Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase (original) (raw)
Plasmodium falciparum Purine Nucleoside Phosphorylase: CRYSTAL STRUCTURES, IMMUCILLIN INHIBITORS, AND DUAL CATALYTIC FUNCTION
Gary Evans
Journal of Biological Chemistry, 2004
View PDFchevron_right
Purine Nucleoside Phosphorylase: A Potential Target for the Development of Drugs to Treat T-Cell- and Apicomplexan Parasite-Mediated Diseases
Luiz Basso
Current Drug Targets, 2007
View PDFchevron_right
Energetic Mapping of Transition State Analogue Interactions with Human and Plasmodium falciparum Purine Nucleoside Phosphorylases
Andrzej Lewandowicz
Journal of Biological Chemistry, 2005
View PDFchevron_right
Anopheles gambiae Purine Nucleoside Phosphorylase: Catalysis, Structure, and Inhibition
Mahmoud Ghanem
Biochemistry, 2007
View PDFchevron_right
Toxoplasma gondii Purine Nucleoside Phosphorylase Biochemical Characterization, Inhibitor Profiles, and Comparison with the Plasmodium falciparum Ortholog
David Roos
Journal of Biological Chemistry, 2006
View PDFchevron_right
The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase
Ronald Parry
Proceedings of the …, 2002
View PDFchevron_right
Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases
Acchank Mhdp
BMC Structural Biology, 2009
View PDFchevron_right
Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model
Jemie Line
PLOS One, 2011
View PDFchevron_right
Inhibition and Structure of Trichomonas vaginalis Purine Nucleoside Phosphorylase with Picomolar Transition State Analogues †
Gary Evans
Biochemistry, 2007
View PDFchevron_right
Crystal structure ofEscherichia colipurine nucleoside phosphorylase in complex with 7-deazahypoxanthine
Inna Kuranova
Acta Crystallographica Section F Structural Biology Communications, 2018
View PDFchevron_right
Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding
David Roos
The EMBO Journal, 1998
View PDFchevron_right
Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis
Marija Luić
Scientific Reports
View PDFchevron_right
Insights into Phosphate Cooperativity and Influence of Substrate Modifications on Binding and Catalysis of Hexameric Purine Nucleoside Phosphorylases
Mario Murakami, P. Giuseppe, Camila Ramos Santos
PLoS ONE, 2012
View PDFchevron_right
Synthesis of Second-Generation Transition State Analogues of Human Purine Nucleoside Phosphorylase
Gary Evans
Journal of Medicinal Chemistry, 2003
View PDFchevron_right
Crystal structure ofEscherichia colipurine nucleoside phosphorylase in complex with 7-deazahypoxanthine
Ilya Fateev
Acta Crystallographica Section F: Structural Biology Communications, 2018
View PDFchevron_right
Structural studies of PNP from Toxoplasma gondii
Santiago Santos
International Journal of Bioinformatics Research and Applications, 2009
View PDFchevron_right
Still a Long Way to Fully Understanding the Molecular Mechanism of Escherichia coli Purine Nucleoside Phosphorylase
Beata Wielgus-kutrowska
Croatica Chemica Acta, 2013
View PDFchevron_right
The Crystal Structure of Toxoplasma gondii Pyruvate Kinase 1
Juan Daniel Sosa Pizarro
PLoS ONE, 2010
View PDFchevron_right
Purine-less Death in Plasmodium falciparum Induced by Immucillin-H, a Transition State Analogue of Purine Nucleoside Phosphorylase
Gary Evans
Journal of Biological Chemistry, 2002
View PDFchevron_right
Differential Distortion of Purine Substrates by Human and Plasmodium falciparum Hypoxanthine-Guanine Phosphoribosyltransferase to Catalyse the Formation of Mononucleotides
Mrinalini Puranik
ChemPhysChem, 2015
View PDFchevron_right
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine–guanine–xanthine phosphoribosyltransferase
luke guddat
Bioorganic & Medicinal Chemistry, 2009
View PDFchevron_right
Atomic Dissection of the Hydrogen Bond Network for Transition-State Analogue Binding to Purine Nucleoside Phosphorylase †
Andrzej Lewandowicz
Biochemistry, 2002
View PDFchevron_right
Targeting a Novel Plasmodium falciparum Purine Recycling Pathway with Specific Immucillins
vishal singh
Journal of Biological Chemistry, 2004
View PDFchevron_right
Purine Nucleoside Phosphorylase. 2. Catalytic Mechanism †
Wayne C Guida
Biochemistry, 1997
View PDFchevron_right
Third-Generation Immucillins: Syntheses and Bioactivities of Acyclic Immucillin Inhibitors of Human Purine Nucleoside Phosphorylase
Gary Evans
Journal of Medicinal Chemistry, 2009
View PDFchevron_right
Molecular dynamics studies of a hexameric purine nucleoside phosphorylase
Rafael Caceres
Journal of Molecular Modeling, 2010
View PDFchevron_right