Review on wound healing (original) (raw)
Related papers
Wound Healing Process, Phases of Wound Healing and Risk Factors: A Review
Wound healing is a complex process in which the skin (or another organ) repairs itself after injury. Various cells and biological molecules work together in this process to repair the damaged tissue. The first step in wound healing is for the body to stop the bleeding. This is done by clotting factors in the blood coming into contact with damaged endothelial cells lining the blood vessels. Once bleeding has stopped, repair cells called fibroblasts migrate into the area to start synthesizing collagen fibers and other materials needed to rebuild the tissue. At the same time, new blood vessels begin to form, and inflammatory cells help clear away debris. As collagen is laid down and cross-linked, a temporary scaffold is formed that will eventually be replaced by permanent scar tissue. The rate of wound healing varies depending on many factors, including age, nutrition, immune status, and chronic health conditions.
Overview of Wound Healing and Management
The Surgical clinics of North America, 2017
Wound healing is a highly complex chain of events, and although it may never be possible to eliminate the risk of experiencing a wound, clinicians' armamentarium continues to expand with methods to manage it. The phases of wound healing are the inflammatory phase, the proliferative phase, and the maturation phase. The pathway of healing is determined by characteristics of the wound on initial presentation, and it is vital to select the appropriate method to treat the wound based on its ability to avoid hypoxia, infection, excessive edema, and foreign bodies.
2013
In this case blood escapes the body and bleeding is clearly visible. It is further classified as: Incised wound, laceration or tear wound, Abrasions or superficial wounds, Puncture wounds, Penetration wounds and gunshot wounds. 7 Closed wounds In closed wounds blood escapes the circulatory system but remains in the body. It includes Contusion or bruises, heamatomas or blood tumor, Crush injury etc. Acute wounds Acute wound is a tissue injury that normally precedes through an orderly and timely reparative process that result in sustained restoration of anatomic and functional integrity. Acute wounds are usually caused by cuts or surgical incisions and complete the wound healing process within the expected time frame. 8 Chronic wounds Chronic wounds are wounds that have failed to progress through the normal stages of healing and therefore enter a state of pathologic inflammation chronic wounds either require a prolonged time to heal or recur frequently. Local infection, hypoxia, trauma, foreign bodies and systemic problems such as diabetes mellitus, malnutrition, immunodeficiency or medications are the most frequent causes of chronic wounds. 9 WOUND HEALING MECHANISM Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with ABSTRACT A wound may be defined as a break in the epithelial integrity of the skin or may also be defined as a loss or contravention of cellular and anatomic or functional permanence of living tissue. Wound healing is the process of repair that follows injury to the skin and proper healing of wounds is crucial for the re-establishment of disrupted anatomical continuity and disturbed functional status of the skin. The phyto-medicines for wound healing are not only economical and inexpensive but are also supposedly safe as hyper sensitive reactions are rarely encountered with the use of these agents. Many plants have proved to possess momentous healing properties in poles apart from type of wounds. Nature has best owed on us a very rich botanical wealth and a large number of diverse types of plants grow in different parts of the country. This review examine about wound healing prospective of plants, its family, part used, extract used, model used and references which are supportive for researchers for expansion of novel wound healing formulation.
The physiology of wound healing The physiology of wound healing
Wound healing is a complex biological process which results in the restoration of tissue integrity. Physiologically, it can be broken down into four distinct phases of haemostasis, inflammation, proliferation and tissue remodelling. This article describes the cellular basis of wound healing and the extracellular signalling processes which control them. The function of platelets, neutrophils, macrophages and fibroblasts are considered in detail. The concept of healing by primary and secondary intention is discussed. Many factors are known to adversely affect healing including malnutrition, hypoxia, immunosuppression, chronic disease and surgery. It is essential that surgeons understand the key physiological processes involved in healing in order to minimize patient morbidity from delayed healing.
European Surgical Research, 2012
The skin is the biggest organ of the human being and has many functions. Therefore, the healing of a skin wound displays an extraordinary mechanism of cascading cellular functions which is unique in nature. As healing and regeneration processes take place in all parts of the human body, this review focuses on the healing processes of the skin and highlights the classical wound healing phases. While regeneration describes the specific substitution of the tissue, i.e. the superficial epidermis, mucosa or fetal skin, skin repair displays an unspecific form of healing in which the wound heals by fibrosis and scar formation. The first stage of acute wound healing is dedicated to hemostasis and the formation of a provisional wound matrix, which occurs immediately after injury and is completed after some hours. Furthermore, this phase initiates the inflammatory process. The inflammatory phase of the wound healing cascade gets activated during the coagulation phase and can roughly be divide...
Journal of The American Academy of Dermatology, 1988
This report reflects the best data available at the time the report was prepared, but caution should be exercised in interpreting the data. The results of future studies may require alteration of the conclusions or recommendations set forth in this report.
Chronic wounds and current treatments
Journal of applied biotechnology & bioengineering, 2023
Wound healing is a complex physiological activity that occurs in the body when cell tissue is injured. 1 The process occurs in four overlapping stages and includes many different cytokines, mediators, and the vascular system. The four stages include homeostasis, inflammation, proliferation, and tissue remodeling. The inflammation and proliferation stages overlap each other and use similar cell types. The whole wound-healing process takes a couple of days to seal the wound but years for it to completely heal. 1 Once a wound has been created the homeostasis stage begins immediately to help control the bleeding. 2 The body begins with vascular constriction and fibrin clots to stop the bleeding. Several growth factors: (TGF)-β, platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and epidermal growth factor (EGF) are released to help repair the tissue. 2 The wound healing-healing process moves onto the inflammatory stage once the inflammatory cells move to the wound. The inflammation cells are followed by neutrophils, macrophages, and lymphocytes to help prevent infection and remove anything that would hamper the wound-healing process. The proliferation stage occurs during the inflammation stage with the introduction of macrophages. 3 The macrophages are important to heal cell tissues in the wound. The proliferation stage helps repair and create new tissue for the wound. Fibroblasts and endothelial cells are released during this stage to help create new cells that were lost from the wound. 3
Wound Healing and Wound Management
1994
The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publishers can give no guarantee for information about drug dosage and applications thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature.
Turkish Journal of Medical Sciences
Background/aim: People have used many natural materials such as plant leaves, roots, liquids derived from plants, and animal products to treat wounds throughout history. It can be said that the research on wound care in recent years have focused on traditional and natural products again. This study aimed to investigate the effects of sweetgum oil, propolis, silk protein, and Ankaferd Blood Stopper (ABS) on wound healing in an experimental excisional wound model. Materials and methods: Including 36 Balb/c inbreed mice in the study were divided equally into four groups. Two circular excisional wounds were created on the dorsal skin of mice under anesthesia using a punch biopsy device. The wounds of the first group of mice were topically dressed with sweetgum oil, the second group mice with propolis, the third group mice with silk protein, and the fourth group mice with ABS daily. Tissue samples were taken from the wounds of mice on the 7th and 14th day of wound formation, and histological examinations were performed. On the 14th day, the wounds created in all mice were healed, and the experiment was terminated. Results: Mice in the silk protein group had faster wound healing. There was no statistical difference between the groups in immunohistochemical examinations. In the ABS group, the findings of the inflammatory process were more prominent. Conclusion: In conclusions, propolis, sweetgum oil, silk protein, and ABS positively affect different parameters in wound healing and support wound healing.