The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism (original) (raw)

New light on multidrug binding by an ATP-binding-cassette transporter

Akanksha Bapna

Trends in Pharmacological Sciences, 2006

The ATP Binding Cassette Multidrug Transporter LmrA and Lipid Transporter MsbA Have Overlapping Substrate Specificities

Hendrik W . van Veen, Sanjay Shahi

Journal of Biological Chemistry, 2003

Reversible Transport by the ATP-binding Cassette Multidrug Export Pump LmrA: ATP SYNTHESIS AT THE EXPENSE OF DOWNHILL ETHIDIUM UPTAKE

Journal of Biological Chemistry, 2004

A critical role of a carboxylate in proton conduction by the ATP-binding cassette multidrug transporter LmrA

The FASEB Journal, 2005

Conformational Change Induced by ATP Binding in the Multidrug ATP-Binding Cassette Transporter BmrA †

Sergio Marco

Biochemistry, 2008

Biochemical Society Transactions, 2005

Towards the molecular mechanism of prokaryotic and eukaryotic multidrug transporters

Seminars in Cell & Developmental Biology, 2001

STRUCTURE AND FUNCTION OF MULTIDRUG TRANSPORTER PROTEINS AND MECHANISM OF RESISTANCE TO AVAILABLE CHEMOTHERAPY

IJAR Indexing

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity

Joseph Shiloach

Journal of Biological Chemistry, 2016

Multidrug efflux pumps: Substrate selection in ATP-binding cassette multidrug efflux pumps - first come, first served?

Karl Kuchler

Febs Journal, 2010

Nucleotides and transported substrates modulate different steps of the ATPase catalytic cycle of MRP1 multidrug transporter

Zsofia Szentpetery, Balazs Sarkadi

Biochemical Journal, 2004

Transmembrane Transport of Endo- and Xenobiotics by Mammalian ATP-Binding Cassette Multidrug Resistance Proteins

Physiological Reviews, 2006

Multidrug resistance mediated by the ATP‐binding cassette transporter protein MRP

BioEssays, 1998

The role of multidrug transporters in drug availability, metabolism and toxicity

Flóra Szeri

Toxicology letters, 2003

The Role of Half-Transporters in Multidrug Resistance

Thomas Litman

Journal of Bioenergetics and Biomembranes, 2001

Insight into Pleiotropic Drug Resistance ATP-binding Cassette Pump Drug Transport through Mutagenesis of Cdr1p Transmembrane Domains

Richard Cannon

Journal of Biological Chemistry, 2013

Multidrug transporters from bacteria to man: similarities in structure and function

Seminars in Cancer Biology, 1997

Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2

Emily Crowley

Febs Journal, 2008

Mutations Define Cross-talk between the N-terminal Nucleotide-binding Domain and Transmembrane Helix-2 of the Yeast Multidrug Transporter Pdr5: POSSIBLE CONSERVATION OF A SIGNALING INTERFACE FOR COUPLING ATP HYDROLYSIS TO DRUG TRANSPORT

Suresh Ambudkar

Journal of Biological Chemistry, 2008

Charged Amino Acids in the Sixth Transmembrane Helix of Multidrug Resistance Protein 1 (MRP1/ABCC1) Are Critical Determinants of Transport Activity

Journal of Biological Chemistry, 2002

Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein

Suresh Ambudkar

Proceedings of the National Academy of Sciences, 2020

Molecular analysis of the multidrug transporter, P-glycoprotein

Ursula Germann

Cytotechnology, 1998

The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle

Anna Seelig

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014

ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1

Peter Jansen

British Journal of Pharmacology, 1999

Structure of a human multidrug transporter in an inward-facing conformation

Journal of Structural Biology, 2010