Subclinical GvHD in non-irradiated F1 hybrids: severe lymphoid-tissue GvHD causing prolonged immune dysfunction (original) (raw)
Significant MLR but not CTL responses against recipient antigens generated in T cells from bone marrow chimeras recovered from acute GVHD
Kazuya Iwabuchi
Bone Marrow Transplantation, 2000
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A novel approach for prevention of lethal GVHD by selective elimination of alloreactive donor lymphocytes prior to stem cell transplantation
Soumya Panigrahi
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Donor Bone Marrow-Derived T Cells Inhibit GVHD Induced by Donor Lymphocyte Infusion in Established Mixed Allogeneic Hematopoietic Chimeras
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PLoS ONE, 2012
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Alleviation of chronic GVHD in mice by oral immuneregulation toward recipient pretransplant splenocytes does not jeopardize the graft versus leukemia effect
Meir Ohana
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Restricted helper function of F1 hybrid T cells positively selected to heterologous erythrocytes in irradiated parental strain mice. I. Failure to collaborate with B cells of the opposite parental strain not associated with active suppression
J. Sprent
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Complete allogeneic hematopoietic chimerism achieved by in utero hematopoietic cell transplantation and cotransplantation of LLME-treated, MHC-sensitized donor lymphocytes.
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Clonal deletion is one mechanism responsible for tolerance in mixed hematopoietic chimeras
Susan Orloff
Transplantation Proceedings, 1997
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Different subsets of T cells in the adult mouse bone marrow and spleen induce or suppress acute graft-versus-host disease
Bari Nazario
The Journal of Immunology
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Allosuppressor and allohelper T cells in acute and chronic graft-vs- host disease. V. F1 mice with secondary chronic GVHD contain F1- reactive allohelper but no allosuppressor T cells
Ernst Gleichmann
Journal of Experimental Medicine, 1984
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lethal acute GVHD
Francis Blankenberg
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GVHD: A Continuing Barrier to the Safety of Allogeneic Transplantation
Martin Guimond
Biology of Blood and Marrow Transplantation, 2009
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Negative selection of T cells causing lethal graft-versus-host disease across minor histocompatibility barriers. Role of the H-2 complex
J. Sprent
Journal of Experimental Medicine, 1980
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Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD
Francis Blankenberg
Blood, 2005
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Attenuation of GVHD for allo-bone marrow transplantation recipient by fasL-fas pathway in an H-2 haplotype disparate mouse combination
Zhongbo Hu
Journal of Huazhong University of Science and Technology [Medical Sciences], 2004
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Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease
Thomas Sproule, Sebastian Joyce
Blood, 2002
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Capacity of genetically different T lymphocytes to induce lethal graft-versus-host disease correlates with their capacity to generate suppression but not with their capacity to generate anti-F1 killer cells. A non-H-2 locus determines the inability to induce lethal graft-versus-host disease
Ernst Gleichmann
The Journal of experimental medicine, 1981
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Progression from Acute to Chronic Disease in a Murine Parent-into-F1 Model of Graft-Versus-Host Disease
Edna Mozes
The Journal of Immunology, 2000
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Immune Responses to MHC Homozygous Lymphoid Cells in Murine F1 Hybrid Recipients: Implications for Transfusion Associated Graft-Versus Host Disease
Loren Fast
1994
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Autoimmunization and Lymphomagenesis in Parent-F1 Combinations Differing at the Major Histocompatibility Complex: Model for Spontaneous Disease Caused by Altered Self-Antigens?
Ernst Gleichmann
Immunological Reviews, 1976
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Distinct fates of self-specific T cells developing in irradiation bone marrow chimeras: clonal deletion, clonal anergy, or in vitro responsiveness to self-Mls-1a controlled by hemopoietic cells in the thymus
Yolande Chvatchko
Journal of Experimental Medicine, 1990
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Risk factors for the development of acute and chronic GvHD after allogeneic hematopoietic stem cell transplantation in children and adolescents
anita lawitschka
Biology of Blood and Marrow Transplantation, 2005
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T-helper function of parent leads to F1 chimeras. Presence of a separate T-cell subgroup able to stimulate allogeneic B cells but not syngeneic B cells
J. Sprent
Journal of Experimental Medicine, 1979
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mouse model of infusion-induced bone marrow failure Bystander destruction of hematopoietic progenitor and stem cells in a
Rodrigo Calado
2010
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Mouse models of graft-versus-host disease
James Ferrara
StemBook
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Combined host-conditioning with CTLA4-Ig, tacrolimus, anti-lymphocyte serum, and low-dose radiation leads to stable mixed hematopoietic chimerism
Si Pham
Experimental Hematology, 2001
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Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remis...
Michael Maris
Blood, 2003
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T-cell depletion to prevent GVHD after unrelated-donor marrow transplantation
Piero De Stefano
Lancet, 2005
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Induction of stable long-term mixed hematopoietic chimerism following nonmyeloablative conditioning with T cell-depleting antibodies, cyclophosphamide, and thymic irradiation leads to donor-specific in vitro and in vivo tolerance
Megan Sykes
Biology of Blood and Marrow Transplantation, 2001
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Analysis of risk factors for the development of GVHD after T cell-depleted allogeneic BMT: Effect of HLA disparity, ABO incompatibility, and method of T-cell depletion
Carolyn Keever-taylor, Colleen Lawton
Biology of Blood and Marrow Transplantation, 2001
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Host-Reactive Cytotoxic T Lymphocyte Precursors in Long-lived Fully Allogeneic Mouse Bone Marrow Chimeras
Hermann Wagner
Scandinavian Journal of Immunology, 1986
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Low-Dose Total-Body Irradiation and Fludarabine Followed by Hematopoietic Cell Transplantation From HLA-Identical Sibling Donors Do Not Induce Complete T-Cell Donor …
Carmen martínez
Experimental …, 2003
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Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based nonmyeloablative conditioning regimen
Megan Sykes
Biology of Blood and Marrow Transplantation, 1999
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Loss of graft-versus-host reactivity of mouse lymphocytes during serial passage through irradiated allogeneic hosts
Bengt Andersson
Cellular Immunology, 1973
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Counterflow centrifugation allows addition of appropriate numbers of T cells to allogeneic marrow and blood stem cell grafts to prevent severe GVHD without substantial loss of mature and immature progenitor cells
Frank Preijers
Bone Marrow Transplantation, 1999
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A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses
Pavan Reddy
Nature Medicine, 2005
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