Sculpting Metal-binding Environments in De Novo Designed Three-helix Bundles (original) (raw)

Design of a Three-Helix Bundle Capable of Binding Heavy Metals in a Triscysteine Environment

William Degrado

Angewandte Chemie International Edition, 2011

View PDFchevron_right

Apoprotein Structure and Metal Binding Characterization of a de Novo Designed Peptide, α 3 DIV, that Sequesters Toxic Heavy Metals

J. Plegaria

View PDFchevron_right

Soft metal ions, Cd(II) and Hg (II), induce triple-stranded α-helical assembly and folding of a de novo designed peptide in their trigonal geometries

Hidekazu Hiroaki, Daisuke Kohda

Protein Science, 2000

View PDFchevron_right

Two-Metal Ion, Ni(II) and Cu(II), Binding α-Helical Coiled Coil Peptide

Hidekazu Hiroaki

Journal of the American Chemical Society, 2004

View PDFchevron_right

Comparison of the Binding of Cadmium(II), Mercury(II), and Arsenic(III) to the de Novo Designed Peptides TRI L12C and TRI L16C

James E Penner-Hahn

Journal of the American Chemical Society, 2002

View PDFchevron_right

Artificial Metalloproteins: At the Interface between Biology and Chemistry

Ankita Biswas

JACS Au

View PDFchevron_right

Synthesis of functionalized de novo designed 8?16 kDa model proteins towards metal ion-binding and esterase activity

Peter W Thulstrup

Organic & Biomolecular Chemistry, 2007

View PDFchevron_right

De Novo-Designed Metallopeptides with Type 2 Copper Centers: Modulation of Reduction Potentials and Nitrite Reductase Activities

James E Penner-Hahn

Journal of the American Chemical Society, 2013

View PDFchevron_right

Using Nonnatural Amino Acids to Control Metal-Coordination Number in Three-Stranded Coiled Coils

Kyung-Hoon Lee

Angewandte Chemie International Edition, 2006

View PDFchevron_right

Metal-Chelating Amino Acids As Building Blocks For Synthetic Receptors Sensing Metal Ions And Histidine-Tagged Proteins

Robert Tampé

ChemBioChem, 2003

View PDFchevron_right

Characterization of interactions and metal ion binding sites in proteins

Robert Jernigan

Current Opinion in Structural Biology, 1994

View PDFchevron_right

Engineering a cysteine ligand into the zinc binding site of human carbonic anhydrase II

Joseph Krebs

Biochemistry, 1993

View PDFchevron_right

αRep A3: A Versatile Artificial Scaffold for Metalloenzyme Design

Rémy Ricoux

Chemistry: A European Journal, 2017

View PDFchevron_right

From Unnatural Amino Acid Incorporation to Artificial Metalloenzymes

Arwa Makki

2016

View PDFchevron_right

Response of a designed metalloprotein to changes in metal ion coordination, exogenous ligands, and active site volume determined by X-ray crystallography

Don Engel

Journal of the …, 2005

View PDFchevron_right

Towards the role of metal ions in the structural variability of proteins: CdII speciation of a metal ion binding loop motif

Béla Gyurcsik

Metallomics, 2011

View PDFchevron_right

De novo design and structural characterization of proteins and metalloproteins

William Degrado

1999

View PDFchevron_right

Proteins as diverse, efficient, and evolvable scaffolds for artificial metalloenzymes

Woon Ju Song

Chemical Communications, 2020

View PDFchevron_right

Histidine Analog Amino Acids Providing Metal-Binding Sites Derived from Bioinorganic Model Systems

Ulf Diederichsen

European Journal of Organic Chemistry, 2009

View PDFchevron_right

Computational Design and Characterization of a Monomeric Helical Dinuclear Metalloprotein

Janez Mavri

Journal of Molecular Biology, 2003

View PDFchevron_right

Peptide folding, metal-binding mechanisms, and binding site structures in metallothioneins

Maureen Merrifield

Experimental biology and medicine (Maywood, N.J.), 2006

View PDFchevron_right

Direct observation of structurally encoded metal discrimination and ether bond formation in a heterodinuclear metalloprotein

J. Lehtio

Proceedings of the National Academy of Sciences, 2013

View PDFchevron_right

De novo design of a non-natural fold for an iron-sulfur protein: Alpha-helical coiled-coil with a four-iron four-sulfur cluster binding site in its central core

Joanna Grzyb

2010

View PDFchevron_right

New Force Field Parameters for Metalloproteins I: Divalent Copper Ion Centers Including Three Histidine Residues and an Oxygen-Ligated Amino Acid Residue

Orkid Coskuner

View PDFchevron_right

Metal-dependent protein folding: Metallation of metallothionein

Martin Stillman

Journal of Inorganic Biochemistry, 2006

View PDFchevron_right

Role of aminoacidic residues inside active sites of metalloproteins

Claudio Luchinat

Pure and Applied Chemistry, 1988

View PDFchevron_right

Engineering Metalloprotein Functions in Designed and Native Scaffolds

Daniele D'Alonzo

Trends in Biochemical Sciences, 2019

View PDFchevron_right

Use of a non-rigid region in T4 lysozyme to design an adaptable metal-binding site

Gerard Ostheimer

Protein Engineering Design and Selection, 2000

View PDFchevron_right

Toward the de Novo Design of a Catalytically Active Helix Bundle: A Substrate-Accessible Carboxylate-Bridged Dinuclear Metal Center

Herschel Wade

Journal of The American Chemical Society, 2001

View PDFchevron_right

Identifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coils

John Stuckey

Proceedings of the National Academy of Sciences, 2007

View PDFchevron_right

A De Novo Designed Metalloenzyme for the Hydration of CO 2

Aniruddha Deb

Angew. Chem., 2014

View PDFchevron_right

Development of artificial metalloenzymes via covalent modification of proteins

Gina Popa

2010

View PDFchevron_right

Developing metalloprotein models for diagnostic and sensing applications

Rosa Vitale

2013

View PDFchevron_right

A de novo evolved domain improves the cadmium detoxification capacity of limpet metallothioneins

Ricard Albalat

Scientific Reports, 2023

View PDFchevron_right