The Role of 3D Modelling and Printing in Orthopaedic Tissue Engineering: A Review of the Current Literature (original) (raw)

On 3D printed scaffolds for orthopedic tissue engineering applications

SN Applied Sciences

This paper outlines an in vitro evaluation of 3D printed scaffold of polylactic acid (PLA) blended with hydroxyapatite (HAp) and chitosan (CS) for orthopedic tissue engineering applications. In the first stage, selected composition/proportion of PLA-HAp-CS (based on melt flow-ability, mechanical and thermal properties) was 3D printed with fused deposition modeling (FDM) process. The 3D printed scaffolds were used for process capability analysis to ascertain the industrial usability of PLA-HAp-CS composite scaffold for batch production (especially in assembly applications). Further, in the second stage, an in vitro evaluation was performed to investigate the linkages of fibroblast cells for 3D printed scaffold. The results of study outline the rapid increase in growth of fibroblast cells for FDM-printed scaffolds of PLA-HAp-CS thus ensuring its capability of supporting cell adhesion and cell proliferation. Further, the dimensional variations and Shore D hardness of 3D printed scaffolds are under statistically control, with process capability indices (Cp and Cpk ≥ 1).

3D printing of bone tissue engineering scaffolds

Bioactive Materials, 2020

Tissue engineering is promising in realizing successful treatments of human body tissue loss that current methods cannot treat well or achieve satisfactory clinical outcomes. In scaffold-based bone tissue engineering, a high performance scaffold underpins the success of a bone tissue engineering strategy and a major direction in the field is to produce bone tissue engineering scaffolds with desirable shape, structural, physical, chemical and biological features for enhanced biological performance and for regenerating complex bone tissues. Three-dimensional (3D) printing can produce customized scaffolds that are highly desirable for bone tissue engineering. The enormous interest in 3D printing and 3D printed objects by the science, engineering and medical communities has led to various developments of the 3D printing technology and wide investigations of 3D printed products in many industries, including biomedical engineering, over the past decade. It is now possible to create novel bone tissue engineering scaffolds with customized shape, architecture, favorable macro-micro structure, wettability, mechanical strength and cellular responses. This article provides a concise review of recent advances in the R & D of 3D printing of bone tissue engineering scaffolds. It also presents our philosophy and research in the designing and fabrication of bone tissue engineering scaffolds through 3D printing.

The use of additive manufacturing for design of 3D scaffolds for bone tissue engineering

7th International Conference on Advances in Mechanical Engineering and Mechanics, 2019

In the biomedical sector, bio-fabrication is a practical guide to the new inherently transdisciplinary scientific field that focuses on bio-production processes and a related range of emerging technologies. Tissue engineering has emerged by bringing the ability to confront the shortage of organs caused by the lack of donors. Through this multidisciplinary approach, new functional tissues are made by cells that are primarily associated with a matrix that supports and guides tissue development. This regeneration task is accomplished through the development of technologies that create or manipulate biomolecules, biological materials, cells and tissues, in order to synthesize a new tissue, an organ, or apparatus that will be implanted at the level of the wound. Tissue organ defects may be corrected by surgery but this may not be possible for personal or medical reasons. The 3D bio impression reconstruction solution is a good alternative but can count on the artistic talent and the availability of the epithet. In this work, a semi-automatic method using computer aided design (CAD) and bio-fabrication will be developed for the design of an artificial tissue. A 3D model of artificial tissue cases of tissue implantation in the bone defect of the leg will be designed under CAD software to be transferred into the bio-design process.

Bone Tissue Engineering through 3D Bioprinting of Bioceramic Scaffolds: A Review and Update

Life

Trauma and bone loss from infections, tumors, and congenital diseases make bone repair and regeneration the greatest challenges in orthopedic, craniofacial, and plastic surgeries. The shortage of donors, intrinsic limitations, and complications in transplantation have led to more focus and interest in regenerative medicine. Structures that closely mimic bone tissue can be produced by this unique technology. The steady development of three-dimensional (3D)-printed bone tissue engineering scaffold therapy has played an important role in achieving the desired goal. Bioceramic scaffolds are widely studied and appear to be the most promising solution. In addition, 3D printing technology can simulate mechanical and biological surface properties and print with high precision complex internal and external structures to match their functional properties. Inkjet, extrusion, and light-based 3D printing are among the rapidly advancing bone bioprinting technologies. Furthermore, stem cell therap...

3D Printing for Hip Implant Applications: A Review

Polymers, 2020

There is a rising demand for replacement, regeneration of tissues and organ repairs for patients who suffer from diseased/damaged bones or tissues such as hip pains. The hip replacement treatment relies on the implant, which may not always meet the requirements due to mechanical and biocompatibility issues which in turn may aggravate the pain. To surpass these limitations, researchers are investigating the use of scaffolds as another approach for implants. Three-dimensional (3D) printing offers significant potential as an efficient fabrication technique on personalized organs as it is capable of biomimicking the intricate designs found in nature. In this review, the determining factors for hip replacement and the different fabrication techniques such as direct 3D printing, Fused Deposition Modelling (FDM), Selective Laser Sintering (SLS) and stereolithography (SLA) for hip replacement. The study also covers surface modifications of 3D printed implants and provides an overview on 3D ...

Designing and preparing by FDM 3D printing of polymeric scaffolds with potential application in tissue engineering

Engineering of Biomaterials, 2016

Introduction The aim of this research is to develop a procedure to prepare the biodegradable polymeric scaffolds using 3D printing by fused deposition modeling (FDM). Mechanical damages of the bone and cartilage tissue within joints are a common result of sport and communication accidents. This type of defects usually causes a pain and limitation of a movement range. The basic problem of the therapeutic procedure is a limited ability of the cartilage tissue to regenerate [1]. One of the most effective methods of supporting of this process is to apply the polymeric scaffolds with shape, dimension, infill and material adequate to the type of the damage. 3D printing by fused deposition modeling is one of the most interesting method of the polymers processing [2,3]. Thermoplastic material in form of a filament is melted and casted layer by layer to produce three dimensional object. The structure of this product could be precisely described by designed computer model.

3D Printing of Personalized Artificial Bone Scaffolds

3D printing and additive manufacturing, 2015

Additive manufacturing technologies, including three-dimensional printing (3DP), have unlocked new possibilities for bone tissue engineering. Long-term regeneration of normal anatomic structure, shape, and function is clinically important subsequent to bone trauma, tumor, infection, nonunion after fracture, or congenital abnormality. Due to the great complexity in structure and properties of bone across the population, along with variation in the type of injury or defect, currently available treatments for larger bone defects that support load often fail in replicating the anatomic shape and structure of the lost bone tissue. 3DP could provide the ability to print bone substitute materials with a controlled chemistry, shape, porosity, and topography, thus allowing printing of personalized bone grafts customized to the patient and the specific clinical condition. 3DP and related fabrication approaches of bone grafts may one day revolutionize the way clinicians currently treat bone defects. This article gives a brief overview of the current advances in 3DP and existing materials with an emphasis on ceramics used for 3DP of bone scaffolds. Furthermore, it addresses some of the current limitations of this technique and discusses potential future directions and strategies for improving fabrication of personalized artificial bone constructs.

Design and 3D Printing of Scaffolds and Tissues 3D Printing-Review

A growing number of three-dimensional (3D)-printing processes have been applied to tissue engineering. This paper presents a state-of-the-art study of 3D-printing technologies for tissue-engineering applications, with particular focus on the development of a computer-aided scaffold design system; the direct 3D printing of functionally graded scaffolds; the modeling of selective laser sintering (SLS) and fused deposition modeling (FDM) processes; the indirect additive manufacturing of scaffolds, with both micro and macro features; the development of a bioreactor; and 3D/4D bioprinting. Technological limitations will be discussed so as to highlight the possibility of future improvements for new 3D-printing methodologies for tissue engineering.

Overview of Emerging Technology in Orthopedic Surgery: What is the Value in 3D Modeling and Printing?

Techniques in Orthopaedics, 2016

Three-dimensional printing and modeling has evolved significantly since first introduced in the 1980s. In the last 5 years, this revolution in technology has become far more accessible and affordable, and is already mainstream in many areas of medicine. Nowhere is this more apparent than in orthopedics, and many surgeons already incorporate aspects of 3D modeling and virtual procedures in their routine clinical practice. However, this technology promises to become even more prevalent as creative applications continue to be developed, and further innovations are certain to come. There are important public policy aspects to consider, both economic and regulatory. Regulatory issues are currently still under development, but will need to take into account sterilization, quality assurance, and product liability. The mechanical integrity of 3D-printed implants is influenced by the unique characteristics of the print process, including the energy density of the laser, the resolution of the print, and the orientation of the print on the build platform. Introduction of expensive new technology should only be done after careful consideration of the costs associated, the potential benefits, and the value that can be derived. The value in 3D modeling and printing can be considered relative to the initial costs, the experience of a 3D modeling unit, the complexity of a particular case, and the clinical expertise of the surgeons involved. There is significant potential value derived from modeling most displaced intraarticular fractures, once a 3D modeling unit is established and proficient. However, the greatest value comes from modeling the most highly complex cases. When the pathology is most abnormal, 3D modeling/printing can be a valuable clinical adjunct for even the most expert and experienced surgeons. Although currently hospital-based 3D modeling/printing units are uncommon, they will soon become far more common. For surgeons in developing nations, 3D printing may currently be prohibitively expensive, but 3D modeling is relatively inexpensive and therefore far more accessible. As 3D printer prices continue to fall, the ability to rapidly manufacture prototypes and patient-specific models will inevitably spread through these regions as well. However, the future for 3D-printed medical models, devices, and implants will be limited unless we are able to document their clinical superiority and confirm their value with respect to patient outcomes. Level of Evidence: Level V-expert opinion.