Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors (original) (raw)

Disparate spinal and supraspinal opioid antinociceptive responses in β-endorphin-deficient mutant mice

Judith Grisel

Neuroscience, 2000

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Spinal mu-opioid receptor-expressing dorsal horn neurons: Role in nociception and morphine antinociception

Ronald Wiley

The Journal of Neuroscience the Official Journal of the Society For Neuroscience, 2008

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Direct evidence for the up-regulation of spinal u-opioid receptor function after repeated stimulation of kappa-opioid receptors in the mouse

Junaidi Khotib

European Journal of Neuroscience, 2003

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Characterization of supraspinal antinociceptive actions of opiod delta agonists in the rat

Victor Hruby

Pain, 1995

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Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones

Miguel Martin

European Journal of Neuroscience, 2003

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Sensitivity to μ-opioid receptor-mediated anti-nociception is determined by cross-regulation between μ- and δ-opioid receptors at supraspinal level

Javier Garzón

British Journal of Pharmacology, 2012

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Neuropathic Pain Activates the Endogenous Opioid System in Mouse Spinal Cord and Induces Opioid Receptor Tolerance

Jay Malan

Journal of Neuroscience, 2004

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Morphine Tolerance in Spinal Cord Is Due to Interaction between micro- and delta -Receptors

Pal Riba

Journal of Pharmacology and Experimental Therapeutics, 2002

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Different μ receptor subtypes mediate spinal and supraspinal analgesia in mice

Richard Bodnar, Dennis Paul

European Journal of Pharmacology, 1989

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The Role of Spinal Opioid Receptors in Antinociceptive Effects Produced by Intrathecal Administration of Hydromorphone and Buprenorphine in the Rat

Anil Rattan

Anesthesia & Analgesia, 2002

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Intrathecal CART (55-102) enhances the spinal analgesic actions of morphine in mice

Richard Hunter

Brain Research, 2004

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Spinal and Peripheral Mechanisms Involved in the Enhancement of Morphine Analgesia in Acutely Inflamed Mice

Luis Emilio Farfan Menendez

Cellular and Molecular Neurobiology, 2009

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Evaluation of the effects of specific opioid receptor agonists in a rodent model of spinal cord injury

Miriam Aceves

Spinal Cord, 2016

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Spinal -Opioid Receptor-Expressing Dorsal Horn Neurons: Role in Nociception and Morphine Antinociception

Ronald Wiley

Journal of Neuroscience, 2008

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A Comparison of the Antinociceptive and Adverse Effects of the mu-Opioid Agonist Morphine and the delta-Opioid Agonist SNC80

Theo Meert

Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology, 2005

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A study of the antinociceptive interaction between intrathecal opioids and α-adrenergic agonists in the spinal cord of the rat

John Axcel Bautista

1996

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Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene

Horace Loh

Journal of Biomedical Science, 2010

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Coexpression of - and -opioid receptors in nociceptive sensory neurons

zhengbin li, Y.-q. Zhong

Proceedings of the National Academy of Sciences, 2010

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Stimulus intensity and the comparative efficacy of ω- and κ-opioid agonists on nociceptive spinal reflexes in the rat

Juan Herrero

Brain Research, 1994

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Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury

Srinivasa Raja

PAIN, 2008

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Contribution of mu and delta opioid receptors to the pharmacological profile of kappa opioid receptor subtypes

Richard van Rijn

European Journal of Pain, 2012

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L-type and T-type calcium channel blockade potentiate the analgesic effects of morphine and selective μ opioid agonist, but not to selective δ and κ agonist at the level of the spinal cord in mice

Ahmet Dogrul

Pain, 2001

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Antinociceptive and Adverse Effects of µ- and κ-Opioid Receptor Agonists: A Comparison of Morphine and U50488-H

Theo Meert

Basic & Clinical Pharmacology & Toxicology, 2008

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Spinal L-Type Calcium Channel Blockade Abolishes Opioid-Induced Sensory Hypersensitivity and Antinociceptive Tolerance

Michael Ossipov

Anesthesia & Analgesia, 2005

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Effect of κ-opioid receptor agonists on morphine analgesia in morphine-naive and morphine-tolerant rats

ramarao poduri

European Journal of Pharmacology, 1988

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Effects of systemic, intracerebral, or intrathecal administration on an N-methyl-D-aspartate receptor antagonist on associative morphine analgesic tolerance and hyperalgesia in rats

Fred Westbrook

Behavioral Neuroscience, 1998

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Medullary μ and δ opioid receptors modulate mesencephalic morphine analgesia in rats

Richard Bodnar

Brain Research, 1993

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Morphine hyperalgesia in mice is unrelated to opioid activity, analgesia, or tolerance: Evidence for multiple diverse hyperalgesic systems

Gad Klein

Brain Research, 2006

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Abnormal nociception and opiate sensitivity of STOP null mice exhibiting elevated levels of the endogenous alkaloid morphine

Pierrick Poisbeau, Yannick Goumon

Molecular Pain, 2010

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Signaling pathway of morphine induced acute thermal hyperalgesia in mice

George B Stefano

PAIN, 2006

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