CA1A2X-competitive inhibitors of farnesyltransferase as anti-cancer agents (original) (raw)
Farnesyl Transferase Inhibitors as Potential Anticancer Agents
Sounak Bagchi
Mini Reviews in Medicinal Chemistry, 2018
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Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase
Dinesh Patel
Drug Development Research, 1995
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Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice
Scott Mosser
Proceedings of the National Academy of Sciences, 1994
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Inhibition of human tumor cell growthIn vitro andIn vivo by a specific inhibitor of human farnesyltransferase: BIM-46068
Gilles Favre
International Journal of Cancer, 1999
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Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor
Veeraswamy Manne
Cancer research, 2001
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Inhibitors of farnesyl:protein transferase—A possible cancer chemotherapeutic
Daniele Leonard
1996
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Farnesyltransferase Inhibitors: Overview of their Action and Role in Solid Malignancy Therapy
Alfredo Cesario
Letters in Drug Design & Discovery, 2005
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Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
Alison Todd
Cancer research, 2001
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A novel class of highly potent, selective, and non-peptidic inhibitor of ras farnesyltransferase (FTase)
Jin-ho Lee
Bioorganic & Medicinal Chemistry Letters, 2001
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Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?
Channing Der
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1997
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Farnesyltransferase inhibitors versus Ras inhibitors
Charles Omer
Current Opinion in Chemical Biology, 1997
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Farnesyl protein transferase inhibitors as targeted therapies for hematologic malignancies
Judith Karp
Seminars in Hematology, 2001
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Inhibition of human tumor cell growthin vivo by an orally bioavailable inhibitor of human farnesyltransferase, BIM-46228
Gilles Favre
International Journal of Cancer, 2001
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Inhibition of farnesyltransferase with A-176120, a novel and potent farnesyl pyrophosphate analogue
David Arendsen
European Journal of Cancer, 2000
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Sepp-Lorenzino L, Ma Z, Rands E, Kohl NE, Gibbs JB, Oliff A, Rosen NA peptidomimetic inhibitor of farnesylprotein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res 55: 5302-5309
Laura Sepp-lorenzino
Cancer Research
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Activity of SCH 66336, a tricyclic farnesyltransferase inhibitor, against human tumor colony-forming units
Elzbieta Izbicka
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, 1999
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Apoptotic and Cytostatic Farnesyltransferase Inhibitors Have Distinct Pharmacology and Efficacy Profiles in Tumor Models
Chiang Yu
Cancer Research, 2004
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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice
Stacy Remiszewski
Cancer research, 1998
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Farnesyl transferase inhibitors: the next targeted therapies for breast cancer?
Fadlo Khuri
Endocrine Related Cancer, 2004
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Farnesyl Diphosphate-Based Inhibitors of Ras Farnesyl Protein Transferase
Veeraswamy Manne
Journal of Medicinal Chemistry, 1995
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Potent, non-thiol inhibitors of farnesyltransferase
Scott Mosser
Bioorganic & Medicinal Chemistry Letters, 1998
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C-Terminal Modifications of Histidyl- N -benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice
Barbara Gibbs, Scott Bur
Journal of Medicinal Chemistry, 1997
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Preparation of a clinically investigated ras farnesyl transferase inhibitor
David Askin
Journal of Heterocyclic Chemistry, 2003
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Discovery of a Series of Cyclohexylethylamine-Containing Protein Farnesyltransferase Inhibitors Exhibiting Potent Cellular Activity
James Wasicak
Journal of Medicinal Chemistry, 1999
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Structure−Activity Relationship of 3-Substituted N -(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11 H -benzo[5,6]cyclohepta[1,2- b ]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds
George Njoroge
Journal of Medicinal Chemistry, 1997
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Novel Tricyclic Inhibitors of Farnesyl Protein Transferase
George Njoroge
Journal of Biological Chemistry, 1995
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Potent and Selective Farnesyl Transferase Inhibitors
Juozas Domarkas
Journal of Medicinal Chemistry, 2004
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