A multi-axial RNA joint with a large range of motion promotes sampling of an active ribozyme conformation (original) (raw)

RNA Dynamics by Design: Biasing Ensembles Towards the Ligand‐Bound State

andrew stelzer

Angewandte …, 2010

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Correlating Structural Dynamics and Function in Single Ribozyme Molecules

Steven Chu

Science, 2002

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Molecular dynamics in the hairpin ribozyme: Calculational and experimental aspects

OMONDI OCHIENG

2015

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Molecular dynamics investigations of hammerhead ribozyme RNA

E. Westhof

European Biophysics Journal, 1998

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Roles of Long-Range Tertiary Interactions in Limiting Dynamics of the Tetrahymena Group I Ribozyme

Steve Bonilla

Journal of the American Chemical Society, 2014

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RNA Kink-Turns as Molecular Elbows: Hydration, Cation Binding, and Large-Scale Dynamics

Filip Razga

Structure, 2006

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Structural Dynamics of Precursor and Product of the RNA Enzyme from the Hepatitis Delta Virus as Revealed by Molecular Dynamics Simulations

Nils Walter

Journal of Molecular Biology, 2005

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Structural basis for heterogeneous kinetics: Reengineering the hairpin ribozyme

Nils Walter

Proceedings of the National Academy of Sciences, 1998

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Molecular Dynamics of Rna Structural Motif. Temperature Enhanced Sampling of the Conformational Space

Tadeusz Kulinski

Computational Methods in Science and Technology, 2002

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Base and Sugar Requirements for RNA Cleavage of Essential Nucleoside Residues in Internal Loop B of the Hairpin Ribozyme: Implications for Secondary Structure

Leonid Beigelman

Nucleic Acids Research, 1996

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The effect of structure in a long target RNA on ribozyme cleavage efficiency

Thomas Campbell

Nucleic Acids Research, 1997

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Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch

H. Al Hashimi

Nucleic Acids Research, 2012

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Extensive Molecular Dynamics Simulations Showing That Canonical G8 and Protonated A38H+ Forms Are Most Consistent with Crystal Structures of Hairpin Ribozyme

Nils Walter

Journal of Physical Chemistry B, 2010

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Simulation of the structure and dynamics of nonhelical RNA motifs

Martin Zacharias

Current Opinion in Structural Biology, 2000

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Rearrangement of a Stable RNA Secondary Structure during VS Ribozyme Catalysis

Richard Collins III

Molecular Cell, 2000

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Extensive Molecular Dynamics Simulations Showing That Canonical G8 and Protonated A38H + Forms Are Most Consistent with Crystal Structures of Hairpin Ribozyme

Nils Walter

The Journal of Physical Chemistry B, 2010

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RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview

Nils Walter

Chemical Reviews, 2018

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Ribosome-dependent conformational flexibility changes and RNA dynamics of IRES domains revealed by differential SHAPE

Gloria Lozano

Scientific Reports

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Conformationally restricted nucleotides as a probe of structure-function relationships in RNA

Ite Laird-offringa

RNA, 2008

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Global Structure and Flexibility of Hairpin Ribozymes with Extended Terminal Helices

Dietmar Porschke, Nils Walter

Journal of Molecular Biology, 1999

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Molecular dynamics simulation studies of a protein–RNA complex with a selectively modified binding interface

Anne Baranger

Biopolymers, 2006

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Entropy-Driven Folding of an RNA Helical Junction: An Isothermal Titration Calorimetric Analysis of the Hammerhead Ribozyme †

Peter Mikulecky

Biochemistry, 2004

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Native-like RNA Tertiary Structures Using a Sequence-Encoded Cleavage Agent and Refinement by Discrete Molecular Dynamics

Nikolay Dokholyan

Journal of the American Chemical Society, 2009

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Cation-Specific Structural Accommodation within a Catalytic RNA

John Burke

Biochemistry, 2006

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Sequence elements outside the catalytic core of natural hairpin ribozymes modulate the reactions differentially

Gerhard Steger

Biological Chemistry, 2011

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Elbow Flexibility of the kt38 RNA Kink-Turn Motif Investigated by Free-Energy Molecular Dynamics Simulations

Martin Zacharias

Biophysical Journal, 2009

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Inter-domain cross-linking and molecular modelling of the hairpin ribozyme

E. Westhof

Journal of Molecular Biology, 1997

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Inter-domain cross-linking and molecular modelling of the hairpin ribozyme 1 1 Edited by A. R. Fresh

Eric Westhof

Journal of Molecular Biology, 1997

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Triplex structures in an RNA pseudoknot enhance mechanical stability and increase efficiency of -1 ribosomal frameshifting

Ming-Yuan Chou

Proceedings of the National Academy of Sciences of the United States of America, 2009

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Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase

Steve Seibold

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010

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