Effect of Moringa oleifera Leaves Extract Against Hematology and Blood Biochemical Value of Patients with Iron Deficiency Anemia (original) (raw)
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Iron deficiency anaemia (IDA) is most prevalent among Indian women in reproductive age from lower socio economic strata and 80% of women with anaemia suffer from IDA. This study was done with the intention of finding efficient substitutes in the form of non haem iron of vegetable origin i.e. Moringa oleifera leaves (drumstick) and jaggery to treat anaemia. Women belonging to lower socioeconomic strata in suburban/rural Bangalore aged 15-45 were the target group. A simple random sampling of 60 women suffering from IDA was taken where 30 women were assigned to the intervention group and 30 to the control group. Diagnosis of anaemia was done using Tallqvist's haemoglobin scale. The intervention group was then given a therapy which consisted of 100gm of Moringa oleifera and jaggery (dry weight) in a ratio of 80:20 for thirty days. The inhibitors of iron absorption (milk, phytates, and tannins) were not taken along with the supplements. After thirty days the haemoglobin levels were analysed again and recorded. The results were analysed based on percentages and proportions. Student's t test was used to find out any significant difference between intervention and the control group. At the end of the supplementation period (30 days), the women in intervention group showed an increase in haemoglobin level. By the Student's t test, the post intervention data is highly significant,t=4.109 (P <0.001).This study shows that Moringa oleifera with jaggery has significantly improved haemoglobin levels of anaemic women. This can be promoted in the community for women with iron deficiency anaemia. Further studies with larger samples maybe performed to corroborate the above data.
Anti-Anemia Effect of Standardized Extract of Moringa Oleifera Lamk. Leaves on Aniline Induced Rats
Pharmacognosy Journal, 2016
Background: The leaves of Moringa (Moringa oleifera Lamk.) have been empirically used as anti-anemia for pregnant woman. Objectives: In the present study, the effect of ethanolic extract of moringa leaves was evaluated on the hematology parameters (hemoglobin, red blood cell count, hematocrit), on aniline induced white female rats. Materials and Methods: Thirty female rats strain Sprague-Dawley were divided into six groups: normal, anemia and ferrous fumarate group, and three groups of Moringa leaves extract. All groups, except normal group, induced by aniline at dose 0.005 ml/ g bw intraperitonially. On fifth day, normal and anemia groups were given 0.5% CMC, ferrous fumarate group was given ferrous fumarate orally and three other groups were given Moringa leaves extract at doses 198 mg, 396 mg, and 792 mg/200 g bw until the eleventh day. Results: The results showed that as Moringa leaves extracts increased the level of hemoglobin, red blood cell count, hematocrit, and total iron content in blood. Moreover, Moringa leaves extract at dose 792 mg/200 g bw can improve red blood cell's morphology and increased the level of hemoglobin and red blood cell count significantly (p<0.05). Conclusion: The ethanolic extract of Moringa leaves showed anti-anemia on aniline-induced rats.
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya, 2020
The iron deficiency anemia is kind of anemia because the less of iron that make the function to tie oxygen is down. Young girl is one of sufferer group who's prone to get anemia. The long consequence of anemia for the young girl will disturb fatal function of some organ in their body. In general arise of headache symptoms and pain in the centre of head. And the in pregnancy will increase some complication risk such as maternal death. Premature born and perinatal death. One of nature ingredients (herbal) which is reported to have high iron content is kelor leaf (Moringa oleifera L) for about 28, 29 mg/100 g kelor. The purpose of this research is to know the effectiveness of Kelor leave fraction ((Moringa oleifera L) to increase hemoglobin grade with preclinical. Experimental research with complete random design (RAL) has been done in February till April 2019 in medical faculty laboratory of universitas sriwijaya Palembang. Sample of the research is female rat that has inclusion criteria as much 30 rats. Divided into 5 group. That is negative control group. Positive control (ferrous fumarate 60%), n-heksan fraction, ethyl acetate, and 1% concentration of kelor leave ethanol, the data of Hb all of subject before and after treatment from subject of iron deficiency anemia has collected by using Easy Touch GCHb tool. The analysis data of this research used SPSS 2.2 version. The result of the research said that the hemoglobin grade before and after treatment showed significant increasing(p<0,05) for n-hexane fraction and acetate ethyl >45%. While ethanol fraction only 32%.
This study evaluated the effectiveness of dry Moringa oleifera leaf powder in the management of anaemia in adult albino rats. The proximate, mineral, vitamin and phytochemical composition of dry M. oleifera leaf powder were analysed. Twelve adult albino rats grouped into three were used. Cyclophosphamide was used to induce anaemia into them. The percentage proximate values were protein (26.28%), ash (7.69%), carbohydrate (49.35%), crude fibre (7.48%) and moisture (7.05%). The rats whose feed were supplemented with M. oleifera leaf powder showed superior attributes to the unsupplemented group. The study showed dry M. oleifera leaf powder is promising in the management of anaemia.
Evaluation of Moringa Oleifera Lam Leaves (Moringaceae) Diets Against Induced Anemia in Wistar Rats
EAS Journal of Nutrition and Food Sciences, 2020
The effect of oleifera leaves diets against anemia was investigated in Wistar rats. Three groups of six rats each were formed. Moringa Hemolytic anemia was induced in rats by phenylhydrazine at a dose of 40 mg/kg body weight intraperitoneally for two successive days. The rats, which received phenylhydrazine were subjected to Ranferon® (Reference substance) and two régimes food P50% and P100% contained respectively 50% and 100% of sheet Moringa oleifera from day 2 (D2) until the end of the experiment to day 28 (D28). Blood was taken from all the rats to days D0, D2, D5, D14 and D28. Diets made from leaves of Moringa oleifera (P50% and P100%) and Ranferon® have significantly restored the red blood cell parameters changed by phenylhydrazine. In addition, P50% provided better values of erythrocyte parameters than P100%. However, no significant change in body weight was observed. This study revealed that these diets based on Moringa oleifera leaves has excellent therapeutic efficacy, thus confirming the use of this dietary supplement in the treatment of anemia.
Utilization Potentials of Moringa oleifera Leaves Syrup in Prevention of Anemia
https://ijshr.com/IJSHR\_Vol.4\_Issue.4\_Oct2019/IJSHR\_Abstract.001.html, 2019
Background: Anemia is still remains as the main nutritional problem in Indonesia. Based on Indonesia basic health research 2018, the prevalence of anemia in Indonesia was 23,7%. The prevalence of anemia in children under 5 years was 38.5%, and in pregnant women was 48,9%. Indonesia has a large number of natural plants that contain rich of nutrients such as Moringa oleifera. The leaves are 25 times more iron than spinach. Aims: This study aims to analyze the content of Fe level and the organoleptics of Moringa oleifera leaves syrup as an alternative food product in prevention of anemia. Methods: This was an experimental study using a completely randomized design (CRD) consisting of one factor and 3 repetitions. The samples were: Moringa oleifera leaves mixed with pineapple as treatment samples and Moringa oleifera leaves without pineapple as control. The 5 points hedonic scales were conducted for the organoleptic test: dislike extremely, dislike, neither like nor dislike, like, like extremely assessed by 30 panelists. The Fe level assessed by spectrophotometers. Results: The highest average of color preference, aroma, taste test and Fe level was Sample 1. The treatment samples had good aroma and a acceptable taste because they were mixed with pineapple which contains Bromelin enzyme which can reduce the bitter taste of Moringa oleifera leaves. Conclusions: Syrup of Moringa oleifera leaves mixed with pineapple could be an alternative food product in prevention of anemia. Keywords: syrup, Moringa oleifera, prevention, anemia
IP Journal of Nutrition, Metabolism and Health Science
Iron deficiency anemia is a cause of concern for pregnant and lactating mother globally. As per NFHS 5 Data, 52.2% pregnant women (Both Urban and Rural) are anemic in India. Iron Deficiency Anemia is associated with maternal and neonates’ mortality, restricted cognition development, low birth weight babies, Premature babies and majorly stunting which affects the nutritional status throughout the vicious cycle. Postpartum anemia is associated with an impaired quality of life, reduced cognitive abilities, emotional instability, and depression and constitutes a significant health problem in women of reproductive age. Multipronged strategies are required to curtail maternal anemia. Food based approach to prevent anemia is the most sustainable strategy. To investigate the impact of moringa oleifera leaves powder capsules on haemoglobin levels of postpartum mothers. The study was conducted in one of the govt. hospitals of Vadodara District of Gujarat, India and was a part of larger study ...
African Journal of Food, Agriculture, Nutrition and Development, 2011
A randomized study was conducted to test the efficacy of Moringa powder on iron status and weight gain in women. In an open-labelled randomized trial, 82 moderately anaemic, lactating women, aged 26.7± 6.5 years, received a weekly dose of either 100g of Moringa powder(Moringa group) or 120 mg iron sulphate with 0.5 mg folic acid (Control group). Data from 64 women (33 from Moringa group and 31 from Control group) were analyzed. Baseline parameters, socioeconomic , anthropometry, haematology, plasma ferritin, and acute phase proteins were comparable in both groups. Low plasma ferritin (< 12 μg/l) indicating iron deficiency was found in 13 and 14 women from the Moringa and Control groups, respectively. After 3 months of treatment, mean haemoglobin concentrations significantly increased in both groups (p<0.001) but iron stores were unchanged in the Moringa group while they significantly increased in the Control group indicating that consumption of Moringa leaves failed to restore iron stores in anaemic subjects. A slight improvement was observed in the prevalence of anaemia in both groups but anaemia still persisted due to other reasons than iron deficiency anaemia. None of the groups gained weight during the 3 months. However, the average weight lost was less important in the Moringa group (-0.8 ± 2.1 kg) compared to the control group (-1.2± 2.3 kg) but the difference was not significant (p=0.45).The amount of digestible protein in the powder could suggest that the consumption of Moringa was beneficial to the rural women by preventing weight loss during the rainy season. Micronutrient status improvement of vulnerable people in developing countries like Senegal should combine diet-based strategies through production and consumption of animal derived food, vegetable, fruits and food fortification program. However, Moringa Oleifera is one example of local food that can be used in nutritional intervention program, but its use needs additional rigorous clinical trials to confirm its nutritional benefits.
Role Of Moringa Oleifera Leaf Extract In Increasing Hemoglobin Levels In Pregnant Rats With Anemia
Journal of Health Science, 2021
Anemia is one of the epidemic health problems in society and the most common nutritional problem. The Moringa oleifera is rich in excellent dietary content and can complement the body's needs. This study aims to determine Moringa oilefera leaf extract's effectiveness in increasing hemoglobin levels in pregnant rats (Ratus norvegicus) with anemia. This paper used a true experimental research design with a pre-post test randomized control group design. This study utilized female rats (Ratus norvegicus), pregnant 8-12 weeks, weighing 200 grams. Experimental procedures were four treatments with three repetitions. Types of treatment were negative control and positive control (administration of Moringa oilefera leaf extract) at a dose of 0.18 g / head, 0.36 g / head, and 0.72 g/head. Analysis using one way ANOVA with an error rate of 0.05. The results showed p<0.005, which means a significant increase in hemoglobin levels in the group given the treatment of moringa leaf extract...
The Effect of Moringa Leaf Capsule on the Hemoglobin Levels in Young Women at Smp Sabbihisma Padang
KnE Life Sciences, 2019
In adolescents, the iron not only functions as energy metabolism in the body but also helps to improve learning achievement. Iron deficiency can lead to fatigue, and the concentration, memory and learning abilities can be disrupted. It can also lead to anemia, especially in young women. The purpose of this study was to determine the effect of leaf moringa capsules on the hemoglobin levels in adolescent girls in Sabbihisma Junior High School. This research used a quasi method of pretest and posttest experiment with control group design. The sample of the study were 32 people, 16 cases (moringa leaf capsule) and 16 control groups. Data collection was done through observation and laboratory examination of hemoglobin levels before and after treatment. The data were tested with paired sample t-test. The results showed that there was a significant difference in female hemoglobin levels in the case group with p = 0,000, while the control group was not significant with p = 0,091.