A prosthetic group for the rapid introduction of fluorine into peptides and functionalized drugs (original) (raw)
Utilization of N, N, N′, N′-TetramethylfluoroformamidiniumHexafluoro-phosphate (TFFH) in Peptide and Organic Synthesis
Ayman El-Faham
Synlett, 2009
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Fluorinated Aromatic Amino Acids and its Therapeutic Applications
Kiran Andra
Biochemistry & Analytical Biochemistry, 2015
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Organic & Biomolecular Chemistry Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif
Mohammed S A L A H Ayoup, David Cordes
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Peptide modification by introduction of?-trifluoromethyl substituted amino acids
Kathleen Gaa
Amino Acids, 1995
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Rapid and high-yielding cysteine labelling of peptides with N-succinimidyl 4-[18F]fluorobenzoate
Santiago Rojas
Chemical Communications, 2012
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Automated radiochemical synthesis of [18F]FBEM: A thiol reactive synthon for radiofluorination of peptides and proteins
Lixin Lang
Applied Radiation and Isotopes, 2011
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Fluorocarbon-peptideconjugates (FPC): new concept to increase the metabolic stability of peptides for therapeutic applications
Xavier Iturrioz
Proceedings of the 35th European Peptide Symposium
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Synthesis of b-fluoro-b-proline
Pavel Mykhailiuk
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Peptides Radiofluorination: Main Methods and Highlights
M. Mamede-Lewer
International Journal of Organic Chemistry, 2022
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S-2,4,6-trimethoxybenzyl (Tmob): a novel cysteine protecting group for the N.alpha.-(9-fluorenylmethoxycarbonyl) (Fmoc) strategy of peptide synthesis
George Barany
The Journal of Organic Chemistry, 1992
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Influence of Selective Fluorination on the Biological Activity and Proteolytic Stability of Glucagon-like Peptide-1
Martin Beinborn
Journal of Medicinal Chemistry, 2008
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Synthesis and radioiodination of N-Boc-p-(tri-n-butylstannyl)-L-phenylalanine tetrafluorophenyl ester: Preparation of a radiolabeled phenylalanine derivative for peptide synthesis
D Scott Wilbur
Bioconjugate Chemistry, 1993
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Synthesis of peptides with α,β-dehydroamino acids, VI. Synthesis ofN-benzyloxycarbonyl andN-trifluoroacetyl dipeptides of α,β-dehydro-butyrine, -valine, -leucine, and -isoleucine
Piotr Wieczorek
Liebigs Annalen der Chemie, 1988
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Synthesis of beta-fluoro-beta-proline
Igor Komarov
Tetrahedron Letters, 2011
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Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif
Mohammed S A L A H Ayoup
Org Biomol Chem, 2015
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Author's personal copy Practical syntheses of 4-fluoroprolines
Mukund Chorghade
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Synthesis of peptides employing 9-fluorenylmethyl chloroformate as a coupling agent
Vasanthakumar Ganga Ramu
Letters in Peptide Science, 2003
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The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity
Cecilia Andreu, Gregorio Asensio
Bioorganic & Medicinal Chemistry, 2006
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ChemInform Abstract: Practical Synthesis of 4-Fluoroprolines
Mukund Chorghade
ChemInform, 2009
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Incorporation of cis - and trans -4,5-Difluoromethanoprolines into Polypeptides
Igor Komarov
Organic Letters, 2012
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Hydrolysis, polarity, and conformational impact of C-terminal partially fluorinated ethyl esters in peptide models
Vladimir Kubyshkin
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Fluoro-modified chemotactic peptides: fmlf analogues
Gábor Radics
Journal of Peptide Science, 2004
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Synthesis of 5-(((R,S)-5-((9-Fluorenylmethoxycarbonyl)amino)-10,11-dihydrodibenzo[a,d]cyclohepten-2-yl)oxy)valeric Acid (CHA) and 5-(((R,S)-5-((9-Fluorenylmethoxycarbonyl)amino)dibenzo[a,d]-cyclohepten-2-yl)oxy)valeric Acid (CHE) Handles for the Solid-Phase Synthesis of C-Terminal Peptide Amides ...
Kiyoshi Nokihara
The Journal of Organic Chemistry, 1994
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Synthesis of Cyclic Peptides Constrained with Biarylamine Linkers Using Buchwald−Hartwig C−N Coupling #
Javed Iqbal
The Journal of Organic Chemistry, 2006
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A methodology for simultaneous fluorogenic derivatization and boronate affinity enrichment of 3-nitrotyrosine-containing peptides
Nadya Galeva
Analytical Biochemistry, 2011
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Practical syntheses of 4-fluoroprolines
Mukund Chorghade
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Functionalization of (2S)-Isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4-ones by a Suzuki-Miyaura Cross-Coupling Reaction Using Aryltrifluoroborate Salts: Convenient Enantioselective Preparation of α-Substituted β-Amino Acids
Eusebio Juaristi
European Journal of Organic Chemistry, 2010
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Analysis of New Polyfluorothioacylated Amino Acids Derivatives by in Silico and in Vitro Methods
Krystyna Naumenko
Microbiology&Biotechnology, 2017
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Synthesis of Ψ[CH(RF)NH]Gly-peptides: The dramatic effect of a single fluorine atom on the diastereocontrol of the key aza-Michael reaction
Stefano Meille
Journal of Fluorine Chemistry, 2008
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One-step synthesis of 18F labeled [18F]-N-succinimidyl 4-(fluoromethyl)benzoate for protein labeling
William Eckelman
Applied Radiation and Isotopes, 1994
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Exploiting morph-DAST mediated ring-expansion of substituted cyclic b-amino alcohols for the preparation of cyclic fluorinated amino acids. Synthesis of 5-fluoromethylproline and 5-fluoropipecolic acid
Pavel Mykhailiuk
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Access to Unprotected β-Fluoroalkyl β-Amino Acids and Their α-Hydroxy Derivatives
isabelle gillaizeau
Organic Letters, 2019
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Tactical Applications of Fluorine in Drug Design and Development
Nicholas Meanwell
Fluorine in Heterocyclic Chemistry Volume 1, 2014
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Deprotection/reprotection of the amino group in a-amino acids and peptides. A one-pot procedure in [Bmim][BF4] ionic liquid
Maria Luisa Di Gioia
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A Rapid and Efficient Method for the Fluoroalkylation of Amines and Amides. Development of a Method Suitable for Incorporation of the Short-Lived Positron Emitting …
Dae Yoon Chi
The Journal of …, 1987
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