Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2
Hitoshi Shimano
Journal of Clinical Investigation, 1998
View PDFchevron_right
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
Hitoshi Shimano
Journal of Clinical Investigation, 1996
View PDFchevron_right
Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver
Hitoshi Shimano
Proceedings of the National Academy of Sciences, 1997
View PDFchevron_right
Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes
Hitoshi Shimano
Journal of Biological Chemistry, 1999
View PDFchevron_right
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene
Hitoshi Shimano
Journal of Clinical Investigation, 1997
View PDFchevron_right
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
Hitoshi Shimano
Journal of Clinical Investigation, 1997
View PDFchevron_right
Sterol Regulatory Element-binding Protein-1 (SREBP-1) Is Required to Regulate Glycogen Synthesis and Gluconeogenic Gene Expression in Mouse Liver
Janos Kerner
Journal of Biological Chemistry, 2014
View PDFchevron_right
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes
Naoya Yahagi
Journal of lipid research, 2002
View PDFchevron_right
Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action
Hitoshi Shimano
Journal of Biological Chemistry, 2000
View PDFchevron_right
Selective Proteolytic Processing of Rat Hepatic Sterol Regulatory Element Binding Protein-1 (SREBP-1) and SREBP-2 During Postnatal Development
Donald Jump
Journal of Biological Chemistry, 2003
View PDFchevron_right
A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids
Hitoshi Shimano
Journal of Biological Chemistry, 1999
View PDFchevron_right
Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire Program of Unsaturated Fatty Acid Biosynthesis in Transgenic Mouse Liver
Hitoshi Shimano
Journal of Biological Chemistry, 1998
View PDFchevron_right
Unsaturated Fatty Acids Inhibit Sterol Regulatory Element-Dependent Gene Expression: A Potential Mechanism Contributing to Hypertriglyceridemia
Tilla Worgall
View PDFchevron_right
Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites
Shunbin Xiong
Proceedings of the National Academy of Sciences, 2000
View PDFchevron_right
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Michael Brown
Journal of Clinical Investigation, 2002
View PDFchevron_right
Sterol-regulatory element-binding protein (SREBP)-2 contributes to polygenic hypercholesterolaemia
Jeremy D Kark, Hannes Staehelin
Atherosclerosis, 2002
View PDFchevron_right
Unsaturated Fatty Acids Inhibit Sterol Regulatory Element-Dependent Gene Expression: A Potential Mechanism Contributing to Hypertriglyceridemia in Fat-Restricted Diets
Tilla Worgall
Proceedings of The Society for Experimental Biology and Medicine, 2000
View PDFchevron_right
Human Sterol Regulatory Element-Binding Protein 1a Contributes Significantly to Hepatic Lipogenic Gene Expression
Kathrin Klein
Cellular Physiology and Biochemistry, 2015
View PDFchevron_right
Overactivation of Intestinal SREBP2 in Mice Increases Serum Cholesterol
VINAY SONI
PLoS ONE, 2014
View PDFchevron_right
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
Michael Brown
Cell, 1997
View PDFchevron_right
Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice
Víctor Cortés
eLife, 2017
View PDFchevron_right
Sterol Regulatory Element-Binding Protein-1a Binds to cis Elements in the Promoter of the Rat High Density Lipoprotein Receptor SR-BI Gene 1
Dayami Lopez
Endocrinology, 1999
View PDFchevron_right
In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression
Hitoshi Shimano
Biochemical and Biophysical Research Communications, 2007
View PDFchevron_right
Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance in Lepob/Lepob Mice
Hitoshi Shimano
Journal of Biological Chemistry, 2002
View PDFchevron_right
The Niemann-Pick C1 Gene Is Downregulated in Livers of C57BL/6J Mice by Dietary Fatty Acids, but Not Dietary Cholesterol, through Feedback Inhibition of the SREBP Pathway
Joseph Castillo
Journal of Nutrition, 2012
View PDFchevron_right
Sterol Regulatory Element-binding Protein Negatively Regulates Microsomal Triglyceride Transfer Protein Gene Transcription
Tomoyuki Terada, Tsuneo Imanaka
Journal of Biological Chemistry, 1999
View PDFchevron_right
Mutation in the Gene Encoding Sterol Regulatory Element Binding Protein (SREBP-2) in Hyper-Cholesterolaemic Subjects
Vivek Singh
View PDFchevron_right
Transgenic mice overexpressing SREBP-1a in male ob/ob mice exhibit lipodystrophy and exacerbate insulin resistance
Hitoshi Shimano
Endocrinology, 2018
View PDFchevron_right
Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD)
Mohamed Ahmed
Drug Discovery Today, 2007
View PDFchevron_right
SREBP-1-independent regulation of lipogenic gene expression in adipocytes
Hideto Takahashi, Hitoshi Shimano
The Journal of Lipid Research, 2007
View PDFchevron_right