Anti-Anemia Effect of Standardized Extract of Moringa Oleifera Lamk. Leaves on Aniline Induced Rats (original) (raw)
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Role Of Moringa Oleifera Leaf Extract In Increasing Hemoglobin Levels In Pregnant Rats With Anemia
Journal of Health Science, 2021
Anemia is one of the epidemic health problems in society and the most common nutritional problem. The Moringa oleifera is rich in excellent dietary content and can complement the body's needs. This study aims to determine Moringa oilefera leaf extract's effectiveness in increasing hemoglobin levels in pregnant rats (Ratus norvegicus) with anemia. This paper used a true experimental research design with a pre-post test randomized control group design. This study utilized female rats (Ratus norvegicus), pregnant 8-12 weeks, weighing 200 grams. Experimental procedures were four treatments with three repetitions. Types of treatment were negative control and positive control (administration of Moringa oilefera leaf extract) at a dose of 0.18 g / head, 0.36 g / head, and 0.72 g/head. Analysis using one way ANOVA with an error rate of 0.05. The results showed p<0.005, which means a significant increase in hemoglobin levels in the group given the treatment of moringa leaf extract...
Evaluation of Moringa Oleifera Lam Leaves (Moringaceae) Diets Against Induced Anemia in Wistar Rats
EAS Journal of Nutrition and Food Sciences, 2020
The effect of oleifera leaves diets against anemia was investigated in Wistar rats. Three groups of six rats each were formed. Moringa Hemolytic anemia was induced in rats by phenylhydrazine at a dose of 40 mg/kg body weight intraperitoneally for two successive days. The rats, which received phenylhydrazine were subjected to Ranferon® (Reference substance) and two régimes food P50% and P100% contained respectively 50% and 100% of sheet Moringa oleifera from day 2 (D2) until the end of the experiment to day 28 (D28). Blood was taken from all the rats to days D0, D2, D5, D14 and D28. Diets made from leaves of Moringa oleifera (P50% and P100%) and Ranferon® have significantly restored the red blood cell parameters changed by phenylhydrazine. In addition, P50% provided better values of erythrocyte parameters than P100%. However, no significant change in body weight was observed. This study revealed that these diets based on Moringa oleifera leaves has excellent therapeutic efficacy, thus confirming the use of this dietary supplement in the treatment of anemia.
Journal of Young Pharmacists
Introduction: Approximately (24.8%) the world's population suffers from anemia and 50% of an anemic case is due to iron deficiency. This study investigated the efficacy of Moringa oleifera L leaves to extract as an iron booster and supplement to help overcome anemia in the community. Methods: It was a randomized, double-blind, placebo-controlled study in anemic women (hemoglobin 8-12g/dL), in which the water extract of moringa leaves was examined as an add-on therapy in the subject treated with ferrous sulfate (200mg/ tablet). Thirty-five women subject of 16-49 years old were divided into 17 of moringa leaves and 18 of control. The extract of moringa leaves of 1400 mg was formulated in capsules and was administrated daily for 3 weeks. Results: The result showed there were significantly increase of mean of hemoglobin (0.794±0.81 g/dL), ferritin (29.378±42.48 ng/mL), MCHC (Mean Corpuscular Haemoglobin Concentration) (2.459±2.86 g/dL), RDW (Red Distribution Wide) (1.4±2.07 %) and decreased of platelets (36529.41±59024.48 /uL). The control groups were significantly increased of mean of the hemoglobin (0.644± 0.83g/dL), erythrocytes (0.475±0.523 Tpt/L), hematocrit (2.189±l4.08 %), MCV (Mean Corpuscular Volume)(4.756±8.91 fL), MCH (2.183±2.47 pg) dan RDW (2.844±2.80%).The hematocrit (3.14±1.47%), MCH (Mean Corpuscular Hemoglobin) (3.495±1.33 pg), MCHC (3.264±0.96 g/dL) values of moringa leaves were significantly higher whereas the platelets count (55251.63±23404/uL) of moringa leaves were significantly lower (p<0.05) than those of control group. Conclusion: It can be concluded that moringa leaves extract could improve iron deficiency anemia in women.
The Effect of Moringa Oleifera on Hemoglobin Level in Pregnancy
Nursing and Health Sciences Journal (NHSJ), 2021
Anemia is a form of the body's compensation mechanism for decreasing hemoglobin levels. Anemia in pregnancy is a condition in which hemoglobin is below normal, which is below 11 g/dl. The most common cause of anemia in pregnancy is iron deficiency. Moringa leaves are one type of food that is rich in iron which can overcome anemia. The purpose of the study was to determine the effect of giving Moringa leaf soup on hemoglobin levels of pregnant women in the third trimester at the Oepoi Health Center, Kupang City in 2021. Quasy Experimental research design with a two group pre-test and post-test design. The study population was all pregnant women. The sampling technique is purposive sampling. The sample was 32 pregnant women. Statistical test using t-test. The location of this research was carried out at the Oepoi Health Center, Kupang City from July to August 2021. The research instrument was observation sheet and Hb measuring instrument. The results showed that the average hemogl...
Journal of Medical and Biological Science Research, 2020
The leaves of Moringa oleifera have exceptional nutritional qualities and are used in traditional medicine to treat several diseases including anemia. This study is to propose a formulation for the optimal use of M. oleifera leaf powder in the treatment of anemia in rats. Phenylhydrazine (40 mg/kg) was administered intraperitoneally for 2 days to induce anemia in rats (Rattus norvegicus). The animals were divided into six groups of 6 rats each and treated orally from day D2 to D28. Rats groups 1, 2, 3 and 4 were treated orally, respectively with 400, 800 and 1600 mg/kg of M. oleifera aqueous extract of leaves (AEMo) and Ranferon ®. Groups 5 and 6 were fed ad libitum with diets containing 50% (P50) and 100% (P100) of M. oleifera leaves as a substitute for soybean meal, respectively. Red blood cell (RBC) parameters such as RBCs, hemoglobin (Hb), hematocrit (Ht), mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) were analyzed on days D0, D2, D5, D14 and D28. Results showed a prevalence of 0% in anemic rats treated with P50, AEMo 1600 mg/kg and Ranferon ® versus 16.67% in those treated with P100, AEMo 400 and 800 mg/kg at D28. In addition, P50, AEMo 1600 mg/kg and Ranferon ® significantly (p ˂ 0.001) increased RBCs, Hb, Ht with total recovery especially RBCs and Ht in anemic rats treated with P50 and Ranferon ®. In conclusion, the incorporation in small quantities of M. oleifera leaf powder as a substitute for soybean meal has a better efficacy on anemia than the total leaf extract of the same plant.
International Journal Papier Advance and Scientific Review
The aim of this study was to determine the effect of Moringa oleifera leaf extract supplements, Moringa oleifera leaf extract plus royal jelly and placebo on hemoglobin levels in anemic pregnant women. This research is a randomized controlled double blind design study which was conducted in Polombangkeng Utara District, Takalar Regency for 2 months. The subjects of this study were pregnant women with anemia, the majority of which were 20-35 years old, primigravida parity, income less than UMR, unemployment, higher education, pregnancy distance of more than 2 years with p value> 0.05. Then divided into three groups, namely Moringa capsules plus royal jelly (KRJ) (n = 24), Moringa capsules (KTR) (n = 24) and placeco (PLC) (n = 21). Before and after the intervention, measurements of hemoglobin levels were carried out using the Hemocue tool and interviewing the characteristics of the respondents. The results showed that the average Hb level increased from each group (mean SD): KRJ 10...
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya, 2020
The iron deficiency anemia is kind of anemia because the less of iron that make the function to tie oxygen is down. Young girl is one of sufferer group who's prone to get anemia. The long consequence of anemia for the young girl will disturb fatal function of some organ in their body. In general arise of headache symptoms and pain in the centre of head. And the in pregnancy will increase some complication risk such as maternal death. Premature born and perinatal death. One of nature ingredients (herbal) which is reported to have high iron content is kelor leaf (Moringa oleifera L) for about 28, 29 mg/100 g kelor. The purpose of this research is to know the effectiveness of Kelor leave fraction ((Moringa oleifera L) to increase hemoglobin grade with preclinical. Experimental research with complete random design (RAL) has been done in February till April 2019 in medical faculty laboratory of universitas sriwijaya Palembang. Sample of the research is female rat that has inclusion criteria as much 30 rats. Divided into 5 group. That is negative control group. Positive control (ferrous fumarate 60%), n-heksan fraction, ethyl acetate, and 1% concentration of kelor leave ethanol, the data of Hb all of subject before and after treatment from subject of iron deficiency anemia has collected by using Easy Touch GCHb tool. The analysis data of this research used SPSS 2.2 version. The result of the research said that the hemoglobin grade before and after treatment showed significant increasing(p<0,05) for n-hexane fraction and acetate ethyl >45%. While ethanol fraction only 32%.
https://www.ijrrjournal.com/IJRR\_Vol.7\_Issue.11\_Nov2020/Abstract\_IJRR0041.html, 2020
Pregnant woman needs adequate nutrition to maintain maternal health, fetal development, and preparation for lactation. Inadequate nutrition is one of the causes of anemia in pregnant woman. Anemia in pregnant women in Indonesia is mainly caused by iron deficiency. Pregnant woman with anemia can be at risk of giving birth to low birth weight (LBW). One of the forms of fortification for iron needs can be done by consuming green vegetable including edible amaranth (Amaranthus tricolor) and moringa leaves (Moringa Oleifera). This study aimed to determine the effect of giving edible amaranth and moringa leaves extract in experimental pregnant mice on hemoglobin level and birth weight. This was an experimental research with posttest only control group design on 15 pregnant mice divided into 3 groups (group 1: control, group 2: treatment with edible amaranth extract, group 3: treatment with moringa leaves extract at a dose of 396 mg/200 g of body weight for 17 days. The research was carried out in the Natural Material Chemistry Laboratory of the Faculty of Pharmaceutical, the animal house of the Biomedical Laboratory and the Biochemistry Laboratory of the Faculty of Medicine, University of Andalas. Statistical test with one way ANOVA, the significance is determined if p<0,05. The results showed that the mean of hemoglobin level (g/dL) in the control group: 8,98±0,41, treatment 1: 11,57±0,42, and treatment 2: 12,14±0,43. The mean of birth weight (g) in the control group: 2,99±0,04, treatment 1: 3,09±0,32, and treatment 2: 2,91±0,65. There was an effect of giving edible amaranth and moringa leaves extract in experimental pregnant mice on hemoglobin level with a value of p=0,00 (p<0,05) and there was no effect on birth weight (p=0,794). The conclusion of this study is that there is an effect of giving edible amaranth and moringa leaves extract on hemoglobin level and there is no effect of edible amaranth extract and moringa leaves on birth weight.
Corresponding author. e-mail: Hisham1212ribat@yahoo.com. This study is aimed at finding out the effect of Moringa oleifera on blood parameters and body weights of albino rats (n= 24) and rabbits (n= 10). The rats were divided into four groups; a control group and three experimental groups, while the rabbits were divided into two groups; a control group and an experimental one. The three experimental groups of rats were provided consecutively with100, 200 and 300 mg M. oleifera leave extract/kg of body weight daily for 21 days, while the experimental group of rabbits with 2.5 g fresh leaves of M. oleifera/Kg of body weight which was added to their feed daily for 21 days, and the control groups were fed on their diets without M. oleifera. The results showed significant differences (P < 0.05) in mean cell hemoglobin concentration (MCHC) and platelets (PLT) in the third group of rats (AL 3) and red blood cells (RBCs) count, hemoglobin (Hb) and MCHC in the fourth group (AL 4) while no...
Effect of Moringa oleifera aqueous leaf extract on some haematological indices in Wistar rats
The use of Moringa oleifera leaf extract in the treatment of virtually all ailments calls for further research to support the claim for its ability to boost blood. Thirty six albino rats of the Wistar strain weighing 200-230g were sorted into groups according to their weights and sex. The animals were divided into two groups, male and female. Three (3) test groups (1%, 5%, and 10% w/w) for the males containing five (5) animals each and a control group, for the females, three (3) test groups (1%, 5%, and 10% w/w) and control group with four (4) animals each. The result of haematological indices in female Wistar rats administered aqueous extract of M. oleifera shows that Hb count generally increased significantly in all the groups compared with their control group. Similarly, PCV and WBC generally increased in all the groups, this increase was significant for WBC in all the groups. RBC values showed a non-significant (p>0.05) value at 1% treated group but a significant increases (p...