NMR solution conformation of an antitoxic analogue of alpha-conotoxin GI: identification of a common nicotinic acetylcholine receptor alpha 1-subunit binding surface for small ligands and alpha-conotoxins (original) (raw)

NMR structure determination of α-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold

Biochemical and Biophysical Research Communications, 2006

Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors

Biochemical Journal, 2004

Three-Dimensional Solution Structure of α-Conotoxin MII, an α3β2 Neuronal Nicotinic Acetylcholine Receptor-Targeted Ligand

Biochemistry, 1997

Solution Conformation of αA-conotoxin EIVA, a Potent Neuromuscular Nicotinic Acetylcholine Receptor Antagonist from Conus ermineus

Journal of Biological Chemistry, 2003

Nuclear Magnetic Resonance Solution Conformation of α-Conotoxin AuIB, an α3β4 Subtype-selective Neuronal Nicotinic Acetylcholine Receptor Antagonist

Journal of Biological Chemistry, 2000

Role of CysI–CysIII Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors

ACS Omega

Three-dimensional structure of α-conotoxin EI determined by 1 H NMR spectroscopy

Aldo Yuck Franco

International Journal of Peptide Research and Therapeutics

NMR spatial structure of α-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors 1 Coordinates of α-conotoxin ImI have been deposited in the Brookhaven Protein Data Bank under accession code 1IMI. 1

Maxim Zhmak

Febs Letters, 1999

Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors

Biochemical and Biophysical Research Communications, 2005

Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist α-conotoxin OmIA that discriminates α3 vs. α6 nAChR subtypes

Biochemical and Biophysical Research Communications, 2006

NMR structure of alpha-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor

Ottavia Spiga

Biochemistry, 2002

Alanine Scan of α-Conotoxin RegIIA Reveals a Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist

Journal of Biological Chemistry, 2014

Towards structure determination of neurotoxin II bound to nicotinic acetylcholine receptor: a solid-state NMR approach

Alexander Arseniev

FEBS Letters, 2004

Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor

Lotten Ragnarsson

Scientific reports, 2017

Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors

Owen McDougal

Marine Drugs, 2019

Loop 3 of Short Neurotoxin II is an Additional Interaction Site with Membrane-bound Nicotinic Acetylcholine Receptor as Detected by Solid-state NMR Spectroscopy

Alexander Arseniev

Journal of Molecular Biology, 2009

NMR Structure Determination of a Novel Conotoxin, [Pro 7,13] αA-Conotoxin P IVA † , ‡

Biochemistry, 1997

NMR-based binding screen and structural analysis of the complex formed between α-cobratoxin and an 18-mer cognate peptide derived from the α1 subunit of the nicotinic acetylcholine receptor from torpedo californica

Allison Zumberge

Journal of Biological Chemistry, 2002

NMR Structure of α-Bungarotoxin Free and Bound to a Mimotope of the Nicotinic Acetylcholine Receptor †

Ottavia Spiga

Biochemistry, 2002

Critical Residues Influence the Affinity and Selectivity of α-Conotoxin MI for Nicotinic Acetylcholine Receptors †

Julianne Grose

Biochemistry, 1999

Molecular Engineering of Conotoxins: The Importance of Loop Size to α-Conotoxin Structure and Function

Journal of Medicinal Chemistry, 2008

Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors

Irina Vetter

Biochemical Pharmacology, 2013

Rational Design of -Conotoxin Analogues Targeting 7 Nicotinic Acetylcholine Receptors: IMPROVED ANTAGONISTIC ACTIVITY BY INCORPORATION OF PROLINE DERIVATIVES

Christian Skonberg

Journal of Biological Chemistry, 2009

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant

Maxim Zhmak

Nature Structural & Molecular Biology, 2005

Rational Design of α-Conotoxin Analogues Targeting a7 Nicotinic Acetylcholine Receptors : IMPROVED ANTAGONISTIC ACTIVITY BY INCORPORATION OF PROLINE DERIVATIVES

Kasper Harpsøe

The Journal of Biological Chemistry, 2009

Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor Subtype

Journal of medicinal chemistry, 2018

Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors

Lotten Ragnarsson

Journal of Biological Chemistry