The role of D1–D2 receptor hetero-dimerization in the mechanism of action of clozapine (original) (raw)
Mechanism of action of clozapine in the context of dopamine D1-D2 receptor hetero-dimerization--a working hypothesis
Maciej Kusmider
Pharmacological reports : PR
View PDFchevron_right
Equivalent Occupancy of Dopamine D1 and D2 Receptors With Clozapine: Differentiation From Other Atypical Antipsychotics
Johannes Tauscher
American Journal of Psychiatry, 2004
View PDFchevron_right
Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level
Peter Gmeiner
Scientific reports, 2016
View PDFchevron_right
Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor
Bernard Masereel
European Journal of Pharmacology, 1995
View PDFchevron_right
Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentrations
Yoshiyuki Asai, Fumihiko Yasuno
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2006
View PDFchevron_right
Receptor-Protein Interactions Mediated by the Fourth Transmembrane of D2R Can Be Altered by Treatment with Antipsychotics
craig irving
2017
View PDFchevron_right
Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor
Erik Hjerde, Ingebrigt Sylte
European Journal of Medicinal Chemistry, 2005
View PDFchevron_right
Evaluation of Dopamine D-2 Receptor Occupancy by Clozapine, Risperidone, and Haloperidol In Vivo in the Rodent and Nonhuman Primate Brain Using 18F-Fallypride
Jogeshwar Mukherjee, Bradley Christian
Neuropsychopharmacology, 2001
View PDFchevron_right
Clozapine can induce high dopamine D 2 receptor occupancy in vivo
Tetsuya Suhara
Psychopharmacology, 2002
View PDFchevron_right
The Striatal and Extrastriatal D2/D3 Receptor-Binding Profile of Clozapine in Patients with Schizophrenia
Christoph Hiemke
Neuropsychopharmacology, 2006
View PDFchevron_right
Intrinsic Efficacy of Antipsychotics at Human D2, D3, and D4 Dopamine Receptors: Identification of the Clozapine Metabolite N-Desmethylclozapine as a D2/D3 Partial Agonist
Norman Nash
Journal of Pharmacology and Experimental Therapeutics, 2005
View PDFchevron_right
Double activity imaging reveals distinct cellular targets of haloperidol, clozapine and dopamine D3 receptor selective RGH-1756
Krisztina Kovacs
Neuropharmacology, 2001
View PDFchevron_right
New Insights into the Biology of Schizophrenia through the Mechanism of Action of Clozapine
Rudolf Markstein
Neuropsychopharmacology, 1995
View PDFchevron_right
Occupancy of dopamine D2 receptors by the atypical antipsychotic drugs risperidone and olanzapine: theoretical implications
Anissa Abi-Dargham
Psychopharmacology, 2004
View PDFchevron_right
Effects of chronic neuroleptic treatments on dopamine D1 and D2 receptors: homogenate binding and autoradiographic studies
Ase Ase
Neurochemistry International, 1997
View PDFchevron_right
Why is Clozapine More Effective Than Other Atypical Antipsychotics? Density Functional Theory and Molecular Docking Approach
SÜHEYLA ÜNAL
2019
View PDFchevron_right
Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer
Vanessa Barth
Life Sciences, 2006
View PDFchevron_right
Dopamine D 2/3 receptor binding potential and occupancy in midbrain and temporal cortex by haloperidol, olanzapine and clozapine
Jari Tiihonen
Psychiatry and Clinical Neurosciences, 2009
View PDFchevron_right
Dopamine D2 heteroreceptor complexes and their receptor-receptor interactions in ventral striatum: Novel targets for antipsychotic drugs
Wilber Romero-Fernandez, Michael Di Palma, Sergio Tanganelli, Dasiel O Borroto-Escuela, Luigi Agnati
2014
View PDFchevron_right
Positron emission tomography with (18F)methylspiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol
H. Coenen, H. Karbe
Journal of Neural Transmission, 1991
View PDFchevron_right
Time Course of Dopamine-D 2 and Serotonin-5-HT 2 Receptor Occupancy Rates by Haloperidol and Clozapine In Vivo
Tomiki Sumiyoshi
Psychiatry and Clinical Neurosciences, 1993
View PDFchevron_right
Role of the extracellular amino terminus and first membrane-spanning helix of dopamine D1 and D5 receptors in shaping ligand selectivity and efficacy
Mario Tiberi
Cellular Signalling, 2010
View PDFchevron_right
The Importance of Dopamine D4 Receptors in the Action and Development of Antipsychotic Agents
Gavin Reynolds
Drugs, 1996
View PDFchevron_right
Iodine-123-Iodobenzamide SPECT Assessment of Dopamine D2 Receptor Occupancy in Risperidone-Treated Schizophrenic Patients
Josef Scherer
Journal of Nuclear Medicine
View PDFchevron_right
Endogenous dopamine limits the binding of antipsychotic drugs to D3 receptors in the rat brain: a quantitative autoradiographic study
Josee Leysen
The Histochemical Journal, 1996
View PDFchevron_right
Antipsychotic drugs which elicit little or no Parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors
P. Seeman
Molecular Psychiatry, 1998
View PDFchevron_right
Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics
Fumihiko Yasuno
The International Journal of Neuropsychopharmacology, 2004
View PDFchevron_right
Dopamine D2 receptor occupancy in vivo by the novel atypical antipsychotic olanzapine — a123 IBZM single photon emission tomography (SPET) study
Peter Ell
Psychopharmacology, 1996
View PDFchevron_right
Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors
Robert McQuade
European Journal of Pharmacology, 2009
View PDFchevron_right
The Effect of Antipsychotics on the High-Affinity State of D2 and D3 Receptors
Ariel Graff-Guerrero
Archives of General Psychiatry, 2009
View PDFchevron_right
In vitro biochemical evidence that the psychotomimetics phencyclidine, ketamine and dizocilpine (MK-801) are inactive at cloned human and rat dopamine D 2 receptors
Shaun Jordan
European Journal of Pharmacology, 2006
View PDFchevron_right