Revealing electronic features governing hydrolysis of cephalosporins in the active site of the L1 metallo-β-lactamase
Vladimir Tsirelson
RSC Advances, 2020
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Mechanism of inhibition of the PC1 .beta.-lactamase of Staphylococcus aureus by cephalosporins: importance of the 3'-leaving group
rex pratt
Biochemistry, 1985
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Stability of TEM β-lactamase mutants hydrolyzing third generation cephalosporins
Jean-marie Frère
Proteins: Structure, Function, and Genetics, 1995
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Cephalosporin Substrate Specificity Determinants of TEM-1 beta -Lactamase
T. Palzkill
Journal of Biological Chemistry, 1997
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The N···H hydrogen bond strength in the transition state at the limiting step determines the reactivity of cephalosporins in the active site of L1 metallo-β-lactamase
Vladimir Tsirelson
Mendeleev Communications, 2019
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Crystallographic Structure of a Phosphonate Derivative of the Enterobacter cloacae P99 Cephalosporinase: Mechanistic Interpretation of a .beta.-Lactamase Transition-State Analog
rex pratt
Biochemistry, 1994
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In Silico Molecular Docking Study for Prediction of Binding Affinities to Penicillin Binding Proteins and β-Lactamases of Amino Acids-Cephalexin conjugates
Shakir Alwan
2023
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In situ product removal during enzymatic cephalexin synthesis by complexation
M. Strubel
Enzyme and Microbial Technology, 2002
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An insight into the biophysical characterization of different states of cefotaxime hydrolyzing β-lactamase 15 (CTX-M-15)
Anas Shamsi
Journal of Biomolecular Structure and Dynamics, 2014
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A survey of the kinetic parameters of class C β-lactamases. Cephalosporins and other β-lactam compounds
Gianfranco Amicosante
Biochemical Journal, 1988
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Comparative study of the enzymatic synthesis of cephalexin at high substrate concentration in aqueous and organic media using statistical model
Carolina Aguirre
Biotechnology and Bioprocess Engineering, 2012
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Micellar catalysis of the intramolecular aminolysis of the ?-lactam antibiotic cephaclor
Iolanda Cuccovia
Journal of Physical Organic Chemistry, 1991
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Optimization of cephalexin synthesis with immobilized penicillin acylase in ethylene glycol medium at low temperatures
claudia altamirano
Journal of Molecular Catalysis B: Enzymatic, 2004
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Synthesis of Cephalexin in Aqueous Medium with Carrier-bound and Carrier-free Penicillin Acylase Biocatalysts
CAROLINA AGUIRRE
Applied Biochemistry and Biotechnology, 2009
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Interactions of Ceftobiprole with -Lactamases from Molecular Classes A to D
Karen Bush
Antimicrobial Agents and Chemotherapy, 2007
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Diffusion-limited component of reactions catalyzed by Bacillus cereus .beta.-lactamase I
Larry Hardy
Biochemistry, 1984
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Binding of cephalothin and cefotaxime to D-Ala-D-Ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum .beta.-lactamases
Alexandre Kuzin
Biochemistry, 1995
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Interaction of β -lactamases I and II from Bacillus cereus with semisynthetic cephamycins. Kinetic studies
Margarita Menéndez
Biochemical Journal, 1991
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Role of β-lactam carboxyl group on binding of penicillins and cephalosporins to class C β-lactamases
Josefa Donoso, J. Frau
Proteins: Structure, Function, and Genetics, 2003
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The Catalytic Mechanism of beta -Lactamases: NMR Titration of an Active-Site Lysine Residue of the TEM-1 Enzyme
Eveline Fonze
Proceedings of the National Academy of Sciences of the United States of America, 1996
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Structure of a cephalosporin synthase
Inger Andersson
Nature, 1998
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Computational analysis of the interactions of a novel cephalosporin derivative with β-lactamases
Margherita De Rosa
BMC Structural Biology
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Molecular Dynamics Simulations of the TEM-1 β-Lactamase Complexed with Cephalothin
Natalia Diaz
Journal of Medicinal Chemistry, 2005
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The QM/MM-QTAIM approach reveals the nature of the different reactivity of cephalosporins in the active site of L1 metallo-β-lactamase
Vladimir Tsirelson
New Journal of Chemistry, 2019
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Modeling of the enzymatic kinetic synthesis of cephalexin—Influence of substrate concentration and temperature
Rik Beeftink
Biotechnology and Bioengineering, 2001
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Kinetics and Mechanism of the Hydrolysis of Depsipeptides Catalyzed by the β-Lactamase of Enterobacter cloacae P99 †
rex pratt
Biochemistry, 1996
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Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase
Jean-marie Frère
Proceedings of the National Academy of Sciences, 1993
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The Evolution of Cefotaximase Activity in the TEM β-Lactamase
Brian Dominy
Journal of Molecular Biology, 2012
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Production of cephalexin in organic medium at high substrate concentrations with CLEA of penicillin acylase and PGA-450
claudia altamirano
Enzyme and Microbial Technology, 2007
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Evaluation of the incidence of diffusional restrictions on the enzymatic reactions of hydrolysis of penicillin G and synthesis of cephalexin
Pedro Valencia
Enzyme and Microbial Technology, 2010
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Cefotaxime, des-Cefotaxime and Ceftazidime: in vitro activity and stability to hydrolysis from TEM-derived extended spectrum beta-lactamases
Gianfranco Amicosante
PubMed, 2002
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Partition and substrate concentration effect in the enzymatic synthesis of cephalexin in aqueous two-phase systems
Judith Vergara
Process Biochemistry, 2010
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Benchmark studies of hydrogen bond governing reactivity of cephalosporins in L1 metallo‐β‐lactamase: Efficient and reliable QSPR equations
Vladimir Tsirelson
International Journal of Quantum Chemistry, 2020
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Synthesis of cephalexin with immobilized penicillin acylase at very high substrate concentrations in fully aqueous medium
Carolina Aguirre
Journal of Molecular Catalysis B: Enzymatic, 2007
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Design, Synthesis and Preliminary Antimicrobial Evaluation of New Derivatives of Cephalexin
Shakir Alwan
2015
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