. Majority of the patients underwent surgical resection (78.8%). Radiation was given to 47 (26.8%) patients. A half of the patients, 89 (50%), were lost to follow-up. Forty-two (24%) patients expired, 20 (11.4%) are alive with residual disease while 15 patients (8.5%) were cured with no evidence of recurrence and regular follow-ups. Conclusion This is the only study from Pakistan showing demographics of the childhood brain tumors. Significant improvement needs to be made for timely diagnosis, early referrals, and collaborated team efforts with multidisciplinary tumor board to improve outcome.
Spectrum of pediatric brain tumors in India: A multi-institutional study
Neurology India, 2011
Background : Till date there is no published multi-institutional data regarding the epidemiological profile of pediatric brain tumors in India. Aim : The present retrospective study analyses the histological spectrum of pediatric age group brain tumors in seven tertiary care hospitals in India. Material and Methods : Data regarding frequencies of various primary brain tumors (diagnosed according to the World Health Organization (WHO) classification), in 3936 pediatric patients (<18 yrs of age), was collected from seven tertiary care hospitals in India.Results : The most common primary pediatric brain tumors were astrocytic tumors (34.7%), followed by medulloblastoma and supratentorial primitive neuro-ectodermal tumors (22.4%), craniopharyngiomas (10.2%) and ependymal tumors (9.8%). The most common astrocytic tumor was pilocytic astrocytoma. In comparison to adults, oligodendrogliomas and lymphomas were rare in children. Conclusions : Our study is the first such report on the histological spectrum of brain tumors in children in India. Except for a slightly higher frequency of craniopharyngiomas, the histological profile of pediatric brain tumors in India is similar to that reported in the Western literature.
Child's Nervous System, 2021
OBJECTIVE: There are several reports regarding the epidemiology of pediatric primary brain tumors. However, little is known about the profile in Indonesia, particularly in Surabaya. The authors report the results of epidemiological analysis of a retrospective review of childhood primary brain tumors in a single tertiary health-care center. MATERIAL-METHODS: We conducted a retrospective study of all cases of primary brain tumors from 1 to 18 years diagnosed at the Department of Neurosurgery Faculty of Medicine Universitas Airlangga/dr. Soetomo General Academic Hospital, Surabaya, Indonesia between January 2015 and December 2019. RESULTS: One hundred and fifty-one primary brain tumors were reviewed with a mean of 30.2 cases per year. Accord- ing to the gender, 56.9% (86 cases) of the tumors occurred in males. The mean age was 9.24 years. Of all the tumors, 55% were situated in the supratentorial compartment. In the infratentorial compartment, 78% (53 cases) of tumors are located in the cerebellum. In the supratentorial compartment, 35% (29 cases) of tumors are located in the sellar/suprasellar region. The most common types of tumors diagnosed were pilocytic astrocytoma and medulloblastoma together accounting for half of the cases (50%, 75 cases) (26.5% and 23.5% respectively), followed by glioblastoma multiforme (GBM) (6%, 9 cases), ependymoma (6%, 9 cases), germinoma (5.3%, 8 cases), craniopharyngioma (4.6%, 7 cases), ganglioglioma (3.3%, 5 cases), supratentorial central nervous system (CNS) embryonal tumor/primitive neuroectodermal tumor (PNET) (2.6%, 4 cases), and meningioma (2.6%, 4 cases). The other tumors represent 20.2%. CONCLUSION: This retrospective study on 151 consecutive patients established a baseline of pediatric primary brain tumors pattern on the basis of histopathological experience at a tertiary health-care center in Surabaya, Indonesia.
Primary pediatric brain tumors
Cancer, 2005
The purpose of the current study was to investigate a hospital series of 986 cases of primary pediatric brain tumors in Taiwan.
Clinico-morphological pattern of intracranial tumors in children
JPMA. The Journal of the Pakistan Medical Association, 1999
The objective of present study was to observe the histopathological pattern of intracranial tumors in children (< 15 yrs) and to correlate the site of lesion along with the histological diagnosis. The study included consecutive cases of intracranial tumors diagnosed in children (< 15 yrs.) in the section of histopathology at the Aga Khan University Hospital, Karachi during the period of three years. The initial histological evaluation of these lesions was performed on H and E stained section of paraffin embedded tissue. Special stains and immunohistochemical analysis was done whenever indicated. During the study period, fifty-four cases of intracranial tumors were diagnosed in children. The age ranged from 1-1/2 years to 4 years with male to female ratio of 1.1:1. Astrocytoma comprised 39% of all intracranial tumors of childhood. Medulloblastoma (18.6%) ranked the second most prevalent brain tumor followed by empendymoma (13%), oligodendroglioma 7.5% while non-Hodgkin's ly...
Pediatric Central nervous system tumors, single institutional experience
Mosul Journal of Nursing
Objectives: The characteristics of 144 Iraqi children with primary CNS tumors were reviewed to identify median age at presentation, the disease distribution in terms of gender, main presenting symptoms, most common grade and histological subtypes, with predominant subsites in which central nervous system malignancies arise from, according to WHO 2016 classification. Patients and methods: Medical records were used to collect data on primary CNS malignancies in children under the age of 18 years, in a single tertiary center in Kurdistan/Iraq, Zhianawa cancer center, the study time period was from March 2009 to December 2021 (12 years period study). We classified age into 5 subgroups: (Infancy) less than 1, 1-4 years old, 5-9 years old, 10-14 years old and above 15. Results: The study showed that, males were more frequently affected than females, median age at diagnosis was 8.7 years old, predominate age group was (5-9) %38, followed by (10-14) 24.3%. Medulloblastoma which is grade IV tumor was the most common histopathology subtype in 30% of the cases, followed by Astrocytoma and Brain stem glioma as the 2nd and 3rd histopathology. Infratentorial location was the most common involved location in central nervous system (57.6%), followed by supratentorial (40.3%), spinal cord (%2.08) only. Conclusion: Pediatric CNS tumors in this study have specific characteristics when compared to those seen elsewhere in the world. Grade IV and infratentorial location for example, are the most common in our children.
Epidemiologic profile of pediatric brain tumors in Morocco
Child's Nervous System, 2010
Introduction Brain tumors are the most common solid tumors diagnosed among children below 15 years worldwide. However, little is known about the profile of pediatric brain tumors in Africa. The purpose of this study was to further elaborate the epidemiological profile of pediatric brain tumors in Africa, specifically Morocco. Methods A retrospective review was conducted of all patients with primary brain tumors in the age group 0-19 years, from 2003 to 2007, from multiple centers in two cities of Rabat and Casablanca, Morocco. Only patients with histopathological confirmation were included (n=542). Descriptive epidemiologic profiles were created for the patients by age, sex, and histological subtypes of brain tumors. Results Overall medulloblastoma was the most common brain tumor (34.5%), followed by pilocytic astrocytoma (17.3%) and diffuse astrocytoma grade 2 (12.5%). Brain tumors occurred most commonly in 5-9-year age group followed by 10-14-year age group with the former being more common among males and the latter being more common among females. We also found medulloblastoma to be the most common brain tumor in the 0-14-year-olds. Conclusions In this rare study focused on pediatric brain tumors in Morocco, most of the findings were consistent with past studies from other parts of the world. However, we found medulloblastoma to be the most common pediatric brain tumor followed by astrocytoma.