Shear-induced unfolding activates von Willebrand factor A2 domain for proteolysis (original) (raw)

A Conformation-Sensitive Monoclonal Antibody against the A2 Domain of von Willebrand Factor Reduces Its Proteolysis by ADAMTS13

Ningzheng Dong

PLoS ONE, 2011

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Long-Ranged Protein-Glycan Interactions Stabilize Von Willebrand Factor A2 Domain from Mechanical Unfolding

Alparslan Oztekin

Biophysical Journal, 2019

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The linker between the D3 and A1 domains of vWF suppresses A1-GPIbα catch bonds by site-specific binding to the A1 domain

Miguel Cruz

Protein Science, 2013

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Mutational constraints on local unfolding inhibit the rheological adaptation of von Willebrand factor

choel kim

The Journal of biological chemistry, 2015

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Thrombospondin1 and ADAMTS13 competitively bind to VWF A2 and A3 domains in vitro

YIMING ZHAO

Thrombosis Research, 2010

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Destabilization of the A1 Domain in von Willebrand Factor Dissociates the A1A2A3 Tri-domain and Provokes Spontaneous Binding to Glycoprotein Ib and Platelet Activation under Shear Stress

Erik Sedlák

Journal of Biological Chemistry, 2010

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Molecular Mapping of the Chloride-binding Site in von Willebrand Factor (VWF): ENERGETICS AND CONFORMATIONAL EFFECTS ON THE VWF/ADAMTS-13 INTERACTION

Roberta Palla

Journal of Biological Chemistry, 2006

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VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13

Toshiyuki Miyata

Blood, 2004

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Amino acid residues Arg659, Arg660, and Tyr661 in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor

Long Zheng

Blood, 2010

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Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor

Toshiyuki Miyata

Proceedings of the National Academy of Sciences, 2009

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Carboxyl Terminus of ADAMTS13 Directly Inhibits Platelet Aggregation and Ultra Large von Willebrand Factor String Formation Under Flow in a Free-Thiol–Dependent Manner

Long Zheng

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013

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Conformational activation of ADAMTS13

Rebecca Phillips

Proceedings of the National Academy of Sciences of the United States of America, 2014

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Multi-step binding of ADAMTS-13 to von Willebrand factor

Hendrik Feys

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Structural Basis of Regulation of von Willebrand Factor Binding to Glycoprotein Ib

Mark Blenner

Journal of Biological Chemistry, 2014

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The N-terminal Flanking Region of the A1 Domain Regulates the Force-dependent Binding of von Willebrand Factor to Platelet Glycoprotein Ib

Miguel Cruz

Journal of Biological Chemistry, 2013

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The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow

Long Zheng

Blood, 2007

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Article Force-Sensitive Autoinhibition of the von Willebrand Factor Is Mediated by Interdomain Interactions

Dmitry Kolyanov

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The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet-decorated VWF strings in vivo

Hans Deckmyn, Hendrik Feys

2010

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An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF

Jan Voorberg

Blood, 2010

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Local Elongation of Endothelial Cell-anchored von Willebrand Factor Strings Precedes ADAMTS13 Protein-mediated Proteolysis

Hendrik Feys

Journal of Biological …, 2011

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Shear-induced unfolding triggers adhesion of von Willebrand factor fibers

Achim Wixforth

Proceedings of the National Academy of Sciences, 2007

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N-linked glycosylation of VWF modulates its interaction with ADAMTS13

Alexander Millington

Blood, 2008

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Allosteric activation of ADAMTS13 by von Willebrand factor

Hendrik Feys, Lisa Westfield, Garima Gupta

Proceedings of the National Academy of Sciences of the United States of America, 2014

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Fluid Shear Induces Conformation Change in Human Blood Protein von Willebrand Factor in Solution

Efrosyni Themistou

Biophysical Journal, 2009

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Shear-induced Disulfide Bond Formation Regulates Adhesion Activity of von Willebrand Factor

Hiuwan Choi

Journal of Biological Chemistry, 2007

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Exploring the “minimal” structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering

Lisa Westfield

Blood, 2019

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Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF

Tadayuki Yago

Journal of Clinical Investigation, 2008

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Rearranging Exosites in Noncatalytic Domains Can Redirect the Substrate Specificity of ADAMTS Proteases

Jian Zhu, Lisa Westfield

Journal of Biological Chemistry, 2012

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Shear-dependent changes in the three-dimensional structure of human von Willebrand factor

Steven Eppell

Blood, 1996

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Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress

Erin Wiswall

Blood, 2008

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Turbulent Flow Promotes Cleavage of VWF (von Willebrand Factor) by ADAMTS13 (A Disintegrin and Metalloproteinase With a Thrombospondin Type-1 Motif, Member 13)

MARIA BORTOT

Arteriosclerosis, Thrombosis, and Vascular Biology, 2019

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fluid shear stress Platelet-VWF complexes are preferred substrates of ADAMTS13 under

Erin Wiswall

2010

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The distal carboxylterminal domains of mADAMTS13 influence proteolysis of platelet-decorated von Willebrand factor strings in vivo

Hendrik Feys

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ADAMTS13 cleavage efficiency is altered by mutagenic and, to a lesser extent, polymorphic sequence changes in the A1 and A2 domains of von Willebrand factor

Colleen Notley

British Journal of Haematology, 2008

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Structure–function and regulation of ADAMTS‐13 protease

Long Zheng

Journal of Thrombosis and Haemostasis, 2013

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