The effects of statins on the mevalonic acid pathway in recombinant yeast strains expressing human HMG-CoA reductase
Beata Burzynska
BMC Biotechnology, 2013
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The Impact of Simvastatin on Lipidomic Markers of Cardiovascular Risk in Human Liver Cells Is Secondary to the Modulation of Intracellular Cholesterol
Dr. Sudip Paul
Metabolites, 2021
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Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells
Heinrich Wieland
Biochemical Pharmacology, 2001
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Simvastatin, an HMG-CoA reductase inhibitor, induces the synthesis and secretion of apolipoprotein AI in HepG2 cells and primary hamster hepatocytes
Changiz Taghibiglou
Atherosclerosis, 2002
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Functional expression of human HMG-CoA reductase in Saccharomyces cerevisiae : a system to analyse normal and mutated versions of the enzyme in the context of statin treatment
Beata Burzynska
Journal of Applied Microbiology, 2009
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Short and long-term effects of atorvastatin, lovastatin and simvastatin on the cellular metabolism of cholesteryl esters and VLDL secretion in rat hepatocytes
gonzalo hernández
Atherosclerosis, 2000
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The effect of simvastatin on lipid droplets accumulation in human embryonic kidney cells and pancreatic cancer cells
Helena Gbelcova
Lipids in Health and Disease, 2013
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Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin
Weiming Ruan
Circulation, 2008
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Effects of simvastatin on malondialdehyde level and esterase activity in plasma and tissue of normolipidemic rats
Antonija Vukšić, Paško Konjevoda
Pharmacological Reports, 2015
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Characterization of Peroxisomal 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase in UT2* Cells: Sterol Biosynthesis, Phosphorylation, Degradation, and Statin Inhibition †
Skaidrite Krisans
Biochemistry, 2000
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Cholesterol and Its Metabolites in Tumor Growth: Therapeutic Potential of Statins in Cancer Treatment
Vittoria Rago
Frontiers in Endocrinology, 2019
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Effects of statins on myocarditis: A review of underlying molecular mechanisms
Peter E Penson
Progress in Cardiovascular Diseases, 2021
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Simvastatin: In Vitro Metabolic Profiling of a Potent Competitive HMG-CoA Reductase Inhibitor
A.f.m. Motiur Rahman
Separations
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Low simvastatin concentrations reduce oleic acid-induced steatosis in HepG2 cells: An in�vitro model of non-alcoholic fatty liver disease
Mohammad Alkhatatbeh
Experimental and Therapeutic Medicine, 2016
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Essential fatty acids as possible mediators of the actions of statins
Undurti Das
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2001
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Differential modulation by simvastatin of the metabolic pathways in the n-9, n-6 and n-3 fatty acid series, in human monocytic and hepatocytic cell lines
Patrizia Risè
Biochemical Pharmacology, 2005
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Effect of simvastatin on the uptake and metabolic conversion of palmitic, dihomo-γ-linoleic and α-linolenic acids in A549 cells
Maria Jose Bellini
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2003
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Effect of simvastatin on the uptake and metabolic conversion of palmitic, dihomo-[gamma]-linoleic and [alpha]-linolenic acids in A549 cells
mónica polo
… leukotrienes and essential …, 2003
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The lipid and non-lipid effects of statins
Robin Poston
Pharmacology & Therapeutics, 2003
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Impaired HMG-CoA Reductase Activity Caused by Genetic Variants or Statin Exposure: Impact on Human Adipose Tissue, β-Cells and Metabolome
Azazul Islam Chowdhury
Metabolites, 2021
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Molecular Mechanisms of HDL-Cholesterol Elevation by Statins and Its Effects on HDL Functions
Shizuya Yamashita
Journal of Atherosclerosis and Thrombosis, 2010
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Simvastatin reduces atherogenesis and promotes the expression of hepatic genes associated with reverse cholesterol transport in apoE-knockout mice fed high-fat diet
Shutong Yao
Lipids in Health and Disease, 2011
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Low-Density Lipoprotein Level Reduction by the 3-Hydroxy-3-Methylglutaryl Coenzyme-A Inhibitor Simvastatin Is Accompanied by a Related Reduction of F 2 -Isoprostane Formation in Hypercholesterolemic Subjects
paola marchesani
Circulation, 2002
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Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease
David Lefer
Cardiovascular Research, 2001
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Effects of Simvastatin on Plasma Lipoprotein Concentrations and Very-Low-Density Lipoprotein Secretion in the Rat
Jacqueline Férézou
Journal of Clinical Biochemistry and Nutrition, 1995
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Cellular cholesterol efflux to plasma from moderately hypercholesterolaemic type 1 diabetic patients is enhanced, and is unaffected by simvastatin treatment
Arie Van Tol
Diabetologia, 2005
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Potency of select statin drugs in a new mouse model of hyperlipidemia and atherosclerosis
Thomas Johnston
International Journal of Pharmaceutics, 2001
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Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study
Hongjie Zhu
Metabolomics, 2010
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Simvastatin reduces ergosterol levels, inhibits growth and causes loss of mtDNA in Candida glabrata
Ian Macreadie
FEMS yeast research, 2007
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Statins: 3Hydroxy3-methylglutaryl-CoA (HMG-CoA) Reductase Inhibitors Demonstrate AntiAtherosclerotic Character due to Their Antioxidant Capacity
Mohan Dhale
Applied Biochemistry and Biotechnology, 2011
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Low-Density Lipoprotein Level Reduction by the 3-Hydroxy-3-Methylglutaryl Coenzyme-A Inhibitor Simvastatin Is Accompanied by a Related Reduction of F2-Isoprostane Formation in Hypercholesterolemic Subjects: No Further Effect of Vitamin E
Raffaella Muraro
Circulation, 2002
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Different statins produce highly divergent changes in gene expression profiles of human hepatoma cells: a pilot study
Roksana Iwanicka-nowicka, Beata Burzynska
Acta biochimica Polonica, 2011
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Effects of high-dose statin on the human hepatic expression of genes involved in carbohydrate and triglyceride metabolism
Camilla Pramfalk
Journal of internal medicine, 2011
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