Multiple Membrane-Cytoplasmic Domain Contacts in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mediate Regulation of Channel Gating
Nikolay Dokholyan
Journal of Biological Chemistry, 2008
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Conformational Changes Relevant to Channel Activity and Folding within the first Nucleotide Binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator
ori kalid, H. Bihler
Journal of Biological Chemistry, 2012
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Asymmetric Structure of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore Suggested by Mutagenesis of the Twelfth Transmembrane Region †
Jyoti Gupta
Biochemistry, 2001
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Functional organization of cytoplasmic portals controlling access to the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel pore
Elizabeth Cowley
The Journal of biological chemistry, 2018
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A Topological Switch in the Cystic Fibrosis Transmembrane Conductance Regulator Modulates Channel Activity and Sensitivity to Disease-Causing Mutation
Maud Sigoillot
2020
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Three-dimensional Reconstruction of Human Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Revealed an Ellipsoidal Structure with Orifices beneath the Putative Transmembrane Domain
Mio Mio
Journal of Biological Chemistry, 2008
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Interdomain but Not Intermolecular Interactions Observed in CFTR Channels
Melissa Harrington
Biochemical and Biophysical Research Communications, 2001
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Two Small Molecules Restore Stability to a Sub-population of the Cystic Fibrosis Transmembrane conductance Regulator with the Predominant Disease-causing Mutation
Robert Ford
The Journal of biological chemistry, 2017
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Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop
Kevin Kirk
The Journal of biological chemistry, 2015
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Identification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment
E. Guiraldes
Biophysical Journal, 1996
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Transmembrane helical interactions in the CFTR channel pore
Andrei Aleksandrov
PLOS Computational Biology
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Destabilization of the Transmembrane Domain Induces Misfolding in a Phenotypic Mutant of Cystic Fibrosis Transmembrane Conductance Regulator
Anthony Partridge, Craig Daniels
Journal of Biological Chemistry, 2004
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Chloride Channel and Chloride Conductance Regulator Domains of CFTR, the Cystic Fibrosis Transmembrane Conductance Regulator
Erik Schwiebert
Proceedings of the …, 1998
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Purification and Crystallization of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
Robert Ford
Journal of Biological Chemistry, 2004
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Stability to a Sub-population of the Cystic Fibrosis Transmembrane conductance Regulator with the Predominant Disease-causing
Robert Ford
2017
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C Terminus of Nucleotide Binding Domain 1 Contains Critical Features for Cystic Fibrosis Transmembrane Conductance Regulator Trafficking and Activation
Frédéric Becq
Journal of Biological Chemistry, 2010
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Activating Cystic Fibrosis Transmembrane Conductance Regulator Channels with Pore Blocker Analogs
Kevin Kirk
Journal of Biological Chemistry, 2005
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Structure and function of the cystic fibrosis transmembrane conductance regulator
anibal lopes
Brazilian Journal of Medical and Biological Research, 1999
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Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Cl- Channel by Its R Domain
Don-on Mak
Journal of Biological Chemistry, 2001
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New Model of Cystic Fibrosis Transmembrane Conductance Regulator Proposes Active Channel-like Conformation
Nir Ben-tal
Journal of Chemical Information and Modeling, 2012
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Probing Conformational Rescue Induced by a Chemical Corrector of F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutant
wilson yu
Journal of Biological Chemistry, 2011
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A Combined Analysis of the Cystic Fibrosis Transmembrane Conductance Regulator: Implications for Structure and Disease Models
Gordon Cramb
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Characterization of the internalization pathways for the cystic fibrosis transmembrane conductance regulator
Neil Bradbury
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Mutation-Specific Potency and Efficacy of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Potentiators
Nicole Pedemonte
Journal of Pharmacology and Experimental Therapeutics, 2009
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Crystallographic and single-particle analyses of native- and nucleotide-bound forms of the cystic fibrosis transmembrane conductance regulator (CFTR) protein
Robert Ford
Biochemical Society Transactions, 2005
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The H-loop in the Second Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator is Required for Efficient Chloride Channel Closing
Michał Milewski
Cellular Physiology and Biochemistry, 2010
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Relationship between nucleotide binding and ion channel gating in cystic fibrosis transmembrane conductance regulator
Andrei Aleksandrov
The Journal of Physiology, 2009
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The H-loop in the Second Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator is Required for Efficient Chloride Channel …
Michal Milewski
Cellular Physiology …, 2010
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